Details

Advanced Chemical Biology


Advanced Chemical Biology

Chemical Dissection and Reprogramming of Biological Systems
1. Aufl.

von: Howard C. Hang, Matthew R. Pratt, Jennifer A. Prescher

102,99 €

Verlag: Wiley-VCH
Format: PDF
Veröffentl.: 03.02.2023
ISBN/EAN: 9783527826292
Sprache: englisch
Anzahl Seiten: 800

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Beschreibungen

<b>Advanced Chemical Biology</b> <p><b>The modern approach to teaching chemical biology</b> <p><i>Advanced Chemical Biology</i> is organized around the central dogma of life, progressing from genes to proteins and higher-order cellular structures, including core application areas such as imaging, chemical genetics, activity-based protein profiling, and natural product discovery and biosynthesis. Advanced topics and applications in, e. g., microbiology, developmental biology, and neurobiology, are covered in separate sections. <p> Every chapter is homogeneous in style and layout, consisting of a short historical introduction followed by a description of the underlying concepts and a selection of recent examples of how the concept has been turned into practice. The subdivision of the contents into core and supplemental chapters enables a flexible use in teaching, both for a one-semester and a two-semester course. <p> Written by authors and editors coming from the leading scientific institutions that have developed the concepts and technologies for this discipline, <i>Advanced Chemical Biology</i> includes specific information on topics like: <ul><li>DNA function, synthesis and engineering, chemical approaches to genome integrity, and RNA function, synthesis, and probing</li> <li>Chemical approaches to transcription and RNA regulation in vivo, chemical biology of genome engineering, and peptide/protein synthesis and engineering</li> <li>Directed evolution for chemical biology, chemical biology of cellular metabolism, chemical biology of lipids, and protein post-translational modifications</li> <li>Chemical glycobiology, chemical and enzymatic modification of proteins, genetic code expansion, bio-orthogonal chemistry, and cellular imaging</li></ul> <p>With its broad scope and focus on turning concepts into applications, <i>Advanced Chemical Biology</i> is an excellent starting point for anyone entering the field and looking for a guide to the wide range of available methods and strategies that chemical biology has to offer. <p><b>With a Foreword by Nobel Laureate Carolyn Bertozzi.</b>
CORE TOPICS<br> Introduction<br> DNA function, synthesis and engineering<br> Chemical approaches to genome integrity and engineering<br> RNA function, synthesis and engineering<br> Chemical approaches to transcription and RNA regulation in vivo<br> Peptide synthesis and engineering<br> Protein engineering and semisynthesis<br> Biomolecular structure determination<br> Biomolecular structure prediction and design<br> Directed Evolution<br> Cellular metabolism<br> Membrane biology and lipid signaling<br> Posttranslational modifications<br> Chemical glycobiology<br> Bioconjugation<br> Genetic code expansion<br> Bioorthogonal chemistry<br> Cellular imaging<br> In vivo imaging<br> Natural product biosynthesis<br> Natural product discovery<br> Activity-based protein profiling<br> Chemical genetics<br> Development of small molecule probes and therapeutics<br> SUPPLEMENTAL TOPICS<br> Metals in biology<br> Chemical redox-biology<br> Chemical microbiology<br> Chemical mammalian cell biology<br> Chemical developmental biology<br> Chemical immunology<br> Chemical neurobiology<br> Chemical plant biology<br> Chemical virology<br> Chemical parasitology
Interessante Richtung des Lehrbuches, stärker aus chemischer Perspektive betrachtet. Erweitert dadurch den Blickwinkel aufs Fach gerade für Wissenschaftler die stärker aus der biologischen Richtung kommen.<br> Prof. Dr. David Kostner, Hochschule München, Biotechnologie (11/2023)
<p><b>Howard C. Hang,</b> PhD, Scripps Research, La Jolla, USA.</p> <p><b>Matthew R. Pratt,</b> PhD, University of Southern California, Los Angeles, USA.</p> <p><b>Jennifer A. Prescher,</b> PhD, University of California, Irvine, USA.</p>
<p><b>The modern approach to teaching chemical biology</b> <p><i>Advanced Chemical Biology</i> is organized around the central dogma of life, progressing from genes to proteins and higher-order cellular structures, including core application areas such as imaging, chemical genetics, activity-based protein profiling, and natural product discovery and biosynthesis. Advanced topics and applications in, e. g., microbiology, developmental biology, and neurobiology, are covered in separate sections. <p> Every chapter is homogeneous in style and layout, consisting of a short historical introduction followed by a description of the underlying concepts and a selection of recent examples of how the concept has been turned into practice. The subdivision of the contents into core and supplemental chapters enables a flexible use in teaching, both for a one-semester and a two-semester course. <p> Written by authors and editors coming from the leading scientific institutions that have developed the concepts and technologies for this discipline, <i>Advanced Chemical Biology</i> includes specific information on topics like: <ul><li>DNA function, synthesis and engineering, chemical approaches to genome integrity, and RNA function, synthesis, and probing</li> <li>Chemical approaches to transcription and RNA regulation in vivo, chemical biology of genome engineering, and peptide/protein synthesis and engineering</li> <li>Directed evolution for chemical biology, chemical biology of cellular metabolism, chemical biology of lipids, and protein post-translational modifications</li> <li>Chemical glycobiology, chemical and enzymatic modification of proteins, genetic code expansion, bio-orthogonal chemistry, and cellular imaging</li></ul> <p>With its broad scope and focus on turning concepts into applications, <i>Advanced Chemical Biology</i> is an excellent starting point for anyone entering the field and looking for a guide to the wide range of available methods and strategies that chemical biology has to offer. <p><b>With a Foreword by Nobel Laureate Carolyn Bertozzi.</b>

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