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PREFACE xi<br /> <i>Tahira Farooqui and Akhlaq A. Farooqui</i> <p>FOREWORD xiii<br /> <i>Grace Y. Sun</i></p> <p>ACKNOWLEDGMENTS xv<br /> <i>Tahira Farooqui and Akhlaq A. Farooqui</i></p> <p>CONTRIBUTORS xvii</p> <p><b>PART I OXIDATIVE STRESS IN VERTEBRATES</b></p> <p>1 Generation of Reactive Oxygen Species in the Brain: Signaling for Neural Cell Survival or Suicide 3<br /> <i>Akhlaq A. Farooqui</i></p> <p>2 Free Radicals, Signal Transduction, and Human Disease 17<br /> <i>Klaudia Jomova and Marian Valko</i></p> <p>3 Oxidative Stress and its Biochemical Consequences in Mitochondrial DNA Mutation-Associated Diseases: Implications of Redox Therapy for Mitochondrial Diseases 33<br /> <i>Shi-Bei Wu, Yu-Ting Wu, Yi-Shing Ma, and Yau-Huei Wei</i></p> <p>4 Oxidative Stress in Kainic Acid Neurotoxicity: Implications for the Pathogenesis of Neurotraumatic and Neurodegenerative Diseases 51<br /> <i>Akhlaq A. Farooqui</i></p> <p>5 Survival Strategy and Disease Pathogenesis According to the Nrf2-Small Maf Heterodimer 63<br /> <i>Masanobu Morita and Hozumi Motohashi</i></p> <p>6 Caloric Restriction and Oxidative Stress 83<br /> <i>Jan Škrha</i></p> <p>7 Pathogenesis of Neurodegenerative Diseases: Contribution of Oxidative Stress and Neuroinflammation 103<br /> <i>Tahira Farooqui and Akhlaq A. Farooqui</i></p> <p>8 Neurosteroids in Oxidative Stress-Mediated Injury in Alzheimer Disease 117<br /> <i>Amandine Grimm, Ayikoe Guy Mensah-Nyagan, and Anne Eckert</i></p> <p>9 Oxidative Stress in Adult Neurogenesis and in the Pathogenesis of Alzheimer Disease 129<br /> <i>Philippe Taupin</i></p> <p>10 Oxidative Stress and Parkinson Disease 139<br /> <i>Kah-Leong Lim, Doyle Graham, and Xiao-Hui Ng</i></p> <p>11 Oxidative Stress in Cardiovascular Diseases 153<br /> <i>Michael E. Andrades and Rodrigo Lorenzi</i></p> <p>12 Oxidative Stress and Aging: A Comparison between Vertebrates and Invertebrates 167<br /> <i>Syed Ibrahim Rizvi and Kanti Bhooshan Pandey</i></p> <p>13 Oxidative Stress-Mediated Signaling Pathways by Environmental Stressors 175<br /> <i>Hideko Sone and Hiromi Akanuma</i></p> <p>14 Selenoproteins in Cellular Redox Regulation and Signaling 195<br /> <i>Arjun V. Raman and Marla J. Berry</i></p> <p>15 Antioxidant Therapy and its Effectiveness in Oxidative Stress-Mediated Disorders 209<br /> <i>Tommaso Iannitti and Beniamino Palmieri</i></p> <p>16 The Protective Role of Grape Seed Polyphenols Against Oxidative Stress in Treating Neurodegenerative Diseases 235<br /> <i>Giulio Maria Pasinetti</i></p> <p>17 Pharmacological and Therapeutic Properties of Propolis (Bee Glue) 245<br /> <i>Kandangath Raghavan Anilakumar, Farhath Khanum, and Amarinder Singh Bawa</i></p> <p><b>PART II OXIDATIVE STRESS IN INVERTEBRATES</b></p> <p>18 Endocrine Control of Oxidative Stress in Insects 261<br /> <i>Natraj Krishnan and Dalibor Kodri´k</i></p> <p>19 Oxidative Stress in the Airway System of the Fruit Fly Drosophila melanogaster 271<br /> <i>Thomas Roeder</i></p> <p>20 Molecular Mechanisms of Antioxidant Protective Processes in Honeybee Apis mellifera 279<br /> <i>Alexey G. Nikolenko, Elena S. Saltykova, and Louisa R. Gaifullina</i></p> <p>21 Molecular Basis of Iron-induced Oxidative Stress in the Honeybee Brain: A Potential Model System of Olfactory Dysfunction in Neurological Diseases 295<br /> <i>Tahira Farooqui</i></p> <p>22 Modulation of Oxidative Stress by Keap1/Nrf2 Signaling in Drosophila: Implications for Human Diseases 309<br /> <i>Gerasimos P. Sykiotis, M. Mahidur Rahman, and Dirk Bohmann</i></p> <p>23 Orchestration of Oxidative Stress Responses in Drosophila melanogaster: A Promoter Analysis Study of Circadian Regulatory Motifs 327<br /> <i>Kuntol Rakshit and Natraj Krishnan</i></p> <p>24 The Protective Role of Sestrins Against Chronic TOR Activation and Oxidative Stress 337<br /> <i>Jun Hee Lee and Ethan Bier</i></p> <p>25 Current Advances in the Studies of Oxidative Stress and Age-Related Memory Impairment in C. elegans 347<br /> <i>Shin Murakami, Kelly Cabana, and Danielle Anderson</i></p> <p>26 Oxidative Challenge and Redox Sensing in Mollusks: Effects of Natural and Anthropic Stressors 361<br /> <i>Julie Letendre, Franc¸ois Leboulenger, and Fabrice Durand</i></p> <p>27 Perspective and Directions for Future Studies 377<br /> <i>Tahira Farooqui and Akhlaq A. Farooqui</i></p> <p>INDEX 385</p>

<b>TAHIRA FAROOQUI</b> has published extensively on drug receptor interactions, biogenic amines in vertebrate and invertebrate nervous systems, glycerophospholipid and sphingolipid metabolism, and molecular mechanisms in the brain, as well as on the neuromodulatory role of octopamine in the reinforcement pathway involved in olfactory learning and memory. <p><b>AKHLAQ A. FAROOQUI</b> is a leader in the fields of signal transduction, brain phospholipase A₂, bioactive ether lipid metabolism, and polyunsaturated fatty acid metabolism, among others. Farooqui has published on the generation and identification of glycerophospholipid-, sphingolipid-, and cholesterol-derived lipid mediators in kainic acid-mediated neurotoxicity by lipidomics.</p>

<b>Unique comparative treatment of oxidative stress and antioxidant defenses in vertebrates and invertebrates</b> <p>In one expertly edited and organized volume, <i>Oxidative Stress in Vertebrates and Invertebrates</i> brings together and analyzes the latest research findings in the field in order to present our current state of knowledge. The text bridges the gap between basic science and clinical studies, making it possible for readers to apply basic science to better understand and manage chronic diseases associated with oxidative stress. Moreover, it provides a unique comparative treatment of oxidative stress and antioxidant defenses in vertebrates and invertebrates, examining basic mechanisms, biomarkers, and oxidative stress-mediated chronic diseases.</p> <p>Featuring contributions from leading experts in oxidative stress-mediated cell signaling, the text is divided into two sections.</p> <p>Part I, Oxidative Stress in Vertebrate Systems, explores such topics as:</p> <ul> <li> <p>Generation of reactive oxygen species and their role in cell survival and suicide</p> </li> <li> <p>Oxidative stress and neuroinflammation in Alzheimer's disease and Parkinson's disease</p> </li> <li> <p>Comparison of oxidative stress in aging between vertebrates and invertebrates</p> </li> </ul> <p>Part II, Oxidative Stress in Invertebrate Systems, explores such topics as:</p> <ul> <li> <p>Effect of oxidative stress on insect endocrine control</p> </li> <li> <p>Innate immune system in airway epithelial cells of <i>Drosophila</i></p> </li> <li> <p>Oxidative challenge and redox sensing in molluscs</p> </li> </ul> <p>The final chapter provides a perspective on emerging research and directions for future investigations. Throughout the text, readers will find plenty of figures and line drawings of signal transduction pathways that illustrate key concepts and processes. Extensive references to the primary literature plus a bibliography facilitate further research into each topic.</p> <p>This text is recommended for biochemists, neuropharmacologists, toxicologists, and clinicians who need a state-of-the-science understanding of the mechanisms of oxidative stress in vertebrate and invertebrate systems.</p>

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