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GENERAL FEATURES of APOPTOSIS<br> Apoptosis and Autoimmunity (Keith, Elkon)<br> Caspase Knockouts: Matters of Life and Death (Lakhani, Lu, Flavell)<br> CLEARANCE OF APOPTOTIC CELLS<br> Anti-inflammatory and Immunoregulatory Effects of Apoptotic Cells (Voll, Herrmann Girkontaite, Kolowos, Kalden)<br> Complement and Apoptosis (Mevorach)<br> Soluble Factors that Bind to Dying Cells Control the Outcome of Corpse Disposal: the Role of Pentraxins, Collectins, and Auto-antibodies (Rovere-Querini)<br> The Role of ATP-binding Cassette Transporters in the Clearance of Apoptotic Cells: A Tale of Two Systems (Rigot, Chimini)<br> Innate Immunity and Apoptosis: CD14-dependent Clearance of Apoptotic Cells (Gregory, Devitt)<br> AUTOIMMUNITY CAUSED BY DEFECTIVE EXECUTION OF APOPTOSIS OR DEFECTIVE CLEARANCE OF APOPTOTIC CELLS<br> Autoimmune Lymphoproliferative Syndromes (ALPS) (Rieux-Laucat, Deist, Fischer)<br> Infection and Inflammation as Cofactors for Autoimmunity of Systematic Lupus Erythematosus Patients (Lorenz)<br> Apoptosis in Rheumatoid Arthritis (Yamanishi, Firestein)<br> Systemic Lupus Erythematosus (SLE) (Beyer, Kuenkele, Gaipl, Kolowos, Voll, Baumann, Kalden, Herrmann)<br> IMMUNOGENICITY OF APOPTOTIC CELLS<br> Dendritic Cells Pulsed with Apoptotic Tumour Cells as Vaccines (Jenne, Sauter)<br> The Immune Response against Apoptotic Cells (Manfredi)<br> "ALTERED SELF" IN DYING CELLS<br> Autoantigens as Substrates for Apoptotic Proteases: Implications for the Pathogenesis of Systemic Autoimmune Disease (Rosen, Casciola-Rosen)<br> Distinct Cleavage Products of Nuclear Autoantigens in Apoptosis and Necrosis: Implications for Autoimmunity (Casiano, Molinaro, Holder, Wu)<br> 'Tissue' Transglutaminase and Autoimmunity (Amendola, Piacentini)<br> Modification of RNA -<br> Antigens in apoptosis (Utz)<br> THE ROLE OF DNA BINDING PROTEINS FOR SYSTEMIC AUTOIMMUNITY<br> Nucleosomes and anti-Nucleosome Autoantibodies as Mediators of Glomerular Pathology in Systemic Lupus Erythematosus (Dieker, van der Vlag Berden)<br> GLOSSARY

“...illustrated by original figures, schemas, and tables and contains interesting experimental data...well written and organized....” (<i>Pharmaceutical Research</i>, Vol. 20, No. 12, December 2003)

<p><strong>Joachim R. Kalden</strong> is the editor of <em>Apoptosis and Autoimmunity: From Mechanisms to Treatments</em>, published by Wiley. <p><strong>Martin Herrmann</strong> is the editor of <em>Apoptosis and Autoimmunity: From Mechanisms to Treatments</em>, published by Wiley.

Apoptosis and autoimmunity are hot topics in cell biology and immunology and interrelations between the two phenomena were reflected in the lectures given at the centenary celebrations of the Nobel Prize in 2001. Animal models and clinical observations indicate that the defective execution of apoptosis or defective clearance of apoptotic cells may cause severe dysfunctions, resulting in such autoimmune diseases as rheumatoid arthritis and lupus erythematosus. <p>This is the first book to provide a concise insight into the molecular and cellular mechanisms of regular and misdirected apoptosis as well as its implications for the development of autoimmune diseases.</p> <p>Researchers and clinicians alike will appreciate the perspectives on new strategies in diagnostics and therapy. The text is rounded off by a glossary explaining over 100 related terms, many of them precisely defined here for the first time.</p>

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