The most important and reliable resource for treating diseases of the liver For more than 55 years, "Schiff" has been acclaimed as the most outstanding liver book in the world. This new 12th edition brings the field completely up to date and includes a companion website that features a wide-variety of accessory materials. The text is evidence-based to offer hepatologists and gastroenterologists treating patients with liver disease a comprehensive and essential resource. The text highlights clinical practice and covers anatomy, pathology, testing, imaging, and the effects of liver disease on other organs. The book is written in clear and accessible terms and key features include: Treatment guidelines and management algorithms for every disease Full-color attractive design throughout the text Informative section overviews for each section Concise key concepts box in every chapter A full liver transplant section This 12th edition is thoroughly revised with the latest clinical information. The new edition offers: Information on acute and chronic liver failure and infections in cirrhosis Over 100 MCQs Downloads for Powerpoint™ making the content ideal for presentations Schiff's Diseases of the Liver is designed to be a first-stop reference for dealing with today’s demanding clinical situations.
Contributors, viii Foreword, xiii Preface, xiv About the Companion Website, xvi Part I Overview: Clinical Fundamentals of Hepatology 1 History Taking and Physical Examination for the Patient with Liver Disease, 3Esperance A. Schaefer and Lawrence S. Friedman 2 Laboratory Tests, Noninvasive Markers of Fibrosis, Liver Biopsy, and Laparoscopy, 17Michael P. Curry and Lennox J. Jeffers 3 Noninvasive and Invasive Imaging of the Liver and Biliary Tract, 38Koushik K. Das, Matthew A.Morgan, and Gregory G. Ginsberg Part II General Considerations 4 Physioanatomic Considerations, 73Ian R. Wanless 5 Bilirubin Metabolism and Jaundice, 103Allan W. Wolkoff and Paul D. Berk 6 Hepatic Histopathology, 135Zachary D. Goodman 7 Mechanisms of Liver Injury, 200Harmeet Malhi and Gregory J. Gores 8 Hepatic Manifestations of Systemic Disorders, 218Stuart C. Gordon and Humberto C. Gonzalez 9 The Liver in Pregnancy, 244Nancy Reau and Yannick Bacq Part III Consequences of Liver Disease 10 Hepatic Fibrosis, 271Scott L. Friedman 11 Preoperative Evaluation of the Patient with Liver Disease, 290Patrick S. Kamath and Mark T. Keegan 12 Management of Portal Hypertension, 304Guadalupe Garcia-Tsao and Juan G. Abraldes 13 Renal Complications of Liver Disease and the Hepatorenal Syndrome, 336Xingxing S. Cheng and W. Ray Kim 14 Pulmonary Manifestations of Liver Disease, 353Michael B. Fallon and Anil Seetharam 15 Ascites and Spontaneous Bacterial Peritonitis, 365Vicente Arroyo and Javier Fern´andez 16 Hepatic Encephalopathy, 387Chathur Acharya and Jasmohan S. Bajaj 17 Acute Liver Failure, 411Robert J. Fontana and Khurram Bari 18 Acute-on-Chronic Liver Failure, 432Florence Wong 19 Malnutrition and Liver Disease, 460Craig McClain, Irina Kirpich, and Laura Smart Part IV Cholestatic Disorders 20 Primary Sclerosing Cholangitis, 491John M. Vierling 21 Primary Biliary Cholangitis, 523Cynthia Levy, Andres F. Carrion, and Marlyn J. Mayo 22 Autoimmune Hepatitis, 546Gideon M. Hirschfield and Gwilym J. Webb Part V Viral Hepatitis 23 Hepatitis A and E, 565Kenneth E. Sherman and Shyam Kottilil 24 Hepatitis B and D, 584Marc G. Ghany and Naveen Gara 25 Hepatitis C, 628Michael W. Fried, Jama M. Darling, and Stanley M. Lemon Part VI Alcohol- and Drug-induced Liver Disease 26 Alcoholic Liver Disease, 701Mack C. Mitchell and Gyongyi Szabo 27 Drug-induced Hepatotoxicity, 740Dominique Larrey, Jose Ursic-Bedoya, and Lucy Meunier 28 Mechanisms of Drug-induced Liver Injury, 774Paul B. Watkins and Merrie Mosedale Part VII Genetic and Metabolic Disease 29 Wilson Disease, 801Michael L. Schilsky and Aftab Ala 30 Hemochromatosis and Iron Storage Disorders, 820Kris V. Kowdley and Priya Handa 31 Alpha-1 Antitrypsin Deficiency, 843David H. Perlmutter 32 Nonalcoholic Fatty Liver Disease, 867Curtis K. Argo, Zachary H. Henry, and Stephen H. Caldwell Part VIII Vascular Diseases of the Liver 33 Vascular Liver Disease, 911Dominique-Charles Valla 34 The Liver in Circulatory Failure, 935Santiago J. Munoz, Hanisha R. Manickavasagan, and Idean Amirjazil Part IX Benign and Malignant Tumors; Cystic Disorders 35 Benign Tumors, Nodules, and Cystic Diseases of the Liver, 949Julien Calderaro and Jessica Zucman-Rossi 36 Hepatocellular Carcinoma, 977Maddie Kubiliun and Jorge A. Marrero 37 Surgical Options in Liver Cancers, 989Garrett R. Roll and John Paul Roberts Part X Infectious and Granulomatous Disease 38 Amoebic and Pyogenic Liver Abscesses, 1005Marco A. Olivera-Mart´?nez and David Kershenobich 39 Parasitic Diseases, 1013Michael A. Dunn 40 Granulomas of the Liver, 1028James H. Lewis Part XI Elements of Liver Transplantation 41 Selection of Candidates and Timing of Liver Transplantation, 1055Meaghan Phipps, Alyson N. Fox, and Robert S. Brown Jr. 42 Immunosuppression: The Global Picture, 1065Caroline C. Jadlowiec, Timucin Taner, and Russell H. Wiesner 43 The First Six Months Following Liver Transplantation, 1079K. Rajender Reddy and Manuel Mendizabal 44 Long-term Management of the Liver Transplant Patient, 1093Timothy M. McCashland 45 The Liver Transplant Procedure, 1107Bijan Eghtesad, Koji Hashimoto, and John Fung 46 Recurrent Disease Following Liver Transplantation, 1127Haripriya Maddur and Josh Levitsky 47 The Role of Retransplantation, 1143Peter L. Abt and Kim M. Olthoff 48 Controversies in Liver Transplantation, 1156James F. Trotter Index, 1169
About the Editors EUGENE R. SCHIFF MD, MACP, FRCP, MACG, FAASLD is Professor of Medicine, University of Miami Miller School of Medicine, and Director, Schiff Center for Liver Diseases, Miami, USA. WILLIS C. MADDREY MD, MACP, FRCP, FAASLD is Professor of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, USA. K. RAJENDER REDDY MD, FAASLD is Ruimy Family President's Distinguished Professor of Medicine, Director of Hepatology, and Medical Director of Liver Transplantation, University of Pennsylvania, Philadelphia, USA.
The most important and reliable resource for treating diseases of the liver For more than 55 years, “Schiff” has been acclaimed as the most outstanding liver book in the world. This new 12th edition brings the field completely up to date and includes a companion website. The text is evidence-based to offer hepatologists and gastroenterologists treating patients with liver disease a comprehensive and essential resource. The text highlights clinical practice and covers anatomy, pathology, testing, imaging, and the effects of liver disease on other organs. The book is written in clear and accessible terms and key features include: Treatment guidelines and management algorithms for every disease Attractive full-color design throughout the text Concise key concepts box in every chapter A full liver transplant section This 12th edition is thoroughly revised with the latest clinical information. The new edition also offers: Information on acute and chronic liver failure and infections in cirrhosis Over 100 MCQs and PowerPoints of all figures from the print book on a companion website Schiff’s Diseases of the Liver is designed to be a first-stop reference for dealing with today’s demanding clinical situations.