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<p>List of Contributors</p> <p>Preface to the Fourth Edition</p> <p>Preface to the First Edition</p> <p>Historical Introduction: The Drug Treatment of Epilepsy from 1857 to 2015 <br /><i>Simon Shorvon</i></p> <p><b>Section I ? Introduction (Lead editor: Simon Shorvon)</b></p> <p>1 Definition (Terminology) and Classification in Epilepsy: A Historical Survey and Current Formulation, with Special Reference to the ILAE 1<br /><i>Simon Shorvon</i></p> <p>2 Differential Diagnosis of Epilepsy 24<br /><i>Mark Cook</i></p> <p>3 Mechanisms of Epileptogenesis 38<br /><i>Giuliano Avanzini and Silvana Franceschetti</i></p> <p>4 Antiepileptic Drug Discovery 52<br /><i>H. Steve White and Melissa Barker-Haliski</i></p> <p>5 Antiepileptic Drug Development 61<br /><i>Dieter Schmidt</i></p> <p>6 Mechanisms of Antiepileptic Drug Action 75<br /><i>Matthew C. Walker and Rainer Surges</i></p> <p>7 Mechanisms of Drug Resistance and Tolerance 92<br /><i>Wolfgang Loscher and Dieter Schmidt</i></p> <p>8 Epilepsy Biomarkers 103<br /><i>Jerome Engel, Jr. and Asla Pitkanen</i></p> <p><b>Section II ? Principles of Medical Management (Lead editor: Simon Shorvon)</b></p> <p>9 General Principles of Medical Management 110<br /><i>Emilio Perucca</i></p> <p>10 Pharmacokinetic Optimization of Therapy 124<br /><i>Svein I. Johannessen, Cecilie Johannessen Landmark and Emilio Perucca</i></p> <p>11 Management of Chronic Active Epilepsy in Adults 139<br /><i>Simon Shorvon</i></p> <p>12 Management of Epilepsy in Remission 148<br /><i>Patrick Kwan, Howan Leung and Xiaoting Hao</i></p> <p>13 Management of Epilepsy in Neonates and Infants 156<br /><i>Elissa G. Yozawitz and Solomon L. Moshe</i></p> <p>14 Management of Childhood Epilepsy Syndromes 174<br /><i>Colin D. Ferrie</i></p> <p>15 Management of Epilepsy in People with Intellectual Disabilities 193<br /><i>Eylert Brodtkorb</i></p> <p>16 Management of Epilepsy in the Elderly 205<br /><i>Hiba Arif Haider and Lawrence J. Hirsch</i></p> <p>17 Emergency Treatment of Seizures and Status Epilepticus 221<br /><i>Matthew C. Walker and Simon Shorvon</i></p> <p>18 Management of Medical Comorbidity Associated with Epilepsy 245<br /><i>Gagandeep Singh</i></p> <p>19 Psychiatric Features of Epilepsy and their Management 259<br /><i>Brent Elliott and Simon Shorvon</i></p> <p>20 Prevention and Management of Side-effects of Antiepileptic Drugs 275<br /><i>Gaetano Zaccara and Piero Perucca</i></p> <p>21 Ketogenic Diets 288<br /><i>Eric H. Kossoff and Courtney A. Haney</i></p> <p>22 Complementary and Alternative Treatments for Epilepsy 298<br /><i>Sallie Baxendale</i></p> <p>23 Reproductive Aspects of Epilepsy Treatment 311<br /><i>Torbjorn Tomson</i></p> <p>24 Genetic Counselling in Epilepsy 323<br /><i>Federico Zara</i></p> <p>25 Drug Interactions 344<br /><i>Edoardo Spina and Domenico Italiano</i></p> <p>26 Medical Treatment of Epilepsy in Resource-Poor Countries 360<br /><i>Patrick Adjei</i></p> <p><b>Section III ? Antiepileptic Drugs (Lead editor: Emilio Perucca)</b></p> <p>27 Introduction to the Choice of Antiepileptic Drugs 365<br /><i>Emilio Perucca</i></p> <p>28 Acetazolamide 376<br /><i>Miri Y. Neufeld</i></p> <p>29 Adrenocorticotropic Hormone and Corticosteroids 388<br /><i>Federico Vigevano and Maria Roberta Cilio</i></p> <p>30 Benzodiazepines Used in the Treatment of Epilepsy 398<br /><i>Eugen Trinka and Francesco Brigo</i></p> <p>31 Brivaracetam 418<br /><i>Joseph D?Souza and Emilio Perucca</i></p> <p>32 Carbamazepine 431<br /><i>Torbjorn Tomson and Svein I. Johannessen</i></p> <p>33 Eslicarbazepine Acetate 447<br /><i>Meir Bialer and Christian Elger</i></p> <p>34 Ethosuximide 460<br /><i>Tracy A. Glauser and Emilio Perucca</i></p> <p>35 Felbamate 472<br /><i>Ilo E. Leppik and James R. White</i></p> <p>36 Gabapentin 479<br /><i>Ernest R. Somerville, Andrew W. Michell and Arjune Sen</i></p> <p>37 Lacosamide 489<br /><i>Rajesh Sachdeo and Roopal Karia</i></p> <p>38 Lamotrigine 498<br /><i>Awais Riaz and Fumisuke Matsuo</i></p> <p>39 Levetiracetam 516<br /><i>Derek J. Chong and Jacqueline A. French</i></p> <p>40 Oxcarbazepine 533<br /><i>Edward Faught and Hyunmi Kim</i></p> <p>41 Perampanel 546<br /><i>Martin Brodie</i></p> <p>42 Phenobarbital, Primidone and Other Barbiturates 555<br /><i>Roberto Michelucci and Elena Pasini</i></p> <p>43 Phenytoin 574<br /><i>Mervyn J. Eadie</i></p> <p>44 Piracetam 589<br /><i>Simon D. Shorvon</i></p> <p>45 Pregabalin 595<br /><i>Sylvain Rheims and Philippe Ryvlin</i></p> <p>46 Retigabine 606<br /><i>Michel Baulac</i></p> <p>47 Rufinamide 617<br /><i>Victor Biton</i></p> <p>48 Stiripentol 628<br /><i>Tapani Keranen</i></p> <p>49 Tiagabine 633<br /><i>Reetta Kalviainen</i></p> <p>50 Topiramate 642<br /><i>J. Helen Cross and Catherine J. Riney</i></p> <p>51 Valproate 652<br /><i>Anthony G. Marson and Graeme J. Sills</i></p> <p>52 Vigabatrin 667<br /><i>Gunter Kramer and Gabriele Ch. Wohlrab</i></p> <p>53 Zonisamide 680<br /><i>Michel Baulac</i></p> <p>54 Other Less Commonly Used Antiepileptic Drugs 689<br /><i>Martin Holtkamp</i></p> <p>55 Drugs in Clinical Development 701<br /><i>Norman Delanty and H. Steve White</i></p> <p><b>Section IV ? Presurgical Assessment and Epilepsy Surgery (Lead editor: Jerome Engel, Jr.)</b></p> <p>56 Overview of Surgical Treatment for Epilepsy 709<br /><i>Jerome Engel, Jr.</i></p> <p>57 Scalp EEG in the Epilepsy Surgery Evaluation 723<br /><i>Christine B. Baca and John M. Stern</i></p> <p>58 Invasive EEG in Presurgical Evaluation of Epilepsy 733<br /><i>Dennis Spencer, Dang K. Nguyen and Adithya Sivaraju</i></p> <p>59 MEG in Epilepsy Surgery Evaluation 756<br /><i>Hermann Stefan and Paul Boon</i></p> <p>60 MRI in Presurgical Evaluation 764<br /><i>Christian E. Elger and Bernd Weber</i></p> <p>61 PET and SPECT in Presurgical Evaluation of Epilepsy 775<br /><i>Karolien Goffin and Wim Van Paesschen</i></p> <p>62 Special Neurophysiological Techniques 787<br /><i>Francois Mauguiere and Julien Jung</i></p> <p>63 Neuropsychological Testing in Presurgical Evaluation 804<br /><i>Marilyn Jones-Gotman and Gail L. Risse</i></p> <p>64 Presurgical Psychiatric Evaluation 817<br /><i>Andres M. Kanner</i></p> <p>65 Mesial Temporal Lobe Surgery and Other Lobar Resections 829<br /><i>James Leiphart and Itzhak Fried</i></p> <p>66 Resective Surgery of Neoplasms 842<br /><i>Nicholas M. Wetjen and Gregory D. Cascino</i></p> <p>67 Resective Surgery of Vascular and Infective Lesions for Epilepsy 858<br /><i>Christopher E. Uff and Neil D. Kitchen</i><br /><br />68 Surgery of Developmental Anomalies Causing Epilepsy 878<br /><i>Ahyuda Oh, Joshua J. Chern and Youssef G. Comair</i></p> <p>69 Hemispheric Operations for Epilepsy 887<br /><i>Georg Dorfmuller, Christine Bulteau and Olivier Delalande</i></p> <p>70 Corpus Callosum Operations 895<br /><i>David W. Roberts</i></p> <p>71 Hypothalamic Hamartoma 903<br /><i>John F. Kerrigan</i></p> <p>72 Multiple Subpial Transection 916<br /><i>Adriana Bermeo-Ovalle and Michael C. Smith</i></p> <p>73 Awake Surgery for Epilepsy 922<br /><i>Webster H. Pilcher</i></p> <p>74 Epilepsy Surgery in Children 931<br /><i>Jason S. Hauptman and Gary W. Mathern</i></p> <p>75 Complications of Epilepsy Surgery 941<br /><i>Charles E. Polkey</i></p> <p>76 Anaesthesia for Epilepsy Surgery 952<br /><i>Barbara M. Van de Wiele</i></p> <p>77 Vagus and Trigeminal Nerve Stimulation 959<br /><i>Steven C. Schachter</i></p> <p>78 Brain Stimulation for Epilepsy 967<br /><i>Gregory K. Bergey and Robert S. Fisher</i></p> <p>79 Non-Resective Approaches for Medically Intractable Epilepsy 980<br /><i>Thomas J. Gianaris, Andrea G. Scherer and Nicholas M. Barbaro</i></p> <p>80 Future Focal Treatment Approaches to Epilepsy 987<br /><i>Laura Mantoan Ritter and Hannah Cock</i></p> <p>81 Epilepsy Surgery in Countries with Limited Resources 999<br /><i>Andre Palmini and Kurupath Radhakrishnan</i></p> <p>Index 1008</p>

<p><b>Simon Shorvon MA MB BChir MD FRCP<br /></b>Professor in Clinical Neurology and Clinical SubDean, UCL Institute of Neurology, University College London and Consultant Neurologist, National Hospital for Neurology and Neurosurgery, Queen Square, London, UK</p> <p><b>Emilio Perucca MD PhD FRCP(Edin)<br /></b>Professor of Medical Pharmacology, Clinical Pharmacology Unit, Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy; and Director, Clinical Trial Center, C Mondino National Neurological Institute, Pavia, Italy</p> <p><b>Jerome Engel Jr MD PhD<br /></b>Director, Seizure Disorder Center, Jonathan Sinay Distinguished Professor, Neurology, Neurobiology, Psychiatry and Behavioural Sciences, David Geffen School of Medicine at UCLA, Los Angeles, California, USA</p>

<p><b>An indispensable clinical reference work which offers a clear practical clinical guide to the whole field of epilepsy therapy.</b></p> <p>A wide range of treatment options are available for epilepsy, which depend on the nature of the epilepsy and the circumstances of the individual patient. Identifying the best regimen can be complex, and neurologists, paediatricians, epileptologists and trainees need a clear, concise yet comprehensive guide to the best treatment options.</p> <p><i>The Treatment of Epilepsy</i>, fourth edition, provides such a guide, describing all conventional pharmacological, medical and surgical options available for the treatment of epilepsy, and putting them in their appropriate clinical context. The book is compiled by three editors actively involved with the International League of Epilepsy, and written by renowned international experts in the field from 18 countries. </p> <ul> <li>This fourth edition has been extensively revised incorporating the many recent developments in therapy,</li> <li>The first two sections cover the background to, and principles of, treatment in different clinical situations,</li> <li>Section three comprises a series of systematic reviews of contemporary drug therapy, devoting one chapter to each anti-epileptic drug and covering all clinically-relevant aspects,</li> <li>Section four focuses on the surgical options, devoting individual chapters to each of the modalities of presurgical assessment and to each surgical operation or approach,</li> <li>Drug and prescribing data presented in clear tables for quick clinical referral,</li> <li>The text consists of 81 chapters and a historical introduction, and is now in full color with many clear tables and figures.</li> </ul> <p> <b>Praise for previous editions:</b></p> <p>"<i>Treatment of Epileps</i>y is a vital contribution to the field. The book's primary focus is on the medical and surgical evaluation and treatment of the disease. Experts around the globe who have made seminal contributions to the treatment of epilepsy have contributed to the book, which preserves its flow and focus extremely well.… 'This book is highly recommended' … 'for anybody who is involved in the evaluation and medical care of patients with epilepsy.'"  (<i>NEJM</i>, February 2005)</p> "I would highly recommend <i>The Treatment of Epilepsy</i> for neurologists, neurosurgeons, psychiatrists, pediatricians, and internists, as well as nurse practitioners, physician's assistants, and others who are interested in delving into the details of the treatment of epilepsy." (<i>Epilepsy & Behavior</i>, 6 October 2010)

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