Details

Peptides


Peptides

Chemistry and Biology
2. Aufl.

von: Norbert Sewald, Hans-Dieter Jakubke

124,99 €

Verlag: Wiley-VCH
Format: EPUB
Veröffentl.: 19.11.2015
ISBN/EAN: 9783527802654
Sprache: englisch
Anzahl Seiten: 594

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Beschreibungen

Thoroughly updated, incorporating around 25 % new material, Sewald/Jakubke remains the only modern and scientifically up-to-date advanced textbook on peptide biochemistry, distilling the knowledge of hundreds of publications into a highly readable synopsis of this diverse field. The authors explain the broad fundamentals of peptide synthesis and structure, systematically addressing important families of biologically active peptides, and adopting an interdisciplinary approach that covers application areas in biotechnology, pharmaceutical science, and biomedicine. One major focus is on such "hot" research topics as pseudopeptides, peptidomimetics, and combinatorial synthesis. This new edition also features study questions for each learning unit, for easier self-study and classroom teaching.
INTRODUCTION AND BACKGROUND FUNDAMENTAL CHEMICAL AND STRUCTURAL PRINCIPLES Definitions and Main Conformational Features of the Peptide Bond Building Blocks, Classification, and Nomenclature Analysis of the Covalent Structure of Peptides and Proteins Three-Dimensional Structure Methods of Structural Analysis BIOLOGY OF PEPTIDES Historical Aspects and Biological Functions Biosynthesis Selected Biologically Active Peptides PEPTIDE SYNTHESIS Principles and Objectives Protection of Functional Groups Peptide Bond Formation Racemization During Synthesis Solid-Phase Peptide Synthesis (SPPS) Biochemical Synthesis SYNTHESIS CONCEPTS FOR PEPTIDES AND PROTEINS Strategy and Tactics Solution Phase Synthesis (SPS) NEW: Solution Phase/Solid Phase-Hybrid Approaches Optimized Strategies on Polymeric Support Chemical Ligation Strategies SYNTHESIS OF SPECIAL PEPTIDES AND PEPTIDE CONJUGATES Cyclopeptides Cystine Peptides Glycopeptides Phosphopeptides Lipopeptides Sulfated Peptides PEPTIDE AND PROTEIN DESIGN, PSEUDOPEPTIDES, AND PEPTIDOMIMETICS Peptide Design Modified Peptides Peptidomimetics Pseudobiopolymers Macropeptides and De-Novo Design of Peptides and Proteins COMBINATORIAL PEPTIDE SYNTHESIS Parallel Synthesis Synthesis of Mixtures APPLICATION OF PEPTIDES AND PROTEINS NEW: General Production Strategies NEW: Improvement of the Therapeutic Potential Protein Pharmaceuticals Peptide Pharmaceuticals PEPTIDES IN PROTEOMICS NEW: Genome and Proteome NEW: Separation Methods NEW: Peptide and Protein Analysis in Proteomics NEW: Activity-Based Proteomics
Norbert Sewald studied Chemistry at the Technical University of Munich, Germany, where he also obtained his PhD degree. After postdoctoral work with J. E. Baldwin in Oxford, UK, he became an Assitant Professor at Leipzig University. Since 1999 he is full Professor at the University of Bielefeld where he holds the chair in Organic and Bioorganic Chemistry. His main scientific interest is in peptide chemistry, bioactive peptides., and their application in biochemistry and medical sciences. He has authored more than 120 publications and together with Hans-Dieter Jakubke, has written the book Peptides from A - Z, also published by Wiley-VCH. Hans-Dieter Jakubke studied Chemistry at the Martin-Luther-University Halle-Wittenberg, Germany. After finishing his PhD and postdoctoral work with Josef Rudinger in Prague (Czeck Republic), he was appointed Assistant Professor at the Department of Biochemistry in Halle, and Full Professor of Biochemistry at the University of Leipzig in 1977. He was director of the Department of Biochemistry from 1993-1997 and member of the Council of the European Peptide Society from 1990-1994. He authored several textbooks and encyclopedias on various aspects of chemistry and biochemistry including peptide research.
With peptides playing such a valuable role in the body, the need for a modern and scientifically up-to-date advanced textbook is critical for both students and teachers. This book on peptide science distils the knowledge of hundreds of publications into a highly readable synopsis of this diverse field. Commencing with the broad fundamentals of peptide synthesis and structure, systematic explanations of the important families of biologically active peptides are given, and the interdisciplinary approach covers application areas in biotechnology, pharmaceutical science, and biomedicine. One major focus is on such "hot" research topics as pseudopeptides, peptidomimetics, combinatorial synthesis, and proteomics. This new edition has been fully revised and now features study questions and exercises for each learning unit, didactically enhanced for easier self-study and classroom teaching. Norbert Sewald studied Chemistry at the Technical University of Munich, Germany, where he also obtained his PhD degree. After postdoctoral work with J. E. Baldwin in Oxford, UK, he became an Assitant Professor at Leipzig University. Since 1999 he is full Professor at the University of Bielefeld where he holds the chair in Organic and Bioorganic Chemistry. His main scientific interest is in peptide chemistry, bioactive peptides., and their application in biochemistry and medical sciences. He has authored more than 120 publications and together with Hans-Dieter Jakubke, has written the book Peptides from A - Z, also published by Wiley-VCH. Hans-Dieter Jakubke studied Chemistry at the Martin-Luther-University Halle-Wittenberg, Germany. After finishing his PhD and postdoctoral work with Josef Rudinger in Prague (Czeck Republic), he was appointed Assistant Professor at the Department of Biochemistry in Halle, and Full Professor of Biochemistry at the University of Leipzig in 1977. He was director of the Department of Biochemistry from 1993-1997 and member of the Council of the European Peptide Society from 1990-1994. He authored several textbooks and encyclopedias on various aspects of chemistry and biochemistry including peptide research.

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