Table of Contents
Cover
Introduction to the Series Roger Adams, 1942
Introduction to the Series Scott E. Denmark, 2008
Preface to Volume 96
Andrew S. Kende
Chapter 1: Catalytic, Enantioselective Hydrogenation of Heteroaromatic Compounds
Introduction
Mechanism and Stereochemistry
Scope and Limitations
Applications to Synthesis
Comparison With Other Methods
Experimental Conditions
Experimental Procedures
Tabular Survey
References
Chapter 2: Transition‐Metal‐Catalyzed Hydroacylation
Acknowledgements
Introduction
Mechanism and Stereochemistry
Scope and Limitations
Applications to Synthesis
Comparison with Other Methods
Experimental Conditions
Experimental Procedures
Tabular Survey
References
Supplemental References for Table 1B
Supplemental References for Table 2A
Supplemental References for Table 2B
Supplemental References for Table 2C
Supplemental References for Table 4B
Cumulative Chapter Titles by Volume
Author Index, Volumes 1-96
Chapter and Topic Index, Volumes 1–96
End User License Agreement
List of Tables
Chapter 01
Table A. Summary of Recommended Conditions for the Hydrogenation of Quinolines.
Table B. Summary of Recommended Conditions for the Hydrogenation of Isoquinolines.
Table C. Summary of the Recommended Conditions for the Hydrogenation of Quinoxalines.
Table D. Summary of Recommended Conditions for the Hydrogenation of Pyridines.
Table E. Summary of Recommended Conditions for Hydrogenation of Indoles and Pyrroles.
List of Illustrations
Chapter 02
Scheme 1
Scheme 2
Scheme 3
Figure 1 Select substrates containing directing groups.
Figure 2 Strained and electronically activated olefins that promote intermolecular hydroacylation.
Scheme 4
Scheme 5
Scheme 6
Scheme 7
Scheme 8
Scheme 9
Scheme 10
Scheme 11
Figure 3 Stable acylrhodium hydride and acylrhodium alkyl complexes prepared via stoichiometric synthesis.
Scheme 12
Scheme 13
Scheme 14
Scheme 15
Scheme 16
Scheme 17
Scheme 18
Scheme 19
Scheme 20
Scheme 21
Scheme 22
Scheme 23
Scheme 24
Scheme 25
Scheme 26
Scheme 27
Figure 4 The free‐energy profile for intramolecular alkynal
trans
‐hydroacylation.
Scheme 28
Scheme 29
Scheme 30
Scheme 31
Scheme 32
Scheme 33
Scheme 34
Scheme 35
Scheme 36
Figure 5 Proposed turnover‐limiting homobimetallic oxidative addition.
Scheme 37
Scheme 38
Scheme 39
Figure 6 Computed energies of aldehyde–nickel complexes and the origin of chemoselectivity.
Scheme 40
Figure 7 2‐Pyridylmethylformate, which contains a removable 2‐pyridylcarbinol moiety.
Scheme 41
Scheme 42
Scheme 43
Scheme 44
Scheme 45
Scheme 46
Scheme 47
Scheme 48
Scheme 49
Scheme 50
Scheme 51
Scheme 52
Scheme 53
Scheme 54
Scheme 55
Scheme 56
Scheme 57
Scheme 58
Scheme 59
Scheme 60
Scheme 61
Scheme 62
Scheme 63
Scheme 64
Scheme 65
Scheme 66
Scheme 67
Scheme 68
Figure 8 A monodentate ligand gives rise to a coordinatively saturated rhodium complex.
Scheme 69
Scheme 70
Scheme 71
Scheme 72
Scheme 73
Scheme 74
Scheme 75
Scheme 76
Scheme 77
Scheme 78
Figure 9 Coordination of norbornadience to rhodium in the presence of a monodentate ligand (intermediate
168
) and a bidentate ligand (intermediate
169
).
Scheme 79
Scheme 80
Scheme 81
Scheme 82
Scheme 83
Scheme 84
Scheme 85
Scheme 86
Scheme 87
Scheme 88
Scheme 89
Scheme 90
Scheme 91
Scheme 92
Scheme 93
Scheme 94
Scheme 95
Scheme 96
Scheme 97
Scheme 98
Scheme 99
Scheme 100
Scheme 101
Scheme 102
Scheme 103
Scheme 104
Scheme 105
Scheme 106
Scheme 107
Scheme 108
Scheme 109
Scheme 110
Scheme 111
Scheme 112
Scheme 113
Scheme 114
Scheme 115
Scheme 116
Scheme 117
Scheme 118
Scheme 119
Scheme 120
Scheme 121
Scheme 122
Scheme 123
Scheme 124
Scheme 125
Scheme 126
Scheme 127
Scheme 128
Scheme 129
Scheme 130
Scheme 131
Scheme 132
Scheme 133
Scheme 134
Figure 10 Nepetalactones formed from compound
254
.
Figure 11 Iridomyrmecins formed from compound
256
.
Scheme 135
Scheme 136
Scheme 137
Scheme 138
Scheme 139
Scheme 140
Scheme 141
Scheme 142
Scheme 143
Chapter 01
Scheme 1
Scheme 2
Scheme 3
Scheme 4
Scheme 5
Scheme 6
Scheme 7
Scheme 8
Scheme 9
Scheme 10
Scheme 11
Figure 1 Representative axial chiral diphosphine ligands used for the hydrogenation of heteroarenes.
Scheme 12
Scheme 13
Figure 2 Dendrimeric ligand with a BINAP core.
Figure 3 Diphosphinite and diphosphonite ligands used for the hydrogenation of heteroarenes.
Figure 4 Phosphine–phosphoramidite ligands used for the hydrogenation of heteroarenes.
Figure 5 Ferrocene‐derived chiral
P
,
N
‐ligand used for the hydrogenation of heteroarenes.
Figure 6 Ir(I) complex prepared from naphthalene‐bridged
P
,
N
‐type sulfoximine ligand.
Scheme 14
Scheme 15
Scheme 16
Scheme 17
Scheme 18
Scheme 19
Scheme 20
Scheme 21
Scheme 22
Scheme 23
Scheme 24
Scheme 25
Scheme 26
Scheme 27
Scheme 28
Scheme 29
Scheme 30
Scheme 31
Scheme 32
Scheme 33
Scheme 34
Scheme 35
Scheme 36
Scheme 37
Scheme 38
Scheme 39
Scheme 40
Figure 7 Ligands used for the hydrogenation of indoles.
Scheme 41
Scheme 42
Scheme 43
Scheme 44
Scheme 45
Scheme 46
Scheme 47
Scheme 48
Scheme 49
Scheme 50
Scheme 51
Scheme 52
Scheme 53
Scheme 54
Scheme 55
Scheme 56
Scheme 57
Scheme 58
Scheme 59
Scheme 60
Scheme 61
Scheme 62
Scheme 63
Scheme 64
Scheme 65
Scheme 66
Scheme 67
Scheme 68
Scheme 69
Scheme 70
Scheme 71
Scheme 72
Scheme 73
Scheme 74
Scheme 75
Scheme 76
Scheme 77
Scheme 78
Scheme 79
Scheme 80
Scheme 81
Scheme 82
Scheme 83
Scheme 84
Scheme 85
Scheme 86
Scheme 87
Guide
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