Barbara J. Bain
MB BS, FRACP, FRCPath
Professor in Diagnostic Haematology,
Imperial College London and Honorary Consultant Haematologist,
St Mary's Hospital, Praed Street, London.
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Library of Congress Cataloging-in-Publication Data
Names: Bain, Barbara J., author.
Title: Multiple choice questions for haematology and core medical trainees / Barbara J. Bain.
Other titles: Multiple choice questions and extending matching questions for haematology and core medical trainees
Description: Chichester, West Sussex, UK ; Ames, Iowa : John Wiley & Sons, Inc., [2016] | Includes bibliographical references and index.
Identifiers: LCCN 2015044915 (print) | LCCN 2015047076 (ebook) | ISBN 9781119210528 (pbk.) | ISBN 9781119210559 (pdf) | ISBN 9781119210535 (epub)
Subjects: | MESH: Hematologic Diseases—Examination Questions. | Blood Physiological Phenomena—Examination Questions.
Classification: LCC RC633 (print) | LCC RC633 (ebook) | NLM WH 18.2 | DDC 616.1/50076—dc23
LC record available at http://lccn.loc.gov/2015044915
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This book has been written to help haematology trainees preparing for the part 1 examination of the Royal College of Pathologists. It will also be of use to core medical trainees preparing for the examinations of the Royal College of Physicians and the Royal Australasian College of Physicians and to haematology and general medicine trainees in other countries where methods of examination are similar. There is a considerable paediatric content so the book will also be useful to those preparing for examination of the Royal College of Paediatrics and Child Health. The two formats that are most used by these Royal Colleges have been used, Single Best Answer and Extended Matching Question. Detailed feedback and, when appropriate, relevant references are given for each question so that those who select the wrong answer will understand why another answer is preferred. Because of the detailed feedback and because some of the questions are quite searching, the book is an educational tool as well as a way to prepare for examinations. It will thus be of value also to advanced trainees including those preparing for the part 2 RCPath examination. Since the book incorporates much recent knowledge it may well also be of use to consultant haematologists wanting to update themselves as well as to those who are involved in training and examining.
Barbara J. Bain, 2016
Standard abbreviations (not defined in text) and normal ranges for the full blood count (FBC) in Caucasian adults are shown in this table. Normal ranges for children and for other tests are given in relation to the individual cases when necessary.
| Males | Females | Units | |
| White blood cell count (WBC) | 3.7–7.9 | 3.9–11.1 | × 109/l |
| Red blood cell count (RBC) | 4.32–5.66 | 3.88–4.99 | × 1012/l |
| Haemoglobin concentration (Hb) | 133–167 | 118–148 | g/l |
| Haematocrit (Hct) | 0.39–0.50 | 0.36–0.44 | l/l |
| Mean cell volume (MCV) | 82–98 | fl | |
| Mean cell haemoglobin (MCH) | 27.3–32.6 | pg | |
| Mean cell haemoglobin concentration (MCHC) | 316–349 | g/l | |
| Neutrophils | 1.7–6.1 | 1.7–7.5 | × 109/l |
| Lymphocytes | 1.0–3.2 | × 109/l | |
| Monocytes | 0.2–0.6 | × 109/l | |
| Eosinophils | 0.03–0.06 | × 109/l | |
| Basophils | 0.02–0.29 | × 109/l | |
| Platelets | 143–332 | 169–358 | × 109/l |
| aHUS | atypical haemolytic uraemic syndrome |
| ABVD | doxorubicin, bleomycin, vinblastine, dacarbazine |
| ADAMTS13 | a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 |
| AIDS | acquired immune deficiency syndrome |
| ALL | acute lymphoblastic leukaemia |
| AML | acute myeloid leukaemia |
| APTT | activated partial thromboplastin time |
| ATLL | adult T-cell leukaemia/lymphoma |
| BEACOPP | bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, prednisone |
| C | complement |
| CD | cluster of differentiation |
| CHOP | cyclophosphamide, doxorubicin, vincristine, prednisolone |
| CLL | chronic lymphocytic leukaemia |
| CT | computed tomography |
| DNA | deoxyribonucleic acid |
| DVT | deep vein thrombosis |
| ESR | erythrocyte sedimentation rate |
| G6PD | glucose-6-phosphate dehydrogenase |
| HIT | heparin-induced thrombocytopenia |
| HIV | human immunodeficiency virus |
| HPLC | high performance liquid chromatography |
| Ig | immunoglobulin |
| INR | international normalised ratio |
| LDH | lactate dehydrogenase |
| MALT | mucosa-associated lymphoid tissue |
| MRI | magnetic resonance imaging |
| NK | natural killer |
| NRBC | nucleated red blood cells |
| PET | positron emission tomography |
| PNH | paroxysmal nocturnal haemoglobinuria |
| PT | prothrombin time |
| R-CHOP | rituximab + CHOP |
| RDW | red cell distribution width |
| RiCoF | ristocetin co-factor |
| RNA | ribonucleic acid |
| SLE | systemic lupus erythematosus |
| TdT | terminal deoxynucleotidyl transferase |
| TTP | thrombotic thrombocytopenic purpura |
| VWF | von Willebrand factor |
This section comprises 50 Single Best Answer (SBA) questions. They are divided into questions 1–31, which are more relevant to the part 1 MRCP examination and questions 32–50, which are more relevant to the part 2 MRCP examination. Although having a general medical slant, these questions are also appropriate for haematology specialist trainees. Normal ranges are given in parentheses. Answers and feedback will be found on pages 101–123.