CONTENTS

Cover

Related Titles

Title Page

About the Editors

List of Contributors

Preface

Chapter 1: Chemical Engineering Science and Green Chemistry – The Challenge of Sustainability

1.1 Sustainability Challenge for the Chemical Industry
1.2 From Green to Sustainable Chemistry
1.3 Chemical Engineering Science for Sustainability
1.4 Trends in Chemical Engineering Science
1.5 Topics Covered in This Book
Acknowledgment
References

Part One: Molecular Engineering of Materials, Reactions, and Processes

Chapter 2: Recent Advances in the Molecular Engineering of Solvents for Reactions
1. 2.1 Introduction
2. 2.2 Solvent Effects on Reactions
3. 2.3 Design or Selection of Solvents for Chemical Reactions
4. 2.4 A Case Study
5. 2.5 Conclusions
6. Acknowledgments
7. References
Chapter 3: Hierarchically Structured Pt and Non-Pt-Based Electrocatalysts for PEM Fuel Cells
1. 3.1 Introduction
2. 3.2 Pure Hollow Pt Nanoparticles
3. 3.3 Hollow Pt Metal Alloys
4. 3.4 Non-Pt Alloy Nanostructures
5. 3.5 Conclusions and Outlook
6. Acknowledgment
7. References
Chapter 4: New Frontiers in Biocatalysis
1. 4.1 Introduction
2. 4.2 Recent Advances in Biocatalysis
3. 4.3 Biocatalytic Retrosynthesis
4. 4.4 Process-Driven Protein Engineering
5. 4.5 Process Developments
6. 4.6 Future Perspectives
7. References

Part Two: Innovations in Design, Unit Operations, and Manufacturing

Chapter 5: Conceptual Process Design and Process Optimization
1. 5.1 Introduction
2. 5.2 Mathematical Background
3. 5.3 Synthesis
4. 5.4 Superstructure-Based Techniques
5. 5.5 Integrated Process Design, Operation, and Control
6. 5.6 Water and Energy Processes
7. 5.7 Conclusions and Outlook
8. References
Chapter 6: Development of Novel Multiphase Microreactors: Recent Developments and Future Challenges
1. 6.1 Principles and Features
2. 6.2 Experimental Practice
3. 6.3 Modeling Features
4. 6.4 Applications
5. 6.5 Conclusions and Outlook
6. References
Chapter 7: Process Intensification through Continuous Manufacturing: Implications for Unit Operation and Process Design
1. 7.1 Continuous Processes as a Means of Process Intensification
2. 7.2 Equipment for Continuous Processes
3. 7.3 Process Development and Implementation for Continuous Processes
4. 7.4 Selected Case Studies
5. 7.5 Conclusion and Outlook
6. References
Chapter 8: How Technical Innovation in Manufacturing Is Fostered through Business Innovation
1. 8.1 General Introduction
2. 8.2 Concept of Chemical Leasing and Take Back Chemicals
3. 8.3 General Economic, Technical, and Management Aspects
4. 8.4 Compatibility of the Service Model with the Actual Legislation: Some Important Aspects 1)
5. 8.5 General Conclusion
6. References
Chapter 9: Applications of 3D Printing in Synthetic Process and Analytical Chemistry
1. 9.1 Introduction
2. 9.2 Chemical Reactors Manufacturing by Additive Manufacturing Techniques
3. 9.3 3D Printing Applied to Flow Chemistry
4. 9.4 Applications of 3D Printed Flow Devices in Analytical Chemistry
5. 9.5 Future Trends
6. 9.6 Conclusions
7. References

Part Three: Enabling Technologies

Chapter 10: Process Analytical Chemistry and Nondestructive Analytical Methods: The Green Chemistry Approach for Reaction Monitoring, Control, and Analysis
1. 10.1 Green Chemistry and Chemical Analysis in Manufacturing
2. 10.2 Process Analytical Chemistry: Concept and Objectives
3. 10.3 Vibrational Spectroscopy
4. 10.4 Challenges to Overcome
5. 10.5 Applications of Process Analytical Chemistry and Nondestructive Analyses
6. 10.6 Future Trends in PAC
7. Acknowledgments
8. References
Chapter 11: NMR Spectroscopy and Microscopy in Reaction Engineering and Catalysis
1. 11.1 Introduction
2. 11.2 Basic Principles of NMR
3. 11.3 The NMR Toolkit in Reaction Engineering and Catalysis
4. 11.4 Summary
5. References
Chapter 12: An Introduction to Closed-Loop Process Optimization and Online Analysis
1. 12.1 Introduction
2. 12.2 Principles of Self-Optimization and Requirements for Experimental Systems
3. 12.3 Analytical Techniques for Closed-Loop Optimization
4. 12.4 Decision Algorithms in Closed-Loop Optimization
5. 12.5 Application Examples of Closed-Loop Discovery and Optimization
6. 12.6 Conclusions and Future Directions
7. Acknowledgments
8. References

Index

End User License Agreement

List of Illustrations

Figure 1.1

Figure 1.2

Figure 1.3

Scheme 1.1

Figure 1.4

Figure 2.1

Figure 2.2

Figure 2.3

Figure 2.4

Figure 3.1

Figure 3.2

Figure 3.3

Figure 3.4

Figure 3.5

Figure 3.6

Figure 3.7

Figure 3.8

Figure 3.9

Figure 3.10

Figure 3.11

Figure 4.1

Figure 4.2

Figure 4.3

Figure 4.4

Figure 4.5

Figure 4.6

Figure 5.1

Figure 5.2

Figure 5.3

Figure 6.1

Figure 6.2

Figure 6.3

Figure 6.4

Figure 6.5

Figure 6.6

Figure 6.7

Figure 6.8

Scheme 6.1

Figure 6.9

Figure 6.10

Scheme 6.2

Scheme 6.3

Figure 6.11

Scheme 6.4

Scheme 6.5

Scheme 6.6

Scheme 6.7

Figure 7.1

Figure 7.2

Scheme 7.1

Scheme 7.2

Scheme 7.3

Figure 7.3

Scheme 7.4

Figure 7.4

Figure 7.5

Figure 8.1

Figure 8.2

Figure 9.1

Figure 9.2

Scheme 9.1

Figure 9.3

Figure 9.4

Figure 9.5

Figure 9.6

Figure 9.7

Figure 9.8

Figure 9.9

Figure 9.10

Figure 9.11

Figure 9.12

Figure 9.13

Figure 9.14

Figure 9.15

Figure 9.16

Figure 9.17

Figure 9.18

Figure 9.19

Figure 9.20

Figure 9.21

Figure 9.22

Figure 9.23

Figure 9.24

Figure 9.25

Figure 9.26

Figure 9.27

Figure 9.28

Figure 9.29

Figure 9.30

Figure 9.31

Figure 9.32

Figure 9.33

Figure 10.1

Figure 10.2

Figure 10.3

Figure 10.4

Figure 10.5

Figure 10.6

Figure 10.7

Figure 11.1

Figure 11.2

Figure 11.3

Figure 11.4

Figure 11.5

Figure 11.6

Figure 11.7

Figure 11.8

Figure 11.9

Figure 11.10

Figure 11.11

Figure 11.12

Figure 11.13

Figure 11.14

Figure 11.15

Figure 11.16

Figure 11.17

Figure 11.18

Figure 11.19

Figure 11.20

Figure 11.21

Figure 11.22

Figure 11.23

Figure 11.24

Figure 12.1

Figure 12.2

Figure 12.3

Figure 12.4

Scheme 12.1

Figure 12.5

Scheme 12.2

Scheme 12.3

Figure 12.6

Scheme 12.4

Figure 12.7

Scheme 12.5

Scheme 12.6

Figure 12.8

Scheme 12.7

Figure 12.9

Figure 12.10

Scheme 12.8

Figure 12.11

Figure 12.12

Scheme 12.9

Figure 12.13

Figure 12.14

Figure 12.15

Scheme 12.10

Figure 12.16

Figure 12.17

Scheme 12.11

Figure 12.18

Scheme 12.12

Figure 12.19

Scheme 12.13

List of Contributors

Claire S. Adjiman

Department of Chemical

EngineeringCentre for Process Systems Engineering

Imperial College London

London SW7 2AZ

United Kingdom

Thomas Bieringer

Bayer AG

Engineering & Technology

Kaiser-Wilhelm-Allee 1

51368 Leverkusen

Germany

Richard A. Bourne

University of Leeds

School of Chemistry

Leeds LS6 9JT

Gert De Bruyn

Royal Haskoning DHV

Laan 1914 nr 35

3818 EX Amersfoort

The Netherlands

Marc-Olivier Coppens

University College London

EPSRC “Frontier Engineering” Centre for Nature Inspired Engineering

Torrington Place

London WC1E 7JE

Leroy Cronin

University of Glasgow

School of Chemistry

University Avenue

Glasgow G12 8QQ

Carmine D'Agostino

The University of Manchester

School of Chemical Engineering

and Analytical Science

The Mill, Sackville Street

Manchester M13 9PL

Vincenza Dragone

University of Glasgow

School of Chemistry

University Avenue

Glasgow G12 8QQ

Nicolas Eghbali

Royal Haskoning DHV

Laan 1914 nr 35

3818 EX Amersfoort

The Netherlands

Sebastian Falß

Invite GmbH

Kaiser-Wilhelm-Allee 50

51373 Leverkusen

Germany

Amparo Galindo

Department of Chemical

Engineering Centre for Process

Systems Engineering

Imperial College London

London SW7 2AZ

United Kingdom

Miriam Fontalvo Gómez

Universidad del Atlántico

Department of Chemistry

km 7 Antigua via Puerto Colombia

Barranquilla

Colombia

Manuel Holtkamp

Invite GmbH

Kaiser-Wilhelm-Allee 50

51373 Leverkusen

Germany

Marianne Hoppenbrouwers

University of Hasselt

Faculty of Law

Martelarenlaan 42

3500 Hasselt

Belgium

Christopher S. Horbaczewskyj

University of Leeds

School of Chemistry

Leeds LS6 9JT

Nicolai Kloye

Bayer AG

Engineering & Technology

Kaiser-Wilhelm-Allee 1

51368 Leverkusen

Germany

Norbert Kockmann

TU Dortmund University

Biochemical and Chemical Engineering

Emil-Figge-Strasse 68

44227 Dortmund

Germany

Alexei A. Lapkin

University of Cambridge

Department of Chemical Engineering and Biotechnology

Philippa Fawcett Drive

Cambridge CB3 0AS

and

Cambridge Centre for Advanced Research and Education in Singapore Ltd.

1 Create Way, CREATE Tower #05-05

138602 Singapore

Singapore

Ung Lee

RWTH Aachen University

Aachener Verfahrenstechnik

Process Systems Engineering (SVT)

Turmstr. 46

52056 Aachen

Germany

Steven Lemain

Royal Haskoning DHV

Laan 1914 nr 35

3818 EX Amersfoort

The Netherlands

Mick D. Mantle

University of Cambridge

Department of Chemical Engineering and Biotechnology

Philippa Fawcett Drive

West Cambridge Site

Cambridge CB3 0AS

Alexander Mitsos

RWTH Aachen University

Aachener Verfahrenstechnik

Process Systems Engineering (SVT)

Turmstr. 46

52056 Aachen

Germany

Angelina Prokofyeva

Bayer AG

Engineering & Technology

Kaiser-Wilhelm-Allee 1

51368 Leverkusen

Germany

Evgeny Rebrov

University of Warwick

School of Engineering

and

Tver State Technical University

Laboratory of Biotechnology and ChemistryKomsomolsky Pr. 5, Tver, 170026

Russia

Sebastian Recker

RWTH Aachen University

Aachener Verfahrenstechnik

Process Systems Engineering (SVT)

Turmstr. 46

52056 Aachen

Germany

Boris Johnson Restrepo

Universidad de Cartagena

Environmental Chemistry Research Group

School of Exact and Natural Sciences

Campus of San Pablo

130015 Cartagena

Colombia

Rodolfo J. Romañach

University of Puerto Rico

Center for Structured Organic Particulate Systems (C-SOPS)

Mayagüez Campus

Mayagüez 00681-9000

Puerto Rico

Victor Sans

The University of Nottingham

Department of Chemical and Environmental Engineering Faculty of Engineering

University Park

Nottingham

NG7 2RD

Andrew J. Sederman

University of Cambridge

Department of Chemical Engineering and Biotechnology

Philippa Fawcett Drive

West Cambridge Site

Cambridge CB3 0AS

Eirini Siougkrou

Department of Chemical

Engineering

Centre for Process Systems Engineering

Imperial College London

London SW7 2AZ

United Kingdom

Mirko Skiborowski

Technical University of Dortmund

Department of Biochemical and Chemical Engineering

Emil-Figge-Str. 70

44227 Dortmund

Germany

Torsten Stelzer

University of Puerto Rico

Department of Pharmaceutical Sciences

Medical Sciences Campus

San Juan 00936

Puerto Rico

and

University of Puerto Rico

Crystallization Design Institute

Molecular Sciences Research Center

San Juan 00926

Puerto Rico

Panagiotis Trogadas

University College London

EPSRC “Frontier Engineering”

Centre for Nature Inspired

Engineering

Torrington Place

London WC1E 7JE

Nicholas J. Turner

University of Manchester

Manchester Institute of Biotechnology

School of Chemistry

131 Princess Street

Manchester M1 7DN

Bart Vander Velpen

Royal HaskoningDHV

Laan 1914 nr 35

3818 EX Amersfoort

The Netherlands

Charlotte E. Willans

University of Leeds

School of Chemistry

Leeds LS6 9JT

John M. Woodley

Technical University of Denmark

Department of Chemical and Biochemical Engineering

Søltofts Plads

2800 Lyngby

Denmark

Handbook of Green Chemistry

Volume 12: Green Chemical Engineering

About the Editors

List of Contributors

Preface