Cover Page

Translational Toxicology and Therapeutics

Windows of Developmental Susceptibility in Reproduction and Cancer

Edited by

Michael D. Waters

Michael Waters Consulting USA
Hillsborough, NC, USA

Claude L. Hughes

Therapeutic Science and Strategy Unit QuintilesIMS Inc.
Morrisville, NC, USA

Department of Obstetrics and Gynecology
Duke University Medical Center
Durham, NC, USA

Department of Mathematics North Carolina State University
Raleigh, NC, USA

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List of Contributors

Amedeo Amedei

Department of Experimental and Clinical Medicine

University of Florence

Firenze

Italy

 

David Berrigan

Division of Cancer Control and Population Sciences

National Cancer Institute

National Institutes of Health

Rockville, MD

USA

 

William H. Bisson

Knight Cancer Institute

Oregon Health & Science University

Portland, OR

USA

 

Ilaria Chiodi

Institute of Molecular Genetics

Pavia

Italy

 

Annamaria Colacci

Center for Environmental Toxicology and Risk Assessment

Regional Agency for Prevention

Environment and Energy

Emilia Romagna Region

Italy

 

Eli P. Crapper

Department of Obstetrics & Gynaecology

McMaster University

Hamilton

Ontario

Canada

 

Dana C. Dolinoy

Department of Environmental Health Sciences

University of Michigan School of Public Health

Ann Arbor, MI

USA

 

Department of Nutritional Sciences

University of Michigan School of Public Health, Ann Arbor, MI

USA

 

Dean W. Felsher

Division of Oncology

Departments of Medicine and Pathology

Stanford University School of Medicine

Stanford, CA

USA

 

Lynnette R. Ferguson

Discipline of Nutrition and Dietetics and Auckland Cancer Society Research Centre

Faculty of Medical and Health Sciences

The University of Auckland

Auckland

New Zealand

 

Lauren Fordyce

Office of Behavioral and Social Sciences Research

Office of the Director

National Institutes of Health

Bethesda, MD

USA

 

Stefano Forte

Department of Experimental Oncology

Mediterranean Institute of Oncology

Viagrande (CT)

Italy

 

Katelyn J. Foster

Department of Obstetrics & Gynaecology

McMaster University

Hamilton

Ontario

Canada

 

Warren G. Foster

Department of Obstetrics & Gynaecology

McMaster University

Hamilton

Ontario

Canada

 

Department of Reproductive Medicine

University of California San Diego

San Diego, CA

USA

 

Natalie R. Gassman

Department of Oncologic Sciences

University of South Alabama Mitchell Cancer Institute

Mobile, AL

USA

 

Jaclyn M. Goodrich

Department of Environmental Health Sciences, University of Michigan School of Public

Health, Ann Arbor, MI

USA

 

Claude L. Hughes

Therapeutic Science and Strategy Unit

QuintilesIMS Inc.

Morrisville, NC

USA

 

Department of Obstetrics and Gynecology

Duke University Medical Center

Durham, NC

USA

 

Department of Mathematics

North Carolina State University

Raleigh, NC

USA

 

Rebecca Johnson

Nuffield Division of Clinical Laboratory Sciences

Radcliffe Department of Medicine

University of Oxford

John Radcliffe Infirmary

Headington

Oxford

UK

 

Sandeep Kaur

Nutritional Science Research Group

Division of Cancer Prevention

National Cancer Institute

National Institutes of Health

Rockville, MD

USA

 

David Kerr

Nuffield Division of Clinical Laboratory Sciences

Radcliffe Department of Medicine

University of Oxford

John Radcliffe Infirmary

Headington

Oxford

UK

 

Lorenzo Memeo

Department of Experimental Oncology

Mediterranean Institute of Oncology

Viagrande (CT)

Italy

 

Melissa J. Mills

Mills Consulting

LLC

Durham, NC

USA

 

Chiara Mondello

Institute of Molecular Genetics

Pavia

Italy

 

Luke Montrose

Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI

USA

 

David B. Resnik

National Institute of Environmental Health Sciences (NIEHS)

Research Triangle Park, NC

USA

 

R. Brooks Robey

White River Junction Veterans Affairs Medical Center

White River Junction, VT

USA

 

Geisel School of Medicine at Dartmouth

Hanover, NH

USA

 

John M. Rogers

Toxicity Assessment Division

National Health and Environmental Effects Research Laboratory

Office of Research and Development

United States Environmental Protection Agency

Research Triangle Park, NC

USA

 

A. Ivana Scovassi

Institute of Molecular Genetics

Pavia

Italy

 

Harold Seifried

Nutritional Science Research Group

Division of Cancer Prevention

National Cancer Institute

National Institutes of Health

Rockville, MD

USA

 

Ronald D. Snyder

RDS Consulting Services

Mason, OH

USA

 

Shobha Srinivasan

Division of Cancer Control and Population Sciences

National Cancer Institute

National Institutes of Health

Rockville, MD

USA

 

Bernard W. Stewart

Cancer Control Program

South Eastern Sydney Public Health Unit and Faculty of Medicine

University of New South Wales

Sydney

Australia

 

Elaine Trujillo

Nutritional Science Research Group

Division of Cancer Prevention

National Cancer Institute

National Institutes of Health

Rockville, MD

USA

 

Monica Vaccari

Center for Environmental Toxicology and Risk Assessment

Regional Agency for Prevention

Environment and Energy

Emilia Romagna Region

Italy

 

Suryanarayana V. Vulimiri

National Center for Environmental Assessment

Office of Research and Development

United States Environmental Protection Agency

Washington, DC

USA

 

Kylie Wasser

Department of Human Kinetics

Western University

London

Ontario

Canada

 

Michael D. Waters

Michael Waters Consulting USA

Hillsborough, NC

USA

 

Barbara A. Wetmore

Office of Research and Development

U.S. Environmental Protection Agency

Research Triangle Park, NC

USA

 

Samuel H. Wilson

Genome Integrity and Structural Biology Laboratory

National Institute of Environmental Health Sciences (NIEHS)

Research Triangle Park, NC

USA

 

Fengyu Zhang

Global Clinical and Translational Research Institute

Bethesda, MD

USA

Part One
Introduction: The Case for Concern about Mutation and Cancer Susceptibility during Critical Windows of Development and the Opportunity to Translate Toxicology into a Therapeutic Discipline