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<p>Contributors</p> <p>Preface</p> <p><b>I. Introduction</b></p> <p>1. Historical Events That Spawned the Field of Plasmid Biology</p> <p><b>II. Plasmid Replication Systems and Their Control</b></p> <p>2. Iteron Plasmids</p> <p>3. Mechanisms of Theta Plasmid Replication</p> <p>4. Plasmid Rolling-Circle Replication</p> <p>5. Replication and Maintenance of Linear Phage-Plasmid N15</p> <p>6. Plasmid Replication Control by Antisense RNAs</p> <p>7. Topological Behavior of Plasmid DNA</p> <p><b>III. Plasmid Maintenance, Transfer and Barriers</b></p> <p>8. Plasmid Partition Mechanisms</p> <p>9. Resolution of Multimeric Forms of Circular Plasmids and Chromosomes</p> <p>10. Conditional Activation of Toxin-Antitoxin Systems: Postsegregational Killing and Beyond</p> <p>11. The Interplay between Different Stability Systems Contributes to Faithful Segregation: Streptococcus pyogenes pSM19035 as a Model</p> <p>12. The CRISPR-Cas Immune System and Genetic Transfers: Reaching an Equilibrium</p> <p>13. Plasmid Diversity and Adaptation Analyzed by Massive Sequencing of Escherichia coli Plasmids</p> <p>14. Conjugation in Gram-Positive Bacteria</p> <p>15. Mobilizable Rolling-Circle Replicating Plasmids from Gram-Positive Bacteria: A Low-Cost Conjugative Transfer</p> <p><b>IV. Specific Plasmid Systems</b></p> <p>16. The Plasmid Mobilome of the Model Plant Symbiont Sinorhizobium meliloti: Coming up with New Questions and Answers</p> <p>17. The Agrobacterium Ti Plasmids</p> <p>18. The Influence of Biofilms in the Biology of Plasmids</p> <p>19. The Partitioning and Copy Number Control Systems of the Selfish Yeast Plasmid: An Optimized Molecular Design for Stable Persistence in Host Cells</p> <p>20. Plasmids from Euryarchaeota</p> <p><b>V. Plasmid Ecology and Evolution</b></p> <p>21. The Plasmidome of Firmicutes: Impact on the Emergence and the Spread of Resistance to Antimicrobials</p> <p>22. Plasmid-Mediated Antimicrobial Resistance in Staphylococci and Other Firmicutes</p> <p>23. Plasmid Detection, Characterization, and Ecology</p> <p>24. Plasmid-Mediated Antibiotic Resistance and Virulence in Gram-Negatives: The Klebsiella pneumoniae Paradigm</p> <p>25. Plasmid-Mediated Quinolone Resistance</p> <p><b>VI. Specialized Functions Mediated By Plasmids</b></p> <p>26. Plasmid-Mediated Tolerance Toward Environmental Pollutants</p> <p>27. Virulence Plasmids of Spore-Forming Bacteria</p> <p>28. Virulence Plasmids of Nonsporulating Gram-Positive Pathogens</p> <p>29. Plasmid-Encoded Iron Uptake Systems</p> <p><b>VII. Plasmids as Genetic Tools</b></p> <p>30. DNA Assembly Tools and Strategies for the Generation of Plasmids</p> <p>31. Plasmids as Tools for Containment</p> <p>32. Mining Environmental Plasmids for Synthetic Biology Parts and Devices</p> <p>33. Using Plasmids as DNA Vaccines for Infectious Diseases</p> <p>34. Plasmid Biopharmaceuticals</p> <p>Index</p>

<p><b>Plasmids</b> <p>First Edition <p><i>Explore the remarkable discoveries in the rapidly expanding field of plasmid biology</i> <p><i>Plasmids</i> are integral to biological research as models for innumerable mechanisms of living cells, as tools for creating the most diverse therapies, and as crucial helpers for understanding the dissemination of microbial populations. Their role in virulence and antibiotic resistance, together with the generalization of "omics" disciplines, has recently ignited a new wave of interest in plasmids. <p>This comprehensive book contains a series of expertly written chapters focused on plasmid biology, mechanistic details of plasmid function, and the increased utilization of plasmids in biotechnology and pharmacology that has occurred in the past decade. <p><i>Plasmids: Biology and Impact in Biotechnology and Discovery</i> serves as an invaluable reference for researchers in the wide range of fields and disciplines that utilize plasmids and can also be used as a textbook for upper-level undergraduate and graduate courses in biotechnology and molecular biology.

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