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<p>Preface xi</p> <p>Contributors xxvii</p> <p><b>Part I The Science of Sleep Medicine 1</b></p> <p>1 Normal Human Sleep 3<br /> <i>Anil Natesan Rama, S. Charles Cho, and Clete A. Kushida</i></p> <p>2 The Neurobiology of Sleep 11<br /> <i>Gerald A. Marks</i></p> <p>3 Physiologic Processes During Sleep 19<br /> <i>Leon Rosenthal</i></p> <p>4 Biological Rhythms and Sleep 25<br /> <i>Robert Y. Moore</i></p> <p>5 Biology of Dreaming 31<br /> <i>Milton Kramer</i></p> <p>6 Psychology of Dreaming 37<br /> <i>Milton Kramer</i></p> <p>7 The Function of Sleep 45<br /> <i>Marcos G. Frank</i></p> <p>8 The Evolution of Sleep: A Phylogenetic Approach 49<br /> <i>John A. Lesku, Niels C. Rattenborg, and Charles J. Amlaner, Jr.</i></p> <p>9 Neuropharmacology of Sleep and Wakefulness 63<br /> <i>Edgar Garcia-Rill, Tiffany Wallace, and Cameron Good</i></p> <p>10 Epidemiology of Sleep Disorders 73<br /> <i>Maurice M. Ohayon and Christian Guilleminault</i></p> <p>11 Classification of Sleep Disorders 83<br /> <i>Andrew L. Chesson, Jr.</i></p> <p><b>Part II Insomnia 91</b></p> <p>12 Insomnia: Prevalence and Daytime Consequences 93<br /> <i>W. David Brown</i></p> <p>13 Causes of Insomnia 99<br /> <i>Edward J. Stepanski</i></p> <p>14 Medications that Can Cause Insomnia 103<br /> <i>Carolyn H. Welsh and Randolph V. Fugit</i></p> <p>15 Fatal Familial Insomnia 111<br /> <i>Charles A. Polnitsky</i></p> <p>16 Evaluation of Insomnia 117<br /> <i>Douglas E. Moul and Daniel J. Buysse</i></p> <p>17 Pharmacologic Therapy of Insomnia 125<br /> <i>Teofilo Lee-Chiong and Michael Sateia</i></p> <p>18 Nonpharmacologic Therapy of Insomnia 133<br /> <i>Melanie K. Means and Jack D. Edinger</i></p> <p><b>Part III Excessive Sleepiness 137</b></p> <p>19 Sleep Deprivation and Its Effects on Cognitive Performance 139<br /> <i>Jillian Dorrian and David F. Dinges</i></p> <p>20 Narcolepsy 145<br /> <i>Rafael Pelayo and Maria Cecilia Lopes</i></p> <p>21 Idiopathic Hypersomnia 151<br /> <i>Stephen N. Brooks</i></p> <p>22 Post-traumatic and Recurrent Hypersomnia 157<br /> <i>Carolyn M. D’Ambrosio and Joshua Baron</i></p> <p>23 Sleeping Sickness 163<br /> <i>Alain Buguet, Florian Chapotot, Raymond Cespuglio, Sylvie Bisser, and Bernard Bouteille</i></p> <p>24 Medications that Induce Sleepiness 175<br /> <i>J. F. Pagel</i></p> <p>25 Evaluation of Excessive Sleepiness 183<br /> <i>Merrill S. Wise</i></p> <p>26 Therapy for Excessive Sleepiness 191<br /> <i>Max Hirshkowitz</i></p> <p>27 Napping 197<br /> <i>Masaya Takahashi and Kosuke Kaida</i></p> <p>28 Sleep Loss, Sleepiness, Performance, and Safety 203<br /> <i>Roger R. Rosa</i></p> <p><b>Part IV Sleep Disordered Breathing Syndromes 209</b></p> <p>29 Physiology of Sleep Disordered Breathing 211<br /> <i>B. Tucker Woodson</i></p> <p>30 Snoring 223<br /> <i>Eric J. Olson and John G. Park</i></p> <p>31 Overview of Obstructive Sleep Apnea in Adults 231<br /> <i>Mark H. Sanders and Rachel J. Givelber</i></p> <p>32 Upper Airway Resistance Syndrome 241<br /> Robert D. Ballard</p> <p>33 Central Sleep Apnea 249<br /> <i>S. Javaheri</i></p> <p>34 Obesity Hypoventilation Syndrome 263<br /> <i>John G. Park</i></p> <p>35 Cardiovascular Complications of Obstructive Sleep Apnea 267<br /> <i>Peter Y. Hahn, Lyle J. Olson, and Virend K. Somers</i></p> <p>36 Pulmonary Hypertension and Sleep Disordered Breathing 275<br /> <i>Brooke G. Judd</i></p> <p>37 Neurocognitive and Functional Impairment in Obstructive Sleep Apnea 279<br /> <i>W. David Brown</i></p> <p>38 Sleep Apnea and Cerebrovascular Disease 287<br /> <i>Vahid Mohsenin and Henry Yaggi</i></p> <p>39 Radiographic and Endoscopic Evaluation of the Upper Airway 293<br /> <i>Richard J. Schwab and Neil S. Kline</i></p> <p>40 Evaluation of Sleep Disordered Breathing: Polysomnography 303<br /> <i>Reena Mehra and Kingman P. Strohl</i></p> <p>41 Evaluation of Sleep Disordered Breathing 2: Portable Sleep Monitoring 317<br /> <i>Michael R. Littner</i></p> <p>42 Indications for Treatment of Obstructive Sleep Apnea in Adults 331<br /> <i>Nilesh B. Dav</i><i>é and Patrick J. Strollo</i></p> <p>43 Medical Treatment of Obstructive Sleep Apnea: Life-Style Changes, Weight Reduction, and Postural Therapy 337<br /> <i>Sheldon Kapen</i></p> <p>44 Pharmacological Treatment of Sleep Disordered Breathing 347<br /> <i>David W. Hudgel</i></p> <p>45 Positive Airway Pressure Therapy for Obstructive Sleep Apnea 355<br /> <i>Max Hirshkowitz and Teofilo Lee-Chiong</i></p> <p>46 Upper Airway Surgery for Obstructive Sleep Apnea 365<br /> <i>Aaron E. Sher</i></p> <p>47 Oral Devices Therapy for Obstructive Sleep Apnea 373<br /> <i>Dennis R. Bailey</i></p> <p><b>Part V Circadian Rhythm Sleep Disorders 381</b></p> <p>48 Advanced, Delayed, Irregular, and Free-Running Sleep–Wake Disorders 383<br /> <i>Yaron Dagan, Katy Borodkin, and Liat Ayalon</i></p> <p>49 Jet Lag 389<br /> <i>Timothy H. Monk</i></p> <p>50 Shift Work Sleep Disorder 395<br /> <i>Gary S. Richardson</i></p> <p>51 Neurological and Medical Disorders Associated with Circadian Rhythm Disturbances 401<br /> <i>Ramadevi Gourineni and Phyllis C. Zee</i></p> <p>52 Psychiatric Disorders Associated with Circadian Rhythm Disturbances 409<br /> <i>Stephany Jones and Ruth M. Benca</i></p> <p>53 Therapy of Circadian Sleep Disorders 415<br /> <i>Robert Sack and Kyle Johnson</i></p> <p><b>Part VI Parasomnias 423</b></p> <p>54 Disorders of Arousal and Sleep-Related Movement Disorders 425<br /> <i>Keith Cavanaugh and Norman R. Friedman</i></p> <p>55 Sleepwalking 429<br /> <i>Rosalind D. Cartwright</i></p> <p>56 REM Sleep Behavior Disorder and REM-Related Parasomnias 435<br /> <i>Maja Tippmann-Peikert, Timothy I. Morgenthaler, Bradley F. Boeve, and Michael H. Silber</i></p> <p>57 Nocturnal Enuresis in Children 443<br /> <i>Marie-Jos</i><i>èphe Challamel and Pierre Cochat</i></p> <p>58 Sleep Bruxism 449<br /> <i>Gaby Bader</i></p> <p>59 Sleep-Related Eating Disorders 457<br /> <i>R. Robert Auger and Timothy I. Morgenthaler</i></p> <p>60 Other Parasomnias 463<br /> <i>Asher Qureshi</i></p> <p><b>Part VII Movement Disorders 471</b></p> <p>61 Restless Legs Syndrome 473<br /> <i>Philip M. Becker</i></p> <p>62 Periodic Limb Movement Disorder 483<br /> <i>Basheer Y. Khassawneh</i></p> <p><b>Part VIII Sleep in Infants and Children 487</b></p> <p>63 Ontogeny of EEG Sleep from Neonatal Through Infancy Periods 489<br /> <i>Mark S. Scher</i></p> <p>64 Sleep in Infants and Children 507<br /> <i>Stephen H. Sheldon</i></p> <p>65 Sleep and Breathing During Early Postnatal Life 511<br /> <i>Aviv D. Goldbart, Riva Tauman, and David Gozal</i></p> <p>66 Congenital Syndromes Affecting Respiratory Control During Sleep 517<br /> <i>Manisha B. Witmans, Maida L. Chen, Sally L. Davidson Ward, and Thomas G. Keens</i></p> <p>67 Sudden Infant Deaths 529<br /> <i>A. Kahn, P. Franco, J. Groswasser, S. Scaillet, B. Dan, I. Kato, T. Sawaguchi, and I. Kelmanson</i></p> <p>68 Obstructive Sleep Apnea in Children 535<br /> <i>Preetam Bandla and Carole L. Marcus</i></p> <p>69 The Sleepless Child 541<br /> <i>William H. Moorcroft</i></p> <p>70 The Sleepy Child 547<br /> <i>Gerald Rosen</i></p> <p>71 Craniofacial Syndromes and Sleep Disorders 551<br /> <i>Laurel M. Wills, James Q. Swift, and Karlind T. Moller</i></p> <p>72 Medical Disorders 561<br /> <i>John M. Palmer and Lee J. Brooks</i></p> <p>73 Sleep in Children with Neurological Disorders 567<br /> <i>Suresh Kotagal</i></p> <p>74 Sleep in Children with Neuromuscular Disease 575<br /> <i>Deborah C. Givan</i></p> <p>75 Sleep in Children with Behavioral and Psychiatric Disorders 581<br /> <i>Judith A. Owens and Katherine Finn Davis</i></p> <p>76 Circadian Rhythm Disorders in Infants, Children, and Adolescents 589<br /> <i>John H. Herman</i></p> <p><b>Part IX Sleep in the Elderly 597</b></p> <p>77 Normal Sleep in Aging 599<br /> <i>Liat Ayalon and Sonia Ancoli-Israel</i></p> <p>78 Sleep Disordered Breathing in Older Adults 605<br /> <i>Nalaka Gooneratne</i></p> <p>79 Insomnia and Aging 611<br /> <i>Leah Friedman</i></p> <p>80 Sleep in Institutionalized Older Adults 615<br /> <i>Jennifer L. Martin and Cathy A. Alessi</i></p> <p><b>Part X Sleep Among Women 621</b></p> <p>81 Patterns of Sleep in Women: An Overview 623<br /> <i>Helen S. Driver</i></p> <p>82 Sleep During Pregnancy and Postpartum 629<br /> <i>Kathryn A. Lee</i></p> <p>83 Menstrual-Related Sleep Disorders 637<br /> <i>Grace W. Pien and Elizabeth A. Beothy</i></p> <p>84 Sleep Disordered Breathing in Women 643<br /> <i>M. Safwan Badr</i></p> <p>85 Sleep During the Perimenopausal Period 651<i><br /> Naomi L. Rogers and Ronald R. Grunstein</i></p> <p>86 Sleep During Postmenopause 657<br /> <i>Karen E. Moe</i></p> <p><b>Part XI Sleep in the Respiratory Disorders 661</b></p> <p>87 Respiratory Control During Sleep 663<br /> <i>William R. Krimsky and James C. Leiter</i></p> <p>88 Asthma 669<br /> <i>David A. Beuther and Richard J. Martin</i></p> <p>89 Chronic Obstructive Pulmonary Disease and Sleep 677<br /> <i>Conrad Iber</i></p> <p>90 Sleep and Breathing in Cystic Fibrosis 685<br /> <i>Amanda J. Piper, Maree A. Milross, and Peter T.P. Bye</i></p> <p>91 Restrictive Thoracic and Neuromuscular Disorders 693<br /> <i>Christophe Perrin, Carolyn D’Ambrosio, Alexander White, Erik Garpestad, and Nicholas S. Hill</i></p> <p>92 Noninvasive Ventilation and Sleep 705<br /> <i>G. Liistro and D. Rodenstein</i></p> <p><b>Part XII Sleep in the Cardiac Disorders 711</b></p> <p>93 Hypertension and Cardiovascular Disease 713<br /> <i>Robert D. Ballard</i></p> <p>94 Congestive Heart Failure 721<br /> <i>Emilio Mazza and Indira Gurubhagavatula</i></p> <p>95 Cardiac Arrhythmias and Sudden Death During Sleep 727<br /> <i>Richard L. Verrier and Mark E. Josephson</i></p> <p><b>Part XIII Sleep in the Other Medical Disorders 733</b></p> <p>96 Sleep and the Gastrointestinal Tract 735<br /> <i>William C. Orr</i></p> <p>97 Renal Disease 741<br /> <i>Kathy P. Parker</i></p> <p>98 Endocrine and Metabolic Disorders and Sleep 745<br /> <i>Alexandros N. Vgontzas, Slobodanka Pejovic, and George P. Chrousos</i></p> <p>99 Sleep in Fibromyalgia and Chronic Pain 759<br /> <i>Susan M. Harding and Teofilo Lee-Chiong</i></p> <p>100 Sleep and the Immune Response 767<br /> <i>James M. Krueger and Jeannine A. Majde</i></p> <p><b>Part XIV Sleep in the Neurologic Disorders 773</b></p> <p>101 Alzheimer’s Dementia 775<br /> <i>Michael V. Vitiello</i></p> <p>102 Neurodegenerative Disorders 783<br /> <i>David G. Harper</i></p> <p>103 Parkinson’s Disease 789<br /> <i>Michael H. Silber</i></p> <p>104 Seizures 793<br /> <i>Margaret N. Shouse</i></p> <p>105 Headaches and Sleep 805<br /> <i>Glen P. Greenough</i></p> <p>106 Cerebrovascular Disorders 809<br /> <i>Bishoy Labib and Sarkis M. Nazarian</i></p> <p>107 Brain and Spinal Cord Injury 817<br /> <i>Richard J. Castriotta</i></p> <p>108 The Blind Patient 823<br /> <i>Damien Leger and Arnaud Metlaine</i></p> <p><b>Part XV Sleep in the Psychiatric Disorders 827</b></p> <p>109 Schizophrenia 829<br /> <i>Rachel J. Norwood and Teofilo Lee-Chiong</i></p> <p>110 Mood Disorders 837<br /> <i>Roseanne Armitage</i></p> <p>111 Anxiety Disorders and Sleep 845<br /> <i>Michael Weissberg</i></p> <p>Appendix 851</p> <p>112 Trauma and Post-traumatic Stress Disorder 857<br /> <i>Giora Pillar, Louise Harder, and Atul Malhotra</i></p> <p>113 Alcohol, Alcoholism, and Sleep 867<br /> <i>Maren Hyde, Timothy Roehrs, and Thomas Roth</i></p> <p>114 Drugs of Abuse and Sleep 873<br /> <i>Maren Hyde, Timothy Roehrs, and Thomas Roth</i></p> <p><b>Part XVI Sleep in Special Patient Groups 879</b></p> <p>115 Sleep and the Caregiver 881<br /> <i>Patricia A. Carter</i></p> <p>116 Sleep in Patients with HIV Disease 885<br /> <i>Suzan E. Jaffe</i></p> <p>117 The Patient with Cancer 893<br /> <i>Christine A. Engstrom</i></p> <p>118 Sleep in the Intensive Care Unit 899<br /> <i>Samuel L. Krachman and Wissam Chatila</i></p> <p>119 Sleep and the Cardiac Surgery Patient 909<br /> <i>Nancy S. Redeker and Christine Hedges</i></p> <p>120 Sleep Disturbances After Noncardiac Surgery 913<br /> <i>Ismail Gögenur and Jacob Rosenberg</i></p> <p>121 Relevance of Anesthesiology for Sleep Medicine 927<br /> <i>Ralph Lydic and Helen A. Baghdoyan</i></p> <p>122 Sleep at High Altitudes 933<br /> <i>Wissam Chatila and Samuel Krachman</i></p> <p>123 Sleep and Aviation 939<br /> <i>John A. Caldwell</i></p> <p>124 Sleep, Exercise, and Sports 947<br /> <i>Carol A. Enderlin and Kathy C. Richards</i></p> <p>125 Sleep, Sleep Loss, and Circadian Influences on Performance and Professionalism of Health Care Workers 953<br /> <i>Sigrid Carlen Veasey</i></p> <p>126 The Student with Sleep Complaints 959<br /> <i>Jagdeep Bijwadia and Donn Dexter</i></p> <p><b>Part XVII Sleep Assessment Methods 965</b></p> <p>127 The Sleep Interview and Sleep Questionnaires 967<br /> <i>Charles J. Bae and Joseph A. Golish</i></p> <p>128 Polysomnography 973<br /> <i>Nancy A. Collop</i></p> <p>129 Pediatric Polysomnography 977<br /> <i>May L. Griebel and Linda K. Moyer</i></p> <p>130 Introduction to Sleep Electroencephalography 989<br /> <i>Selim R. Benbadis</i></p> <p>131 Monitoring Respiration During Sleep 1025<br /> <i>Ulysses J. Magalang, Rami Khayat, and Naeem Ali</i></p> <p>132 Recording and Monitoring Limb Movements During Sleep 1031<br /> <i>Crintz E. Scott</i></p> <p>133 Actigraphy 1035<br /> <i>Christine Acebo</i></p> <p>134 pH Monitoring and Other Esophageal Tests 1039<br /> <i>Gary R. Cott</i></p> <p>135 Psychological Assessment of the Sleep Patient 1045<br /> <i>Amy B. Robinson Ikelheimer and Brian Hoyt</i></p> <p>136 Operating and Managing a Sleep Disorders Center 1051<br /> <i>Richard S. Rosenberg</i></p> <p>137 Accrediting a Sleep Program 1055<br /> <i>Donna Arand</i></p> <p>Index 1059</p>

"This complete and practical reference guide…is essential reading for those interested in sleep medicine." (<i>E-STREAMS</i>, September 2007) <p>“The book is easy to read and the style from chapter to chapter is remarkably consistent, which is a very difficult feat, considering that 215 authors contributed to this book’s 1,058 pages.” (<i>Respiratory Care</i>, June 2007)</p> <p>"The text stands alone as an insightful and comprehensive 'encyclopedia' detailing the phenomenon of sleep." (<i>The Journal of the American Medical Association</i>, April 18, 2007)</p> <p>"I highly recommend this book to the clinicians and medical students who would like to sleep well, knowing that they have done everything possible to make their patients' sleep restful and healthy." (<i>New England Journal of Medicine</i>, January 11, 2007)</p> <p>"...no other publication in the field can begin to compare with the breadth or depth of the 'Handbook'...I cannot imagine a functioning sleep disorders clinic without at least one copy on standby as a ready reference." (<i>PscyCRITIQUES</i>, July 19, 2006)</p> <p>"<i>Sleep: A Comprehensive Handbook</i> is a first-rate textbook with concise, up-to-date information covering a wide range of subjects pertinent to the practice of sleep medicine." (<i>Doody's Health Services</i>)</p>

<b>TEOFILO L. LEE-CHIONG</b>, MD, is Associate Professor, Department of Medicine, National Jewish Medical and Research Center in Denver, Colorado. He has served as associate professor in the Department of Medicine at the University of Arkansas College of Medicine, where he was awarded the Red Sash Award for Excellence in Medical Education (2000). He performed his residency and fellowship in internal medicine and pulmonary and critical care at Yale University School of Medicine, followed by a post-fellowship in sleep medicine at Dartmouth Medical School.

<b>A unique new resource on sleep medicine</b> <p>Written by contemporary experts from around the world, <i>Sleep: A Comprehensive Handbook</i> covers the entire field of sleep medicine. Taking a novel approach, the text features both syndrome- and patient-oriented coverage, making it ideally suited for both clinical use and academic study.</p> <p><i>Sleep: A Comprehensive Handbook</i> begins with a brief introduction to the basic science of sleep, from neurobiology to physiologic processes. This leads into sections offering comprehensive coverage of insomnia, sleep apnea, narcolepsy, parasomnias, movement disorders, and much more. Sleep and related disorders are also discussed, followed by chapters on considerations for special patient groups. Special materials for practitioners include a sample interview and questionnaire as well as a chapter on operating and managing a sleep center. The text concludes with discussions of sleep assessment methods such as polysomnography, actigraphy, and video EEG monitoring.</p> <p>With full coverage of over 100 key topics in sleep medicine, <i>Sleep: A Comprehensive Handbook</i> offers the most practical, thorough, yet handy resource available on adult and pediatric sleep medicine.</p>

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