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<p>About the Companion Website xvii</p> <p><b>Section 1 Anatomy of the Pancreas 1</b></p> <p>1 Development of the Pancreas and Related Structures 3<br /> <i>Brian Lewis and Junhao Mao</i></p> <p>2 Anatomy, Histology, and Fine Structure of the Pancreas 9<br /> <i>Daniel S. Longnecker and Elizabeth D. Thompson</i></p> <p>3 Congenital and Inherited Anomalies of the Pancreas 23<br /> <i>Heiko Witt and Martin Zenker</i></p> <p><b>Section 2 Physiology and Pathophysiology of Pancreatic Functions 33</b></p> <p>4 Physiology of Acinar Cell Secretion 35<br /> <i>Ole H. Petersen</i></p> <p>5 Physiology of Duct Cell Secretion 48<br /> <i>Wei- Yin Lin, Paramita Sarkar, and Shmuel Muallem</i></p> <p>6 Physiology and Pathophysiology of Function of Sphincter of Oddi 56<br /> <i>Savio George Barreto and James Toouli</i></p> <p>7 Neurohormonal and Hormonal Control of Pancreatic Secretion 65<br /> <i>Chung Owyang and Matthew J. DiMagno</i></p> <p>8 Regulation of Pancreatic Protein Synthesis and Growth 75<br /> <i>Maria Dolors Sans and John A. Williams</i></p> <p>9 Fibrogenesis in the Pancreas: The Role of Pancreatic Stellate Cells 86<br /> <i>Minoti V. Apte, Romano C. Pirola, and Jeremy S. Wilson</i></p> <p>10 Pancreatic Endocrine–Exocrine Relationship 98<br /> <i>Kenichiro Furuyama and Yoshiya Kawaguchi</i></p> <p><b>Section 3 Acute Pancreatitis 105</b></p> <p>11 Epidemiology and Etiology of Alcohol- Induced Pancreatitis 107<br /> <i>Jeremy S. Wilson, Romano C. Pirola, and Minoti V. Apte</i></p> <p>12 Epidemiology and Etiology of Biliary Acute Pancreatitis 119<br /> <i>Ippei Ikoma, Ko Tomishima, and Hiroyuki Isayama</i></p> <p>13 Genetic Factors in Acute Pancreatitis 128<br /> <i>Mitchell L. Ramsey and Georgios I. Papachristou</i></p> <p>14 The Role of the Intestine and Mesenteric Lymph in the Development of Organ Dysfunction in Severe Acute Pancreatitis 138<br /> <i>Alistair B.J. Escott, Anthony R.J. Phillips, and John A. Windsor</i></p> <p>15 The Role of Neurogenic Inflammation in Pancreatitis 146<br /> <i>Metrah Mohammad Nader and Jami L. Saloman</i></p> <p>16 Molecular, Biochemical, and Metabolic Abnormalities of Acute Pancreatitis 155<br /> <i>Ujjwal M. Mahajan, F. Ulrich Weiss, Markus M. Lerch, and Julia Mayerle</i></p> <p>17 Histopathology of Acute Pancreatitis 164<br /> <i>Günter Klöppel</i></p> <p>18 Severity Classification of Acute Pancreatitis 170<br /> <i>John A. Windsor</i></p> <p>19 Clinical Assessment and Biochemical Markers to Objectify Severity and Prognosis 176<br /> <i>Bettina M. Rau and Claus Schäfer</i></p> <p>20 Acute Pancreatitis Associated with Congenital Anomalies 185<br /> <i>Charlotte S. Austin, Christopher R. Schlieve, Andrew L. Warshaw, and Tracy C. Grikscheit</i></p> <p>21 Acute Pancreatitis in Children 191<br /> <i>Mark E. Lowe and Véronique D. Morinville</i></p> <p>22 Acute Pancreatitis Associated with Metabolic, Infections and Drug- Related Diseases 199<br /> <i>Ali A. Aghdassi, Mats L. Wiese, Quang Trung Tran, and Markus M. Lerch</i></p> <p>23 Radiologic Diagnosis and Staging of Severe Acute Pancreatitis 208<br /> <i>Yoshihisa Tsuji</i></p> <p>24 Conservative Therapy of Acute Pancreatitis: Volume Substitution and Enteral and Parenteral Nutrition 222<br /> <i>Steven M. Hadley, Jr. and Timothy B. Gardner</i></p> <p>25 ICU Treatment of Severe Acute Pancreatitis 230<br /> <i>Scott R. Gunn and David C. Whitcomb</i></p> <p>26 Clinical Course and Medical Treatment of Acute Pancreatitis— Use of Antibiotics in Severe Acute Pancreatitis: Indications and Limitations 238<br /> <i>Rainer Isenmann and Mathias Wittau</i></p> <p>27 Indications for Interventional and Surgical Treatment of Necrotizing Pancreatitis 244<br /> <i>Lily V. Saadat and Thomas E. Clancy</i></p> <p>28 Management of Infected Necrosis: Step- Up Approach 254<br /> <i>Hester C. Timmerhuis, Marc G. Besselink, and Hjalmar C. van Santvoort</i></p> <p>29 Management of Infected Pancreatic Necroses: An Endoscopic Approach 260<br /> <i>Todd H. Baron</i></p> <p>30 Minimally Invasive Debridement and Lavage of Necrotizing Pancreatitis 266<br /> <i>Kulbir Mann and Michael G.T. Raraty</i></p> <p>31 Open Surgical Debridement of Necrotizing Pancreatitis: Late Postoperative Morbidity and Outcome 271<br /> <i>Dongya Huang, Zipeng Lu, and Yi Miao</i></p> <p>32 Endoscopic Treatment of Acute Biliary Pancreatitis 278<br /> <i>Ichiro Yasuda, Tsuyoshi Mukai, and Toru Ito</i></p> <p>33 Strategies for the Treatment of Pancreatic Pseudocysts and Walled- Off Necrosis After Acute Pancreatitis: Interventional Endoscopic Approaches 284<br /> <i>Georg Beyer and Julia Mayerle</i></p> <p>34 Pseudocysts and Walled- Off Necrosis After Acute Pancreatitis: Surgical Approach 288<br /> <i>Naohiro Sata, Masaru Koizumi, and Alan Kawarai Lefor</i></p> <p>35 Management of Fluid Collection in Acute Pancreatitis 294<br /> <i>Georg Beyer, Simon Sirtl, Christoph Ammer- Herrmenau, and Albrecht Neesse</i></p> <p>36 Management of Pancreatic Fistula in Acute Pancreatitis 300<br /> <i>Marta Sandini, Thilo Hackert, and Markus W. Büchler</i></p> <p>37 Long- Term Outcome After Acute Pancreatitis 306<br /> <i>Christin Tjaden and Thilo Hackert</i></p> <p><b>Section 4 Chronic Pancreatitis 315</b></p> <p>38 Definition and Classification of Chronic Pancreatitis 317<br /> <i>David C. Whitcomb</i></p> <p>39 Molecular Understanding of Chronic Pancreatitis 326<br /> <i>Bomi Lee, Monique T. Barakat, and Sohail Z. Husain</i></p> <p>40 Natural History of Recurrent Acute and Chronic Pancreatitis 334<br /> <i>Rohit Das, Jorge D. Machicado, and Dhiraj Yadav</i></p> <p>41 Pediatric Recurrent Acute and Chronic Pancreatitis: Role of Pancreas Divisum 344<br /> <i>Jiri Snajdauf, Michal Rygl, Barbora Kucerova, and Natalia Newland</i></p> <p>42 Clinical and Laboratory Diagnosis of Chronic Pancreatitis 349<br /> <i>Georg Beyer, Markus M. Lerch, and Julia Mayerle</i></p> <p>43 Abdominal Imaging for the Diagnosis of Chronic Pancreatitis 357<br /> <i>Atsushi Irisawa and Akira Yamamiya</i></p> <p>44 Endoscopic Ultrasound for Diagnosis of Chronic Pancreatitis Versus Pancreatic Cancer 366<br /> <i>J. Enrique Domínguez- Muñoz, Julio Iglesias- García, José Lariño- Noia, and Daniel de la Iglesia- García</i></p> <p>45 Hereditary Pancreatitis and Complex Genetic Causes 375<br /> <i>Celeste Shelton Ohlsen and David C. Whitcomb</i></p> <p>46 Epidemiology and Pathophysiology of Tropical Chronic Pancreatitis 383<br /> <i>Shailesh V. Shrikhande and Savio G. Barreto</i></p> <p>47 CFTR- Associated Pancreatic Disease 390<br /> <i>Chee Y. Ooi and Aliye Uc</i></p> <p>48 Alcohol and Smoking in Chronic Pancreatitis 396<br /> <i>Atsushi Masamune, Kazuhiro Kikuta, and Kiyoshi Kume</i></p> <p>49 Idiopathic and Rare Causes of Chronic Pancreatitis 404<br /> <i>Morihisa Hirota and Tooru Shimosegawa</i></p> <p>50 Early Chronic Pancreatitis 412<br /> <i>Kazuhiro Kikuta and Atsushi Masamune</i></p> <p>51 Chronic Pancreatitis with Inflammatory Mass in the Pancreatic Head 418<br /> <i>Ulrich F. Wellner, Kim C. Honselmann, and Tobias Keck</i></p> <p>52 Structural Complications: Strictures, Stones, Pseudocysts, and Vascular Complications 424<br /> <i>Xiaodong Tian, Xiaochao Guo, and Yinmo Yang</i></p> <p>53 Nutritional Evaluation and Support: An Overview 430<br /> <i>Sinead N. Duggan and Stephen J. O’Keefe</i></p> <p>54 Exocrine Pancreatic Insufficiency 436<br /> <i>Chris E. Forsmark</i></p> <p>55 Bone Disease in Chronic Pancreatitis 442<br /> <i>Sinead N. Duggan</i></p> <p>56 Diabetes from Exocrine Pancreatic Disease 445<br /> <i>Nao Fujimori, Tetsuhide Ito, and Yoshihiro Ogawa</i></p> <p>57 Oxidative Stress and Antioxidants in Chronic Pancreatitis 451<br /> <i>Soumya Jagannath Mahapatra and Pramod Kumar Garg</i></p> <p>58 Pain Mechanisms in Chronic Pancreatitis 460<br /> <i>Pierluigi Di Sebastiano, Fabio Francesco di Mola, Tommaso Grottola, and Rossana Percario</i></p> <p>59 Pain Management in Chronic Pancreatitis 467<br /> <i>Louise Kuhlmann, Søren S. Olesen, and Asbjørn M. Drewes</i></p> <p>60 Adjunctive Therapy in Chronic Pancreatitis 474<br /> <i>Anna Evans Phillips</i></p> <p>61 Pancreatic Cancer Risks in Chronic Pancreatitis 480<br /> <i>Patrick Maisonneuve and Albert B. Lowenfels</i></p> <p>62 Evidence of Endoscopic and Interventional Treatment of Chronic Pancreatitis and Pseudocysts 486<br /> <i>Jörg Schirra, Simon Sirtl MD, Markus M. Lerch, and Julia Mayerle</i></p> <p>63 Major Pancreatic Resection for Chronic Pancreatitis: Indication, Goals, and Limitations 496<br /> <i>Faik G. Uzunoglu and Jakob R. Izbicki</i></p> <p>64 Pancreatic Drainage Procedures: Techniques and Results 501<br /> <i>Ulrich F. Wellner, Dirk Bausch, and Tobias Keck</i></p> <p>65 Duodenum- Preserving Pancreatic Head Resections for Chronic Pancreatitis: Techniques and Results 506<br /> <i>Hans G. Beger, Bertram Poch, Yang Yinmo, and Waldemar Uhl</i></p> <p>66 Total Pancreatectomy with Islet Autotransplant 515<br /> <i>Greg Beilman, Zachary Bergman, and Melena Bellin</i></p> <p>67 Minimally Invasive Surgical Management of Chronic Pancreatitis 523<br /> <i>Gilbert Z. Murimwa, Herbert J. Zeh III, and Matthew R. Porembka</i></p> <p><b>Section 5 Autoimmune Pancreatitis 533</b></p> <p>68 Epidemiology of Autoimmune Pancreatitis 535<br /> <i>Terumi Kamisawa</i></p> <p>69 Molecular Immunology and Pathogenesis of Autoimmune Pancreatitis 540<br /> <i>Yoh Zen</i></p> <p>70 Clinical Manifestation of Type 1 Autoimmune Pancreatitis 546<br /> <i>Tooru Shimosegawa</i></p> <p>71 Clinical Manifestation of Type 2 Autoimmune Pancreatitis 554<br /> <i>Nicolò de Pretis and Luca Frulloni</i></p> <p>72 Clinical Diagnostic Criteria for Autoimmune Pancreatitis 561<br /> <i>Tooru Shimosegawa</i></p> <p>73 Laboratory Diagnosis of Autoimmune Pancreatitis 568<br /> <i>J- Matthias Löhr and Miroslav Vujasinovic</i></p> <p>74 What is the Evidence Measuring Immune Markers 573<br /> <i>Shigeyuki Kawa, Takayuki Watanabe, and Norihiro Ashihara</i></p> <p>75 Autoimmune Pancreatitis and IgG4- Related Disease 579<br /> <i>Kazuichi Okazaki, Tsukasa Ikeura, and Kazushige Uchida</i></p> <p>76 Imaging Diagnosis of Autoimmune Pancreatitis 595<br /> <i>Kazuichi Okazaki, Makoto Takaoka, Tsukasa Ikeura, and Kazushige Uchida</i></p> <p>77 Medical Management of Autoimmune Pancreatitis 600<br /> <i>Shounak Majumder and Suresh T. Chari</i></p> <p>78 Management of Intractable Autoimmune Pancreatitis 605<br /> <i>Shounak Majumder and Suresh T. Chari</i></p> <p>79 Long- Term Outcome After Treatment of Autoimmune Pancreatitis 609<br /> <i>Luca Frulloni and Nicolò de Pretis</i></p> <p><b>Section 6 Neoplastic Tumors of the Exocrine Tissue: Benign Cystic Neoplasms of the Pancreas 615</b></p> <p>80 Epidemiology of Cystic Neoplasms of the Pancreas 617<br /> <i>Shounak Majumder and Suresh T. Chari</i></p> <p>81 Histologic Classification and Staging of Cystic Neoplasms 623<br /> <i>Noriyoshi Fukushima and Giuseppe Zamboni</i></p> <p>82 Molecular Mechanisms of Cystic Neoplasia- 630<br /> <i>Nickolas Papadopoulos and Ralph H. Hruban</i></p> <p>83 Clinical Presentation of Pancreatic Cystic Neoplasms 638<br /> <i>Masao Tanaka</i></p> <p>84 Evaluation of Cystic Lesions Using EUS, MRI, and CT 642<br /> <i>Anne Marie Lennon and Atif Zaheer</i></p> <p>85 Cytologic Evaluation of Cystic Neoplasms: The Role of Liquid Biopsy 652<br /> <i>Abdulwahab Ewaz and Michelle D. Reid</i></p> <p>86 Natural History of Cystic Neoplasms: IPMN, MCN, SCN, and SPN 666<br /> <i>Rosa Klotz, Thilo Hackert, and Markus W. Büchler</i></p> <p>87 Surveillance or Surgical Treatment in Asymptomatic Cystic Neoplasm 674<br /> <i>Klaus Sahora and Carlos Fernández- del Castillo</i></p> <p>88 Artificial Intelligence in the Detection and Surveillance of Cystic Neoplasms 680<br /> <i>Linda C. Chu and Elliot K. Fishman</i></p> <p>89 Oncologic Resection of IPMN and MCN: Open Approach―Results 688<br /> <i>Marco Del Chiaro, Michael J. Kirsch, and Richard D. Schulick</i></p> <p>90 Surgical Treatment of Cystic Neoplasms: Laparoscopic and Robotic Approach—Results 693<br /> <i>Benedict Kinny- Köster, Christopher L. Wolfgang, Markus W. Büchler, and Thilo Hackert</i></p> <p>91 Robotic- assisted Resection of Cystic Neoplasms 700<br /> <i>Kimberly Kopecky and Jin He</i></p> <p>92 Duodenum- preserving Pancreatic Head Resection for Cystic Neoplasms of the Pancreatic Head: Indications and Limitations 709<br /> <i>Hans G. Beger and Bertram Poch</i></p> <p>93 Pancreatic Middle Segment Resection of Cystic Neoplasms: Indications and Limitations 715<br /> <i>Calogero Iacono and Mario De Bellis</i></p> <p>0005474686.indd 11 05-25-2023 11:30:31</p> <p>94 Tumor Enucleation for Cystic Neoplasms of the Pancreas: Indications and Limitations 723<br /> <i>Rachel C. Kim, C. Max Schmidt, and Henry A. Pitt</i></p> <p>95 Duodenum- preserving Pancreatic Head Resection and Local Extirpation of SPTP in Children and Adolescents: Indications and long- term results 732<br /> <i>Jiri Snajdauf, Michal Rygl, Barbora Kucerova, and Natalia Newland</i></p> <p>96 Management of Recurrence of Cystic Neoplasms 737<br /> <i>Anna Nießen, Christopher L. Wolfgang, Thilo Hackert, and Markus W. Büchler</i></p> <p>97 Long- term Outcome after Observation and Surgical Treatment of Cystic Neoplasms: What is the Evidence? 744<br /> <i>Roberto Salvia, Giovanni Marchegiani, Giampaolo Perri, and Claudio Bassi</i></p> <p><b>Section 7 Neoplastic Tumors of the Endocrine Pancreas: Neuroendocrine Tumors of the Pancreas 751</b></p> <p>98 Epidemiology and Classification of Neuroendocrine Tumors of the Pancreas 753<br /> <i>J.J. Mukherjee, K.O. Lee, and Gregory Kaltsas</i></p> <p>99 Pathology of Neuroendocrine Neoplasms 763<br /> <i>Atsuko Kasajima and Hironobu Sasano</i></p> <p>100 Molecular Genetics of Neuroendocrine Tumors 771<br /> <i>Nickolas Papadopoulos and Ralph H. Hruban</i></p> <p>101 What is the Origin of Pancreatic Endocrine Tumors? 781<br /> <i>Aurel Perren, Iacovos P. Michael, and Ilaria Marinoni</i></p> <p>102 Clinical Manifestation of Endocrine Tumors of the Pancreas 791<br /> <i>Tetsuhide Ito, Keijiro Ueda, Nao Fujimori, and Robert T. Jensen</i></p> <p>103 Evidence of Hormonal, Laboratory, Biochemical, and Instrumental Diagnostics of Neuroendocrine Tumors of the Pancreas 799<br /> <i>K.O. Lee, Gregory Kaltsas, and J.J. Mukherjee</i></p> <p>104 Pancreatic Neuroendocrine Tumors in Multiple Neoplasia Syndromes 808<br /> <i>Anja Rinke and Thomas Matthias Gress</i></p> <p>105 Nonfunctioning Pancreatic Neuroendocrine Neoplasms: Diagnosis and Management Principles 815<br /> <i>Takao Ohtsuka, Yuto Hozaka, and Hiroshi Kurahara</i></p> <p>106 Medical and Nucleotide Treatment of Neuroendocrine Tumors of the Pancreas 820<br /> <i>Marina Tsoli and Gregory Kaltsas</i></p> <p>107 Interventional Radiology in the Treatment of Pancreatic Neuroendocrine Tumors 829<br /> <i>Tetsuya Idichi, Hiroshi Kurahara, and Takao Ohtsuka</i></p> <p>108 Enucleation of Benign, Neuroendocrine Tumors of the Pancreas 833<br /> <i>Frank Weber, Andreas Machens, and Henning Dralle</i></p> <p>109 Duodenum- Preserving Pancreatic Head Resection or Local Extirpation of Neuroendocrine Tumors of the Pancreas Larger than 2 cm 841<br /> <i>Takashi Hatori</i></p> <p>110 Individualized Surgery for Nonfunctional Pancreatic Neuroendocrine Tumors (NF- pNET) <2 cm: Indication, Surgical Principles, and Long- term Outcome 849<br /> <i>Charles de Ponthaud, Julien de Martino, and Sébastien Gaujoux</i></p> <p>111 Surgical Treatment of Endocrine Tumors: Major Oncologic Resection 857<br /> <i>Frank Weber, Andreas Machens, and Henning Dralle</i></p> <p>112 The Management of Insulinoma 865<br /> <i>Keijiro Ueda, Nao Fujimori, Robert T. Jensen, and Tetsuhide Ito</i></p> <p>113 Evidence of Medical and Surgical Treatment of Gastrinoma 872<br /> <i>Ryuichiro Doi</i></p> <p>114 Rare Neuroendocrine Tumors of Pancreas: Management and Evidence of Surgical Treatment 876<br /> <i>Ryuichiro Doi</i></p> <p>115 Treatment of Neuroendocrine Neoplasia of the Pancreas and Biliary Tract 882<br /> <i>Andrea Frilling, Ashley K. Clift, and Vito Cicinnati</i></p> <p>116 Survival after Treatment of Endocrine Tumors 891<br /> <i>Zhe Cao and Taiping Zhang</i></p> <p><b>Section 8 Neoplastic Tumors of Exocrine Tissue: Pancreatic Cancer 897</b></p> <p>117 Epidemiology of Pancreatic Cancer 899<br /> <i>Evelina Mocci and Alison P. Klein</i></p> <p>118 Smoking, a Risk for Pancreatic Cancer: Experimental and Clinical Data 905<br /> <i>Uwe A. Wittel, Bradley R. Hall, and Surinder K. Batra</i></p> <p>119 Molecular Understanding of the Development of Ductal Pancreatic Cancer 912<br /> <i>Jae W. Lee, Ralph H. Hruban, and Laura D. Wood</i></p> <p>120 From Tissue Turnover to the Cell of Origin of Pancreatic Cancer: An Updated View 921<br /> <i>Bo Kong, Eva Thoma, and Christoph W. Michalski</i></p> <p>121 Microbiome of Pancreatic Cancer: Involvement in Cancer Development and Chemo- /Immunotherapy 928<br /> <i>Xianjun Yu</i></p> <p>122 Molecular Subtypes and Clinical Applications 934<br /> <i>Maarten F. Bijlsma and Peter Bailey</i></p> <p>123 Tumor Microenvironment: Immune Cells and Immunosuppressive Functions of Carcinoma- associated Fibroblasts and Macrophages 942<br /> <i>Tony Pang, Zhihong Xu, Chamini Perera, and Minoti V. Apte</i></p> <p>124 Familial Pancreatic Cancer 951<br /> <i>Alison P. Klein</i></p> <p>125 Pathology of Exocrine Pancreatic Tumors 957<br /> <i>Meredith E. Pittman and Ralph H. Hruban</i></p> <p>126 Pancreatic Cancer: Precancerous Lesions 969<br /> <i>Michael J. Pflüger, Michaël Noë, and Lodewijk A.A. Brosens</i></p> <p>127 Clinical History and Risk Factors of Pancreatic Cancer 982<br /> <i>Norbert Hüser, Volker Aßfalg, and Helmut Friess</i></p> <p>128 The Role of Endoscopic Ultrasonography in the Diagnosis and Differential Diagnosis of Neoplastic Lesions 989<br /> <i>Yoshiki Hirooka, Senju Hashimoto, and Eizaburo Ohno</i></p> <p>129 Radiologic Diagnosis of Pancreatic Cancer: CT, MRI 997<br /> <i>Hannah S. Recht and Elliot K. Fishman</i></p> <p>130 Screening of Hereditary Pancreatic Cancer 1012<br /> <i>Michael Goggins</i></p> <p>131 The Role of PET in Diagnosis of Pancreatic Cancer and Cancer Recurrence 1021<br /> <i>Norbert Hüser, Volker Aßfalg, Isabel Rauscher, and Helmut Friess</i></p> <p>132 Tumor Markers in Pancreatic Malignancies 1028<br /> <i>Shin Hamada and Atsushi Masamune</i></p> <p>133 The Role of Laparoscopy and Peritoneal Cytology in the Management of Pancreatic Cancer 1033<br /> <i>Yosuke Kasai, Kyoichi Takaori, and Etsuro Hatano</i></p> <p>134 Clinical Assessment and Staging of Advanced Pancreatic Cancer 1037<br /> <i>James M. Lindberg, Giles F. Whalen, and Jennifer LaFemina</i></p> <p>135 Pancreatic Cancer: Indications for Resection 1047<br /> <i>Akimasa Nakao and Suguru Yamada</i></p> <p>136 Pancreatoduodenectomy for Pancreatic Cancer: Short- and Long- term Outcome after Kausch- Whipple and Pylorus- preserving Pancreatoduodenectomy 1055<br /> <i>Benedict Kinny- Köster, John L. Cameron, and Jin He</i></p> <p>137 Left Pancreatectomy for Body and Tail Cancer 1063<br /> <i>Jony van Hilst, Mohammad Abu Hilal, and Marc G Besselink</i></p> <p>138 Total Pancreatectomy: Indications and Limitations 1071<br /> <i>Seiko Hirono and Hiroki Yamaue</i></p> <p>139 Minimally Invasive Resection for Pancreatic Cancer 1078<br /> <i>Patricio M. Polanco, Imad Radi, and Herbert J. Zeh iii</i></p> <p>140 Robotic Resection for Pancreatic Cancer 1093<br /> <i>Renyi Qin</i></p> <p>141 Extended Radical Surgery for Pancreatic Cancer 1099<br /> <i>Thilo Hackert, Anna Nießen, and Markus W. Büchler</i></p> <p>142 Palliative Pancreatic Resection: Is It Justified? 1108<br /> <i>Kira C. Steinkraus, Max Heckler, Christoph W. Michalski, and Felix J. Hüttner</i></p> <p>143 Outcome of Patients after R0 Resection for Locally Advanced Pancreatic Cancer Combined with Hepatic Metastasectomy: Indications and Limitations 1113<br /> <i>Tingbo Liang</i></p> <p>144 Bypass Surgery for Advanced Pancreatic Cancer 1117<br /> <i>Eva Thoma, Thilo Hackert, Christoph W. Michalski, and Felix J. Hüttner</i></p> <p>145 Endoscopic and Interventional Palliation of Pancreatic Cancer 1122<br /> <i>Kazumasa Nagai and Takao Itoi</i></p> <p>146 Neoadjuvant Treatment of Pancreatic Cancer: Evidence for Treatment Effect 1131<br /> <i>Robert A. Wolff</i></p> <p>147 Locally Advanced Pancreatic Cancer: Does the Addition of Stereotactic Body Radiation Therapy to Neoadjuvant Chemotherapy Lead to a Significant Survival Improvement after R0 Resection? 1141<br /> <i>Marco Del Chiaro, Michael J. Kirsch, and Richard D. Schulick</i></p> <p>148 Adjuvant Chemotherapy in Pancreatic Cancer: First Line and Second Line Treatment— Benefits of Survival 1143<br /> <i>Kulbir Mann, Robert P. Jones, Paula Ghaneh, and John P. Neoptolemos</i></p> <p>149 Role of Radiation Therapy for Pancreatic Cancer 1153<br /> <i>Baho U. Sidiqi, Abhinav V. Reddy, Joseph M. Herman, and Amol K. Narang</i></p> <p>150 Immunotherapy for Pancreatic Cancer: Checkpoint Blockade and Vaccine Therapy 1164<br /> <i>Arsen Osipov, Adrian G. Murphy, and Lei Zheng</i></p> <p>151 Targeted Therapies for Pancreatic Cancer 1180<br /> <i>Anirban Maitra</i></p> <p>152 Precision Cancer Medicine 1188<br /> <i>Grace Oh, Surajit Dhara, and Diane Simeone</i></p> <p>153 Palliative Chemotherapy for Advanced Pancreatic Cancer: Treatment Modalities, Side- effects, and Benefits of Survival 1196<br /> <i>Christoph Springfeld and Thomas Seufferlein</i></p> <p>154 Management of Pain in Pancreatic Cancer 1201<br /> <i>Annie W. Hsu, Ayodeji Omosule, and Michael Erdek</i></p> <p>155 Management of Cancer Recurrence 1208<br /> <i>Oliver Strobel, Martin Loos, and Markus W. Büchler</i></p> <p>156 Survival and Late Morbidity after Resection of Pancreatic Cancer 1218<br /> <i>Avinoam Nevler and Charles J. Yeo</i></p> <p><b>Section 9 Periampullary Cancers and Tumors Other Than Pancreatic Cancer 1233</b></p> <p>157 Periampullary Tumors: Clinical Presentation and Diagnostic Strategies 1235<br /> <i>Jon M. Harrison and Keith D. Lillemoe</i></p> <p>158 Histology and Genetics of Cancer of the Papilla, Distal Common Bile Duct, and Duodenum 1242<br /> <i>Yue Xue, Michelle D. Reid, and Volkan Adsay</i></p> <p>159 Adenoma and Adenocarcinoma of the Ampulla of Vater: Diagnosis and Management 1254<br /> <i>Sahin Coban, Omer Basar, and William R. Brugge</i></p> <p>160 Endoscopic Treatment of Adenomas of the Ampulla of Vater: Techniques, Results, Benefits, and Limitations 1264<br /> <i>Natsuyo Yamamoto and Hiroyuki Isayama</i></p> <p>161 Surgical Treatment of Papillary and Ampullary Tumors: Management and Long- term Results 1272<br /> <i>Norbert Hüser, Volker Aßfalg, and Helmut Friess</i></p> <p>162 Surgical Treatment of Duodenal Cancer 1281<br /> <i>Fuyuhiko Motoi</i></p> <p>163 Surgical Treatment of Distal Cholangiocarcinoma 1284<br /> <i>Shunsuke Onoe, Yukihiro Yokoyama, and Tomoki Ebata</i></p> <p>164 Adjuvant and Palliative Chemotherapy of Periampullary Cancers 1291<br /> <i>Arachchige D.N.R. Ponweera, Paula Ghaneh, and John P. Neoptolemos</i></p> <p>165 Long- term Survival After Resection of Periampullary Cancer 1299<br /> <i>Hideyuki Yoshitomi, Masayuki Ohtsuka, and Masaru Miyazaki</i></p> <p><b>Section 10 Transplantation of the Pancreas 1309</b></p> <p>166 Transplantation of Pancreatic Islets 1311<br /> <i>Joseph Sushil Rao, Melena D. Bellin, and Bernhard J. Hering</i></p> <p>167 Transplantation of the Pancreas 1323<br /> <i>Rainer W.G. Gruessner and Angelika C. Gruessner</i></p> <p>Index 1333</p>

<p><b>Hans G. Beger, MD, FACS (Hon.), JSS (Hon.), CSS (Hon.),</b> Professor Emeritus of Surgery, University of Ulm, Ulm, Germany. <p><b>Markus W. Büchler, MD, FACS (Hon.), FRCS (Hon.), FASA (Hon.)</b> Professor of Surgery, University of Heidelberg, Heidelberg, Germany. <p><b>Ralph H. Hruban, MD,</b> Baxley Professor and Director, Department of Pathology and Director of the Sol Goldman Pancreatic Research Center, Johns Hopkins University School of Medicine, Baltimore, USA. <p><b>Julia Mayerle, MD,</b> Professor of Internal Medicine, Gastroenterology and Hepatology, Chair Department of Medicine II, LMU Klinikum, Ludwig-Maximilians-University, Munich, Germany. <p><b>John P. Neoptolemos, MA, MB, BCHIR, MD FRCS, FMEDSCI, MAE</b> Professor of Surgery, Department of Surgery, University of Heidelberg, Heidelberg, Germany. <p><b>Tooru Shimosegawa, MD, PhD,</b> Professor Emeritus Department of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan. <p><b>Andrew L. Warshaw, MD, FACS, FRCSEd (Hon.),</b> W. Gerald Austen Distinguished Professor of Surgery, Harvard Medical School, and Surgeon-in-Chief Emeritus, Massachusetts General Hospital, Boston, USA. <p><b>David C. Whitcomb, MD, PhD,</b> Professor of Medicine, Cell Biology & Physiology, and Human Genetics, Division of Gastroenterology, Hepatology, and Nutrition, University of Pittsburgh and UPMC, Pennsylvania, USA. <p><b>Yupei Zhao, MD, FICS (Hon.), FACS (Hon.), FRCS (Engl) (Hon.), FCSHK (Hon.),</b> Professor of Surgery, Department of General Surgery, Peking Union Medical College Hospital, Beijing, P.R. China.

<p><b>The newest edition of the essential guide to pancreatic medicine</b> <p>The fourth edition of <i>The Pancreas: An Integrated Textbook of Basic Science, Medicine, and Surgery</i> integrates the cutting-edge research of recent years to update its presentation of this fast-growing subject. It details every known disorder of the pancreas, grounding them in a thorough understanding of pancreatic function, enhanced with high quality illustration and graphs. It also includes step-by-step guidance for relevant endoscopic techniques and surgical procedures. <p><i>The Pancreas</i> readers will also find: <ul><li>New comprehensive insights into three pancreatic diseases: autoimmune pancreatitis, cystic neoplasms, and neuroendocrine tumors</li> <li>An editorial team with decades of clinical and research experience in the US, Europe, and Asia</li> <li>Over 500 downloadable illustrations for use in scientific presentations</li></ul> <p><i>The Pancreas</i> is a foundational reference for clinicians and researchers in gastroenterology and gastrointestinal surgery.

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