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Nutraceuticals and Natural Product Derivatives


Nutraceuticals and Natural Product Derivatives

Disease Prevention & Drug Discovery
1. Aufl.

von: Mohammad Fahad Ullah, Aamir Ahmad

153,99 €

Verlag: Wiley-Blackwell
Format: PDF
Veröffentl.: 11.12.2018
ISBN/EAN: 9781119436690
Sprache: englisch
Anzahl Seiten: 456

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Beschreibungen

Introduces readers to the growing applications of nutraceuticals and other natural product derivatives This comprehensive book presents a prophylactic and therapeutic approach to chronic disease prevention strategy by highlighting the translational potential of plant-derived dietary and non-dietary factors from epidemiological, laboratory, and clinical studies. It also shares the experiences of highly reputed experts working in the area of phytomedicine and nutraceutical agents in chemoprevention, to promote the significance of natural products and dietary factors as an elite priority for containing chronic diseases in the human population. Nutraceuticals and Natural Product Derivatives: Disease Prevention & Drug Discovery starts by examining natural food sources for the control of glycemia and the prevention of diabetic complications. It then looks at the anti-aging effects of sulfur-containing amino acids and nutraceuticals, and the potential of garcinia fruits to combat metabolic syndrome. Other topics covered include honey- and propolis-mediated regulation of protein networks in cancer cells; recent trends in drug discovery against Alzheimer’s disease; the therapeutic potential of metalloherbal nanoceuticals; and much more. Offers an alternative, natural approach to the prevention of chronic diseases Emphasizes the potential of plant-derived dietary and non-dietary factors from epidemiological, laboratory, and clinical studies Features contributions from world-renowned experts in the field of phytomedicine and nutraceutical agents in chemoprevention Includes prevention strategies in normal/risk populations through routine inclusion of specific dietary regimens and as therapeutic strategy for better management through adjuvant interventions with conventional treatment protocols Nutraceuticals and Natural Product Derivatives: Disease Prevention & Drug Discovery will appeal to graduate students and professionals in cell and molecular biology, translational research, pharmacology/drug discovery, medicinal chemistry, and clinical nutrition.
List of Contributors xvii Foreword xxi Preface xxv Books Description xxix Expert Commentary xxxi 1 Natural Food Sources for the Control of Glycemia and the Prevention of Diabetic Complications 1Carlo Pesce, Carla Iacobini, and Stefano Menini 1.1 Introduction: Obesity, Metabolic Syndrome, and Type 2 Diabetes Epidemics: The Role of Nutrition 1 1.2 Phytochemicals of Nutraceutical Importance and Functional Foods of Plant Origin 3 1.2.1 Dietary Oils 3 1.2.2 Vegetables and Fruits 4 1.3 Nutraceuticals and Functional Foods of Animal Origin 8 1.3.1 The Case of Carnosine 8 1.4 Nutraceuticals of Both Plant and Animal Origin 9 1.5 Probiotics, Prebiotics, and Symbiotics 12 1.6 Conclusion 15 References 17 2 Anti?Aging Effects of Sulfur?Containing Amino Acids and Nutraceuticals 25Geetika Garg, Abhishek Kumar Singh, Sandeep Singh, and Syed Ibrahim Rizvi 2.1 Aging and Nutrition 25 2.2 Natural Antioxidants 26 2.2.1 Sulfur?Containing Amino Acids and Their Role as Antioxidants 26 2.2.2 Anti?Aging Effects of L?Cysteine 27 2.3 N?Acetyl?L?Cysteine 28 2.3.1 Neuroprotective Effects of N?Acetyl?L?Cysteine 29 2.3.2 N?Acetyl?L?Cysteine in Combination with Other Antioxidants 29 2.4 Methionine 30 2.4.1 Methionine Restriction 30 2.5 Sulfur?Containing Nutraceuticals and Foods Rich in Sulfur?Containing Amino Acids 31 2.5.1 Whey Protein 32 2.5.2 Anti?Aging Effects of Whey Protein 32 2.6 Conclusion 33 Acknowledgments 33 Conflict of Interest 33 References 33 3 Garcinia Fruits: Their Potential to Combat Metabolic Syndrome 39Oliver John, Lindsay Brown, and Sunil K. Panchal 3.1 Introduction 39 3.2 Overview of Compounds in Garcinia Species 40 3.2.1 Garcinia mangostana 44 3.2.1.1 Chemical Properties 51 3.2.1.2 Biological Activities of G. mangostana 51 3.2.1.3 Toxicity 55 3.2.2 Garcinia cambogia 56 3.2.2.1 Chemical Properties 56 3.2.2.2 Biological Activities 57 3.2.2.3 Toxicity 59 3.2.2.4 Future Research 59 3.2.3 Garcinia humilis 59 3.2.3.1 Chemical Properties 59 3.2.3.2 Biological Activities 60 3.2.4 Garcinia dulcis 61 3.2.4.1 Chemical Properties 61 3.2.4.2 Biological Properties 61 3.2.4.3 Potential Research 62 3.3 Limitations 62 3.4 Conclusion 64 References 64 4 Pro?Angiogenic and Anti?Angiogenic Effects of Small Molecules from Natural Products 81Jingyi Ma and Xuelin Zhou 4.1 Biological mechanisms of Angiogenesis 81 4.2 Pharmacological Models for Angiogenesis Study 82 4.3 Pro?Angiogenic Effects of Small Molecules from Natural Products 83 4.3.1 Natural Products as Sources for Screening Pro?Angiogenic Stimulators 83 4.3.2 Flavonoids 84 4.3.3 Saponins 84 4.3.4 Salvianolic Acids 85 4.3.5 Other Small Molecules 85 4.3.5.1 Ferulic Acid 85 4.3.5.2 Aloe vera–Derived Compounds 85 4.3.6 Summary 86 4.4 Anti?Angiogenic Effects of Small Molecules from Natural Products 86 4.4.1 Natural Products as Sources for Screening Angiogenic Inhibitors 87 4.4.2 Flavonoids 87 4.4.3 Diterpenoids 89 4.4.4 Polyphenol 90 4.4.5 Saponins 92 4.4.6 Alkaloids 93 4.4.7 Chalcone 93 4.4.8 Anthraquinone 93 4.4.9 Carotenoids 94 4.4.10 Other Small Molecules 94 4.4.10.1 Cucurbitacin B 94 4.4.10.2 Honokiol 95 4.4.10.3 Shikonin 95 4.4.10.4 Hyperforin 95 4.4.10.5 Glyceollins 95 4.4.10.6 Sulforaphane 99 4.4.11 Summary 99 4.5 Conclusion 99 Acknowledgment 99 Conflict of Interest 99 References 100 5 Nutraceuticals and Natural Product Derivatives in the Premises of Disease Prevention 111Mohammad Fahad Ullah, Showket Hussain Bhat, and Faisel M. Abu?Duhier 5.1 Introduction: How Significant Is the Role of Natural Molecules in Disease Prevention? 111 5.2 Natural Products in Cancer Chemoprevention 113 5.3 Natural Products in the Management of Diabetes 117 5.4 Natural Products as Therapeutic Agents against Gout Disease 122 5.5 Herbal Derivatives in Prevention of Alzheimer’s Disease 124 5.6 Conclusion 127 Acknowledgments 127 References 127 6 Honey? and Propolis?Mediated Regulation of Protein Networks in Cancer Cells 137Ammad Ahmad Farooqi, Mirna Azalea Romero, Aliye Aras,Muhammad Zahid Qureshi, and Lara Hanna Wakim 6.1 Introduction 137 6.2 Honey?Mediated Targeting of Signal Transducer and Activator of Transcription (STAT) Proteins 138 6.3 Reactive Oxygen Species (ROS) Production in Cancer Cells 138 6.4 Apoptosis 139 6.5 Regulation of DNA Damage 139 6.6 Combinatorial Strategies: It Takes Two to Tango 139 6.7 Bioactive Propolis Chemicals as Tumor Necrosis Factor (TNF)?Related Apoptosis?Inducing Ligand (TRAIL) Sensitizers 141 6.8 Bioactive Chemicals of Propolis Target Different Proteins of Cell?Signaling Pathways 142 6.9 Conclusion 142 References 142 7 Antiproliferative Effects and Mechanism of Action of Phytosterols Derived from Bioactive Plant Extracts 145Gabriel Lopez?Garcia, Amparo Alegria, Reyes Barbera, and Antonio Cilla 7.1 Introduction 145 7.2 Mechanisms of the Anticancer Actions of Phytosterols 146 7.3 Anticancer Effects of Phytosterols 147 7.3.1 Plant Extracts Containing Phytosterols 148 7.3.2 Isolated Phytosterols from Plant Extracts 155 7.4 Conclusions 161 Acknowledgments 162 References 162 8 Yerba Mate (Ilex paraguariensis A. St. Hil.): A Promising Adjuvant in the Treatment of Diabetes, Obesity, and Metabolic Syndrome 167Vanesa Gesser Correa, Rubia Carvalho Gomes Correa, Tatiane Francielli Vieira, Adelar Bracht, Rosane Marina Peralta, and Eloa Angelica Koehnlein 8.1 Introduction 167 8.2 Nutritional Composition of Ilex paraguariensis 169 8.3 Composition in Bioactive Compounds 170 8.4 Yerba Mate: Research Trends and Main Findings over 20 Years 171 8.5 Biological Activities of Yerba Mate Related to Diabetes, Obesity,and Metabolic Syndrome 172 8.5.1 In Vitro Studies 172 8.5.2 Animal Studies 174 8.5.3 Clinical Trials 176 8.6 Summarizing Conclusion and Perspectives 177 References 178 9 Role of Natural Antioxidants from Selected Plants Belonging to the Scrophulariaceae and Buddlejaceae Families in the Prevention and Treatment of Neurodegenerative Diseases 183Cigdem Kahraman, Zeliha S. Akdemir, and I. Irem Tatli 9.1 Introduction 183 9.2 Natural Antioxidants from Verbascum Species (Mullein) for Their Therapeutic Activities against Neurodegenerative Diseases 188 9.3 Natural Antioxidants from Scrophularia Species (Figwort) for Their Therapeutic Activities against Neurodegenerative Diseases 200 9.4 Natural Antioxidants from Buddleja Species (Butterfly Bush) for Their Therapeutic Activities against Neurodegenerative Diseases 209 9.5 Secondary Metabolites and Their Therapeutic Activities against Neurodegenerative Diseases 221 9.6 Conclusions 225 Acknowledgments 226 References 226 10 Recent Trends in Drug Discovery against Alzheimer’s Disease: Use of Natural Products and Nutraceuticals from Botanicals 237Sudatta Maity, Samapika Nandy, and Abhijit Dey 10.1 Introduction 237 10.2 Symptoms 237 10.3 Etiopathogenesis 238 10.4 Conventional Therapy 239 10.5 Complementary and Alternative Therapies (CATs) for AD 239 10.6 Research Methodology 240 10.7 Neuroprotective Biomolecules: Possible Roles against AD Pathogenesis 241 10.7.1 1?O?acetyllycorine 241 10.7.2 ??Iso?cubebenol 245 10.7.3 ??Onocerin 245 10.7.4 Acteoside 256 10.7.5 Apigenin 256 10.7.6 ??Asarone 256 10.7.7 Baicalein and Baicalin 256 10.7.8 Bellidin, Bellidifolin, Bellidin 8?O???Glucopyranoside and Bellidifolin 8?O???Glucopyranoside 256 10.7.9 Catalpol 257 10.7.10 Cryptotanshinone 257 10.7.11 Curcuminoids 257 10.7.12 Cynatroside B 258 10.7.13 Galantamine 258 10.7.14 Genistein 258 10.7.15 Huperzine A 258 10.7.16 Icariin 259 10.7.17 Isorhynchophylline 259 10.7.18 Luteolin 259 10.7.19 Melatonin 259 10.7.20 Naringenin 260 10.7.21 Piceatannol 260 10.7.22 p?coumaric acid 260 10.7.23 Piperine 260 10.7.24 Quercetin 261 10.7.25 Salidroside 261 10.7.26 Silibinin 261 10.7.27 Stepharanine, Cyclanoline, and N?Methyl Stepholidine 262 10.7.28 Tripchlorolide (T4) 262 10.7.29 Triptexanthoside C 262 10.7.30 Ursolic Acid 262 10.7.31 Xanthoceraside 262 10.7.32 Xylocoside G 263 10.7.33 Zeatin 263 10.7.34 z?Ligustilide 263 10.8 Conclusion 263 Abbreviations 264 References 266 11 Therapeutic Potential of Metalloherbal Nanoceuticals: Current Status and Future Perspectives 279Shazia Usmani, Muhammad Arif, and Syed Misbah Hasan 11.1 Historical Background of Indian Herbal Medicine 279 11.2 Concept of Herbalism 280 11.3 Positive Correlation between Phytopharmacology and Phytochemistry: Need of the Hour 280 11.4 Validation of Herbal Therapeutics: An Indispensable Boon for Ayurveda 281 11.4.1 Reverse Pharmacology–Based Validation of Herbal Drugs [14] 281 11.4.2 Amplifying Approaches for Validation of Traditional Medicine 282 11.4.3 Scientific Integration of Traditional Herbals in Clinical Practice 282 11.4.3.1 Evidence?Based Benefits of Herbs 282 11.4.4 Bhasmas: The Metal?Based Ayurvedic Medicine 283 11.4.4.1 Preparation of Bhasmas 283 11.4.5 Steps Involved in the Preparation of Bhasmas 284 11.4.5.1 Characterization of Bhasma 285 11.5 Metals Commonly Employed for Preparation of Bhasmas 286 11.5.1 Swarna (Gold) 286 11.5.2 Parada (Mercury) 287 11.5.2.1 Tamra (Copper) 287 11.5.2.2 Lauha (Iron) 288 11.5.2.3 Rajata (Silver) 288 11.5.2.4 Yashada (Zinc) 289 11.5.2.5 Naga (Lead) 289 11.5.2.6 Vanga (Tin) 290 11.6 Toxicity Aspect: An Issue of Concern in the Use of Herbomineral Formulations 290 11.6.1 Conflictive Opposition by Western Medicine Philosophy 291 11.6.2 Conclusive Statements Supported by Varied Research Works 292 11.6.3 Future Prospects in Light of Knowledge within Ayurvedic Texts and Its Application as Nanomedicine 298 References 298 12 Green Tea Polyphenols: A Putative Mechanism for Cytotoxic Action against Cancer Cells 305Mohd Farhan, Uzma Shamim, and S.M. Hadi 12.1 Dietary Constituents and Their Role in Prevention of Cancer 305 12.2 Cancer Chemoprevention by Dietary Polyphenols 306 12.3 Polyphenolic Compounds and Their Chemical Classification 308 12.4 Dietary Sources of Plant?Derived Polyphenolic Compounds 311 12.5 Metabolism of Polyphenolic Compounds in Humans 314 12.6 Polyphenols and Their Therapeutic Potential 316 12.6.1 Anticancer Properties 316 12.6.2 Prospective Anticancer Mechanisms of Plant?Derived Dietary Polyphenols 318 12.6.2.1 Antioxidant Action 319 12.6.2.2 Pro?Oxidant Action 319 Acknowledgments 321 References 321 13 Nature’s Armamentarium against Malaria: Antimalarials and Their Semisynthetic Derivatives 333Fyaz M.D. Ismail 13.1 Introduction 333 13.2 Synthetic Drugs Allow Mass Prophylaxis of Malarial Infections 336 13.3 The Cooperative World War II Wartime Program 338 13.4 The Post?Chloroquine Era: A Return to Finding Drugs from Nature 340 13.5 Compounds from Plant Sources 340 13.5.1 South America 342 13.5.1.1 Quassinoids 342 13.5.1.2 Amazonia Plants 344 13.5.1.3 Plants Deserving Further Investigation 345 13.5.2 Promising Antimalarials Native to Africa 347 13.5.2.1 Burkina Faso 347 13.5.2.2 Congo 347 13.5.2.3 Ethiopia 349 13.5.2.4 Kenya 350 13.5.2.5 Madagascar 351 13.5.3 North America and Europe 351 13.5.3.1 Helanin 352 13.5.4 India and East Asia 353 13.5.4.1 China 354 13.5.4.2 Japan and Korea 359 13.5.5 Australia 359 13.6 The Future 361 13.7 Conclusion 363 References 363 14 Nutraceutical?Based Pharmacological Intervention in the Management of Liver Diseases 375Aaliya Shah and Syed Mudassar 14.1 Liver: A Multifunctional Organ 375 14.2 Biomarkers of Hepatic Injury 377 14.3 Nutraceutical Intervention in the Management of Liver Diseases 377 14.3.1 Vitamins 378 14.3.1.1 Vitamin D 378 14.3.1.2 Vitamin C 379 14.3.1.3 Vitamin E 379 14.3.2 Dietary Polyphenols 380 14.3.2.1 Flavonoids 380 14.3.3 Anthocyanins, Isoflavones, and Flavanones 380 14.3.4 Stilbenes 381 14.3.5 Curcuminoids 381 14.3.6 Silymarin 381 14.3.7 Beverages (Coffee and Tea) 381 14.3.8 Polyunsaturated Fatty Acids (PUFAs) 382 14.3.8.1 Short?Chain, Medium?Chain, and Long?Chain Fatty Acids (SCFAs, MCFAs, and LCFAs) 382 14.3.8.2 Polyunsaturated Fatty Acids 382 14.3.9 Probiotics 383 14.3.10 Fruits 384 14.3.10.1 Grape 384 14.3.10.2 Black Currant 384 14.3.10.3 Plum 384 14.3.10.4 Pomegranate 384 14.3.10.5 Gac Fruit 385 14.3.11 Vegetables 385 14.3.11.1 Celery Seeds 385 14.3.11.2 Spices 385 14.3.11.3 Saffron 385 14.3.11.4 Soy 386 14.3.11.5 Cereals 386 14.4 Conclusion 386 References 386 Index 395ftoc.
About the Editors Mohammad Fahad Ullah, is an Assistant Professor of Biochemistry in the Department of Medical Laboratory Technology (FAMS) and a Research Scientist at Prince Fahd Research Chair, University of Tabuk, Saudi Arabia. Aamir Ahmad, is an Assistant Professor of Oncologic Sciences at University of South Alabama's Mitchell Cancer Institute, Mobile, AL, USA.
Introduces readers to the growing applications of nutraceuticals and other natural product derivatives This comprehensive book presents a prophylactic and therapeutic approach to chronic disease prevention strategy by highlighting the translational potential of plant-derived dietary and non-dietary factors from epidemiological, laboratory, and clinical studies. It also shares the experiences of highly reputed experts working in the area of phytomedicine and nutraceutical agents in chemoprevention, to promote the significance of natural products and dietary factors as an elite priority for containing chronic diseases in the human population. Nutraceuticals and Natural Product Derivatives: Disease Prevention & Drug Discovery starts by examining natural food sources for the control of glycemia and the prevention of diabetic complications. It then looks at the anti-aging effects of sulfur-containing amino acids and nutraceuticals, and the potential of garcinia fruits to combat metabolic syndrome. Other topics covered include honey- and propolis- mediated regulation of protein networks in cancer cells; recent trends in drug discovery against Alzheimer's disease; the therapeutic potential of metalloherbal nanoceuticals; and much more. Offers an alternative, natural approach to the prevention of chronic diseases Emphasizes the potential of plant-derived dietary and non-dietary factors from epidemiological, laboratory, and clinical studies Features contributions from world- renowned experts in the field of phytomedicine and nutraceutical agents in chemoprevention Includes prevention strategies in normal/risk populations through routine inclusion of specific dietary regimens and as therapeutic strategy for better management through adjuvant interventions with conventional treatment protocols Nutraceuticals and Natural Product Derivatives: Disease Prevention & Drug Discovery will appeal to graduate students and professionals in cell and molecular biology, translational research, pharmacology/drug discovery, medicinal chemistry, and clinical nutrition.

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