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<p>Foreword xv</p> <p>Preface xvii</p> <p><b>1 Introduction 1</b><br /><i>Yu-Feng Li and Hongzhe Sun</i></p> <p>1.1 A Brief Introduction to Metallomics 1</p> <p>1.2 Key Issues and Challenges in Metallomics 3</p> <p>1.3 About the Structure of this Book 4</p> <p><b>2 Nanometallomics 11</b><br /><i>Hongxin Xie, Liming Wang, Jiating Zhao, Yuxi Gao, Bai Li, and Yu-Feng Li</i></p> <p>2.1 The Concept of Nanometallomics 11</p> <p>2.2 The Analytical Techniques in Nanometallomics 12</p> <p>2.3 The Application of Nanometallomics in Nanotoxicology 17</p> <p>2.4 Conclusions and Perspectives 21</p> <p><b>3 Environmetallomics 33</b><br /><i>Lihong Liu, Ligang Hu, Baowei Chen, Bin He, and Guibin Jiang</i></p> <p>3.1 The Concept of Environmetallomics 33</p> <p>3.2 The Analytical Techniques in Environmetallomics 34</p> <p>3.3 The Application of Environmetallomics in Environmental Science and Ecotoxicological Science and the Perspectives 43</p> <p><b>4 Agrometallomics 49</b><br /><i>Xuefei Mao, Xue Li, Tengpeng Liu, and Yajie Lei</i></p> <p>4.1 The Concept of Agrometallomics 49</p> <p>4.2 Analytical Techniques in Agrometallomics 52</p> <p>4.3 Application and Perspectives of Agrometallomics in Agricultural Science and Food Science 127</p> <p><b>5 Metrometallomics 153</b><br /><i>Liuxing Feng</i></p> <p>5.1 The Concept of Metrometallomics 153</p> <p>5.2 The Analytical Techniques in Metrometallomics 154</p> <p>5.3 The Application of Metrometallomics in Life Science and the Perspectives 159</p> <p><b>6 Medimetallomics and Clinimetallomics 193</b><br /><i>Guohuan Yin, Ang Li, Meiduo Zhao, Jing Xu, Jing Ma, Bo Zhou, Huiling Li, and Qun Xu</i></p> <p>6.1 The Concept of Medimetallomics and Clinimetallomics 193</p> <p>6.2 The Analytical Techniques in Medimetallomics and Clinimetallomics 195</p> <p>6.3 The Application of Medimetallomics and Clinimetallomics in Medical and Clinical Science and the Perspectives 204</p> <p><b>7 Matermetallomics 237</b><br /><i>Qing Li, Zhao-Qing Cai, Wen-Xin Cui, and Zheng Wang</i></p> <p>7.1 The Concept of Matermetallomics 237</p> <p>7.2 The Analytical Techniques in Matermetallomics 243</p> <p>7.3 The Application of Matermetallomics in Material Science and the Perspectives 256</p> <p><b>8 Archaeometallomics 265</b><br /><i>Li Li, Yue Zhou, Sijia Li, Lingtong Yan, Heyang Sun, and Xiangqian Feng</i></p> <p>8.1 The Concept of Archaeometallomics 265</p> <p>8.2 The Analytical Techniques in Archaeometallomics 266</p> <p>8.3 The Application of Archaeometallomics in Archaeological Science 269</p> <p>8.4 Summary and Perspectives 279</p> <p><b>9 Metallomics in Toxicology 285</b><br /><i>Ruixia Wang, Ming Gao, Jiahao Chen, Mengying Qi, and Ming Xu</i></p> <p>9.1 Metallomic Research on the Toxicology of Metals 285</p> <p>9.2 Recent Progresses in Understanding the Health Effects of Heavy Metals 287</p> <p>9.3 Knowledge Gaps, Challenges, and Perspectives 297</p> <p><b>10 Pathometallomics: Taking Neurodegenerative Disease as an Example 311</b><br /><i>Xiubo Du, Xuexia Li, and Qiong Liu</i></p> <p>10.1 Introduction to Pathometallomics 311</p> <p>10.2 Application of Pathometallomics in Neurodegenerative Diseases 314</p> <p>10.3 The Perspectives of Pathometallomics 338</p> <p><b>11 Oncometallomics: Metallomics in Cancer Studies 349</b><br /><i>Xin Wang, Chao Li, and Yu-Feng Li</i></p> <p>11.1 Introduction to Oncometallomics 349</p> <p>11.2 The Application of Oncometallomics in Cancer Studies 351</p> <p>11.3 The Metallome that Involved in the Occurrence and Development of Cancer 355</p> <p>11.4 Conclusions and Perspectives 356</p> <p><b>12 Bio-elementomics 363</b><br /><i>Dongfang Wang, Jing Wu, Bing Cao, Lailai Yan, Qianqian Zhao, Tiebing Liu, and Jingyu Wang</i></p> <p>12.1 Introduction 363</p> <p>12.2 Basic Laws of Bio-elementomics 364</p> <p>12.3 Rare-Earth Elementome 367</p> <p>12.4 Limitations of Bio-elementomics 371</p> <p>12.5 Perspectives 373</p> <p><b>13 Methodology and Tools for Metallomics 377</b><br /><i>Xiaowen Yan, Ming Xu, and Qiuquan Wang</i></p> <p>13.1 Brief Description of Metallomics 377</p> <p>13.2 Methodologic Strategy for Metallomic Research 380</p> <p>13.3 Tools for Metallomics 383</p> <p>13.4 Concluding Remarks 387</p> <p><b>14 ICP-MS for Single-Cell Analysis in Metallomics 391</b><br /><i>Man He, Beibei Chen, and Bin Hu</i></p> <p>14.1 Introduction 391</p> <p>14.2 ICP-MS Instrumental Optimization for Single-Cell Analysis 392</p> <p>14.3 Microfluidic Platform for Single-Cells Analysis 401</p> <p>14.4 ICP-MS-Based Single-Cells Analysis in Metallomics 408</p> <p>14.5 Summary and Perspectives 419</p> <p><b>15 Novel ICP-MS-based Techniques for Metallomics 429</b><br /><i>Panpan Chang and Meng Wang</i></p> <p>15.1 Introduction 429</p> <p>15.2 ICP-MS: A Powerful Method in Metallomics 430</p> <p>15.3 Recent Advances in ICP-MS-based Metallomics 433</p> <p>15.4 Conclusions 442</p> <p><b>16 Machine Learning for Data Mining in Metallomics 449</b><br /><i>Wei Wang and Xin Wang</i></p> <p>16.1 Data Mining Methods in Metallomics 450</p> <p>16.2 Application of Machine Learning for Data Mining in Metallomics 463</p> <p>References 469</p> <p>Index 471</p>

<p> <i><b>Yu-Feng Li, </b> PhD, is the Acting Associate Director of the CAS-HKU Joint Laboratory of Metallomics on Health and Environment, Beijing, China. He is a past recipient of the Chinese Academy of Sciences Lu Jiaxi Young Talent Award and the Young Scientist Award of the First International Symposium on Metallomics, and has published extensively on metallomics and related subjects. </i> <p><i><b>Hongzhe Sun, </b> PhD, is the Director of the CAS-HKU Joint Laboratory of Metallomics on Health and Environment, Hong Kong, China. He has published very widely on metallomics and related subjects, and his past awards include the UC Berkeley Earl L. Muetterties Memorial Lectureship and the Croucher Senior Research Fellowship.</i>

<p> <b>A groundbreaking survey of a field that unites the sciences </b> <p>The metallome of a cellular compartment, such as an enzyme, is the variety and arrangement of its metal ions. Metallomics is the multidisciplinary study of the metallome and its many important interactions with biological molecules and systems. It exists at the intersection of biochemistry and materials science, offering crucial insights into biological processes in which iron, for instance, plays a pivotal role. <p><i>Applied Metallomics </i>is an up-to-the-minute overview of research developments in metallomics, offering both analysis and applications in a vast array of scientific and industrial areas. Moving freely between material science, environmental science, health science, and more, it offers a comprehensive survey of this interdisciplinary research area. As the field of metallomics continues to develop and its applications expand, this book will only be a need of the hour <p><i>Applied Metallomics </i>readers will also find: <ul><li>Detailed treatment of nanometallomics, environmetallomics, agrometallomics, and many more </li> <li>Coverage of machine learning and artificial intelligence techniques with applications in metallomics </li> <li>An author team with vast international research experiences</li> </ul> <p><i>Applied Metallomics </i> is ideal for researchers in many areas touched by metallomics, that include chemistry, biochemistry, biotechnology, bioinorganic chemistry, and more.

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