Details

Reaction Mechanisms in Organic Chemistry


Reaction Mechanisms in Organic Chemistry


1. Aufl.

von: Metin Balci

79,99 €

Verlag: Wiley-VCH
Format: EPUB
Veröffentl.: 23.11.2021
ISBN/EAN: 9783527834594
Sprache: englisch
Anzahl Seiten: 640

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Beschreibungen

<p><b>An accessible and step-by-step exploration of organic reaction mechanisms</b></p> <p>In <i>Reaction Mechanisms in Organic Chemistry, </i>eminent researcher Dr. Metin Balcı explains organic reaction mechanisms step-by-step. The book offers a way for undergraduate and graduate students to understand—rather than memorize—the principles of reaction mechanisms. It includes the most important reaction types, including substitution, elimination, addition, pericyclic, and C-C coupling reactions. <p>Each chapter contains problems and accompanying solutions that cover central concepts in organic chemistry. Students will learn to understand the foundational nature of ideas like Lewis acids and bases, electron density, the mesomeric effect, and the inductive effect via the use of detailed examples and an expansive discussion of the concept of hybridization. <p>Along with sections covering aromaticity and the chemistry of intermediates, the book includes: <ul><li>A thorough introduction to basic concepts in organic reactions, including covalent bonding, hybridization, electrophiles and nucleophiles, and inductive and mesomeric effects</li> <li>Comprehensive explorations of nucleophilic substitution reactions, including optical activity and stereochemistry of SN<sub>2</sub> reactions </li> <li>Practical discussions of elimination reactions, including halogene elimination and Hofmann elimination </li> <li>In-depth examinations of addition reactions, including the addition of water to alkenes and the epoxidation of alkenes </li></ul> <p>Perfect for students of chemistry, biochemistry, and pharmacy, <i>Reaction Mechanisms in Organic Chemistry</i> will also earn a place in the libraries of researchers and lecturers in these fields seeking a one-stop resource on organic reaction mechanisms.
BASIC CONCEPTS<br> Covalent Bonding and Hybridization<br> Electrophiles and Nucleophiles<br> Inductive and Mesomeric Effects<br> Formal Charge And Oxidation Number<br> Acids And Bases<br> Reaction Kinetics And Energy Diagrams <br> <br> NUCLEOPHILIC SUBSTITUTION REACTIONS<br> Unimolecular Substitution Reactions SN1<br> Stereochemistry in SN1 Reactions<br> Optical Activity<br> Bimolecular Substitution Reactions SN2<br> Stereochemistry of SN2 Reactions<br> Nucleophilic Substitution On Allylic Systems: Allylic Rearrangement<br> Internal Nucleophilic Substitution Reaction SNi<br> Neighboring Group Participation in Nucleophilic Substitution Reactions<br> Ambident Nucleophiles<br> Various Nucleophilic Substitution Reactions<br> <br> ELIMINATION REACTIONS<br> Unimolecular Elimination Reactions, E1<br> Bimolecular Elimination Reactions, E2 <br> Unimolecular Conjugate Base<br> Halogene Elimination<br> Hofmann Elimination: Quaternary Ammonium Salts<br> Pyrolitic Eliminations: Intramolecular cis-Elimination Reactions<br> Elimination at the Bridgehead: Bredt?s Rule<br> <br> ADDITION REACTIONS<br> Halogen Addition To Double Bonds: Halogenation<br> Addition of Hydrogen Halides to Double Bonds: Markovnikov?s Rule<br> Anti-Markovnikov Addition of Hydrogen Halides to Alkenes<br> Addition of Water to Alkenes<br> Oxymercuration and Demercuration<br> Hydroboration of Alkenes: Anti-Markovnikov Hydration<br> Epoxidation of the Alkenes<br> Vicinal cis-Dihydroxylation<br> Dihydroxylation via PIFA<br> Enzymatic Dihydroxylation<br> Ozonolysis: Oxidative Cleavage of Alkenes<br> Reduction of Alkenes<br> Addition to Conjugated Dienes<br> <br> CARBONYL COMPOUNDS AND THEIR REACTIONS<br> Structure-Reactivity Relationships<br> Reactions of Carbonyl Compounds<br> Carbonyl Addition Reactions<br> Umpolung: Polarity Inversion of Aldehyde Carbonyl Group<br> Reactions of Aldehydes and Ketones with Amines<br> Reduction of Carbonyl Groups<br> Reaction of Carbonyl Groups with Organometallic Compounds<br> Reaction of Carbonyl Groups with Ylides<br> Phosphonium Ylides and Wittig Reaction<br> Reactivity of alpha-Carbon Atom <br> Keto-Enol Tautomerism<br> Proton-Deuterium Exchange <br> alpha-Halogenation of Ketones and Aldehydes: Haloform Reaction <br> Hell-Volhard-Zelinsky Reaction<br> alpha-Alkylation of Carbonyl Compounds<br> Enolates Derived from 1,3-Dicarbonyl Compounds <br> Condensation Reactions of Carbonyl Compounds <br> Typical Reactions of Acids and Esters <br> Transesterification<br> <br> AROMATIC COMPOUNDS<br> Structure of Benzene <br> Aromatic, Antiaromatic, and Nonaromatic Compounds<br> Determination of the Molecular orbitals of Aromatic Compounds<br> What are the criteria for aromaticity? How does one quantify aromaticity?<br> Homoaromaticity<br> Möbius Aromaticity<br> Aromatic Ions<br> Annulenes<br> Aromaticity in Fused Systems<br> Aromaticity in Heterocyclic Compounds<br> Electrophilic Aromatic Substitution: Chemistry of Benzene<br> Reactivity of Monosubstituted Benzene Derivatives<br> Directing Effects of Substituents: Activating Groups <br> Electrophilic Aromatic Substitution on Disubstituted Benzenes<br> Functionalization of the Side Chain Substituents of Benzene <br> Nucleophilic Aromatic Substitution Reactions<br> Polycyclic Aromatic Compounds<br> Benzenoid Aromatic Compounds<br> <br> REACTIVE INTERMEDIATES<br> Carbocations<br> Carbanions<br> Carbenes<br> Nitrenes<br> Radicals<br> Singlet Oxygen<br> <br> PERICYCLIC REACTIONS<br> Woodward Hoffmann Rules <br> Frontier Orbitals <br> Electrocyclic Reactions <br> Application of Woodward Hoffmann Rules <br> Correlation Diagrams <br> Cycloaddition Reactions <br> Secondary Orbital Interaction <br> Orbital Coefficients <br> Sigmatropic Reactions<br> Cope and Claisen Rearrangement<br> <br> CARBON-CARBON (C-C) COUPLING REACTIONS<br> History<br> Mizoroki-Heck Coupling Reaction<br> Stille-Coupling Reaction <br> Suzuki-Miyaura Coupling Reaction <br> Negishi-Coupling Reaction<br> Sonogashira-Coupling Reaction <br> Kumada-Coupling Reaction <br> Hiyama-Coupling Reaction <br> Hiyama-Denmark Coupling<br> Buchwald-Hartwig Coupling<br> Tsuji-Trost Coupling <br> Palladium-catalyzed Carbonylation Reactions<br> Carbonylative Coupling Reactions with Organometallic Reagents<br> Mo(CO)6-Mediated Carbonylation<br> <br>
<p><b><i>Metin Balcı, PhD, </b>is Professor Emeritus of the Middle East Technical University in Ankara. He received his doctorate in 1976 from the University of Cologne. His research is focused on the synthesis of cyclitols, endoperoxides, cyclic strained compounds, bromine chemistry, and heterocyclic compounds.</i></p>
<p><b>An accessible and step-by-step exploration of organic reaction mechanisms</b></p> <p>In <i>Reaction Mechanisms in Organic Chemistry, </i>eminent researcher Dr. Metin Balcı explains organic reaction mechanisms step-by-step. The book offers a way for undergraduate and graduate students to understand—rather than memorize—the principles of reaction mechanisms. It includes the most important reaction types, including substitution, elimination, addition, pericyclic, and C-C coupling reactions. <p>Each chapter contains problems and accompanying solutions that cover central concepts in organic chemistry. Students will learn to understand the foundational nature of ideas like Lewis acids and bases, electron density, the mesomeric effect, and the inductive effect via the use of detailed examples and an expansive discussion of the concept of hybridization. <p>Along with sections covering aromaticity and the chemistry of intermediates, the book includes: <ul><li>A thorough introduction to basic concepts in organic reactions, including covalent bonding, hybridization, electrophiles and nucleophiles, and inductive and mesomeric effects</li> <li>Comprehensive explorations of nucleophilic substitution reactions, including optical activity and stereochemistry of SN<sub>2</sub> reactions </li> <li>Practical discussions of elimination reactions, including halogene elimination and Hofmann elimination </li> <li>In-depth examinations of addition reactions, including the addition of water to alkenes and the epoxidation of alkenes </li></ul> <p>Perfect for students of chemistry, biochemistry, and pharmacy, <i>Reaction Mechanisms in Organic Chemistry</i> will also earn a place in the libraries of researchers and lecturers in these fields seeking a one-stop resource on organic reaction mechanisms.

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