Details

The Design of Studies for Medical Research


The Design of Studies for Medical Research


1. Aufl.

von: David Machin, Michael J. Campbell

56,99 €

Verlag: Wiley
Format: PDF
Veröffentl.: 13.05.2005
ISBN/EAN: 9780470012987
Sprache: englisch
Anzahl Seiten: 286

DRM-geschütztes eBook, Sie benötigen z.B. Adobe Digital Editions und eine Adobe ID zum Lesen.

Beschreibungen

The same careful rigour imposed on the design of phase III randomised controlled trials is not always applied to medical research in other areas such as trials conducted at earlier stages of drug development.  With the emphasis that is now placed on evidence-based medicine, such care and rigour will inevitably impact on these areas with increasing attention turned to the quality of design.  This title describes what principles can be used to structure research effectively allowing for the required degree of accuracy. Written by two best selling authors, this book includes many examples from medical literature and will be of great value to all groups conducting studies at the interface of clinical and laboratory research.
Preface. Chapter 1. What is Evidence. Chapter 2. Measurement, Forms and Questionnaires. Chapter 3. Principles of Study Size Calculation. Chapter 4. Randomisation. Chapter 5. Cross-sectional Longitudinal Studies. Chapter 6. Surveys, Cohort and Case-Control Studies. Chapter 7. Clinical Trails - General Issues. Chapter 8. Early Clinical Trials. Chapter 9. Phase III Trials. Chapter 10. Diagnosis. Chapter 11. Prognostic Factor Studies. References. Tables. Index.
"…a thorough but concise introduction to study design and data analysis." (E-STREAMS, June 2006) "…a very good attempt to discuss various aspects of clinical research…" (Journal of Biopharmaceutical Statistics, July/August 2006) "This is a well researched, well written, thoughtful, and…easy to read primer…a valuable addition to books for research physicians, medical students, and others…" (Doody's Health Services) "…this book is surprisingly refreshing…could be used in any number of situations with equality utility…" (Canadian Journal of Medical Laboratory Science, 2005)
David Machin, Division of Clinical Trials and Epidemiological Sciences, National Cancer Centre, Singapore and UK Children's Cancer Study Group, University of Leicester, UK and Institute of General Practice and Primary Care, School of Health and Related Sciences, University of Sheffield, UK Michael J. Campbell, Medical Statistics Group, Institute of General Practice and Primary Care, School of Health and Related Sciences, University of Sheffield, UK
Essential Reading for Medical Research Good design is a pre-requisite for successful medical research and The Design of Studies for Medical Research shows just how this can be achieved. The book focuses on how to effectively design studies and covers all key aspects of the process: How to take samples How to randomise Questionnaire and form design Sample size determination Design of laboratory experiments Design of clinical trials Design of epidemiological studies This book is for anyone working in medical research, from the laboratory through to general practice and public health. It will be ideal for anyone embarking upon research for the first time or submitting a research proposal for funding, but is of relevance to all health and allied health professionals Includes examples from the medical literature Highlights and summarises key concepts

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