Cover Page

Dedication

To our children: Charlie, Mollie and Rosie, Aaron and Becca, Edward and Daniel and our spouses: Domini, Michael and Kathy and all the patients who have taught us so much over the years.

 

 

 

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Paediatrics at a Glance

Fourth Edition

 

Lawrence Miall

MBBS, BSc, MMedSc, MRCP, FRCPCH Consultant in Neonatal Medicine and Honorary Senior Lecturer Leeds Teaching Hospitals NHS Trust and University of Leeds

Leeds

 

Mary Rudolf

MBBS, BSc, DCH, FRCPCH, FAAP Professor of Population Health Bar Ilan University Faculty of Medicine in the Galilee, Israel Visiting Professor of Child Health University of Leeds, UK

 

Dominic Smith

MBBS, MMedSc, MRCP, MRCPCH Consultant Paediatrician Department of Child Health York Teaching Hospital and Hull York Medical School

York

 

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Preface

“ ‘What is the use of a book,’ thought Alice, ‘without pictures or conversations?’ ” Lewis Carroll, Alice in Wonderland.

Paediatric medicine requires an understanding of developing anatomy, physiology and psychology as well as a holistic family-orientated approach. There are a wide range of professional challenges: from the technical aspects of intensive care to the ethical and sociological questions relating to issues of autonomy, independence and children's rights. The paediatric environment is very different to the world of adult medicine. This can all be daunting to those who are new to the specialty, but developing the skills and confidence in successfully managing these challenges can enable professionals to make significant differences to the lives of children and families. This makes paediatric medicine amongst the most rewarding of all the medical specialties.

In preparing the fourth edition, we have updated the text to reflect changes in understanding of childhood illness over the last 5 years. The new edition includes advances in genetics, screening and therapy of childhood illness. Multiple choice questions to test and expand on knowledge from the text are included on the companion website. Video clips highlighting clinical signs and examination techniques are available on the companion website.

Children have complex needs that require medical staff to work together with other professionals in child health, psychology, education and social care. There is increasing recognition of the need for all health professionals to have a good understanding of their role in safeguarding vulnerable people. New chapters have been added to expand on psychological issues and ethics in child health. There is a new chapter on Palliative Care, which is an emerging area in the specialty.

We hope that this edition will continue to educate and inspire students and trainees in taking the first steps towards an understanding of children, their illnesses, their resilience in the face of adversity and amazing capacity for recovery. It is a book with many pictures to aid the introduction and revision of the key topics. We hope this will help as students begin their all-important conversations with young patients.

Lawrence Miall
Mary Rudolf
Dominic Smith
Leeds, United Kingdom
February 2016

Acknowledgements

We would like to acknowledge Dr Tim Lee, Dr Adam Glaser, Dr Michael Harari, Dr Claire Wensley and Dr Jemma Cleminson for their contributions to chapters.

Abbreviations

AABR
automated auditory brainstem response
ACTH
adrenocorticotropic hormone
ADD
attention deficit disorder
ADH
anti-diuretic hormone
ADPKD
autosomal dominant polycystic kidney disease
AFP
alpha-fetoprotein
AIDS
acquired immunodeficiency syndrome
ALL
acute lymphoblastic leukaemia
ALT
alanine transaminase
ALTE
acute life-threatening event
AML
acute myeloid leukaemia
ANA
antinuclear antibody
APTT
activated partial thromboplastin time
ARPKD
autosomal recessive polycystic kidney disease
ASD
atrial septal defect
ASOT
antistreptolysin O titre
AVPU
alert, voice, pain, unresponsive
AVSD
atrioventricular septal defect
AXR
abdominal radiograph
AZT
zidovudine (azidothymidine)
BCG
bacille Calmette–Guérin
BMI
body mass index
BP
blood pressure
BSER
brainstem evoked responses
CDH
congenital dislocation of the hip
CF
cystic fibrosis
CFTR
cystic fibrosis transmembrane regulator
CFU
colony-forming unit
CHARGE
coloboma, heart defects, choanal atresia, retarded growth and development, genital hypoplasia, ear anomalies
CHD
congenital heart disease
CMV
cytomegalovirus
CNS
central nervous system
CONI
care of the next infant
CPAP
continuous positive airway pressure
CPR
cardiopulmonary resuscitation
CRP
C-reactive protein
CRT
capillary refill time
CSF
cerebrospinal fluid
CSII
continuous subcutaneous insulin infusion
CT
computed tomography
CXR
chest radiograph
DDH
developmental dysplasia of the hip
DIC
disseminated intravascular coagulation
DIDMOAD
diabetes insipidus, diabetes mellitus, optic atrophy and deafness
DKA
diabetic ketoacidosis
DM
diabetes mellitus
DMD
Duchenne muscular dystrophy
DMSA
dimercaptosuccinic acid
DTPA
diethylenetriamine penta-acetate
EBV
Epstein–Barr virus
ECG
electrocardiogram
EDD
expected due date
EEG
electroencephalogram
ENT
ear, nose and throat
ESR
erythrocyte sedimentation rate
FBC
full blood count
FDP
fibrin degradation product
FSGS
focal segment glomerulosclerosis
FTT
failure to thrive
G6PD
glucose 6-phosphate dehydrogenase
GCS
Glasgow Coma Scale
GH
growth hormone
GI
gastrointestinal
GOR
gastro-oesophageal reflux
GP
general practitioner
GTT
glucose tolerance test
HAART
highly active antiretroviral therapy
Hb
haemoglobin
HbF
fetal haemoglobin
HbS
sickle-cell haemoglobin
HIE
hypoxic-ischaemic encephalopathy
HIV
human immunodeficiency virus
HPLC
high-performance liquid chromatography
HSP
Henoch–Schönlein purpura
HSV
herpes simplex virus
HUS
haemolytic uraemic syndrome
ICP
intracranial pressure
Ig
immunoglobulin
IM
intramuscular
INR
international normalized ratio
IO
intraosseous
IRT
immunoreactive trypsin
ITP
idiopathic thrombocytopenic purpura
IUGR
intrauterine growth retardation
IV
intravenous
IVC
inferior vena cava
IVF
in vitro fertilization
IVH
intraventricular haemorrhage
IVU
intravenous urogram
JCA
juvenile chronic arthritis
LFT
liver function test
LIP
lymphocytic interstitial pneumonitis
LMN
lower motor neuron
LP
lumbar puncture
Mag-3
radioisotope technetium 99mTc mertiatide
MCAD
medium-chain acyl-carnitine deficiency
MCGN
minimal change glomerulonephritis
MCH
mean cell haemoglobin
MCUG
micturating cystourethrogram
MCV
mean cell volume
MDI
metered dose inhaler
MLD
mild learning difficulty
MMR
measles, mumps, rubella
MRI
magnetic resonance imaging
MUAC
mid-upper arm circumference
NEC
necrotizing enterocolitis
NF
neurofibromatosis
NHL
non-Hodgkin's lymphoma
NICU
neonatal intensive care unit
NPA
nasopharyngeal aspirate
NSAID
non-steroidal anti-inflammatory drug
OAE
otoacoustic emissions
OFC
occipitofrontal circumference
ORS
oral rehydration solution
f03-math-0001
partial pressure of carbon dioxide
PCP
pneumocystis pneumonia
PCR
polymerase chain reaction
PCV
packed cell volume
PDA
patent ductus arteriosus
PEFR
peak expiratory flow rate
PKU
phenylketonuria
PNET
primitive neuroectodermal tumour
PR
per rectum
PT
prothrombin time
PTT
partial thromboplastin time
PUJ
pelviureteric junction
PUO
pyrexia of unknown origin
PVL
periventricular leucomalacia
RAST
radio-allergosorbent test
RBC
red blood cell
RDS
respiratory distress syndrome
RNIB
Royal National Institute for the Blind
ROP
retinopathy of prematurity
RSV
respiratory syncytial virus
SCBU
special care baby unit
SCID
severe combined immunodeficiency
SGA
small for gestational age
SIADH
syndrome of inappropriate antidiuretic hormone secretion
SIDS
sudden infant death syndrome
SLD
severe learning difficulty
SSPE
subacute sclerosing encephalitis
STD
sexually transmitted disease
SUDI
sudden unexpected death in infancy
T4
thyroxine
TAPVD
total anomalous pulmonary venous drainage
TB
tuberculosis
TGA
transposition of the great arteries
TNF
tumour necrosis factor
TORCH
toxoplasmosis, other (syphilis), rubella, cytomegalovirus, hepatitis, HIV
TS
tuberous sclerosis
TSH
thyroid stimulating hormone
tTG
tissue transglutaminase
U&E
urea and electrolytes
UMN
upper motor neuron
URTI
upper respiratory tract infection
UTI
urinary tract infection
UV
ultraviolet
VACTERL
vertebral anomalies, anal atresia, cardiac anomalies, tracheo-oesophageal fistula, renal anomalies, limb defects
VER
visual evoked response
VKDB
vitamin K deficiency bleeding
VSD
ventricular septal defect
VUR
vesicoureteric reflux
WCC
white cell count

How to use your textbook

Features contained within your textbook

Each topic is presented in a double-page spread with clear, easy-to-follow diagrams supported by succinct explanatory text.
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Key point boxes give a summary of the topics covered in a topic.
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Your textbook is full of photographs, illustrations and tables.
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image The ‘play icon’ indicates related videos which can be found on the companion website
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About the companion website

image
Photograph of a little girl smiling. She is wearing red glasses and has her hands in either trouser packet.

Part 1
Evaluation of the child

Chapters

  1. 1 Paediatrics and child health
  2. 2 The paediatric consultation
  3. 3 Systems examination
  4. 4 Development and developmental assessment
  5. 5 Growth and puberty
  6. 6 Understanding investigations

Chapter 1
Paediatrics and child health

Diagrammatic  representation of the general socio economic, cultural and environmental conditions.;Diagrammatic representation of a pyramid of care.

Paediatrics is not just about the recognition and treatment of children's illness. It also encompasses child health, covering all aspects of growth and development, promotion of children's health and the prevention of disease. It includes every aspect of life from birth through adulthood. In many countries, such as the UK, paediatric care extends up to the age of 18 and covers all children from the very premature infant to teenagers in the workforce.

All aspects of paediatrics are coloured by the fact that the child is growing and developing both physically and emotionally. Anyone involved in the medical care of children needs to have an understanding of children's normal development and a realization that children must not be considered as mini adults. In paediatrics, more than in any other branch of medicine, the needs of the family and carers must also be taken into consideration. At the end of childhood, a smooth transition of care to adult services is needed, especially for those with chronic conditions.

The changing face of paediatrics and child health

One hundred years ago, infection was the major cause of morbidity and mortality in childhood. Improvements in the environment, sanitation and housing began the trend for advancement in population health, and this was accelerated by the introduction of immunizations and antibiotics. Changes have occurred in society too, many of which are beneficial to children and their health and well-being. Children are better and more widely protected than was the case a century ago. Educational standards, social support, medical care and knowledge about child development have all improved, and child abuse has become unacceptable.

However, inequalities in both wealth and health are increasing, and the ‘gap’ between the richest and poorest has a profound impact on children's lives. Referrals for emotional and behavioural problems are rising dramatically, and childhood obesity is seen as the major public health problem of our time. A relatively new aspect of paediatrics is the understanding that many determinants of adult health have their origins antenatally, in infancy and in the early years of childhood.

Health care has also changed in paediatrics. Over the last 40 years, we have seen more children admitted to hospital, but the experience of hospitalization has changed. Once visiting hours for parents were limited to 30 minutes per day, but now the normal expectation is that parents will stay with their child. Where possible every effort is made to keep children out of hospital, and many aspects of specialized complex care have become available in the community. Even for the acutely ill child, short-stay observation wards now allow serious causes of illness to be excluded and children to be discharged to recover at home. A significant proportion of admissions are for social reasons, for example, if there are concerns that the family is unable to cope or they live too far away to safely send the child home.

The determinants of health

The way health is considered has also changed over the decades. In the early part of the 20th century, health was considered to be the absence of disease. However, in 1948, the World Health Organization changed the way we look at health when it declared that ‘health is a state of complete physical, mental, and social well-being, and not merely the absence of disease and infirmity’. In paediatrics, this has been accompanied by a more holistic approach to children, with greater emphasis on well-being especially for those coping with chronic conditions and disabilities.

Two major factors have changed priorities in the care of children and their services. The first is the understanding that socioeconomic status has a powerful influence over many aspects of children's health. Poverty is now known to be a significant predictor of a number of major measures of health, including:

The other factor that has changed the way we view disease arises from the ‘Barker hypothesis’. Barker and his colleagues brought to light how events in pregnancy and infancy can have a long-term effect on health. Exploring infant growth records from the last century, they showed that babies born small for gestational age were at significantly increased risk for hypertension, cardiovascular disease, diabetes and obesity in adult life, particularly if they showed rapid catch-up growth in the first year of life. Their findings demonstrated how critical the early years are in programming later health outcomes.

Rather reassuringly, economists have shown that although the preschool years are a vulnerable period, they are also a critical period amenable to intervention. The evidence clearly shows that when society invests in the early childhood years and provide support, community programmes, guidance for parents and education, there are profound benefits on many later outcomes such as physical health, academic achievement, mental health, antisocial behaviour and substance abuse.

Types of paediatric problems

With the changing face of childhood disease, health professionals need to be competent at managing a broad variety of conditions. These conditions include the following broad categories:

Some of the particular challenges we need to face are emotional and behavioural problems, childhood obesity, child abuse and neglect, accidents and injuries, sexually transmitted disease and teenage pregnancy, increase in disabilities and chronic illness, substance misuse, suicide and self-harm and poor vaccine uptake.

By directly treating childhood conditions, by ensuring effective screening and prevention programmes and by advocating for better public health interventions, paediatricians and all those working in child health have a fantastic opportunity to influence the long-term outcome of their patients. Paediatrics is a challenging specialty but a very rewarding one.

Chapter 2
The paediatric consultation

Diagrammatic representation of a woman seated on a chair holding a child on her lap while another woman is seated on another chair facing the former.;Diagrammatic representation of three children playing together with a model house.

Communication skills in paediatrics

Paediatricians need to be happy with informality, enjoy humour and appreciate the unpredictability that children bring to consultations! Young children do not have a full understanding of the role of health professionals. Children will naturally be anxious and uncertain in an unfamiliar environment. They may not understand all of the language in the consultation, but they quickly detect a sense of personal warmth, friendliness and relaxed mood in adults around them. It helps to have pictures, toys and videos to help children understand that the room is a good place for children.

In paediatrics, the focus of the consultation changes with the age and understanding of the child. In a young baby, the discussion is entirely with the carers (usually parents) who act as advocates for the child's needs. As children mature, they need to be included in the discussion. It is important to understand children's concerns and their right to be involved in decisions. Paediatricians need also to consider the concerns of the family and communicate sensitively with all family members.

Approaching the consultation

History taking

The history often indicates the diagnosis before examination or investigations. The history can be taken from a parent, a carer or from the child. Record who gave the history and in what context. Use an independent interpreter if there are language difficulties.

Beginning the examination—observation

Much information can be gained by careful observation of the child. This starts while you are first talking to the parents.

The examination of individual systems is discussed in detail in the following chapters.

Presenting complaint Record the main problems in the family's own words
History of presenting complaint Try to get an exact chronology from the time the child was last completely well
Allow the family to describe events themselves; use questions to direct them and probe for specific information
Try to use open questions—‘tell me about the cough’ rather than ‘is the cough worse in the mornings?’ Use direct questions to try to confirm or refute possible diagnoses
Past medical history In young children and infants, this should start from the pregnancy and include details of the delivery and neonatal period, including any feeding, growth or early development problems
Ask about all illnesses and hospital attendances, including accidents
Developmental history Milestones during infancy and school performance
Are there any areas of concern?
Do the parents feel the child's development is comparable to their peer group?
School performance—any academic or behavioural problems?
Immunizations Review immunizations against national schedule
Are there any missed or extra vaccinations?
Drugs and allergies What medication is the child taking? Include over-the-counter preparations
Does the child have any allergies to drugs or foods?
Systems enquiry Ask a series of screening questions for symptoms within systems other than the presenting system
Family and social history What is the family make-up and who lives at home?
Draw a genogram with the family to discuss extended family history
Consanguinity—first-cousin parents increase the risk of genetic disorders
Illnesses or developmental problems in the family
Any family members with long-term conditions
Contact with infection or recent travel
Social history Which school or nursery does the child attend?
Parents' education background, jobs, physical and mental health
Home environment—adults who smoke, housing problems and family stresses
Problem list At the end of the history, prepare a clear problem list to guide further management