Fifth Edition
This edition first published 2020
© 2020 John Wiley & Sons, Inc.
Edition History
4e 2013 John Wiley & Sons, Inc.; 3e 2007 Karen Hrapkiewicz and Leticia Medina; 2e 1998 © Iowa State University Press; 1e 1984 Iowa State University Press
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The right of Lesley A. Colby, Megan H. Nowland, Lucy H. Kennedy to be identified as the authors of this work has been asserted in accordance with law.
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Library of Congress Cataloging‐in‐Publication Data
Names: Colby, Lesley, A., author.
Title: Clinical laboratory animal medicine : an introduction / Lesley A. Colby, DVM, MS, DACLAM, Megan H. Nowland, DVM, DACLAM, Lucy H. Kennedy, DVM, DACLAM.
Description: Fifth edition. | Hoboken, NJ : Wiley‐Blackwell, 2020. | Revision of: Clinical laboratory animal medicine : an introduction / Karen Hrapkiewicz, Lesley Colby, Patricia Denison. Fourth edition. 2013. | Includes bibliographical references and index.
Identifiers: LCCN 2019030439 (print) | LCCN 2019030440 (ebook) | ISBN 9781119489566 (paperback) | ISBN 9781119489634 (adobe pdf) | ISBN 9781119489597 (epub)
Subjects: LCSH: Laboratory animals–Diseases. | Veterinary medicine.
Classification: LCC SF996.5 .H65 2020 (print) | LCC SF996.5 (ebook) | DDC 636.088/5–dc23
LC record available at https://lccn.loc.gov/2019030439
LC ebook record available at https://lccn.loc.gov/2019030440
Cover Design: Wiley
Cover Images: Austin Thomason, Michigan Photography – University of Michigan; Amy Puffenberger, Animal Care & Use Program – University of Michigan
I dedicate this book:
LAC
To my husband, who supports me in all things whether large or unimportant, while reminding me not to take myself too seriously.
MHN
To Carolyn “Kit” Kestrel Leigh Kennedy, whose timely arrival made completing this book a difficult task! And to Scott and Mer, who made it possible anyways.
LHK
The dosages given in this text are derived from published literature, but as few drugs are specifically licensed for use in the species described, the application is often extra‐label and may be empirical or based on clinical experience. The authors have made every attempt to verify all dosages and references; however, despite these efforts, errors in the original sources or in the preparation of this book may have occurred. Users of this text should exercise caution and evaluate all dosages prior to use to determine that they are reasonable.
Lesley A. Colby, DVM, MS, DACLAM, is Associate Professor and Senior Director of Animal Resources and Operations in the Department of Comparative Medicine at the University of Washington (UW). She is Director of the UW's BSL3/ABSL3 Facility and has particular interests in biocontainment, occupational health, and facility design and management. Dr. Colby is a Diplomate of the American College of Laboratory Animal Medicine.
Megan H. Nowland, DVM, DACLAM, is an Associate Professor in the Unit for Laboratory Animal Medicine at the University of Michigan in Ann Arbor, Michigan. There, she directs the Postdoctoral Training Program in Laboratory Animal Medicine, is the Associate Attending Veterinarian and the Assistant Director for Clinical Services.
Lucy H. Kennedy, DVM, DACLAM, is an Assistant Professor in the Unit for Laboratory Animal Medicine at the University of Michigan in Ann Arbor, Michigan. She is also the Managing Director for the Unit for Laboratory Animal Medicine's Germ‐Free Mouse Facility and enjoys the challenges of gnotobiotic mouse research.
The purpose of this book is to provide basic information regarding the safe and responsible conduct of animal research as well as the unique anatomic and physiologic characteristics, husbandry practices, and veterinary care of many of the animals frequently used in research: rodents, rabbits, ferrets, zebrafish, nonhuman primates, and agricultural animals. As the book name implies, we have designed the materials to be especially useful for individuals who are new to animal research as well as for those experienced in this field and expanding their knowledge of additional species. As a result, the book should be a useful resource for practicing veterinarians, veterinary students, veterinary technicians, research scientists, and others interested in learning about the field.
This, the fifth edition of the book, has been revised to include not only updated information but also new chapters on zebrafish and agricultural animals used in biomedical research. Significant changes have been made to expand and/or reorganize the non‐species chapters, to refine drug dosage tables to reflect the drugs most frequently utilized for each species, and to provide recommended reading sources for additional inquiry. As in previous editions of this book, study review questions are provided for each chapter and supplemental materials are provided in an accompanying website.
This book would not have been possible without the contributions of all previous edition authors: Donald Holmes, Karen Hrapkiewicz, Leticia Medina, and Patricia Denison. We thank you for providing such a strong foundation upon which to build. We also acknowledge and thank the many individuals and vendors who provided images for inclusion in the book and website. A very special thanks to our family, friends, and colleagues for their patience and support during the writing of this text. Lastly, our heartfelt thanks to all the animals that have contributed to the remarkable advancements in biomedical research throughout the ages, without whom many of the scientific breakthroughs we now take for granted would not have been possible.
This book is accompanied by a companion Website:
www.wiley.com/go/colby/clinical
The Website includes:
Watch for 
throughout the book. These pinpoint materials that are also available on the Website.