Details

Pathology of Genetically Engineered and Other Mutant Mice


Pathology of Genetically Engineered and Other Mutant Mice


1. Aufl.

von: John P. Sundberg, Peter Vogel, Jerrold M. Ward

173,99 €

Verlag: Wiley-Blackwell
Format: PDF
Veröffentl.: 11.10.2021
ISBN/EAN: 9781119624585
Sprache: englisch
Anzahl Seiten: 560

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Beschreibungen

<b>PATHOLOGY OF GENETICALLY ENGINEERED AND OTHER MUTANT MICE</b> <p><b>An updated and comprehensive reference to pathology in every organ system in genetically modified mice</b> <p>The newly revised and thoroughly updated Second Edition of <i>Pathology of Genetically Engineered and Other Mutant Mice</i> delivers a comprehensive resource for pathologists and biomedical scientists tasked with identifying and understanding pathologic changes in genetically modified mice. The book is organized by body system, and includes descriptions and explanations of a wide range of findings, as well as hundreds of color photographs illustrating both common and rare lesions that may be found in genetically engineered and wild type mice. <p>The book is written by experienced veterinary and medical pathologists working in veterinary medical colleges, medical colleges, and research institutes. Covering the latest discoveries in mouse pathology resulting from advancements in biotechnology research over the last 30 years, this singular and accessible resource is a must-read for veterinary and medical pathologists and researchers working with genetically engineered and other mice. <p>Readers will also benefit from: <ul><li>A thorough introduction to mouse pathology and mouse genetic nomenclature, as well as databases useful for analysis of mutant mice</li> <li>An exploration of concepts related to validating animal models, including the Cinderella Effect</li> <li>Practical discussions of basic necropsy methods and grading lesions for computational analyses</li> <li>Concise diagnostic approaches to the respiratory tract, the oral cavity and GI tract, the cardiovascular system, the liver and pancreas, the skeletal system, and other tissuesl</li></ul> <p>As a one-stop and up to date reference on mouse pathology, <i>Pathology of Genetically Engineered and Other Mutant Mice</i> is an essential book for veterinary and medical pathologists, as well as for scientists, researchers, and toxicologists whose work brings them into contact with genetically modified mice.
<p>Contributors List</p> <p>Preface and Acknowledgements</p> <p>Chapter 1. Introduction to Mouse Pathology<br /><i>Jerrold M. Ward, Peter Vogel, John P. Sundberg</i></p> <p>Chapter 2. The Mouse Online: Open Mouse Biology and Pathology Data Resources for Biomedical Research<br /><i>Dale A. Begley, Paul N. Schofield, and John P. Sundberg</i></p> <p>Chapter 3. Mouse Genetic Nomenclature; the Underpinning of Mouse Genetics<br /><i>John P. Sundberg, Dale Begley, Melissa Berry, Michelle N. Perry, David Shaw, and Paul N. Schofield</i></p> <p>Chapter 4. Discovering and Validating Mouse Models of Human Diseases: The Cinderella Effect<br /><i>John P. Sundberg, Jerrold M. Ward, Peter Vogel, and Paul N. Schofiel</i></p> <p>Chapter 5. Embryos, Placentas, and Neonates<br /><i>Brad Bolon and Jerrold M. Ward</i></p> <p>Chapter 6. Ciliopathies<br /><i>Peter Vogel and Laura L. Janke</i></p> <p>Chapter 7. Hematopoietic and Lymphoid Tissues<br /><i>Harm HogenEsch and John P. Sundberg</i></p> <p>Chapter 8. Hematolymphoid Neoplasms<br /><i>Jerold E. Rehg</i></p> <p>Chapter 9. Immunodeficient and Humanized Mice<br /><i>Sara F. Santagostino, Sébastien Monette, Alessandra Piersigilli, Virginia L. Godfrey, and Harm</i> HogenEsch</p> <p>Chapter 10. Skin, Hair, and Nails<br /><i>John P. Sundberg, Lloyd E. King, Jr., Raoul V. Kuiper </i></p> <p>Chapter 11. Mammary Gland<br /><i>Alexander D. Borowsky and Robert D. Cardiff   </i></p> <p>Chapter 12. Respiratory System<br /><i>Jerry M. Ward and John P. Sundberg</i></p> <p>Chapter 13. Gastrointestinal Tract<br /><i>Jerrold M. Ward, Piper M. Treuting, M. Kay Washington</i></p> <p>Chapter 14. Cardiovascular System<br /><i>Kathleen Gabrielson, Akash Behera, Polina Sysa-Shah, Tyler J. Creamer, and Timothy Cooper</i></p> <p>Chapter 15. Liver and Pancreas<br /><i>Maria L.Z. Dagli, Lucas M. Chaible, and Katja Steiger</i></p> <p>Chapter 16. Neuromuscular System<br /><i>Peter Vogel, Laura L. Janke, and Heather S. Tillman</i></p> <p>Chapter 17. Endocrine System<br /><i>Krista Marie DuBray La Perle</i></p> <p>Chapter 18. Kidney and Urinary Bladder<br /><i>Jeffrey B. Kopp, Cory F. Brayton, Jeffrey Everett, Avi Z. Rosenberg, Jerrold M. Ward</i></p> <p>Chapter 19. Female Reproductive Tract<br /><i>Darlene Dixon and Alexander Nikitin</i></p> <p>Chapter 20. Male Reproductive Tract<br /><i>Sue E. Knoblaugh, Hibret A. Adissu, Colin McKerlie, Robert D. Cardiff</i></p> <p>Chapter 21. Nervous System<br /><i>Jessica M. Snyder, Katherine N. Gibson-Corley, and Enrico Radaelli</i></p> <p>Chapter 22. Eye and Ear<br /><i>Heather Tillman, Laura Janke, Jerold Rehg, Peter Vogel</i></p> <p>Chapter 23. Bones and teeth<br /><i>Peter Vogel, John P. Sundberg, Cheryl Ackert-Bicknell</i></p> <p>Index</p>
<p><b>The editors</b></p> <p><b>John P. Sundberg,</b> DVM, PhD, Dipl. ACVP, is Professor at The Jackson Laboratory in Bar Harbor, Maine, USA and an Adjunct Professor in the Department of Dermatology, Vanderbilt University Medical Center in Nashville, TN, USA. <p><b>Peter Vogel,</B> DVM, PhD, Dipl. ACVP, is Director of the Veterinary Pathology Core Laboratory at St. Jude Children’s Research Hospital in Memphis, Tennessee, USA. <p><b>Jerrold M. Ward,</b> DVM, PhD, Dipl. ACVP, Fellow IATP, is a consultant at Global VetPathology, Montgomery Village, Maryland, USA.
<p><b>An updated and comprehensive reference to pathology in every organ system in genetically modified mice</b></p> <p>The newly revised and thoroughly updated Second Edition of <i>Pathology of Genetically Engineered and Other Mutant Mice</i> delivers a comprehensive resource for pathologists and biomedical scientists tasked with identifying and understanding pathologic changes in genetically modified mice. The book is organized by body system, and includes descriptions and explanations of a wide range of findings, as well as hundreds of color photographs illustrating both common and rare lesions that may be found in genetically engineered and wild type mice. <p>The book is written by experienced veterinary and medical pathologists working in veterinary medical colleges, medical colleges, and research institutes. Covering the latest discoveries in mouse pathology resulting from advancements in biotechnology research over the last 30 years, this singular and accessible resource is a must-read for veterinary and medical pathologists and researchers working with genetically engineered and other mice. <p>Readers will also benefit from: <ul><li>A thorough introduction to mouse pathology and mouse genetic nomenclature, as well as databases useful for analysis of mutant mice</li> <li>An exploration of concepts related to validating animal models, including the Cinderella Effect</li> <li>Practical discussions of basic necropsy methods and grading lesions for computational analyses</li> <li>Concise diagnostic approaches to the respiratory tract, the oral cavity and GI tract, the cardiovascular system, the liver and pancreas, the skeletal system, and other tissuesl</li></ul> <p>As a one-stop and up to date reference on mouse pathology, <i>Pathology of Genetically Engineered and Other Mutant Mice</i> is an essential book for veterinary and medical pathologists, as well as for scientists, researchers, and toxicologists whose work brings them into contact with genetically modified mice.

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