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<p>Preface vii</p> <p>Recommended reading viii</p> <p>Sources of illustrations ix</p> <p>Acknowledgements x</p> <p>List of abbreviations xi</p> <p>About the companion website xiii</p> <p><b>Introduction 1</b></p> <p>1 Overview of the cardiovascular system 2</p> <p><b>Anatomy and histology 5</b></p> <p>2 Gross anatomy and histology of the heart 6</p> <p>3 Vascular anatomy 8</p> <p>4 Vascular histology and smooth muscle cell ultrastructure 10</p> <p><b>Blood and body fluids 13</b></p> <p>5 Constituents of blood 14</p> <p>6 Erythropoiesis, haemoglobin and anaemia 16</p> <p>7 Haemostasis 18</p> <p>8 Thrombosis and anticoagulants 20</p> <p>9 Blood groups and transfusions 22</p> <p><b>Cellular physiology 25</b></p> <p>10 Membrane potential, ion channels and pumps 26</p> <p>11 Electrophysiology of cardiac muscle and origin of the heartbeat 28</p> <p>12 Cardiac muscle excitation–contraction coupling 30</p> <p>13 Electrical conduction system in the heart 32</p> <p>14 The electrocardiogram 34</p> <p>15 Vascular smooth muscle excitation–contraction coupling 36</p> <p><b>Form and function 39</b></p> <p>16 Cardiac cycle 40</p> <p>17 Control of cardiac output 42</p> <p>18 Haemodynamics 44</p> <p>19 Blood pressure and flow in the arteries and arterioles 46</p> <p>20 The microcirculation and lymphatic system and diapedesis 48</p> <p>21 Fluid filtration in the microcirculation 50</p> <p>22 The venous system 52</p> <p>23 Local control of blood flow 54</p> <p>24 Regulation of the vasculature by the endothelium 56</p> <p>25 The pulmonary, skeletal muscle and fetal circulations 58</p> <p>26 The coronary, cutaneous and cerebral circulations 60</p> <p><b>Integration and regulation 63</b></p> <p>27 Cardiovascular reflexes 64</p> <p>28 Autonomic control of the cardiovascular system 66</p> <p>29 The control of blood volume 68</p> <p>30 Cardiovascular effects of exercise 70</p> <p>31 Shock and haemorrhage 72</p> <p><b>History, examination and investigations 75</b></p> <p>32 History and examination of the cardiovascular system 76</p> <p>33 Cardiac imaging 78</p> <p><b>Pathology and therapeutics 81</b></p> <p>34 Risk factors for cardiovascular disease 82</p> <p>35 β‐blockers, angiotensin‐converting enzyme inhibitors, angiotensin receptor blockers and Ca²⁺ channel blockers 84</p> <p>36 Hyperlipidaemias 86</p> <p>37 Atherosclerosis 88</p> <p>38 Mechanisms of primary hypertension 90</p> <p>39 Treatment of hypertension 92</p> <p>40 Stable, microvascular, and vasospastic angina 94</p> <p>41 Pharmacological management of stable, microvascular and vasospastic angina 96</p> <p>42 Non‐ST segment elevation acute coronary syndromes (NSTE‐ACS) 98</p> <p>43 Coronary revascularisation 100</p> <p>44 Pathophysiology of acute myocardial infarction 102</p> <p>45 ST segment elevation myocardial infarction (STEMI) 104</p> <p>46 Heart failure 106</p> <p>47 Treatment of chronic heart failure 108</p> <p>48 Mechanisms of tachyarrhythmia 112</p> <p>49 Atrial fibrillation 114</p> <p>50 Other supraventricular arrhythmias 118</p> <p>51 Ventricular tachyarrhythmias and their non‐pharmacological management 120</p> <p>52 Pharmacological treatment of tachyarrhythmias 122</p> <p>53 Conduction system abnormalities and pacing 124</p> <p>54 Diseases of the aortic valve 126</p> <p>55 Diseases of the mitral valve 128</p> <p>56 Congenital heart disease 130</p> <p>57 Cardiomyopathies and channelopathies 132</p> <p>58 Pulmonary hypertension 134</p> <p>59 Stroke 136</p> <p>Index 139</p>

<p><b>Philip I. Aaronson, BA, PhD</b> is Reader in Pharmacology and Therapeutics at King's College, London.</p> <p><b>Jeremy P. T. Ward, BSc, PhD, FPhysiol</b> is Emeritus Professor of Physiology at King's College, London.</p> <p><b>Michelle J. Connolly, BSc, MBBS, PhD, MRCP</b> is a ST6 Interventional Cardiology Fellow, St George’s Hospital, London.</p>

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