Details

Protein Therapeutics


Protein Therapeutics


Methods and Principles in Medicinal Chemistry 1. Aufl.

von: Tristan Vaughan, Jane Osbourn, Bahija Jallal, Raimund Mannhold, Gerd Folkers, Helmut Buschmann

250,99 €

Verlag: Wiley-VCH
Format: PDF
Veröffentl.: 28.07.2017
ISBN/EAN: 9783527699131
Sprache: englisch
Anzahl Seiten: 480

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Beschreibungen

In this practice-oriented two volume handbook, professionals from some of the largest biopharmaceutical companies and top academic researchers address the key concepts and challenges in the development of protein pharmaceuticals for medicinal chemists and drug developers of all trades. Following an introduction tracing the rapid development of the protein therapeutics market over the last decade, all currently used therapeutic protein scaffolds are surveyed, from human and non-human antibodies to antibody mimetics, bispecific antibodies and antibody-drug conjugates. This ready reference then goes on to review other key aspects such as pharmacokinetics, safety and immunogenicity, manufacture, formulation and delivery. The handbook then takes a look at current key clinical applications for protein therapeutics, from respiratory and inflammation to oncology and immune-oncology, infectious diseases and rescue therapy. Finally, several exciting prospects for the future of protein therapeutics are highlighted and discussed.
Contents to Volume 1 Preface XVII A Personal Foreword XXI Acknowledgements XXIII Part I Introduction to Protein Therapeutics: Past and Present 1 1 Early Recombinant Protein Therapeutics 3Pierre De Meyts 2 Evolution of Antibody Therapeutics 25Hervé Watier and Janice M. Reichert Part II Antibodies: The Ultimate Scaffold for Protein Therapeutics 51 3 Human Antibody Structure and Function 53Ponraj Prabakaran and Dimiter S. Dimitrov 4 Antibodies from Other Species 85Melissa L. Vadnais, Michael F. Criscitiello, and Vaughn V. Smider Part III Discovery and Engineering of Protein Therapeutics 113 5 Human Antibody Discovery Platforms 115William R. Strohl 6 Beyond Antibodies: Engineered Protein Scaffolds for Therapeutic Development 161Nishant K. Mehta and Jennifer R. Cochran 7 Protein Engineering: Methods and Applications 189Claire Dobson 8 Bispecifics 229Jijie Gu, Andrew McCluskey, and Tariq Ghayur 9 Antibody–drug Conjugates (ADCs) 271Dr Philip W. Howard Contents to Volume 2 Preface XVII A Personal Foreword XXI Acknowledgements XXIII Part IV Physiological and Manufacturing Considerations for Biologics 311 10 Pharmacokinetics of Therapeutic Proteins 313Zheng Lu, Jennifer Sheng, and Wenhui Zhang References 334 11 Safety Considerations for Biologics 341Maggie Dempster, Lucinda R. Weir, and Rajni S. Fagg 12 Immunogenicity of Biologics 387Matthew P. Baker, Timothy D. Jones, and Paul Chamberlain 13 Expression Systems for Recombinant Biopharmaceutical Production by Mammalian Cells in Culture 423Adam J. Brown, Devika Kalsi, Alejandro Fernandez-Martell, Joe Cartwright, Nicholas O. W. Barber, Yash D. Patel, Richard Turner, Claire L. Bryant, Yusuf B. Johari, and David C. James Abbreviations 450 References 452 14 Stability, Formulation, and Delivery of Biopharmaceuticals 469Hanns-Christian Mahler and Andrea Allmendinger Part V Clinical Applications 493 15 Protein Therapeutics in Autoimmune and Inflammatory Diseases 495Anthony J. Coyle and Leigh S. Zawel References 511 16 Antibody-Based Therapeutics in Oncology 521Paul A. Moore, Ross La Motte-Mohs, Jonathan C. Li, and Gurunadh R. Chichili 17 Protein Therapeutics in Respiratory Medicine 587 Rahul Shrimanker and Ian D. Pavord 18 Antibodies for the Prevention, Treatment, and Preemption of Infectious Diseases 611Steve Projan 19 Rescue Therapies 621Stephan Glund 20 Biosimilars 645Jun Wang Part VI Future Horizons 661 21 Future Horizons and New Target Class Opportunities 663Herren Wu, Carl Webster, Judy Paterson, Sandrine Guillard, Ron Jackson, and Ralph Minter References 690 Index 701
Tristan Vaughan is Vice President, Research and Development for antibody discovery and protein engineering at MedImmune. Based in Cambridge (UK), Dr. Vaughan leads the work of 110 scientists who are responsible for discovering and engineering around half of MedImmune's biologics portfolio, and who have delivered over 50 protein-based therapeutic candidates into the clinical phases of development. Dr. Vaughan joined MedImmune, previously Cambridge Antibody Technology, in 1993 and developed the platform technology which built the first human antibody libraries of 10 E10 members. He is also a key inventor of Humira and Benlysta. Dr. Vaughan has over 60 publications in peer-reviewed journals to his name. Jane Osbourn is Vice President, Research and Development at MedImmune and Site Leader for MedImmune Cambridge (UK). An expert in antibody engineering, Dr. Osbourn joined MedImmune, formerly Cambridge Antibody Technology, in 1993, and is an originator of key peer-reviewed publications and patents. She made a significant contribution to the discovery and development of marketed drugs (Humira and Benlysta) and more than 40 clinical candidates. Dr. Osbourn has worked across a range of disease areas and currently leads a team of researchers developing biosuperior biologics medicines in oncology, cardiovascular disease and diabetes. In addition, she is Chair of the UK BioIndustry Association, a Director of Babraham Bioscience Technologies and a Director of Cambridge Enterprise. Bahija Jallal is Executive Vice President of AstraZeneca and head of MedImmune, its global biologics research and development arm, based in Gaithersburg (USA). Prior to joining MedImmune, Dr. Jallal worked with Chiron Corporation where she served as vice president, drug assessment and development, and successfully established the company's translational medicine group. In 2013, Dr. Jallal earned the Grace Award from the Cancer Research Institute. She has authored over 70 peer-reviewed publications and has over 15 patents.
In this practice-oriented handbook, professionals from some of the largest biopharmaceutical companies and top academic researchers address the key concepts and challenges in the development of protein pharmaceuticals for medicinal chemists and other professionals working in drug development. Following an introduction tracing the rapid development of the protein therapeutics market over the last decade, all currently used therapeutic protein scaffolds are surveyed, from human and non-human antibodies to antibody mimetics, bispecific antibodies and antibody-drug conjugates. This ready reference then goes on to review other key aspects such as pharmacokinetics, safety and immunogenicity, manufacture, formulation and delivery. The handbook then takes a look at current key clinical applications for protein therapeutics, from respiratory and inflammation to oncology and immune-oncology, infectious diseases and rescue therapy. Finally, several exciting prospects for the future of protein therapeutics are highlighted and discussed.

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