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<p>1 Basics of NMR</p> <p>2 Magnetic Resonance Spectroscopy Instrumentation</p> <p>3 Detection coils for MRS</p> <p>4 A Practical Guide to in-vivo MRS</p> <p>5 Adiabatic Excitation Pulses for MRS</p> <p>6 Localized MRS employing radiofrequency field (B1) gradients</p> <p>7 Single Voxel MRS</p> <p>8 Chemical shift imaging with phase- and sensitivity-encoding</p> <p>9 Spatial Encoding and Decoding with Prior Knowledge from MRI and Spatio-Spectral Correlation</p> <p>10 Accurate Localized Spectroscopy from Anatomically Matched Regions with Optimal Spatial Response Function</p> <p>11 Accelerated Spatially-Encoded MRS of Arbitrarily-Shaped Compartments Using Linear Algebraic Modeling</p> <p>12 High-Speed Spatial-Spectral Encoding with Echo-Planar and Spiral Spectroscopic Imaging</p> <p>13 Direct Water--Fat Imaging Methods: Chemical Shift-Selective and Chemical Shift-Encoded MRI</p> <p>14 Physiological maintenance in animal experiments</p> <p>15 Physiological maintenance in MRI and MRS of large animals</p> <p>16 Physiological Monitoring in human MRS</p> <p>17 Physiologic Motion: Dealing with Cardiac, Respiratory and Other Sporadic Motion in MRS</p> <p>18 Quantifying Spectra in the Frequency Domain</p> <p>19 Quantifying Spectra in the Time Domain</p> <p>20 Advanced spectral quantification: parameter handling, non-parametric pattern modeling and multi-dimensional fitting</p> <p>21 1H-NMR Chemical Shifts and Coupling Constants for Brain Metabolites</p> <p>22 Pattern Recognition Analysis of MR Spectra</p> <p>23 Quantifying Metabolite Ratios and Concentrations by 1H MRS</p> <p>24 Quantifying Metabolite Ratios and Concentrations by Non-1H MRS</p> <p>25 Measuring intra- and extra-cellular pH by MRS</p> <p>26 Temperature Monitoring Using Chemical Shift</p> <p>27 Diffusion-Weighted MRS</p> <p>28 Measuring biochemical reaction rates in vivo with magnetization transfer</p> <p>29 Proton Chemical Exchange Saturation Transfer MRS and MRI</p> <p>30 Two-Dimensional NMR Spectroscopy Plus Spatial Encoding</p> <p>31 Spectral editing</p> <p>32 Multiple quantum MRS</p> <p>33 Hyperpolarization Methods for MRS</p> <p>34 Pulse sequences for hyperpolarized MRS</p> <p>35 MRS of Perfused Cells, Tissues and Organs</p> <p>36 Metabolism and Metabolomics by MRS</p> <p>37 In Vivo 19F MRS</p> <p>38 13C MRS in Human Tissue</p> <p>39 Hyperpolarized 13C MRI and MRS Studies</p> <p>40 Integrating 13C Isotopomer Methods with Hyperpolarization for a Comprehensive Picture of Metabolism</p> <p>41 Muscle studies by 1H MRS</p> <p>42 Muscle Studies by 31P MRS</p> <p>43 Measuring Intracellular Oxygenation with Myoglobin 1H MRS</p> <p>44 Body Fat MRS</p> <p>45 In Vivo MRS of Lipids in Adipose Tissue, Bone Marrow, and Liver</p> <p>46 Assessing Fatty Liver with MRS</p> <p>47 MRS Studies of Muscle and Heart in Obesity and Diabetes</p> <p>48 Studying Cardiac Lipids in Obese and Diabetic patients by 1H MRS</p> <p>49 Cardiac MRS Studies in Rodents and Other Animals</p> <p>50 Assessing Cardiac Transplant Viability with MRS</p> <p>51 MRS in the Failing Heart: from Mice to Humans</p> <p>52 MRS studies of Creatine Kinase metabolism in human heart</p> <p>53 Studying Aging, Dementia, Trauma, Infection, and Developmental Disorders of the Brain with 1H MRS</p> <p>54 Studying Stroke and Cerebral Ischemia by 1H MRS</p> <p>55 31P MRS in Psychiatric Disorders</p> <p>56 The significance of N-Acetyl Aspartate in Human Brain MRS</p> <p>57 MRS in Brain Cancer</p> <p>58 MRS in Breast Cancer</p> <p>59 MRS in Prostate Cancer</p> <p>60 Clinical Trials of MRS Methods</p> <p>61 Clinical Trials that Utilize MRS as a Biomarker</p> <p>62 Properties of NMR-visible isotopes and their biological content in human tissue</p> <p>63 Concentration ranges of common metabolites detected by MRS in healthy human tissue</p> <p>64 Peak Assignments for Some Common Metabolites</p> <p>65 Biochemical reactions and molecular structures of common MRS metabolites</p> <p>66 Some standard formulae used in MRS</p> <p>67 Common MRS Artefacts</p> <p>68 In Vivo Spectra with Peak Assignments</p>

<p><b>Paul A. Bottomley</b>, BSc (Hon.), 1975, PhD, 1978, Physics, University of Nottingham, UK. Research Associate, Johns Hopkins University, Baltimore, 1978–1980. Physicist, G. E. Research and Development Center, 1980–1994. Currently Russell H Morgan Professor and Director of the Division of MR Research, of the Russell H Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University. Fellow and Gold Medal recipient of the Society of Magnetic Resonance in Medicine, 1989; Coolidge Fellowship and medal, G.E. Company, 1990; Gold, Silver, and Bronze patent medals, G.E. Company; Gold Medal, American Roentgen Ray Society 2015; over 40 issued patents, about 180 peer-reviewed papers, 24 book chapters, 13 editorials, and over 225 published abstracts. Research specialties: in vivo NMR, MRI, tissue relaxation times, localized NMR spectroscopy, human cardiac NMR spectroscopy, interventional MRI, and MRI safety.<br /><br /><b>John Griffiths,</b> Qualified in medicine and biochemistry. In the early 1980s, his research group pioneered the use of MRS for studies on living tumors, and he has worked since then on MRI and MRS of cancer, both in vivo and ex vivo. He has published more than 300 peer-reviewed articles to date. His recent interests include the metabolomics of cancer.</p>

<p>In vivo magnetic resonance spectroscopy (MRS) has generated a vast cloud of scientific papers spanning numerous topics in a large diversity of journals, ranging from the physical sciences to the clinical ‘-ology’ literature. In addition, there is a vast amount of accumulated but unpublished inside knowledge on what makes a successful in vivo MRS study that is known only to its present and past practitioners. The goal of this comprehensive text, written by an outstanding group of world experts on MRS in vivo, is to steer a pathway through all of the technologies needed to perform MRS in vivo today and tomorrow, showing how to apply in vivo MRS today, what can and might be done with it, why it is useful, and how the results might be interpreted.</p> <p>The book begins with a first half on methodology that spans the basics of NMR, localization methods and MRS parametric measurements. The reader will find numerous spatial localization and signal processing techniques as well as methods for measuring metabolite diffusion, pH, chemical reaction rates and chemical exchange magnetization transfer, metabolite and fat concentrations, spin coupling, and multiple quantum transitions among non-proton (1H) nuclei. There are “how to” chapters on performing MRS on non-1H nuclei in vivo, and the latest methods for studying hyperpolarizing nuclei and the sequences needed to realize the enormous sensitivity gains now available therefrom.</p> <p>The second half of the book is comprised of applications to healthy and diseased tissues, from animal models to humans, which cover the entire body from head to limb. It starts with cells and tissue extracts, then studies of animals and organs for transplantation. This is followed by a series of critical reviews of the state-of-the-art of clinical and research applications of MRS in obesity, diabetes, heart, brain disorders and cancer. There are two reviews on the current state of clinical trials that employ MRS. The book ends with comprehensive appendices that include tabulations of tissue concentrations of NMR nuclei, common metabolites, spectral assignments, frequently-used equations, typical spectra, and common artefacts appearing in MRS in vivo, which should be of practical value.</p> <p>The audience for this reference book is multi-faceted, ranging from researchers involved in MRS methodology and its applications, to clinicians and biomedical scientists wishing to comprehend the types of clinical information that MRS can deliver, and how MRS can augment our understanding of healthy and disease states.  Undergraduate and postgraduate students, clinical radiological technicians and MRI scanner operators who are learning about MRS or training in magnetic resonance in medicine, as well as those just wishing to update their knowledge of current MRS methods, will find the book a useful compendium of the current state of the art of the field.</p> <p>About eMagRes Handbooks</p> <p>eMagRes publishes a wide range of online articles on all aspects of magnetic resonance in physics, chemistry, biology and medicine. The existence of this large number of articles, written by experts in various fields, is enabling the publication of a series of eMagRes Handbooks on specific areas of NMR and MRI. The chapters of each of these handbooks will comprise a carefully chosen selection of eMagRes articles. In consultation with the eMagRes Editorial Board, the eMagRes Handbooks are coherently planned in advance by specially-selected Editors, and new articles are written to give appropriate complete coverage. The handbooks are intended to be of value and interest to research students, postdoctoral fellows and other researchers learning about the scientific area in question and undertaking relevant experiments, whether in academia or industry.</p> <p>Have the content of this Handbook and the complete content of eMagRes at your fingertips! Visit: <a href="http://www.wileyonlinelibrary.com/ref/eMagRes">www.wileyonlinelibrary.com/ref/eMagRes</a></p> <p>[E-book logo] Also available as an e-book</p>

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