Details

<p>List of Contributors vii</p> <p>Preface and Acknowledgments x</p> <p>1 Introduction to Mouse Pathology 1<i><br /> Jerrold M. Ward, Peter Vogel, and John P. Sundberg</i></p> <p>2 The Mouse Online: Open Mouse Biology and Pathology Data Resources for Biomedical Research 6<br /> <i>Dale A. Begley, Paul N. Schofield, and John P. Sundberg</i></p> <p>3 Mouse Genetic Nomenclature: The Underpinning of Mouse Genetics 22<i><br /> John P. Sundberg, Dale A. Begley, Melissa L. Berry, Michelle N. Perry, David Shaw, and Paul N. Schofield</i></p> <p>4 Discovering and Validating Mouse Models of Human Diseases: The Cinderella Effect 39<i><br /> John P. Sundberg, Jerrold M. Ward, Peter Vogel, and Paul N. Schofield</i></p> <p>5 Embryos, Placentas, and Neonates 48<i><br /> Brad Bolon and Jerrold M. Ward</i></p> <p>6 Ciliopathies 72<i><br /> Peter Vogel and Laura J. Janke</i></p> <p>7 Hematopoietic and Lymphoid Tissues 82<i><br /> Harm HogenEsch and John P. Sundberg</i></p> <p>8 Mouse Hematolymphoid Neoplasms 97<i><br /> Jerold E. Rehg</i></p> <p>9 Immunodeficient and Humanized Mice 132<i><br /> Sara F. Santagostino, Sébastien Monette, Alessandra Piersigilli, Virginia L. Godfrey, and Harm HogenEsch</i></p> <p>10 Skin, Hair, and Nails 159<i><br /> John P. Sundberg, Lloyd E. King, Jr, and Raoul V. Kuiper</i></p> <p>11 Mammary Gland 213<i><br /> Alexander D. Borowsky and Robert D. Cardiff</i></p> <p>12 The Respiratory Tract 237<i><br /> Jerrold M. Ward and John P. Sundberg</i></p> <p>13 The Gastrointestinal Tract 259<i><br /> Jerrold M. Ward, Piper M. Treuting, and M. Kay Washington</i></p> <p>14 Cardiovascular System 284<i><br /> Kathleen L. Gabrielson, Akash Behera, Polina Sysa-Shah, Tyler J. Creamer, and Timothy K. Cooper</i></p> <p>15 Liver and Pancreas 307<i><br /> Maria L.Z. Dagli, Lucas M. Chaible, and Katja Steiger</i></p> <p>16 Neuromuscular System 336<i><br /> Peter Vogel, Laura J. Janke, and Heather W. Sheppard</i></p> <p>17 Endocrine System 355<i><br /> Krista M. D. La Perle</i></p> <p>18 Kidney and Urinary Bladder 378<i><br /> Jeffrey B. Kopp, Avi Z. Rosenberg, Cory F. Brayton, Jeffrey I. Everitt, and Jerrold M. Ward</i></p> <p>19 Female Reproductive System 403<i><br /> Darlene Dixon and Alexander Yu. Nikitin (In Memory of Dr. Joel Mahler)</i></p> <p>20 Male Reproductive System 431<i><br /> Sue E. Knoblaugh, Hibret A. Adissu, Colin McKerlie, and Robert D. Cardiff</i></p> <p>21 Nervous System 462<i><br /> Jessica M. Snyder, Katherine N. Gibson-Corley, and Enrico Radaelli</i></p> <p>22 Eye and Ear 493<i><br /> Heather W. Sheppard, Laura J. Janke, Jerold E. Rehg, and Peter Vogel</i></p> <p>23 Bones and Teeth 520<i><br /> Peter Vogel, John P. Sundberg, and Cheryl Ackert-Bicknell</i></p> <p>Index 541</p>

<p><b>The editors</b></p> <p><b>John P. Sundberg</b>, DVM, PhD, DACVP, is Professor at The Jackson Laboratory in Bar Harbor, Maine, USA and an Adjunct Professor in the Department of Dermatology, Vanderbilt University Medical Center in Nashville, TN, USA.</p> <p><b>Peter Vogel</b>, DVM, PhD, DACVP, is Director of the Veterinary Pathology Core Laboratory at St. Jude Children's Research Hospital in Memphis, Tennessee, USA.</p> <p><b>Jerrold M. Ward</b>, DVM, PhD, DACVP, FIATP,is an Adjunct Faculty member at The Jackson Laboratory, Bar Harbor, Maine, USA and Adjunct Professor in the Department of Biomedical Sciences at Cornell University College of Veterinary Medicine in Ithaca, New York, USA.</p>

<p><b>An updated and comprehensive reference to pathology in every organ system in genetically modified mice</b></p> <p>The newly revised and thoroughly updated Second Edition of <i>Pathology of Genetically Engineered and Other Mutant Mice</i> delivers a comprehensive resource for pathologists and biomedical scientists tasked with identifying and understanding pathologic changes in genetically modified mice. The book is organized by body system, and includes descriptions and explanations of a wide range of findings, as well as hundreds of color photographs illustrating both common and rare lesions that may be found in genetically engineered and wild type mice. <p>The book is written by experienced veterinary and medical pathologists working in veterinary medical colleges, medical colleges, and research institutes. Covering the latest discoveries in mouse pathology resulting from advancements in biotechnology research over the last 30 years, this singular and accessible resource is a must-read for veterinary and medical pathologists and researchers working with genetically engineered and other mice. <p>Readers will also benefit from: <ul><li>A thorough introduction to mouse pathology and mouse genetic nomenclature, as well as databases useful for analysis of mutant mice</li> <li>An exploration of concepts related to validating animal models, including the Cinderella Effect</li> <li>Practical discussions of basic necropsy methods and grading lesions for computational analyses</li> <li>Concise diagnostic approaches to the respiratory tract, the oral cavity and GI tract, the cardiovascular system, the liver and pancreas, the skeletal system, and other tissuesl</li></ul> <p>As a one-stop and up to date reference on mouse pathology, <i>Pathology of Genetically Engineered and Other Mutant Mice</i> is an essential book for veterinary and medical pathologists, as well as for scientists, researchers, and toxicologists whose work brings them into contact with genetically modified mice.

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