The PancreasAn Integrated Textbook of Basic Science, Medicine, and Surgery
This brand new updated edition of the most comprehensive reference book on pancreatic disease details the very latest knowledge on genetics and molecular biological background in terms of anatomy, physiology, pathology, and pathophysiology for all known disorders. Included for the first time, are two brand new sections on the key areas of Autoimmune Pancreatitis and Benign Cystic Neoplasms. In addition, this edition is filled with over 500 high-quality illustrations, line drawings, and radiographs that provide a step-by-step approach to all endoscopic techniques and surgical procedures. Each of these images can be downloaded via an online image bank for use in scientific presentations. Every existing chapter in The Pancreas: An Integrated Textbook of Basic Science, Medicine and Surgery, 3rd Edition has been thoroughly revised and updated to include the many changes in clinical practice since publication of the current edition. The book includes new guidelines for non-surgical and surgical treatment; new molecular biologic pathways to support clinical decision making in targeted treatment of pancreatic cancer; new minimally invasive surgical approaches for pancreatic diseases; and the latest knowledge of neuroendocrine tumors and periampullary tumors. The most encyclopedic book on the pancreas—providing outstanding and clear guidance for the practicing clinician Covers every known pancreatic disorder in detail including its anatomy, physiology, pathology, pathophysiology, diagnosis, and management Completely updated with brand new chapters Over 500 downloadable illustrations An editor and author team of high international repute who present global best-practice The Pancreas: An Integrated Textbook of Basic Science, Medicine and Surgery, 3rd Edition is an important book for gastroenterologists and gastrointestinal surgeons worldwide.
Contributors xiii Preface xxix Abbreviations xxx About the Companion Website xlii Section 1 Anatomy of the Pancreas 1 1 Development of the Pancreas and Related Structures 3Brian Lewis and Junhao Mao 2 Anatomy, Histology, and Fine Structure of the Pancreas 10Daniel S. Longnecker, Fred Gorelick, and Elizabeth D. Thompson 3 Congenital and Inherited Anomalies of the Pancreas 24Martin Zenker and Markus M. Lerch Section 2 Physiology and Pathophysiology of Pancreatic Functions 414 Physiology of Acinar Cell Secretion 43Ole H. Petersen 5 Physiology of Duct Cell Secretion 56Mei Zeng, Laura Vachel, and Shmuel Muallem 6 Pathophysiology of Experimental Pancreatitis 63Vikas Dudeja, Rajinder Dawra, and Ashok K. Saluja 7 Physiology and Pathophysiology of Function of Sphincter of Oddi 75Savio George Barreto and James Toouli 8 Neurohormonal and Hormonal Control of Pancreatic Secretion 84Chung Owyang 9 Regulation of Pancreatic Protein Synthesis and Growth 95Maria Dolors Sans and John A. Williams 10 Fibrogenesis in the Pancreas: The Role of Stellate Cells 106Minoti V. Apte, Romano C. Pirola, and Jeremy S. Wilson 11 Fibrogenesis of the Pancreas: The Role of Macrophages 117Aida Habtezion 12 Insulo–Acinar Relationship 123Keiko Shiratori and Kyoko Shimizu Section 3 Acute Pancreatitis 133 13 Epidemiology and Etiology of Alcohol?Induced Pancreatitis 135Jeremy S. Wilson, Romano C. Pirola, and Minoti V. Apte 14 Epidemiology and Etiology of Acute Biliary Pancreatitis 146Michael G.T. Raraty, Andrea Sheel, and John P. Neoptolemos 15 Genetic Factors in Acute Pancreatitis 158Zachary Zator and Georgios I. Papachristou 16 The Role of the Intestine and Mesenteric Lymph in the Development of Systemic Inflammation and MODS in Severe Acute Pancreatitis 166Alistair B.J. Escott, Anthony R.J. Phillips, and John A. Windsor 17 The Role of Neurogenic Inflammation in Pancreatitis 173Jami L. Saloman, Kathryn M. Albers, and Brian M. Davis 18 Molecular, Biochemical, and Metabolic Abnormalities in Acute Pancreatitis 178Julia Mayerle, Frank Ulrich Weiss, Walter Halangk, and Markus M. Lerch 19 Histopathology of Acute Pancreatitis 193Günter Klöppel 20 Clinical Classification Systems of Acute Pancreatitis 199John A. Windsor and Max S. Petrov 21 Clinical Assessment and Biochemical Markers to Objectify Severity and Prognosis 204Bettina M. Rau and Guido Alsfasser 22 Acute Pancreatitis Associated With Congenital Anomalies 213Christopher R. Schlieve, Andrew L. Warshaw, and Tracy C. Grikscheit 23 Acute Pancreatitis in Children 219Mark E. Lowe and Véronique D. Morinville 24 Acute Pancreatitis Associated With Metabolic Disorders, Infectious Diseases, or Drugs 230Ali A. Aghdassi and Markus M. Lerch 25 Radiologic Diagnosis and Staging of Severe Acute Pancreatitis 238Yoshihisa Tsuji Clinical Course and Medical Treatment of Acute Pancreatitis 251 26 Conservative Therapy of Acute Pancreatitis: Volume Substitution and Enteral and Parenteral Nutrition 251Timothy B. Gardner 27 ICU Treatment of Severe Acute Pancreatitis 258Scott R. Gunn and David C. Whitcomb 28 Use of Antibiotics in Severe Acute Pancreatitis: Indications and Limitations 265Rainer Isenmann and Mathias Wittau Interventional and Surgical Management of Acute Pancreatitis 271 29 Indications for Interventional and Surgical Treatment of Necrotizing Pancreatitis 271Thomas E. Clancy 30 Management of Infected Pancreatic Necroses: An Endoscopic Approach 277Eduardo Rodrigues?Pinto and Todd H. Baron 31 Minimally Invasive Debridement and Lavage of Necrotizing Pancreatitis 283Rebecca Saunders, Michael G.T. Raraty, Chris Halloran, and John P. Neoptolemos 32 Open Surgical Debridement in Necrotizing Pancreatitis 289Lutz Schneider and Markus W. Büchler 33 Endoscopic Treatment of Biliary Acute Pancreatitis 296Ichiro Yasuda, Shinpei Doi, and Masatoshi Mabuchi 34 Strategies for the Treatment of Pancreatic Pseudocysts and Walled?Off Necrosis After Acute Pancreatitis: Interventional Endoscopic Approaches 301Georg Beyer, Julia Mayerle, and Markus M. Lerch 35 Strategies for the Treatment of Pancreatic Pseudocysts and Walled?Off Necrosis After Acute Pancreatitis: Surgical Treatment 305Naohiro Sata, Masaru Koizumi, and Alan K. Lefor 36 Management of Fluid Collection in Acute Pancreatitis 311Felix Lämmerhirt, Frank Ulrich Weiss, and Markus M. Lerch 37 Management of Pancreatic Fistula in Acute Pancreatitis 316Jörg Kaiser, Thilo Hackert, and Markus W. Büchler Long-Term Outcome After Treatment of Acute Pancreatitis 323 38 Long?Term Outcome After Acute Pancreatitis 323Christin Tjaden and Thilo Hackert Section 4 Chronic Pancreatitis 331 39 Molecular Understanding of Chronic Pancreatitis 333John F. Eisses and Sohail Z. Husain 40 Epidemiology and Pathophysiology of Alcoholic Chronic Pancreatitis 342Atsushi Masamune and Tooru Shimosegawa 41 Pain Mechanisms in Chronic Pancreatitis 349Pierluigi di Sebastiano, Tommaso Grottola, and Francesco F. di Mola 42 Natural History of Recurrent Acute and Chronic Pancreatitis 355Rohit Das and Dhiraj Yadav 43 Chronic Pancreatitis with Inflammatory Mass of the Pancreatic Head 365Ulrich F. Wellner and Tobias Keck 44 Early Chronic Pancreatitis 371Tetsuhide Ito, Masayuki Hijioka, and Tooru Shimosegawa 45 Hereditary Chronic Pancreatitis: Molecular Pattern, Clinical Consequences, and Management Principles 374Celeste Shelton and David C. Whitcomb 46 Epidemiology and Pathophysiology of Tropical Chronic Pancreatitis 384Shailesh V. Shrikhande and Savio George Barreto 47 Cystic Fibrosis (CFTR)?Associated Pancreatic Disease 391Chee Y. Ooi and Aliye Uc 48 Clinical and Laboratory Diagnosis of Chronic Pancreatitis 397Julia Mayerle, Peter Simon, and Markus M. Lerch 49 Evidence of Contrast?Enhanced CT and MRI/MRCP 406J. Enrique Domínguez?Muñoz, Roberto García?Figueiras, and Julio Iglesias?García 50 Chronic Pancreatitis: Risk Factors in Cancer 417Albert B. Lowenfels and Patrick Maisonneuve Conservative Treatment of Chronic Pancreatitis 42151 Pain Management in Chronic Pancreatitis 421Kai Bachmann, Stephanie Plagemann, Yogesh Kumar Vashist, and Jakob R. Izbicki 52 Medical Treatment of Chronic Pancreatitis: Pancreatic Digestive Enzymes: Lipases, Proteases 426Mark E. Lowe 53 Nutritional Support of Chronic Pancreatitis 429Sinead N. Duggan and Stephen J. O’Keefe 54 Medical Therapy for Chronic Pancreatitis: Antioxidants 435Chris E. Forsmark Strategies for Endoscopic and Surgical Treatment of Chronic Pancreatitis 439 55 Evidence of Endoscopic and Interventional Treatment of Chronic Pancreatitis and Pseudocysts 439Jörg Schirra, Markus M. Lerch, and Julia Mayerle 56 Indications and Goals of Surgical Treatment 449Ryan T. Groeschl and Michael B. Farnell 57 Pancreatic Duct Drainage Procedure 453Dirk Bausch and Tobias Keck 58 Duodenum?Preserving Pancreatic Head Resection 458Hans G. Beger, Bertram Poch, Yang Yinmo, and Waldemar UhlContents vii 59 Major Pancreatic Resection 467May C. Tee and Michael B. Farnell 60 Laparoscopic Surgery 479Vernissia Tam, Melissa E. Hogg, and Amer Zureikat Management of Diabetes and Long-Term Outcome of Chronic Pancreatitis 488 61 Chronic Pancreatitis: Long?Term Outcome After Medical and Surgical Treatment 488Volker Aßfalg, Norbert Hüser, and Helmut Friess 62 Management of Pancreatic Diabetes Secondary to Chronic Pancreatitis 495Keiko Shiratori Section 5 Autoimmune Pancreatitis 503 63 Epidemiology of Autoimmune Pancreatitis 505Terumi Kamisawa and Tooru Shimosegawa 64 Pathogenesis of Autoimmune Pancreatitis 510Yoh Zen 65 Histology of Autoimmune Pancreatitis 516Rajib Gupta and Vikram Deshpande 66 Clinical Manifestation of Type 1 Autoimmune Pancreatitis 520Tooru Shimosegawa, Morihisa Hirota, and Atsushi Kanno 67 Clinical Manifestations of Type 2 Autoimmune Pancreatitis 534Emma L. Culver and George Webster 68 Laboratory Diagnosis of Autoimmune Pancreatitis 539J.?Matthias Löhr, Pia Maier, and Stephan L. Haas 69 What is the Evidence Measuring Immune Markers 544Shigeyuki Kawa 70 Imaging Diagnosis of Autoimmune Pancreatitis 550Kazuichi Okazaki, Tsukasa Ikeura, Kazushige Uchida, and Makoto Takaoka 71 Medical Management of Autoimmune Pancreatitis 555Shounak Majumder and Suresh T. Chari Long-Term Outcome of Management of Autoimmune Pancreatitis 560 72 Long?Term Outcome After Treatment of Autoimmune Pancreatitis 560Luca Frulloni and Nicolò de Pretis Section 6 Neoplastic Tumors of the Exocrine Tissue: Benign Cystic Neoplasms of the Pancreas 565 73 Epidemiology of Cystic Neoplasms of the Pancreas 567Saurabh Mukewar and Suresh T. Chari 74 Histologic Classification and Staging of Cystic Neoplasms 573Noriyoshi Fukushima and Giuseppe Zamboni 75 Molecular Mechanisms of Cystic Neoplasia 580Nickolas Papadopoulos and Ralph H. Hruban 76 Clinical Presentation of Cystic Neoplasms 589Susumu Hijioka, Kazuo Hara, Nobumasa Mizuno, Nozomi Okuno, and Kenji Yamao 77 Evaluation of Cystic Lesions Using EUS, MRI, and CT 593Anne Marie Lennon and Hiroyuki Maguchi 78 Cytologic Evaluation of Cystic Neoplasms 603Martha Bishop Pitman 79 Natural History of Cystic Neoplasms: IPMN, MCN, SCN, and SPN 611Anna?Katharina Stadler, Thilo Hackert, Stefan Fritz, and Markus W. Büchler 80 Surveillance or Surgical Treatment in Asymptomatic Cystic Neoplasms 618Klaus Sahora and Carlos Fernández? del Castillo Local and Standard Surgical Treatment of Cystic Neoplasms 622 81 Duodenum?Preserving Partial or Total Pancreatic Head Resection 622Hans G. Beger and Bertram Poch 82 Pancreatic Middle Segment Resection 627Calogero Iacono 83 The Indications For and Limitations of Tumor Enucleation 632Rosalie A. Carr, C. Max Schmidt, and Henry A. Pitt 84 Standard Surgical Management of IPMN, MCN, SPN, and SCN Lesions: Open Approach 641Miral Sadaria Grandhi, Barish H. Edil, and Richard D. Schulick 85 Surgical Treatment of Cystic Neoplasms: Laparoscopic Approach 649Richard A. Burkhart, Christopher L. Wolfgang, Markus W. Büchler, and Thilo Hackert 86 Management of Recurrence of Cystic Neoplasms 655Zhi Ven Fong, Christopher L. Wolfgang, and Keith D. Lillemoe Long-Term Outcome of Management of Cystic Neoplasms 660 87 Long?Term Outcome After Observation and Surgical Treatment: What is the Evidence? 660Giovanni Marchegiani, Giuseppe Malleo, and Claudio Bassi Section 7 Neoplastic Tumors of Exocrine Tissue: Pancreatic Cancer 665 88 Epidemiology of Pancreatic Cancer 667Evelina Mocci and Alison P. Klein 89 Smoking, a Risk for Pancreatic Cancer: Experimental and Clinical Data 673Uwe A. Wittel, Bradley R. Hall, and Surinder K. Batra 90 Molecular Understanding of Development of Ductal Pancreatic Cancer 679Laura D. Wood and Ralph H. Hruban 91 Familial Pancreatic Cancer 688Alison P. Klein 92 Pathology of Exocrine Pancreatic Tumors 693Meredith E. Pittman and Ralph H. Hruban 93 Pancreatic Cancer: Precancerous Lesions 705Michaël Noë, Lodewijk A.A. Brosens, and Johan Offerhaus 94 Clinical History and Risk Factors of Pancreatic Cancer 717Norbert Hüser, Volker Aßfalg, and Helmut Friess 95 Pancreatic Cancer Within the Uncinate Process: Radiologic and Clinical Characteristics 724Sebastian Holländer and Dieter Birk 96 The Role of EUS in the Diagnosis and Differential Diagnosis of Neoplastic Lesions 728Susumu Hijioka, Kazuo Hara, Nobumasa Mizuno, Nozomi Okuno, and Kenji Yamao 97 Radiologic Diagnosis of Pancreatic Cancer: CT, MRI 733Siva P. Raman and Elliot K. Fishman 98 Screening of Patients with Hereditary Pancreatic Cancer 745Michael Goggins 99 The Role of PET in Diagnosis of Pancreatic Cancer and Cancer Recurrence 755Norbert Hüser, Volker Aßfalg, Isabel Rauscher, and Helmut Friess 100 Tumor Markers in Pancreatic Malignancies 762Shin Hamada, Atsushi Masamune, and Tooru Shimosegawa 101 The Role of Laparoscopy and Peritoneal Cytology in the Management of Pancreatic Cancer 766Kyoichi Takaori and Shinji Uemoto 102 Clinical Assessment and Staging of Advanced Pancreatic Cancer 770Jennifer LaFemina, Ann K. Friedrich, and Giles F. Whalen Surgical Treatment of Pancreatic Cancer 776 103 Pancreatic Cancer: Indications for Resection 776Akimasa Nakao 104 Pancreaticoduodenectomy for Pancreatic Cancer, Short? and Long?Term Outcomes After Kausch–Whipple and Pylorus?Preserving Resection 783Jin He and John L. Cameron 105 Left Pancreatectomy for Body and Tail Cancer 790Georgios Gemenetzis and Christopher L. Wolfgang 106 Total Pancreatectomy: Indications and Limitations 797Seiko Hirono and Hiroki Yamaue 107 Laparoscopic and Robotic Resection for Pancreatic Cancer 804Deepa Magge, Herbert J. Zeh, and Melissa E. Hogg 108 Extended Radical Surgery for Pancreatic Cancer 814Thilo Hackert, Alexis Ulrich, and Markus W. Büchler 109 Palliative Pancreatoduodenectomy: Benefits and Limitations 823Christoph W. Michalski, Max Heckler, Mert Erkan, and Markus W. Büchler 110 Bypass Surgery for Advanced Pancreatic Cancer 828Jürgen Weitz, Thomas Pausch, Christoph W. Michalski, and Thilo Hackert Nonsurgical Palliation of Pancreatic Cancer 835 111 Endoscopic and Interventional Palliation of Pancreatic Cancer 835Takao Itoi Medical Treatment of Pancreatic Cancer 842 112 Neoadjuvant Treatment of Pancreatic Cancer: Downstaging Results 842Robert A. Wolff and Gauri Varadhachary 113 Adjuvant Chemotherapy in Pancreatic Cancer 847Robert P. Jones, Paula Ghaneh, and John P. Neoptolemos 114 Immunotherapy for Pancreatic Cancer 856Adrian G. Murphy, Elizabeth M. Jaffee, and Lei Zheng 115 Targeted Therapies for Pancreatic Cancer 865Vincent Bernard and Anirban Maitra 116 Palliative Chemotherapy for Advanced Pancreatic Cancer: Survival Benefit and Side Effects of Treatment 872Olusola O. Faluyi, Madhuchanda Chatterjee, and Daniel H. Palmer 117 Management of Pain in Pancreatic Cancer 879Michael Erdek, Indy Wilkinson, and Zackary E. Boomsaad 118 Role of Radio and Proton Beam Therapy for Pancreatic Cancer 886Amol K. Narang, Lauren M. Rosati, Michael D. Chuong, and Joseph M. Herman 119 Management of Cancer Recurrence 895Oliver Strobel and Markus W. Büchler Long-Term Outcome After Treatment of Pancreatic Cancer 906 120 Survival and Late Morbidity After Resection of Pancreatic Cancer 906Avinoam Nevler, Charles J. Yeo, and Jordan M. Winter Section 8 Neoplastic Tumors of the Endocrine Pancreas: Neuroendocrine Tumors of the Pancreas 919 121 Epidemiology and Classification of Neuroendocrine Tumors of the Pancreas 921J.J. Mukherjee, Kok?Onn Lee, and Gregory Kaltsas 122 Pathology of Neuroendocrine Neoplasms 930Atsuko Kasajima and Hironobu Sasano 123 Molecular Genetics of Neuroendocrine Tumors 937Nickolas Papadopoulos and Ralph H. Hruban 124 Clinical Manifestation of Endocrine Tumors of the Pancreas 947Ken Kawabe and Tetsuhide Ito 125 Evidence of Hormonal, Laboratory, Biochemical, and Instrumental Diagnostics of Neuroendocrine Tumors of the Pancreas 953Kok?Onn Lee, Gregory Kaltsas, and J.J. Mukherjee 126 Pancreatic Neuroendocrine Tumors in Multiple Neoplasia Syndromes 961Anja Rinke and Thomas Matthias Gress 127 Nonfunctioning Pancreatic Neuroendocrine Tumors: Diagnosis and Management Principles 967Takao Ohtsuka, Hideyo Kimura, and Masafumi Nakamura 128 Medical and Nucleotide Treatment of Neuroendocrine Tumors of the Pancreas 972Gregory Kaltsas, J.J. Mukherjee, and Kok?Onn Lee 129 Interventional Radiology in the Treatment of Pancreatic Neuroendocrine Tumors 979Takao Ohtsuka, Hideyo Kimura, and Masafumi Nakamura Surgical Management of Endocrine Tumors of the Pancreas 982 130 Surgical Treatment of Endocrine Tumors: Enucleation 982Henning Dralle, Phuong Nguyen Thanh, and Andreas Machens 131 Local Treatment of Endocrine Tumors: Duodenum?Preserving Partial or Total Pancreatic Head Resection and Pancreatic Middle?Segment Resection 989Hans G. Beger and Wataru Kimura 132 Surgical Treatment of Endocrine Tumors: Major Oncologic Resection 994Henning Dralle, Phuong Nguyen Thanh, and Andreas Machens 133 Management of Insulinoma 1002Keijiro Ueda, Linkaku Lee, and Tetsuhide Ito 134 Evidence of Medical and Surgical Treatment of Gastrinoma 1009Ryuichiro Doi 135 Rare Neuroendocrine Tumors of the Pancreas: Management and Evidence of Surgical Treatment 1013Ryuichiro Doi 136 Treatment of Neuroendocrine Tumors of the Pancreas and Biliary Tract 1019Andrea Frilling, Ashley K. Clift, and Vito Cincinnati Long-Term Outcome After Treatment of Neuroendocrine Tumors of the Pancreas 1029 137 Long?Term Outcome After Treatment of Endocrine Tumors 1029Andreas Machens and Henning Dralle Section 9 Periampullary Cancers and Tumors Other Than Pancreatic Cancer 1035 138 Periampullary Cancer: Clinical Presentation and Diagnostic Strategies 1037Amanda B. Cooper and Keith D. Lillemoe 139 Histology and Genetics of Cancer of the Papilla, Distal Common Bile Duct, and Duodenum 1047Yue Xue, Michelle D. Reid, and N. Volkan Adsay 140 Adenoma and Adenocarcinoma of the Ampulla of Vater: Diagnosis and Management 1058Omer Basar and William R. Brugge 141 Endoscopic Treatment of Adenomas of the Ampulla of Vater: Techniques, Results, Benefits, and Limitations 1068Natsuyo Yamamoto, Hiroyuki Isayama, and Kazuhiko Koike 142 Surgical Treatment of Adenoma and Cancer of Papilla of Vater 1074Hans G. Beger, Bertram Poch, and Bettina M. Rau 143 Surgical Treatment of Duodenal Cancer 1081Fuyuhiko Motoi and Michiaki Unno 144 Surgical Treatment of Distal Cholangiocarcinoma 1083Yukihiro Yokoyama, Tomoki Ebata, and Masato Nagino 145 Adjuvant and Palliative Chemotherapy of Periampullary Cancers 1089Eyas Mohamed, Paula Ghaneh, and John P. Neoptolemos Long-Term Survival After Tumor Resection 1097 146 Long?Term Survival After Resection of Periampullary Cancer 1097Masayuki Ohtsuka and Masaru Miyazaki Section 10 Transplantation of the Pancreas 1107 147 Transplantation of Pancreatic Islets 1109Bernhard J. Hering and Melena D. Bellin 148 Transplantation of the Pancreas 1121Hans W. Sollinger and Dixon B. Kaufman Index 1129
The Editors HANS G. BEGER, MD, FACS(Hon), JSS(Hon), CSS(Hon), Founding Editor, Professor Emeritus of Surgery, c/o University of Ulm, Ulm, Germany ANDREW L. WARSHAW, MD, FACS, FRCSEd(Hon), W. Gerald Austen Distinguished Professor of Surgery, Harvard Medical School, Surgeon-in-Chief Emeritus, Massachusetts General Hospital, Boston, MA, USA RALPH H. HRUBAN, MD, Baxley Professor and Director, The Sol Goldman Pancreatic Cancer Research Center, Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA MARKUS W. BÜCHLER, MD, Professor of Surgery and Chair, Department of Surgery, University of Heidelberg, Heidelberg, Germany MARKUS M. LERCH, MD, FRCP, Professor and Chair, Department of Medicine A, University Medicine Greifswald, Greifswald, Germany JOHN P. NEOPTOLEMOS, MA, MB, BCHIR, MD, FRCS, FMEDSCI, Professor of Surgery, Department of Surgery, University of Heidelberg, Heidelberg, Germany TOORU SHIMOSEGAWA, MD, PhD, Professor, Department of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan DAVID C. WHITCOMB, MD, PhD, Professor of Medicine, Cell Biology & Physiology, and Human Genetics, Director, UPMC Precision Medicine Service, University of Pittsburgh and UPMC, Pittsburgh, PA, USA
This updated edition of the most comprehensive reference book on pancreatic disease details the very latest knowledge on genetics and molecular biological background in terms of anatomy, physiology, pathology, and pathophysiology for all known disorders. Included for the first time are two new sections on the key areas of Autoimmune Pancreatitis and Benign Cystic Neoplasms. In addition, this edition is filled with over 500 high-quality illustrations, line drawings, and radiographs that provide a step-by-step approach to all endoscopic techniques and surgical procedures. Each of these images can be downloaded via an online image bank for use in scientific presentations. Every existing chapter has been thoroughly revised and updated to include the many changes in clinical practice since publication of the current edition. The Pancreas: An Integrated Textbook of Basic Science, Medicine, and Surgery, 3rd Edition is an important book for gastroenterologists and gastrointestinal surgeons worldwide.
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