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Contributors vii <p>Preface ix</p> <p><b>Section I Oocyte and Early Embryo 1</b></p> <p>1 Transcription in the Xenopus Oocyte Nucleus 3<br /> <i>Joseph G. Gall</i></p> <p>2 RNA Localization during Oogenesis in Xenopus laevis 16<br /> <i>James O. Deshler</i></p> <p>3 From Oocyte to Fertilizable Egg: Regulated mRNA Translation and the Control of Maternal Gene Expression 38<br /> <i>Chad E. Cragle & Angus M. MacNicol</i></p> <p>4 Polarity of Xenopus Oocytes and Early Embryos 60<br /> <i>Malgorzata Kloc</i></p> <p>5 Germ-Cell Specification in Xenopus 75<br /> <i>Mary Lou King</i></p> <p><b>Section II Midblastula</b> Transition, Gastrulation, and Neurulation 101</p> <p>6 The Xenopus Embryo as a Model System to Study Asymmetric Furrowing in Vertebrate Epithelial Cells 103<br /> <i>Jacek Z. Kubiak, Isabelle Chartrain, & Jean-Pierre Tassan</i></p> <p>7 Induction and Differentiation of the Xenopus Ciliated Embryonic Epidermis 112<br /> <i>Marie Cibois, Pierluigi Scerbo, Virginie Thomé, Andrea Pasini, & Laurent Kodjabachian</i></p> <p>8 Wnt Signaling during Early Xenopus Development 130<br /> <i>François Fagotto</i></p> <p>9 Neural Tube Closure in Xenopus 163<br /> <i>Hitoshi Morita, Makoto Suzuki, & Naoto Ueno</i></p> <p><b>Section III Metamorphosis and Organogenesis 187</b></p> <p>10 Primordial Germ Cell Migration 189<br /> <i>Aliaksandr Dzementsei & Tomas Pieler</i></p> <p>11 Development of Gonads, Sex Determination, and Sex Reversal in Xenopus 199<br /> <i>Rafa³ P. Piprek & Jacek Z. Kubiak</i></p> <p>12 The Xenopus Pronephros: A Kidney Model Making Leaps toward Understanding Tubule Development 215<br /> <i>Rachel K. Miller, Moonsup Lee, & Pierre D. McCrea</i></p> <p>13 Development of Neural Tissues in Xenopus laevis 239<br /> <i>William A. Muñoz, Amy K. Sater, & Pierre D. McCrea</i></p> <p>14 The Development of the Immune System in Xenopus 264<br /> <i>Louis Du Pasquier</i></p> <p>15 Neural Regeneration in Xenopus Tadpoles during Metamorphosis 293<br /> <i>Mauricio Moreno, Karina Tapia, & Juan Larrain</i></p> <p><b>Section IV Novel Techniques and Approaches 309</b></p> <p>16 Atomic Force Microscopy Imaging of Xenopus laevis Oocyte Plasma Membrane 311<br /> <i>Francesco Orsini</i></p> <p>17 Size Scaling of Subcellular Organelles and Structures in Xenopus laevis and Xenopus tropicalis 325<br /> <i>Lisa J. Edens & Daniel L. Levy</i></p> <p>18 A Model for Retinal Regeneration in Xenopus 346<br /> <i>Masasuke Araki</i></p> <p>19 The Xenopus Model for Regeneration Research 368<br /> <i>Ying Chen & Gufa Lin</i></p> <p>20 Genomics and Genome Engineering in Xenopus 383<br /> <i>Léna Vouillot, Aurore Thélie, Thibault Scalvenzi, & Nicolas Pollet</i></p> <p>Index 403</p>

<p><b>Malgorzata Kloc</b> is the Weill Cornell Professor of Cell and Molecular Biology and Director of the Immuno-Biology Laboratory at the Houston Methodist Hospital Research Institute and Adjunct Associate Professor at the University of Texas M D Anderson Cancer Center</p> <p><b>Jacek Z. Kubiak</b> is a DR2 Researcher in the CNRS at the Institute of Genetics and Development and at the University of Rennes 1</p>

<p>Frogs from the genus Xenopus have long been used as model organisms in basic and biomedical research. These frogs have helped unlock key fundamental developmental and cellular processes that have led to important scientific breakthroughs and have had practical application in embryology, cancer research and regenerative medicine. Xenopus Development is a vital resource on the biology and development of these key model organisms, and will be a great tool to researchers using these frogs in various disciplines of<br /> biological science.</p> <p><i>Xenopus Development</i> is divided into four sections, the first three highlight key processes in Xenopus development from embryo to metamophosis. These sections focus on the cellular processes, organogenesis and embryo development. The final section highlights novel techniques and approaches<br /> being used in Xenopus research.</p> <p>Providing thorough and detailed coverage, Xenopus Development, will be a timely and welcome volume for those working in cell and molecular biology, genetics, developmental biology and biomedical research.</p> <p>• Provides broad overview of the developmental biology of both Xenopus laevis and Xenopus tropicalis<br /> • Explores cellular to systems development in key biomedical model organisms<br /> • Timely synthesis of the field of Xenopus biology<br /> • Highlights key biomedical and basic biological findings unlocked by Xenopus</p>

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