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<p>Contributors xi</p> <p>Preface xv</p> <p><b>PART I DEVELOPMENT AND REGENERATION OF CRANIOFACIAL TISSUES AND ORGANS</b></p> <p>1 Molecular Blueprint for Craniofacial Morphogenesis and Development 3<br /> <i>Paul A. Trainor</i></p> <p>2 Cranial Neural Crest Cells in Craniofacial Tissues and Organs 31<br /> <i>Carolina Parada and Yang Chai</i></p> <p>3 Craniofacial Intramembranous Bone Development and Regeneration 51<br /> <i>David P. Rice and Ritva Rice</i></p> <p>4 Temporomandibular Joint Development 71<br /> <i>Shuping Gu and YiPing Chen</i></p> <p>5 Craniofacial Muscle Development 87<br /> <i>Robert G. Kelly</i></p> <p>6 Tooth Morphogenesis and Renewal 109<br /> <i>Maria Jussila, Emma Juuri, and Irma Thesleff</i></p> <p>7 Reptilian Tooth Regeneration 135<br /> <i>Joy M. Richman, John A. Whitlock, and John Abramyan</i></p> <p>8 Tooth Root Development 153<br /> <i>Brian L. Foster, Francisco H. Nociti Jr., and Martha J. Somerman</i></p> <p>9 Systems Biology of Early Tooth Development 179<br /> <i>Daniel J. O’Connell, Joshua W. K. Ho, and Richard L. Maas</i></p> <p><b>PART II STEM CELLS AND THEIR NICHES IN CRANIOFACIAL TISSUES</b></p> <p>10 Stem Cells, Induced Pluripotent Stem Cells, and Their Differentiation to Specified Lineage Fates 205<br /> <i>George T.-J. Huang, Xiao-Ying Zou, Xing Yan, Kyle J. Hewitt, Yulia Shamis, and Jonathan A. Garlick</i></p> <p>11 Bone Marrow Mesenchymal Stem Cells 223<br /> <i>Songtao Shi and Stan Gronthos</i></p> <p>12 Adipose Tissue–Derived Stem Cells and Their Regeneration Potential 241<br /> <i>Jeffrey Gimble, Maryam Rezai Rad, and Shaomian Yao</i></p> <p>13 Skeletal Muscle Stem Cells: Their Origin and Niche Factors 259<br /> <i>Johannes W. Von den Hoff and Sander Grefte</i></p> <p>14 Stem Cells in Salivary Gland Development and Regeneration 271<br /> <i>Isabelle M. A. Lombaert and Matthew P. Hoffman</i></p> <p>15 Stem and Progenitor Cells of Dental and Gingival Tissue Origin 285<br /> <i>Christian Morsczeck, George T.-J. Huang, and Songtao Shi</i></p> <p>16 Regulation and Differentiation Potential of Dental Mesenchymal Stem Cells 303<br /> <i>Lei Wang, Christian Morsczeck, Stan Gronthos, and Songtao Shi</i></p> <p>17 An Incisive Look at Stem Cells: The Mouse Incisor as an Emerging Model for Tooth Renewal 315<br /> <i>Frederic Michon, Andrew H. Jheon, Kerstin Seidel, and Ophir D. Klein</i></p> <p>18 Mesenchymal Stem Cell Niches in Rodent Tooth Pulp 329<br /> <i>Jifan Feng and Paul T. Sharpe</i></p> <p><b>PART III STEM CELL–MEDIATED CRANIOFACIAL TISSUE BIOENGINEERING</b></p> <p>19 Bone Bioengineering: Scaffolds, Growth Factors, and Stem Cells 341<br /> <i>Christopher S. D. Lee, Christopher D. Hermann, Rolando Gittens, Rene Olivares-Navarrete, Zvi Schwartz, and Barbara D. Boyan</i></p> <p>20 Craniofacial Tissue Bioengineering and Regeneration by Endogenous Stem Cells 367<br /> <i>Nan Jiang, Mo Chen, Chang Hun Lee, Jian Zhou, Mildred C. Embree, Kimi Kong, Choko Cho, Avital Mendelson, Ying Zheng, Hemin Nie, and Jeremy J. Mao</i></p> <p>21 Stem Cell–Based Bioengineering of Craniofacial Bone 379<br /> <i>David D. Lo, Daniel T. Montoro, Monica Grova, Jeong S. Hyun, Michael T. Chung, Derrick C. Wan, and Michael T. Longaker</i></p> <p>22 Muscle Tissue Engineering Approaches 395<br /> <i>Johannes W. Von den Hoff and Sander Grefte</i></p> <p>23 Engineering of Dental Tissues: Scaffolds and Preclinical Models 409<br /> <i>Na Yu, Adelina Plachokova, Fang Yang, X. Frank Walboomers, and John A. Jansen</i></p> <p>24 Whole-Tooth Engineering and Cell Sources 431<br /> <i>L. Keller, S. Kuchler-Bopp, and Herv´e Lesot</i></p> <p>25 Bioengineering of Functional Teeth 447<br /> <i>Takashi Tsuji</i></p> <p>26 Pulp and Dentin Regeneration 461<br /> <i>Misako Nakashima and George T.-J. Huang</i></p> <p>27 Bioengineering of Roots and Periodontal Tissues 485<br /> <i>Songlin Wang, Gang Ding, Fulan Wei, and Yi Liu</i></p> <p>28 Periodontal Bioengineering Strategies: The Present Status and Some Developing Trends 501<br /> <i>Fa-Ming Chen and Yan Jin</i></p> <p>Index 525</p>

<p><b>George T.-J. Huang, DDS, MSD, DSc,</b> is the Director for Stem Cells and Regenerative Therapies in the College of Dentistry at the University of Tennessee Health Science Center.</p> <p><b>Irma Thesleff, DDS, PhD,</b> is the Research Director of the Developmental Biology Program at the Institute of Biotechnology at the University of Helsinki.</p>

<p><b>A revealing look at the latest in craniofacial stem cell research and therapy</b></p> <p>With their unique ability to repair and replenish adult tissues, stem cells are increasingly used in cutting-edge medical therapies. This timely work focuses on the role of stem cells in craniofacial development, exploring the rapidly evolving area of dental and craniofacial tissue regeneration.</p> <p>With expert contributions from the forefront of craniofacial research and dentistry, <i>Stem Cells in Craniofacial Development and Regeneration</i> first introduces the development and regeneration of craniofacial tissues and organs, from neural crest cells to early tooth development. It then goes on to examine the different types of stem cells and their niches in craniofacial tissues, including what we can learn from rodent models. Concluding chapters survey the latest trends in stem cell–mediated craniofacial tissue bioengineering and stem cell therapies for treating damaged or lost tissue. <i>Stem Cells in Craniofacial Development and Regeneration:</i></p> <ul> <li>Explains the mechanisms and biology of craniofacial morphogenesis and development</li> <li>Describes bone, tooth, muscle, and temporomandibular joint (TMJ) development and regeneration</li> <li>Covers dental, muscle, salivary gland, induced pluripotent stem cells (iPSCs), and stem cells from bone marrow and adipose tissue</li> <li>Highlights advances in bioengineering for the repair of bone, muscle tissue, teeth, roots, and periodontal tissue</li> <li>Offers information on biological data integration and searching</li> </ul> <p><i>Stem Cells in Craniofacial Development and Regeneration</i> is a must-have reference for craniofacial researchers, developmental biologists, tissue engineers, and dentists. It is also an important guide for students in dentistry and oral-maxillofacial surgery and related fields.</p>

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