Details

Sustainable Flow Chemistry


Sustainable Flow Chemistry

Methods and Applications
1. Aufl.

von: Luigi Vaccaro

138,99 €

Verlag: Wiley-VCH
Format: PDF
Veröffentl.: 14.03.2017
ISBN/EAN: 9783527689088
Sprache: englisch
Anzahl Seiten: 336

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Beschreibungen

This ready reference not only presents the hot and emerging topic of modern flow chemistry, it is also unique in illustrating the important connection to sustainable chemistry.<br> Focusing on more sustainable methods and applications, the text extensively covers every important field from reaction time optimization to waste minimization, and<br> from safety improvements to microwave applications. In addition, green metrics are presented as a key aspect of the book, helping readers to evaluate the efficiency of<br> flow technologies and their impact on the overall efficiency of a chemical process.<br> An invaluable handbook for every chemist working in the laboratory, whether in academia or industry.
Foreword<br /><br />FLOW PHOTOCHEMISTRY - A GREEN TECHNOLOGY WITH A BRIGHT FUTURE<br />Introduction to Synthetic Organic Photochemistry<br />Conventional Batch Photochemistry<br />Continuous-Flow Chemistry<br />Selected Examples of Photochemical Reactions under Flow Conditions<br />Summary, Conclusion, and Outlook<br /><br />CONTINUOUS FLOW SYNTHESIS USING RECYCLABLE REACTION MEDIA<br />Introduction<br />Continuous Flow Reactions Using an Ionic Liquid<br />Continuous Flow Reactions Using a Fluorous Solvent<br />Conclusions<br /><br />SYNTHESIS AND APPLICATION OF H2O2 IN FLOW REACTORS<br />Introduction<br />The Synthesis of Hydrogen Peroxide from Hydrogen and Oxygen in Flow Process with Microtechnology<br />Application of Hydrogen Peroxide in Microreactors<br />Conclusions<br /><br />SCALE-UP OF FLOW PROCESSES IN THE PHARMACEUTICAL INDUSTRY<br />Introduction<br />Stages of Pharmaceutical Development<br />Sustainability of Supply - The Role of Continuous Processing<br />Comparison of Batch to Continuous Large-Scale Processing<br />Scale-Up of a Flow Process<br />Flow Processes in the Manufacture of Pharmaceuticals: Examples of Scale-Up<br />Summary and Outlook on Future Scale-Up<br /><br />ORGANIC SYNTHESIS IN FLOW: TOWARD HIGHER LEVELS OF SUSTAINABILITY<br />Introduction<br />Semi-Automated Optimization<br />Self-Optimizing Microreactor Systems<br />Sustainability in Microreactor Technology<br />Conclusion<br /><br />SUSTAINABLE FLOW CHEMISTRY IN DRUG DISCOVERY<br />Introduction<br />Laboratory Equipment<br />Advantages of Improved Sustainability<br />Sustainable Drug Discovery<br />Conclusions and Outlook<br /><br />FLOW TOOLS TO DEFINE WASTE/TIME/ENERGY-MINIMIZED PROTOCOLS<br />Introduction<br />Minimization of Solvents and Reuse of Catalytic Systems<br />Time/Cost/Energy Saving Examples Using Flow Approach<br />Conclusions<br /><br />THE APPLICATION OF FLOW CHEMISTRY IN THE USE OF HIGHLY REACTIVE INTERMEDIATES AND REAGENTS<br />Introduction<br />Hydrogenation Reactions in Flow<br />Carbonylation in Flow<br />Organometallic Reagents in Flow<br />Synthesis of Azides and Diazoacetates in Flow<br />The Use of Flow Reactors to Prepare Unstable Intermediates Using Photochemistry<br />The Use of Flow Reactors to Prepare Unstable Intermediates Using Electrochemistry<br />Fluorination and Trifluoromethylation in Flow<br />Conclusions<br /><br />NONCONVENTIONAL TECHNIQUES IN SUSTAINABLE FLOW CHEMISTRY<br />Introduction<br />Microwave-Assisted Flow Chemistry<br />Inductive Heating in Flow Chemistry<br />Sonochemistry in Flow Chemistry<br />Organic Electrochemistry in Flow Chemistry<br />Conclusions<br /><br />LIFE CYCLE ASSESSMENT OF FLOW CHEMISTRY PROCESSES<br />Introduction<br />Environmental Sustainability Assessment<br />Flow Processes LCA Case Studies<br />Conclusions<br /><br />SOLIDS IN CONTINUOUS FLOW REACTORS FOR SPECIALTY AND PHARMACEUTICAL SYNTHESES<br />Introduction<br />Mechanisms of Solids Formation in Flow Reactors<br />Manufacture of Solids in Flow: Soft Particles and APIs<br />Use of Solids Suspension Catalyst in Flow<br />Avoiding Blockage of Flow Reactors by Insoluble By-Products: Flow Focusing<br />Green Engineering Aspects<br /><br />Index
Luigi Vaccaro is a Professor of Organic Chemistry (habilitated in 2013 as full Professor) at the Universita degli Studi di Perugia-Italy and is a Guest Professor (Bijzonder Gastdocent) at the University of KU Leuven-Belgium. He is also an Associate Editor of the journals RSC Advances and Beilstein Journal of Organic<br> Chemistry, and a member of the FWO WT&4 Chemistry expert panel and of the OECD-EPA commission on substitution of toxic substances. Prof. Vaccaro is leading the Green S.O.C. group in Perugia and is dedicating his research and teaching activity to the development of sustainable tools for minimizing waste and accessing cleaner products. He is currently focusing on the identification and use of novel biomass-derived solvents and on the design and synthesis of novel polymeric matrices for the preparation of heterogeneous catalytic systems suitable for being used in flow and green reaction media. Recent applications are directed toward the definition of<br> sustainable protocols for cross-coupling and C-H activation processes aimed at the clean synthesis of organic semiconductors and target materials. Luigi<br> Vaccaro is author of ca. 130 scientific publications and received the Europa Medal from Society of Chemical Industry - London (2001), the ADP Award<br> from Merck's Chemistry Council for "Creative work in organic chemistry" (2006 and 2007), the G. Ciamician Medal of the Societa Chimica Italiana (2007) and the Vigevani Visiting Professorship (2014).
This ready reference not only presents the hot and emerging topic of modern flow chemistry, it is also unique in illustrating the important connection to sustainable chemistry. <br> Focusing on more sustainable methods and applications, the text extensively covers every important field from reaction time optimization to waste minimization, and from safety improvements to microwave applications. In addition, green metrics are presented as a key aspect of the book, helping readers to evaluate the efficiency of flow technologies and their impact on the overall efficiency of a chemical process.<br> An invaluable handbook for every chemist working in the laboratory, whether in academia or industry.

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