1. Fowler CJ, Griffiths D, de Groat WC. 2008. The neural control of micturition. Nat Rev Neurosci 9:453–466.[PubMed][CrossRef]
2. Elbadawi A. 1996. Functional anatomy of the organs of micturition. Urol Clin North Am 23:177–210.[PubMed][CrossRef]
3. O’Grady F, Cattell WR. 1966. Kinetics of urinary tract infection. II. The bladder. Br J Urol 38:156–162.[PubMed][CrossRef]
4. Anderson JK, Cadeddu JA. 2012. Surgical anatomy of the retroperitoneum, adrenals, kidneys, and ureters, p 3–6. In Wein AJ, Kavoussi LR, Novick AC, Partin AW, Peters CA (ed), Campbell-Walsh Urology, 10th ed. Saunders Elsevier, Philadelphia. [CrossRef]
5. Macarak EJ, Howard PS. 1999. The role of collagen in bladder filling. Adv Exp Med Biol 462:215–223.[PubMed][CrossRef]
6. Tanagho ER, Pugh RC. 1963. The anatomy and function of the ureterovesical junction. Br J Urol 35:151–165.[PubMed][CrossRef]
7. Viana R, Batourina E, Huang H, Dressler GR, Kobayashi A, Behringer RR, Shapiro E, Hensle T, Lambert S, Mendelsohn C. 2007. The development of the bladder trigone, the center of the anti-reflux mechanism. Development 134:3763–3769.[PubMed][CrossRef]
8. Tanaka ST, Ishii K, Demarco RT, Pope JC IV, Brock JW III, Hayward SW. 2010. Endodermal origin of bladder trigone inferred from mesenchymal-epithelial interaction. J Urol 183:386–391.[PubMed][CrossRef]
9. Liang FX, Bosland MC, Huang H, Romih R, Baptiste S, Deng F-M, Wu XT, Shapiro E, Sun TT. 2005. Cellular basis of urothelial squamous metaplasia: roles of lineage heterogeneity and cell replacement. J Cell Biol 171:835–844.[PubMed][CrossRef]
10. Chung BI, Sommer G, D BJ. 2012. Anatomy of the lower urinary tract and male genitalia, p 59–60. In Wein AJ, Kavoussi LR, Novick AC, Partin AW, Peters CA (ed), Campbell-Walsh Urology, 10th ed. Saunders Elsevier, Philadelphia.
11. Standring S. 2008. The anatomical basis of clinical practice. In Gray’s Anatomy, 40th ed. Churchill Livingstone Elsevier, Philadelphia.
12. Standring S. 2008. Female reproductive system, p 1279–1304. In Gray’s Anatomy. 40th ed. Churchill Livingstone Elsevier, Philadelphia.
13. Stapleton AE, Au-Yeung M, Hooton TM, Fredricks DN, Roberts PL, Czaja CA, Yarova-Yarovaya Y, Tiedler T, Cox M, Stamm WE. 2011. Randomized, placebo- controlled phase 2 trial of a Lactobacillus crispatus probiotic given intravaginally for prevention of recurrent urinary tract infection. Clin Infect Dis 52:1212–1217.[PubMed][CrossRef]
14. Riedel I, Liang FX, Deng F-M, Tu L, Kreibich G, Wu XR, Sun TT, Hergt M, Moll R. 2005. Urothelial umbrella cells of human ureter are heterogeneous with respect to their uroplakin composition: different degrees of urothelial maturity in ureter and bladder? Eur J Cell Biol 84:393–405.[PubMed][CrossRef]
15. Romih R, Korošec P, de Mello W Jr, Jezernik K. 2005. Differentiation of epithelial cells in the urinary tract. Cell Tissue Res 320:259–268.[PubMed][CrossRef]
16. Wu XR, Kong XP, Pellicer A, Kreibich G, Sun T-T. 2009. Uroplakins in urothelial biology, function, and disease. Kidney Int 75:1153–1165.[PubMed][CrossRef]
17. Walker B. 1960. Renewal of cell populations in the female mouse. Am J Anat 107:95–105.[PubMed][CrossRef]
18. Kachar B, Liang F, Lins U, Ding M, Wu XR, Stoffler D, Aebi U, Sun TT. 1999. Three-dimensional analysis of the 16 nm urothelial plaque particle: luminal surface exposure, preferential head-to-head interaction, and hinge formation. J Mol Biol 285:595–608.[PubMed][CrossRef]
19. Hu CC, Liang FX, Zhou G, Tu L, Tang CH, Zhou J, Kreibich G, Sun TT. 2005. Assembly of urothelial plaques: tetraspanin function in membrane protein trafficking. Mol Biol Cell 16:3937–3950.[PubMed][CrossRef]
20. Vergara J, Longley W, Robertson JD. 1969. A hexagonal arrangement of subunits in membrane of mouse urinary bladder. J Mol Biol 46:593–596.[CrossRef]
21. Hicks RM, Ketterer B. 1969. Hexagonal lattice of subunits in the thick luminal membrane of the rat urinary bladder. Nature 224:1304–1305.[CrossRef]
22. Taylor KA, Robertson JD. 1984. Analysis of the three-dimensional structure of the urinary bladder epithelial cell membranes. J Ultrastruct Res 87:23–30.[PubMed][CrossRef]
23. Walz T, Häner M, Wu XR, Henn C, Engel A, Sun TT, Aebi U. 1995. Towards the molecular architecture of the asymmetric unit membrane of the mammalian urinary bladder epithelium: a closed “twisted ribbon” structure. J Mol Biol 248:887–900.[PubMed][CrossRef]
24. Wu XR, Sun TT. 1993. Molecular cloning of a 47 kDa tissue-specific and differentiation-dependent urothelial cell surface glycoprotein. J Cell Sci 106:31–43.[PubMed]
25. Lin JH, Wu XR, Kreibich G, Sun TT. 1994. Precursor sequence, processing, and urothelium-specific expression of a major 15-kDa protein subunit of asymmetric unit membrane. J Biol Chem 269:1775–1784.[PubMed]
26. Yu J, Lin JH, Wu XR, Sun TT. 1994. Uroplakins Ia and Ib, two major differentiation products of bladder epithelium, belong to a family of four transmembrane domain (4TM) proteins. J Cell Biol 125:171–182.[PubMed][CrossRef]
27. Deng FM, Liang FX, Tu L, Resing KA, Hu P, Supino M, Hu CC, Zhou G, Ding M, Kreibich G, Sun TT. 2002. Uroplakin IIIb, a urothelial differentiation marker, dimerizes with uroplakin Ib as an early step of urothelial plaque assembly. 2002. J Cell Biol 59:685–694.[PubMed][CrossRef]
28. Wu XR, Medina JJ, Sun TT. 1995. Selective interactions of UPIa and UPIb, two members of the transmembrane 4 superfamily, with distinct single transmembrane- domained proteins in differentiated urothelial cells. J Biol Chem 270:29752–29759.[PubMed][CrossRef]
29. Tu L, Sun TT, Kreibich G. 2002. Specific heterodimer formation is a prerequisite for uroplakins to exit from the endoplasmic reticulum. Mol Biol Cell 13:4221–4230.[PubMed][CrossRef]
30. Hu P, Deng FM, Liang FX, Hu CM, Auerbach AB, Shapiro E, Wu XR, Kachar B, Sun TT. 2000. Ablation of uroplakin III gene results in small urothelial plaques, urothelial leakage, and vesicoureteral reflux. J Cell Biol 151:961–972.[PubMed][CrossRef]
31. Hu P, Meyers S, Liang FX, Deng FM, Kachar B, Zeidel ML, Sun TT. 2002. Role of membrane proteins in permeability barrier function: uroplakin ablation elevates urothelial permeability. Am J Physiol Renal Physiol 283:F1200–1207.[PubMed][CrossRef]
32. Kong XT, Deng FM, Hu P, Liang FX, Zhou G, Auerbach AB, Geieser N, Nelson PK, Robbins ES, Shapiro E, Kachar B, Sun TT. 2004. Roles of uroplakins in plaque formation, umbrella cell enlargement, and urinary tract diseases. J Cell Biol 167:1195–1204.[PubMed][CrossRef]
33. Minsky BD, Chlapowski FJ. 1978. Morphometric analysis of the translocation of lumenal membrane between cytoplasm and cell surface of transitional epithelial cells during the expansion-contraction cycles of mammalian urinary bladder. J Cell Biol 77:685–697.[PubMed][CrossRef]
34. Lewis SA, de Moura JL. 1982. Incorporation of cytoplasmic vesicles into apical membrane of mammalian urinary bladder epithelium. Nature 297:685–688.[PubMed][CrossRef]
35. Zhou G, Mo WJ, Sebbel P, Min G, Neubert TA, Glockshuber R, Wu XR, Sun TT, Kong XP. 2001. Uroplakin Ia is the urothelial receptor for uropathogenic Escherichia coli: evidence from in vitro FimH binding. J Cell Sci 114:4095–4103.[PubMed]
36. Xie B, Zhou G, Chan SY, Shapiro E, Kong XP, Wu XR, Sun TT, Costello CE. 2006. Distinct glycan structures of uroplakins Ia and Ib: structural basis for the selective binding of FimH adhesin to uroplakin Ia. J Biol Chem 281:14644–14653.[PubMed][CrossRef]
37. Wu XR, Sun TT, Medina JJ. 1996. In vitro binding of type 1-fimbriated Escherichia coli to uroplakins Ia and Ib: relation to urinary tract infections. Proc Natl Acad Sci U S A 93:9630–9635.[PubMed][CrossRef]
38. Chen SL, Hung CS, Pinkner JS, Walker JN, Cusumano CK, Li Z, Bouckaert J, Gordon JI, Hultgren SJ. 2009. Positive selection identifies an in vivo role for FimH during urinary tract infection in addition to mannose binding. Proc Natl Acad Sci U S A 106:22439–22444.[PubMed][CrossRef]
39. Liu B, Hu B, Zhou Z, Guo D, Guo X, Ding P, Feng L, Wang L. 2012. A novel non- homologous recombination-mediated mechanism for Escherichia coli unilateral flagellar phase variation. Nucleic Acids Res 40:4530–4538.[PubMed][CrossRef]
40. Lane MC, Mobley HL. 2007. Role of P-fimbrial-mediated adherence in pyelonephritis and persistence of uropathogenic Escherichia coli (UPEC) in the mammalian kidney. Kidney Int 72:19–25.[PubMed][CrossRef]
41. Thumbikat P, Berry RE, Zhou G, Billips BK, Yaggie RE, Zaichuk T, Sun TT, Schaeffer AJ, Klumpp DJ. 2009. Bacteria-induced uroplakin signaling mediates bladder response to infection. PLoS Pathog 5:e1000415. doi:10.1371/journal.ppat.1000415 [PubMed][CrossRef]
42. Ho PL, Kurtova A, Chan KS. 2012. Normal and neoplastic urothelial stem cells: getting to the root of the problem. Nat Rev Urol 9:583–594.[PubMed][CrossRef]
43. Shin K, Lee J, Guo N, Kim J, Lim A, Qu L, Mysorekar IU, Beachy PA. 2011. Hedgehog/Wnt feedback supports regenerative proliferation of epithelial stem cells in bladder. Nature 472:110–114.[PubMed][CrossRef]
44. Hannan TJ, Totsika M, Mansfield KJ, Moore KH, Schembri MA, Hultgren SJ. 2012. Host-pathogen checkpoints and population bottlenecks in persistent and intracellular uropathogenic Escherichia coli bladder infection. FEMS Microbiol Rev 36:616–648.[PubMed][CrossRef]
45. Bishop BL, Duncan MJ, Song J, Li G, Zaas D, Abraham SN. 2007. Cyclic AMP- regulated exocytosis of Escherichia coli from infected bladder epithelial cells. Nat Med 13:625–630.[PubMed][CrossRef]
46. Guo X, Tu L, Gumper I, Plesken H, Novak EK, Chintala S, Swank RT, Pastores G, Torres P, Izumi T, Sun TT, Sabatini DD, Kreibich G. 2009. Involvement of Vps33a in the fusion of uroplakin-degrading multivesicular bodies with lysosomes. Traffic 10:1350–1361.[PubMed][CrossRef]
47. Chen Y. 2003. Rab27b is associated with fusiform vesicles and may be involved in targeting uroplakins to urothelial apical membranes. Proc Natl Acad Sci U S A g14012–14017.[PubMed][CrossRef]
48. Zhou G, Liang FX, Romih R, Wang Z, Liao Y, Ghiso J, Luque-Garcia JL, Neubert TA, Kreibich G, Alonso MA, Schaeren-Wiemers N, Sun TT. 2012. MAL facilitates the incorporation of exocytic uroplakin-delivering vesicles into the apical membrane of urothelial umbrella cells. Mol Biol Cell 23:1354–1366.[PubMed][CrossRef]
49. Lang RJ, Hashitani H, Tonta MA, Bourke JL, Parkington HC, Suzuki H. 2010. Spontaneous electrical and Ca2+ signals in the mouse renal pelvis that drive pyeloureteric peristalsis. Clin Exp Pharmacol Physiol 37:509–515.[PubMed][CrossRef]
50. Iqbal J, Tonta MA, Mitsui R, Li Q, Kett M, Li J, Parkington HC, Hashitani H, Lang RJ. 2012. Potassium and ANO1/TMEM16A chloride channel profiles distinguish atypical and typical smooth muscle cells from interstitial cells in the mouse renal pelvis. Br J Pharmacol 165:2389–2408.[PubMed][CrossRef]
51. Hurtado R, Bub G, Herzlinger D. 2010. The pelvis-kidney junction contains HCN3, a hyperpolarization-activated cation channel that triggers ureter peristalsis. Kidney Int 77:500–508.[PubMed][CrossRef]
52. Weiss RM. 2012. Physiology and pharmacology of the renal pelvis and ureter. Ch. 59. In Wein AJ, Kavoussi LR, Novick AC, Partin AW, Peters CA (ed), Campbell-Walsh Urology, 10th ed. Saunders Elsevier, Philadelphia. [CrossRef]
53. Floyd RV, Winstanley C, Bakran A, Wray S, Burdyga TV. 2010. Modulation of ureteric Ca signaling and contractility in humans and rats by uropathogenic E. coli. Am J Physio Renal Physiol 298:F900–908.[PubMed][CrossRef]
54. Floyd RV, Upton M, Hultgren SJ, Wray S, Burdyga TV, Winstanley C. 2012. Escherichia coli-mediated impairment of ureteric contractility is uropathogenic E. coli-specific. J Infect Dis 206:1589–1596.[PubMed][CrossRef]
55. Wein AJ. 1981. Classification of neurogenic voiding dysfunction. J Urol 125:605–609.[PubMed]
56. de Groat WC, Yoshimura N. 2001. Pharmacology of the lower urinary tract. Ann Rev Pharmacol Toxicol 41:691–721.[PubMed][CrossRef]
57. Park JM, Bloom DA, McGuire EJ. 1997. The guarding reflex revisited. Br J Urol 80:940–945.[PubMed][CrossRef]
58. Yoshimura N, Chancellor MB. 2012. Physiology and pharmacology of the bladder and urethra, p 1787–1789. In Wein AJ, Kavoussi LR, Novick AC, Partin AW, Peters CA (ed), Campbell-Walsh Urology, 10th ed. Saunders Elsevier, Philadelphia. [CrossRef]
59. Miller NL, Humphreys MR, Coe FL, Evan AP, Bledsoe SB, Handa SE, Lingeman JE. 2010. Nephrocalcinosis: re-defined in the era of endourology. Urol Res 38:421–427.[PubMed][CrossRef]
60. Ginalski JM, Portmann L, Jaeger P. 1990. Does medullary sponge kidney cause nephrolithiasis? Am J Roentgenol 155:299–302.[PubMed][CrossRef]
61. Laube M, Hess B, Terrier F, Vock P, Jaeger P. 1995. Prevalence of medullary sponge kidney in patients with and without nephrolithiasis. Praxis (Bern 1994) 84:1224–1230.[PubMed]
62. Palubinskas AJ. 1963. Renal pyramidal structure opacification in excretory urography and its relation to medullary sponge kidney. Radiology 81:963–970.[PubMed][CrossRef]
63. Forster JA, Taylor J, Browning AJ, Biyani CS. 2007. A review of the natural progression of medullary sponge kidney and a novel grading system based on intravenous urography findings. Urol Int 78:264–269.[PubMed][CrossRef]
64. McPhail EF, Gettman MT, Patterson DE, Rangel LJ, Krambeck AE. 2012. Nephrolithiasis in medullary sponge kidney: evaluation of clinical and metabolic features. Urology 79:277–281.[PubMed][CrossRef]
65. Toyoda K, Miyamoto Y, Ida M, Tada S, Utsunomiya M. 1989. Hyperechoic medulla of the kidneys. Radiology 173:431–434.[PubMed][CrossRef]
66. Ginalski JM, Schnyder P, Portmann L, Jaeger P. 1991. Medullary sponge kidney on axial computed-tomography: comparison with excretory urography. Eur J Radiol 2:104–107.[PubMed][CrossRef]
67. Hida T, Nishie A, Asayama Y, Ishigami K, Fujita N, Inokuchi J, Naito S, Ando S, Honda H. 2012. MR imaging of focal medullary sponge kidney: case report. Magn Reson Med Sci 11:65–69.[PubMed][CrossRef]
68. Chesney RW, Kaufman R, Stapleton FB, Rivas ML. 1989. Association of medullary sponge kidney and medullary dysplasia in Beckwith-Wiedemann syndrome. J Pediatr 115:761–764.[PubMed][CrossRef]
69. Kerr DN, Warrick CK, Hart-Mercer J. 1962. A lesion resembling medullary sponge kidney in patients with congenital hepatic fibrosis. Clin Radiol 13:85–91.[PubMed][CrossRef]
70. Torres VE, Erickson SB, Smith LH, Wilson DM, Hattery RR, Segura JW. 1988. The association of nephrolithiasis and autosomal dominant polycystic kidney disease. Am J Kidney Dis 11:318–325.[PubMed][CrossRef]
71. Gambaro G, Fabris A, Citron L, Tosetto E, Anglani F, Bellan F, Conte M, Bonfante L, Lupo A, D’Angelo A. 2005. An unusual association of contralateral congenital small kidney, reduced renal function and hyperparathyroidism in sponge kidney patients: on the track of the molecular basis. Nephrol Dial Transplant 20:1042–1047.[PubMed][CrossRef]
72. Hulbert JC, Reddy PK, Hunter DW,Castaneda-Zuniga W, Amplatz K, Lange PH. 1986. Percutaneous techniques for the management of caliceal diverticula containing calculi. J Urol 135:225–227.[PubMed]
73. Monga M, Smith R, Ferral H, Thomas R. 2000. Percutaneous ablation of caliceal diverticulum: long-term followup. J Urol 163:28–32.[PubMed][CrossRef]
74. Auge BK, Munver R, Kourambas J, Newman GE, Wu NZ, Preminger GM. 2002. Neoinfundibulotomy for the management of symptomatic caliceal diverticula. J Urol 167:1616–1620.[PubMed][CrossRef]
75. Bellman GC, Silverstein JI, Blickensderfer S, Smith AD. 1993. Technique and follow-up of percutaneous management of caliceal diverticula. Urology 42:21–25.[PubMed][CrossRef]
76. Heyns CF. 2012. Urinary tract infection associated with conditions causing urinary tract obstruction and stasis, excluding urolithiasis and neuropathic bladder. World J Urol 30:77–83.[PubMed][CrossRef]
77. Beeson PB, Guze LB. 1956. Experimental pyelonephritis. I. Effect of ureteral ligation on the course of bacterial infection in the kidney of the rat. J Exp Med 104:803–815.[PubMed][CrossRef]
78. Bitz H, Darmon D, Goldfarb M, Shina A, Block C, Rosen S, Brezis M, Heyman SN. 2001. Transient urethral obstruction predisposes to ascending pyelonephritis and tubulo- interstitial disease: studies inrats. Urol Res 67–73.[PubMed][CrossRef]
79. Fernbach SK, Feinstein KA, Spencer K, Lindstrom CA. 1997. Ureteral duplication and its complications. Radiographics 17:109–127.[PubMed][CrossRef]
80. Chapman CJ, Bailey RR, Janus ED, Abbott GD, Lynn KL. 1985. Vesicoureteric reflux: segregation analysis. Am J Med Genet 20:577–584.[PubMed][CrossRef]
81. Farhat W, McLorie G, Geary D, Capolicchio G, Bägli D, Merguerian P, Khoury A. 2000. The natural history of neonatal vesicoureteral reflux associated with antenatal hydronephrosis. J Urol 164:1057–1060.[PubMed][CrossRef]
82. Hannula A, Venhola M, Renko M, Pokka T, Huttunen N-P, Uhari M. 2010. Vesicoureteral reflux in children with suspected and proven urinary tract infection. Pediatr Nephrol 25:1463–1469.[PubMed][CrossRef]
83. Risdon RA, Yeung CK, Ransley PG. 1993. Reflux nephropathy in children submitted to unilateral nephrectomy: a clinicopathological study. Clin Nephrol 40:308–314.[PubMed]
84. Vermillion CD, Heale WF. 1973. Position and configuration of the ureteral orifice and its relationship to renal scarring in adults. J Urol 109:579–584.[PubMed]
85. Paquin AJ Jr. 1959. Ureterovesical anastomosis: the description and evaluation of a technique. J Urol 82:573–583.[PubMed]
86. Hollowell JG, Greenfield SP. 2002. Screening siblings for vesicoureteral reflux. J Urol 168:2138–2141.[PubMed][CrossRef]
87. Noe HN, Wyatt RJ, Peeden JN Jr, Rivas ML. 1992. The transmission of vesicoureteral reflux from parent to child. J Urol 148:1869–1871.[PubMed]
88. Murawski IJ, Myburgh DB, Favor J, Gupta IR. 2007. Vesico-ureteric reflux and urinary tract development in the Pax21Neu+/ mouse. Am J Physiol Renal Physiol 293:F1736–1745.[PubMed][CrossRef]
89. Yu OH, Murawski IJ, Myburgh DB, Gupta IR. 2004. Overexpression of RET leads to vesicoureteric reflux in mice. Am J Physiol Renal Physiol 287:F1123–1130.[PubMed][CrossRef]
90. Ohtomo Y, Nagaoka R, Kaneko K, Fukuda Y, Miyano T, Yamashiro Y. 2001. Angiotensin converting enzyme gene polymorphism in primary vesicoureteral reflux. Pediatr Nephrol 16:648–652.[PubMed][CrossRef]
91. Rigoli L, Chimenz R, di Bella C, Cavallaro E, Caruso R, Briuglia S, Fede C, Salpietro CD. 2004. Angiotensin-converting enzyme and angiotensin type 2 receptor gene genotype distributions in Italian children with congenital uropathies. Pediatr Res 56:988–993.[PubMed][CrossRef]
92. Loré F, Talidis F, Di Cairano G, Renieri A. 2001. Multiple endocrine neoplasia type 2 syndromes may be associated with renal malformations. J Intern Med 250:37–42.[PubMed][CrossRef]
93. Yang Y, Houle AM, Letendre J, Richter A. 2008. RET Gly691Ser mutation is associated with primary vesicoureteral reflux in the French-Canadian population from Quebec. Hum Mutat 29:695–702.[PubMed][CrossRef]
94. Yoneda A, Cascio S, Green A, Barton D, Puri P. 2002. Angiotensin II type 2 receptor gene is not responsible for familial vesicoureteral reflux. J Urol 168:1138–1141.[CrossRef]
95. Shefelbine SE, Khorana S, Schultz PN, Huang E, Thobe N, Hu ZJ, Fox GM, Jing S, Cote GJ, Gagel RF. 1998. Mutational analysis of the GDNF/RET-GDNFR alpha signaling complex in a kindred with vesicoureteral reflux. Hum Genet 102:474–478.[PubMed][CrossRef]
96. Giltay JC, van de Meerakker J, van Amstel HK, de Jong TP. 2004. No pathogenic mutations in the uroplakin III gene of 25 patients with primary vesicoureteral reflux. J Urol 171:931–932.[PubMed][CrossRef]
97. Jenkins D, Bitner-Glindzicz M, Malcolm S, Allison J, de Bruyn R, Flanagan S, Thomas DF, Belk RA, Feather SA, Bingham C, Southgate J, Woolf AS. 2006. Mutation analyses of Uroplakin II in children with renal tract malformations. Nephrol Dial Transplant 21:3415–3421.[PubMed][CrossRef]
98. Jiang S, Gitlin J, Deng FM, Liang FX, Lee A, Atala A, Bauer SB, Ehrlich GD, Feather SA, Goldberg JD, Goodship JA, Goodship TH, Hermanns M, Hu FZ, Jones KE, Malcolm S, Mendelsohn C, Preston RA, Retik AB, Schneck FX, Wright V, Ye XY, Woolf AS, Wu XR, Ostrer H, Shapiro E, Yu J, Sun TT. 2004. Lack of major involvement of human uroplakin genes in vesicoureteral reflux: implications for disease heterogeneity. Kidney Int 66:10–19.[PubMed][CrossRef]
99. Lambert HJ, Stewart A, Gullett AM, Cordell HJ, Malcolm S, Feather SA, Goodship JA, Goodship TH, Woolf AS; UK VUR Study Group. 2011. Primary, nonsyndromic vesicoureteric reflux and nephropathy in sibling pairs: a United Kingdom cohort for a DNA bank. Clin J Am Soc Nephrol 6:760–766.[PubMed][CrossRef]
100. Berry SJ, Coffey DS, Walsh PC, Ewing LL. 1984. The development of human benign prostatic hyperplasia with age. J Urol 132:474–479.[PubMed]
101. Lepor H. 2005. Pathophysiology of benign prostatic hyperplasia in the aging male population. Rev Urol 7(Suppl 4):S3–S12.[PubMed]
102. Nitti VW, Kim Y, Combs AJ. 1994. Correlation of the AUA symptom index with urodynamics in patients with suspected benign prostatic hyperplasia. Neurourol Urodyn 13:521–527.[PubMed][CrossRef]
103. Barry MJ, Cockett AT, Holtgrewe HL, McConnell JD, Sihelnik SA, Winfield HN. 1993. Relationship of symptoms of prostatism to commonly used physiological and anatomical measures of the severity of benign prostatic hyperplasia. J Urol 150:351–358.[PubMed]
104. Shapiro E, Becich MJ, Hartanto V, Lepor H. 1992. The relative proportion of stromal and epithelial hyperplasia is related to the development of symptomatic benign prostate hyperplasia. J Urol 147:1293–1297.[PubMed]
105. Madigan AA, Sobek KM, Cummings JL, Green WR, Bacich DJ, O’Keefe DS. 2012. Activation of innate anti-viral immune response genes in symptomatic benign prostatic hyperplasia. Genes Immun 13:566–572.[PubMed][CrossRef]
106. Abrams P, Cardozo L, Fall M, Griffiths D, Rosier P, Ulmsten U, Kerrebroeck PV, Victor A, Wein A. 2003. The standardisation of terminology in lower urinary tract function: report from the standardisation sub-committee of the International Continence Society. Urology 61:37–49.[PubMed][CrossRef]
107. Jacobsen SJ, Jacobson DJ, Girman CJ, Roberts RO, Rhodes T, Guess HA, Lieber MM. 1997. Natural history of prostatism: risk factors for acute urinary retention. J Urol 158:481–487.[PubMed][CrossRef]
108. Hooton TM, Stapleton AE, Roberts PL, Winter C, Scholes D, Bavendam T, Stamm WE. 1999. Perineal anatomy and urine-voiding characteristics of young women with and without recurrent urinary tract infections. Clin Infect Dis 29:1600–1601.[PubMed][CrossRef]
109. Nicolle LE. 2003. Asymptomatic bacteriuria: when to screen and when to treat. Infect Dis Clin North Am 17:367–394.[PubMed][CrossRef]
110. Raz R, Gennesin Y, Wasser J, Stoler Z, Rosenfeld S, Rottensterich E, Stamm WE. 2000. Recurrent urinary tract infections in postmenopausal women. Clin Infect Dis 30:152–156.[PubMed][CrossRef]
111. Petros PE, Ulmsten UI. 1990. An integral theory of female urinary incontinence. Experimental and clinical considerations. Acta Obstet Gynecol Scand Suppl 153:7–31.[PubMed][CrossRef]
112. Petros PP, Ulmsten U. 1998. An anatomical classification–a new paradigm for management of female lower urinary tract dysfunction. Eur J Obstet Gynecol Reprod Biol 80:87–94.[PubMed][CrossRef]
113. DeLancey JO. 1997. The pathophysiology of stress urinary incontinence in women and its implications for surgical treatment. World J Urol 15:268–274.[PubMed][CrossRef]
114. Nitti VW, TU LM, Gitlin J. 1999. Diagnosing bladder outlet obstruction in women. J Urol 161:1535–1540.[PubMed][CrossRef]
115. Stika CS. 2010. Atrophic vaginitis. Dermatol Ther 23:514–522.[PubMed][CrossRef]
116. Ronald A, Ludwig E. 2001. Urinary tract infections in adults with diabetes. Inter J Antimicrob Agents 17:287–292.[PubMed][CrossRef]
117. Chen SL, Jackson SL, Boyko EJ. 2009. Diabetes mellitus and urinary tract infection: epidemiology, pathogenesis and proposed studies in animal models. J Urol 182(6 Suppl):S51–56.[PubMed][CrossRef]
118. Hirji I, Guo Z, Andersson SW, Hammar N, Gomez-Caminero A. 2012. Incidence of urinary tract infection among patients with type 2 diabetes in the UK General Practice Research Database (GPRD). J Diabetes Complications 26:513–516.[PubMed][CrossRef]
119. Boyko EJ, Fihn SD, Scholes D, Chen CL, Normand EH, Yarbro P. 2002. Diabetes and the risk of acute urinary tract infection among postmenopausal women. Diabetes Care 25:1778–1783.[PubMed][CrossRef]
120. Boyko EJ, Fihn SD, Scholes D, Abraham L, Monsey B. 2005. Risk of urinary tract infection and asymptomatic bacteriuria among diabetic and nondiabetic postmenopausal women. Am J Epidemiol 161:557–564.[PubMed][CrossRef]
121. Geerlings SE, Stolk RP, Camps MJ, Netten PM, Collet TJ, Hoepelman AI; Diabetes Women Asymptomatic Bacteriuria Utrecht Study Group. 2000. Risk factors for symptomatic urinary tract infection in women with diabetes. Diabetes Care 23:1737–1741.[PubMed][CrossRef]
122. Geerlings SE, Meiland R, van Lith EC, Brouwer EC, Gaastra W, Hoepelman AIM. 2002. Adherence of type 1-fimbriated Escherichia coli to uroepithelial cells: more in diabetic women than in control subjects. Diabetes Care 25:1405–1409.[PubMed][CrossRef]
123. Taganna J, de Boer AR, Wuhrer M, Bouckaert J. 2011. Glycosylation changes as important factors for the susceptibility to urinary tract infection. Biochem Soc Trans 39:349–354.[PubMed][CrossRef]
124. Frimodt-Møller C. 1980. Diabetic cystopathy: epidemiology and related disorders. Ann Intern Med 92:318–321.[PubMed][CrossRef]
125. Yoshimura N, Chancellor MB, Andersson KE, Christ GJ. 2005. Recent advances in understanding the biology of diabetes-associated bladder complications and novel therapy. BJU Int 95:733–738.[PubMed][CrossRef]
126. Daneshgari F, Liu G, Birder L, Hanna-Mitchell AT, Chacko S. 2009. Diabetic bladder dysfunction: current translational knowledge. J Urol 182(6 Suppl):S18–26.[PubMed][CrossRef]
127. Rosen DA, Hung CS, Kline KA, Hultgren SJ. 2008. Streptozocin-induced diabetic mouse model of urinary tract infection. Infect Immun 76:4290–4298.[PubMed][CrossRef]
128. Romero R, Oyarzun E, Mazor M, Sirtori M, Hobbins JC, Bracken M. 1989. Meta- analysis of the relationship between asymptomatic bacteriuria and preterm delivery/low birth weight. Obstet Gynecol 73:576–582.[PubMed]
129. Bolton M, Horvath DJ, Li B, Cortado H, Newsom D, White P, Paritida-Sanchez S, Justice SS. 2012. Intrauterine growth restriction is a direct consequence of localized maternal uropathogenic Escherichia coli cystitis. PLoS One 7:e33897. doi:10.1371/journal.pone.0033897 [PubMed][CrossRef]
130. Faúndes A, Brícola-Filho M, Pinto e Silva JL. 1998. Dilatation of the urinary tract during pregnancy: proposal of a curve of maximal caliceal diameter by gestational age. Am J Obstet Gynecol 178:1082–1086.[PubMed][CrossRef]
131. Marchant DJ. 1972. Effects of pregnancy and progestational agents on the urinary tract. Am J Obstet Gynecol 112:487–501.[PubMed]
132. Chang CP, McDill BW, Neilson JR, Joist HE, Epstein JA, Crabtree GR, Chen F. 2004. Calcineurin is required in urinary tract mesenchyme for the development of the pyeloureteral peristaltic machinery. J Clin Invest 113:1051–1058.[PubMed][CrossRef]
133. Zhang PL, Peters CA, Rosen S. 2000. Ureteropelvic junction obstruction: morphological and clinical studies. Pediatr Nephrol 14:820–826.[PubMed][CrossRef]
134. Murakumo M, Nonomura K, Yamashita T, Ushiki T, Abe K, Koyanagi T. 1997. Structural changes of collagen components and diminution of nerves in congenital ureteropelvic junction obstruction. J Urol 157:1963–1968.[PubMed][CrossRef]
135. Yu J, Carroll TJ, McMahon AP. 2002. Sonic hedgehog regulates proliferation and differentiation of mesenchymal cells in the mouse metanephric kidney. Development 129:5301–5312.[PubMed]
136. Kuwayama F, Miyazaki Y, Ichikawa I. 2002. Embryogenesis of the congenital anomalies of the kidney and the urinary tract. Nephrol Dial Transplant 17:45–47.[PubMed][CrossRef]
137. Yiee JH, Johnson-Welch S, Baker LA, Wilcox DT. 2010. Histologic differences between extrinsic and intrinsic ureteropelvic junction obstruction. Urology 76:181–184.[PubMed][CrossRef]
138. Roth CC, Hubanks JM, Bright BC, Heinlen JE, Donovan BO, Kropp BP, Frimberger D. 2009. Occurrence of urinary tract infection in children with significant upper urinary tract obstruction. Urology 73:74–78.[PubMed][CrossRef]
139. Islek A, Güven AG, Koyun M, Akman S, Alimoglu E. 2011. Probability of urinary tract infection in infants with ureteropelvic junction obstruction: is antibacterial prophylaxis really needed? Pediatr Nephrol 26:1837–1841.[PubMed][CrossRef]
140. Haylen BT, de Ridder D, Freeman RM, Swift SE, Berghmans B, Lee J, Monga A, Petri E, Rizk DE, Sand P, Schaer GN. 2010. An International Urogynecological Association (IUGA)/International Continence Society (ICS) joint report on the terminology for female pelvic floor dysfunction. Neurourol Urodyn 29:4–20.[PubMed][CrossRef]
141. Jørgensen TM, Djurhuus JC, Schrøder HD. 1982. Idiopathic detrusor sphincter dyssynergia in neurologically normal patients with voiding abnormalities. Eur Urol 8:107–110.[PubMed]
142. Groutz A, Blaivas JG, Pies C, Sassone AM. 2001. Learned voiding dysfunction (non- neurogenic, neurogenic bladder) among adults. Neurourol Urodyn 20:259–268.[PubMed][CrossRef]
143. Cameron AP, Gajewski JB. 2009. Bladder outlet obstruction in painful bladder syndrome/interstitial cystitis. Neurourol Urodyn 28:944–948.[PubMed][CrossRef]
144. Pannek J, Einig EM, Einig W. 2009. Clinical management of bladder dysfunction caused by sexual abuse. Urol Int 82:420–425.[PubMed][CrossRef]
145. Wood SK, Baez MA, Bhatnagar S, Valentino RJ. 2009. Social stress-induced bladder dysfunction: potential role of corticotropin-releasing factor. Am J Physiol Regul Integr Comp Physiol 296:R1671–1678.[PubMed][CrossRef]
146. Carlson KV, Rome S, Nitti VW. 2001. Dysfucntional voiding in women. J Urol 165:143–148.[PubMed][CrossRef]
147. Minardi D, d’Anzeo G, Parri G, Polito M Jr, Piergallina M, El Asmar Z, Marchetti M, Muzzonigro G. 2010. The role of uroflowmetry biofeedback and biofeedback training of the pelvic floor muscles in the treatment of recurrent urinary tract infections in women with dysfunctional voiding: a randomized controlled prospective study. Urology 75:1299–1304.[PubMed][CrossRef]
148. Brucker BM, Fong E, Shah S, Kelly C, Rosenblum N, Nitti VW. 2012. Urodynamic differences between dysfunctional voiding and primary bladder neck obstruction in women. Urology 80:55–60.[PubMed][CrossRef]
149. Leadbetter GW Jr, Leadbetter WF. 1959. Diagnosis and treatment of congenital bladder- neck obstruction in children. N Engl J Med 260:633–637.[PubMed][CrossRef]
150. Kuo HC. 2005. Videourodynamic characteristics and lower urinary tract symptoms of female bladder outlet obstruction. Urology 66:1005–1009.[PubMed][CrossRef]
151. Ahmed HU, Shergill IS, Arya M, Shah PJ. 2006. Management of detrusor–external sphincter dyssynergia. Nat Clin Pract Urol 3:368–380.[PubMed][CrossRef]
152. Kim YH, Kattan MW, Boone TB. 1998. Bladder leak point pressure: the measure for sphincterotomy success in spinal cord injured patients with external detrusor-sphincter dyssynergia. J Urol 159:493–497.[PubMed][CrossRef]
153. Abdul-Rahman A, Ismail S, Hamid R, Shah J. 2010. A 20-year follow-up of the mesh wallstent in the treatment of detrusor external sphincter dyssynergia in patients with spinal cord injury. BJU Int 106:1510–1513.[PubMed][CrossRef]
154. Chen SL, Bih LI, Huang YH, Tsai SJ, Lin TB, Kao YL. 2008. Effect of single botulinum toxin A injection to the external urethral sphincter for treating detrusor external sphincter dyssynergia in spinal cord injury. J Rehabil Med 40:744–748.[PubMed][CrossRef]
155. Zaffanello M, Malerba G, Cataldi L, Antoniazzi F, Franchini M, Monti E, Fanos V. 2010. Genetic risk for recurrent urinary tract infections in humans: A systematic review. J Biomed Biotechnol 2010:321082. [PubMed][CrossRef]
156. Hung CS, Dodson KW, Hultgren SJ. 2009. A murine model of urinary tract infection. Nat Protoc 4:1230–1243.[PubMed][CrossRef]
157. Bates JM, Raffi HM, Prasadan K, Mascarenhas R, Laszik Z, Maeda N, Hultgren SJ, Kumar S. 2004. Tamm-Horsfall protein knockout mice are more prone to urinary tract infection: rapid communication. Kidney Int 65:791–797.[PubMed][CrossRef]
158. Mo L, Zhu XH, Huang HY, Shapiro E, Hasty DL, Wu XR. 2004. Ablation of the Tamm-Horsfall protein gene increases susceptibility of mice to bladder colonization by type 1-fimbriated Escherichia coli. Am J Physiol Renal Physiol 286:F795–802.[PubMed][CrossRef]
159. Chromek M, Slamová Z, Bergman P, Kovács L, Podracká L, Ehrén I, Hökfelt T, Gudmundsson GH, Gallo RL, Agerberth B, Brauner A. 2006. The antimicrobial peptide cathelicidin protects the urinary tract against invasive bacterial infection. Nat Med 12:636–641.[PubMed][CrossRef]
160. Morrison G, Kilanowski F, Davidson D, Dorin J. 2002. Characterization of the mouse beta defensin 1, Defb1, mutant mouse model. Infect Immun 70:3053–3060.[PubMed][CrossRef]
161. Zhang D, Zhang G, Hayden MS, Greenblatt MB, Bussey C, Flavell RA, Ghosh S. 2004. A toll-like receptor that prevents infection by uropathogenic bacteria. Science 303:1522–1526.[PubMed][CrossRef]
162. Diamond DA and Mattoo TK. 2012. Endoscopic treatment of primary vesicoureteral reflux. N Engl J Med 366:1218–1226.[PubMed][CrossRef]
163. Standring S. 2008. Kidneys and ureter, p 1230–1231. Gray’s Anatomy. 40th ed. Churchill Livingstone Elsevier, Philadelphia.