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Process Control, Intensification, and Digitalisation in Continuous Biomanufacturing


Process Control, Intensification, and Digitalisation in Continuous Biomanufacturing


1. Aufl.

von: Ganapathy Subramanian

133,99 €

Verlag: Wiley-VCH
Format: PDF
Veröffentl.: 15.12.2021
ISBN/EAN: 9783527827329
Sprache: englisch
Anzahl Seiten: 400

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Beschreibungen

<b>Process Control, Intensification, and Digitalisation in Continuous Biomanufacturing</b> <p><B>Explore new trends in continuous biomanufacturing with contributions from leading practitioners in the field</b> <p>With the increasingly widespread acceptance and investment in the ??technology, the last decade has demonstrated the utility of continuous ??processing in the pharmaceutical industry. <p>In<i> Process Control, Intensification, and Digitalisation in Continuous Biomanufacturing,</i> distinguished biotechnologist Dr. Ganapathy Subramanian delivers a comprehensive exploration of the potential of the continuous processing of biological products and discussions of future directions in advancing continuous processing to meet new challenges and demands in the manufacture of therapeutic products. <p>A stand-alone follow-up to the editor’s <i>Continuous Biomanufacturing: Innovative Technologies and Methods</i> published in 2017, this new edited volume focuses on critical aspects of process intensification, process control, and the digital transformation of biopharmaceutical processes. In addition to topics like the use of multivariant data analysis, regulatory concerns, and automation processes, the book also includes: <ul><li>Thorough introductions to capacitance sensors to control feeding strategies and the continuous production of viral vaccines</li> <li>Comprehensive explorations of strategies for the continuous upstream processing of induced microbial systems</li> <li>Practical discussions of preparative hydrophobic interaction chromatography and the design of modern protein-A-resins for continuous biomanufacturing</li> <li>In-depth examinations of bioprocess intensification approaches and the benefits of single use for process intensification</li></ul> <p>Perfect for biotechnologists, bioengineers, pharmaceutical engineers, and process engineers, <i>Process Control, Intensification, and Digitalisation in Continuous Biomanufacturing </i>is also an indispensable resource for chemical engineers seeking a one-stop reference on continuous biomanufacturing.
1. Capacitance sensors to control feeding strategies.<br> 2. Continuous production of Viral Vaccines<br> 3. Hybrid model as a smart and efficient enables of digitalisation in Bioprocessing<br> 4. Strategies for continuous upstream processing of induced microbial systems<br> 5. Preparative hydrophobic interaction chromatography (HIC) at very high loadings for a demanding ternary protein mixture<br> 6. Designing Modern Protein-A-resins optimized for continuous biomanufacturing<br> <br> <br> <br> 7. Design and operation of intensification continuous bioprocessing by process modelling and control.<br> 8. Bioprocess intensification: Approaches and Goals.<br> 9. Benefits of Single use for process intensification<br> 10. Process intensification based on disposable solution as a first step towards for Continuous Process<br> 11. High Throughput process development approaches for intensifies biomanufacturing<br> 12. Automation <br> <br> <br> 13. Regulatory aspect <br> 14. Online monitoring of living cell concentration using dielectric spectroscopy.<br> 15. Use of Multivariant data analysis (MVDA) for Continuous Bioprocess<br> 16. Landscape and Implementation of DSP Process Analytical Technologies (PAT) enabling IntegratedContinuous Biomanufacturing: Integrated DSP Control Strategy for Advanced Process Control.<br> 17. Failure mode detection and diagnosis in Simulated-Moving Bed (SMB) chromatography <br> 18. The Role of Artificial Intelligence in the Control of Continuous Processing<br> <br>
<p><b>Ganapathy Subramanian</b>, PhD, is a biotechnology consultant with more than 30 years of experience in industry and academia. His professional focus is on the application and development of processing and purification methodologies and chromatographic systems for large-scale use in environmental science.</p>
<p><b>Explore new trends in continuous biomanufacturing with contributions from leading practitioners in the field</b></p> <p>With the increasingly widespread acceptance and investment in the technology, the last decade has demonstrated the utility of continuous processing in the pharmaceutical industry.</p> <p>In<i> Process Control, Intensification, and Digitalisation in Continuous Biomanufacturing,</i> distinguished biotechnologist Dr. Ganapathy Subramanian delivers a comprehensive exploration of the potential of the continuous processing of biological products and discussions of future directions in advancing continuous processing to meet new challenges and demands in the manufacture of therapeutic products.</p> <p>A stand-alone follow-up to the editor's <i>Continuous Biomanufacturing: Innovative Technologies and Methods</i> published in 2017, this new edited volume focuses on critical aspects of process intensification, process control, and the digital transformation of biopharmaceutical processes. In addition to topics like the use of multivariant data analysis, regulatory concerns, and automation processes, the book also includes:</p> <ul> <li>Thorough introductions to capacitance sensors to control feeding strategies and the continuous production of viral vaccines</li> <li>Comprehensive explorations of strategies for the continuous upstream processing of induced microbial systems</li> <li>Practical discussions of preparative hydrophobic interaction chromatography and the design of modern protein-A-resins for continuous biomanufacturing</li> <li>In-depth examinations of bioprocess intensification approaches and the benefits of single use for process intensification</li> </ul> <p>Perfect for biotechnologists, bioengineers, pharmaceutical engineers, and process engineers, <i>Process Control, Intensification, and Digitalisation in Continuous Biomanufacturing</i> is also an indispensable resource for chemical engineers seeking a one-stop reference on continuous biomanufacturing.</p>

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