Table of Contents
Cover
Related Titles
Title Page
Copyright
About the Editors
Series Editors Preface
Preface
List of Contributors
Chapter 1: High-Speed Microfluidic Manipulation of Cells
1.1 Introduction
1.2 Direct Cell Manipulation
1.3 Indirect Cell Manipulation
1.4 Summary
Acknowledgments
References
Chapter 2: Micro and Nano Manipulation and Assembly by Optically Induced Electrokinetics
2.1 Introduction
2.2 Optically Induced Electrokinetic (OEK) Forces
2.3 OEK-Based Manipulation and Assembly
2.4 Summary
References
Chapter 3: Manipulation of DNA by Complex Confinement Using Nanofluidic Slits
3.1 Introduction
3.2 Slitlike Confinement of DNA
3.3 Differential Slitlike Confinement of DNA
3.4 Experimental Studies
3.5 Design of Complex Slitlike Devices
3.6 Fabrication of Complex Slitlike Devices
3.7 Experimental Conditions
3.8 Conclusion
Disclaimer
References
Chapter 4: Microfluidic Approaches for Manipulation and Assemblyof One-Dimensional Nanomaterials
4.1 Introduction
4.2 Microfluidic Assembly
4.3 Summary
References
Chapter 5: Optically Assisted and Dielectrophoretical Manipulation of Cells and Molecules on Microfluidic Platforms
5.1 Introduction
5.2 Operating Principle and Fundamental Physics of the ODEP Platform
5.3 Applications of the ODEP Platform
5.4 Conclusion
References
Chapter 6: On-Chip Microrobot Driven by Permanent Magnetsfor Biomedical Applications
6.1 On-Chip Microrobot
6.2 Characteristics of Microrobot Actuated by Permanent Magnet
6.3 Friction Reduction for On-Chip Robot
6.4 Fluid Friction Reduction for On-Chip Robot
6.5 Applications of On-Chip Robot to Cell Manipulations
6.6 Summary
References
Chapter 7: Silicon Nanotweezers for Molecules and Cells Manipulation and Characterization
7.1 Introduction
7.2 SNT Operation and Design
7.3 SNT Process
7.4 DNA Trapping and Enzymatic Reaction Monitoring
7.5 Cell Trapping and Characterization
7.6 General Concluding Remarks and Perspectives
Acknowledgments
References
Chapter 8: Miniaturized Untethered Tools for Surgery
8.1 Introduction
8.2 Macroscale Untethered Surgical Tools
8.3 Microscale Untethered Surgical Tools
8.4 Nanoscale Untethered Surgical Tools
8.5 Conclusion
Acknowledgments
References
Chapter 9: Single-Chip Scanning Probe Microscopes
9.1 Scanning Probe Microscopy
9.2 The Role of MEMS in SPM
9.3 CMOS–MEMS Manufacturing Processes Applied to sc-SPMs
9.4 Modeling and Design of sc-SPMs
9.5 Imaging Results
9.6 Conclusion
References
Chapter 10: Untethered Magnetic Micromanipulation
10.1 Physics of Micromanipulation
10.2 Sliding Friction and Surface Adhesion
10.3 Fluid Dynamics Effects
10.4 Magnetic Microrobot Actuation
10.5 Locomotion Techniques
10.6 Manipulation Techniques
10.7 Conclusions and Prospects
References
Chapter 11: Microrobotic Tools for Plant Biology
11.1 Why Do We Need a Mechanical Understanding of the Plant Growth Mechanism?
11.2 Microrobotic Platforms for Plant Mechanics
11.3 Biomechanical and Morphological Characterization of Living Cells
11.4 Conclusions
References
Chapter 12: Magnetotactic Bacteria for the Manipulation and Transport of Micro- and Nanometer-Sized Objects
12.1 Introduction
12.2 Magnetotactic Bacteria
12.3 Component Sizes and Related Manipulation Approaches
12.4 Conclusions and Discussion
References
Chapter 13: Stiffness and Kinematic Analysis of a Novel Compliant Parallel Micromanipulator for Biomedical Manipulation
13.1 Introduction
13.2 Design of the Micromanipulator
13.3 Stiffness Modeling of the Micromanipulator
13.4 Kinematics Modeling of the Micromanipulator
13.5 Conclusion
References
Chapter 14: Robotic Micromanipulation of Cells and Small Organisms
14.1 Introduction
14.2 Robotic Microinjection of Cells and Small Organisms
14.3 Robotic Transfer of Biosamples
14.4 Robot-Assisted Mechanical Characterization of Cells
14.5 Conclusion
References
Chapter 15: Industrial Tools for Micromanipulation
5.1 Introduction
5.2 Microrobotics for Scientific Instrumentation
5.3 Microrobotics for Microassembly
5.4 Future Challenges
References
Chapter 16: Robot-Aided Micromanipulation of Biological Cells with Integrated Optical Tweezers and Microfluidic Chip
16.1 Introduction
16.2 Cell Micromanipulation System with Optical Tweezers and Microfluidic Chip
16.3 Enhanced Cell Sorting Strategy
16.4 Novel Cell Manipulation Tool
16.5 Conclusion
References
Chapter 17: Investigating the Molecular Specific Interactions on Cell Surface Using Atomic Force Microscopy
17.1 Background
17.2 Single-Molecule Force Spectroscopy
17.3 Force Spectroscopy of Molecular Interactions on Tumor Cells from Patients
17.4 Mapping the Distribution of Membrane Proteins on Tumor Cells
17.5 Summary
Acknowledgments
References
Chapter 18: Flexible Robotic AFM-Based System for Manipulation and Characterization of Micro- and Nano-Objects
18.1 AFM-Based Flexible Robotic System for Micro- or Nanomanipulation
18.2 In situ Peeling of 1D Nanostructures Using a Dual-Probe Nanotweezer
18.3 In situ Quantification of Living Cell Adhesion Forces: Single-Cell Force Spectroscopy with a Nanotweezer
18.4 Conclusion and Future Directions
References
Chapter 19: Nanorobotic Manipulation of Helical Nanostructures
19.1 Introduction
19.2 Nanorobotic Manipulation Tools and Processes
19.3 Characterization of Helical Nanobelts
19.4 Applications
19.5 Summary
References
Chapter 20: Automated Micro- and Nanohandling Inside the Scanning Electron Microscope
20.1 Introduction and Motivation
20.2 State of the Art
20.3 Automation Environment
20.4 Case Studies
20.5 Outlook
Acknowledgments
References
Chapter 21: Manipulation of Biological Cells under ESEM and Microfluidic Systems
21.1 Introduction
21.2 ESEM-Nanomanipulation System
21.3 ESEM Observation of Single Cells
21.4 Manipulation of Biological Cells under ESEM
21.5 Manipulation of Biological Cells under Microfluidics
21.6 Conclusion
References
Index
End User License Agreement
Pages
xvii
xix
xxi
xxii
xxiii
xxv
xxvi
xxvii
xxviii
xxix
xxx
xxxi
xxxii
xxxiii
xxxiv
xxxv
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
75
76
77
78
79
80
81
82
83
84
85
86
87
88
89
90
91
92
93
94
95
96
97
98
99
100
101
102
103
104
105
106
107
108
109
110
111
112
113
114
115
116
117
119
120
121
122
123
124
125
126
127
128
129
130
131
132
133
134
135
136
137
138
139
140
141
142
143
144
145
146
147
148
149
150
151
152
153
154
155
156
157
158
159
160
161
162
163
164
165
166
167
169
170
171
172
173
174
175
176
177
178
179
180
181
182
183
184
185
186
187
188
189
190
191
192
193
194
195
196
197
198
199
201
202
203
204
205
206
207
208
209
210
211
212
213
214
215
216
217
218
219
220
221
222
223
224
225
226
227
228
229
230
231
232
233
234
235
236
237
238
239
240
241
242
243
244
245
246
247
248
249
250
251
252
253
254
255
256
257
259
260
261
262
263
264
265
266
267
268
269
270
271
272
273
274
275
276
277
278
279
280
281
282
283
284
285
286
287
288
289
290
291
292
293
294
295
296
297
298
299
300
301
302
303
304
305
307
308
309
310
311
312
313
314
315
316
317
318
319
320
321
322
323
324
325
326
327
328
329
330
331
332
333
334
335
336
337
338
339
340
341
342
343
344
345
346
347
348
349
350
351
352
353
354
355
356
357
358
359
360
361
362
363
364
365
366
367
369
370
371
372
373
374
375
376
377
378
379
380
381
382
383
384
385
386
387
388
389
390
391
393
394
395
396
397
398
399
400
401
402
403
404
405
406
407
408
409
410
411
412
413
414
415
416
417
418
419
420
421
422
423
424
425
426
427
428
429
430
431
432
433
434
435
436
437
438
439
441
442
443
444
445
446
447
448
449
450
451
452
453
454
455
456
457
458
459
460
461
462
463
464
465
466
467
468
469
470
471
472
473
474
475
476
477
478
479
480
481
482
483
484
485
486
487
488
489
490
491
492
493
494
495
496
497
498
499
500
501
502
503
505
506
507
508
509
510
511
512
513
514
515
516
517
518
519
520
521
522
523
524
525
526
527
528
529
530
531
532
533
534
535
537
538
539
540
541
542
543
544
545
546
547
548
549
550
551
552
553
554
555
556
557
558
559
560
561
562
563
564
565
566
567
568
569
570
Guide
Cover
Table of Contents
Preface
Begin Reading