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<p>Graphical Abstract xi</p> <p>Foreword xiii</p> <p>Preface xvii</p> <p>Acknowledgments xix</p> <p><b>Section I Historical Review of the Development of Natural Polymers 1</b></p> <p>References 3</p> <p><b>Section II Polysaccharides for Biomedical Application 5</b></p> <p><b>1 Sources, Structures, and Properties of Alginate 7</b></p> <p>1.1 Alginate-Based Hydrogel for Biomedical Application 8</p> <p>1.1.1 Drug and Cell Delivery 8</p> <p>1.1.2 Cell and Organoid Culture 13</p> <p>1.1.3 Tissue Regeneration 15</p> <p>1.1.4 Other Applications 18</p> <p>1.2 Alginate-Based Electrospinning for Biomedical Application 21</p> <p>1.2.1 Drug Delivery 21</p> <p>1.2.2 Tissue Regeneration 23</p> <p>1.3 Alginate-Based 3D Printing for Biomedical Application 28</p> <p>1.3.1 Alginate-Based Bio-Ink and Printing Strategies Improvement 28</p> <p>1.3.2 Attempts at Bionic Matrix Ink 29</p> <p>References 31</p> <p><b>2 Sources, Structures, and Properties of Cellulose 39</b></p> <p>2.1 Cellulose-Based Hydrogel for Biomedical Application 39</p> <p>2.1.1 Drug Delivery 39</p> <p>2.1.2 Cell and Organoid Culture 44</p> <p>2.1.3 Tissue Regeneration 45</p> <p>2.2 Cellulose-Based Electrospinning for Biomedical Application 49</p> <p>2.2.1 Drug Delivery 49</p> <p>2.2.2 Antibacterial 51</p> <p>2.2.3 Tissue Regeneration 52</p> <p>2.3 Cellulose-Based 3D Printing for Biomedical Application 55</p> <p>2.3.1 Improvement of Bio-Ink 55</p> <p>2.3.2 Bacteria and Cell Culture 57</p> <p>References 59</p> <p><b>3 Sources, Structures, and Properties of Hyaluronic Acid 65</b></p> <p>3.1 Hyaluronic-Acid-Based Hydrogel for Biomedical Application 66</p> <p>3.1.1 Cell and Organoids Culture 66</p> <p>3.1.2 Cell Behaviors Regulation 67</p> <p>3.1.3 Drug Delivery 70</p> <p>3.1.4 Tissue Regeneration 71</p> <p>3.2 Hyaluronic-Acid-Based Electrospinning for Biomedical Application 74</p> <p>3.2.1 Drug Delivery and Antibacterial 74</p> <p>3.2.2 Tissue Regeneration 75</p> <p>3.3 Hyaluronic-Acid-Based 3D Printing for Biomedical Application 77</p> <p>3.3.1 Cell and Organoid Culture 77</p> <p>3.3.2 Tissue Regeneration 78</p> <p>References 81</p> <p><b>4 Sources, Structures, and Properties of Chitosan 85</b></p> <p>4.1 Chitosan-Based Hydrogel for Biomedical Application 85</p> <p>4.1.1 Cell and Organoid Culture 85</p> <p>4.1.2 Tissue Regeneration 86</p> <p>4.2 Chitosan-Based Electrospinning for Biomedical Application 91</p> <p>4.2.1 Drug and Cell Delivery 91</p> <p>4.2.2 Tissue Regeneration 92</p> <p>4.3 Chitosan-Based 3D Printing for Biomedical Application 95</p> <p>4.3.1 Cell Behavior Regulation 95</p> <p>4.3.2 Drug Delivery 95</p> <p>4.3.3 Tissue Regeneration 95</p> <p>References 98</p> <p><b>5 Sources, Structures, and Properties of Other Polysaccharides 101</b></p> <p>5.1 Other Polysaccharides-Based Hydrogel for Biomedical Application 102</p> <p>5.1.1 Drug Delivery 102</p> <p>5.1.2 Cell and Organoid Culture 103</p> <p>5.1.3 Tissue Regeneration 104</p> <p>5.2 Other Polysaccharides-Based Electrospinning for Biomedical Application 107</p> <p>5.2.1 Drug Delivery 107</p> <p>5.2.2 Tissue Regeneration 107</p> <p>5.3 Other Polysaccharides 3D Printing for Biomedical Application 109</p> <p>5.3.1 Drug Delivery 109</p> <p>5.3.2 Tissue Regeneration 109</p> <p>References 110</p> <p><b>6 Summary 113</b></p> <p><b>Section III Polypeptides for Biomedical Application 115</b></p> <p><b>7 Sources, Structures, and Properties of Collagen 117</b></p> <p>7.1 Collagen-Based Hydrogel for Biomedical Application 117</p> <p>7.1.1 Drug Delivery 117</p> <p>7.1.2 Cell and Organoid Culture 119</p> <p>7.1.3 Cell Behavior Regulation 119</p> <p>7.1.4 Tissue Regeneration 120</p> <p>7.2 Collagen-Based Electrospinning for Biomedical Application 121</p> <p>7.2.1 Cell and Organoid Culture 121</p> <p>7.2.2 Tissue Regeneration 122</p> <p>7.3 Collagen-Based 3D Printing for Biomedical Application 122</p> <p>7.3.1 Tissue Regeneration 122</p> <p>References 124</p> <p><b>8 Sources, Structures, and Properties of Gelatin 127</b></p> <p>8.1 Gelatin-Based Hydrogel for Biomedical Application 127</p> <p>8.1.1 Cell Culture and Behavior Regulation 127</p> <p>8.1.2 Drug Delivery 129</p> <p>8.1.3 Tissue Regeneration 129</p> <p>8.2 Gelatin-Based Electrospinning for Biomedical Application 129</p> <p>8.2.1 Cell Culture 129</p> <p>8.2.2 Tissue Regeneration 130</p> <p>8.3 Gelatin-Based 3D Printing for Biomedical Application 131</p> <p>8.3.1 Tissue Regeneration 131</p> <p>References 132</p> <p><b>9 Sources, Structures, and Properties of Silk Fibroin 135</b></p> <p>9.1 Silk-Fibroin-Based Hydrogel for Biomedical Application 135</p> <p>9.1.1 Drug Delivery and Cell Culture 135</p> <p>9.1.2 Tissue Regeneration 136</p> <p>9.2 Silk-Fibroin-Based Electrospinning for Biomedical Application 137</p> <p>9.2.1 Drug Delivery and Antibacterial 137</p> <p>9.2.2 Tissue Regeneration 138</p> <p>9.3 Silk-Fibroin-Based 3D Printing for Biomedical Application 138</p> <p>9.3.1 Tissue Regeneration 138</p> <p>References 139</p> <p><b>10 Sources, Structures, and Properties of Other Polypeptides 143</b></p> <p>10.1 Other Polypeptides-Based Hydrogel for Biomedical Application 143</p> <p>10.1.1 Cell Culture and Delivery 143</p> <p>10.1.2 Tissue Engineering and Drug Delivery 144</p> <p>10.2 Other Polypeptides-Based Electrospinning for Biomedical Application 144</p> <p>10.2.1 Drug Delivery 144</p> <p>10.2.2 Tissue Regeneration 145</p> <p>10.3 Other Polypeptides-Based 3D Printing for Biomedical Application 146</p> <p>10.3.1 Cell and Organoid Culture 146</p> <p>10.3.2 Tissue Regeneration 147</p> <p>References 149</p> <p><b>11 Summary 153</b></p> <p><b>Section IV other Kinds of Natural Polymers for Biomedical Application 155</b></p> <p><b>12 Sources, Structures, and Properties of Catechins 157</b></p> <p>12.1 Catechins-Based Hydrogel for Biomedical Application 157</p> <p>12.2 Catechins-Based Electrospinning for Biomedical Application 158</p> <p>12.3 Catechins–Metal Complexes for Biomedical Application 158</p> <p>References 159</p> <p><b>13 Sources, Structures, and Properties of Quercetin 161</b></p> <p>13.1 Quercetin-Based Hydrogel for Biomedical Application 161</p> <p>13.2 Quercetin-Based Electrospinning for Biomedical Application 162</p> <p>13.3 Quercetin–Metal Complexes for Biomedical Application 162</p> <p>References 163</p> <p><b>14 Sources, Structures, and Properties of Resveratrol 167</b></p> <p>14.1 Resveratrol-Based Hydrogel for Biomedical Application 167</p> <p>14.2 Resveratrol-Based Electrospinning for Biomedical Application 168</p> <p>14.3 Resveratrol–Metal Complexes for Biomedical Application 169</p> <p>References 170</p> <p><b>15 Sources, Structures, and Properties of Curcumin 173</b></p> <p>15.1 Curcumin-Based Hydrogel for Biomedical Application 173</p> <p>15.2 Curcumin-Based Electrospinning for Biomedical Application 175</p> <p>15.3 Curcumin–Metal Complexes for Biomedical Application 176</p> <p>References 177</p> <p><b>16 Summary 181</b></p> <p>References 181</p> <p><b>17 Conclusion and Outlook 183</b></p> <p>References 184</p> <p>Declaration of Competing Interest 187</p> <p>Nomenclature 189</p> <p>Index 191</p>

<p><b>Wenguo Cui, PhD,</b> is a Professor at the Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, as well as group leader of Regenerative Biomaterials. He has worked extensively on the development of novel biomaterials and nanomaterials for tissue regeneration, drug delivery, and disease treatment, and his awards and honors include the Fundamental Bone Research Scholar award from the Chinese Medical Association and the Huaxia Medicine Award, among many others.</p> <p><b>Lei Xiang</b> is a doctoral candidate in medicine at the Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. His research concerns novel biomaterials and nanomaterials for tissue regeneration, as well as treatment for sports medicine diseases.</p>

<p><b>Develop natural solutions to biomedical problems with this introduction</b> <p>A natural polymer is one that forms from biosynthetic or biochemical processes typically found in nature, with corresponding advantages in biocompatibility and biodegradability. These advantages give natural polymers a range of applications, from the use of polysaccharides as structural components to the use of polyphenols as antioxidant active ingredients. In biomedical engineering they are clearly preferable to synthetic polymers in numerous cases, and their applications are more numerous every day. <p><i>Natural Polymers for Biomedical Applications</i> offers a comprehensive summary of these polymers and their biomedical applications. It covers the sources, structures, and properties of polysaccharides, polyphenols, and polypeptides, as well as analyzing the latest advances in polymer-based biomedical technologies. The result has ramifications in a vast range of industries and research areas. <p>In <i>Natural Polymers for Biomedical Applications </i>readers will also find: <ul><li>Applications including drug and cell delivery, cell and organoid cultures, tissue regeneration, and more</li><li>Detailed analysis of alginate, cellulose, quercetin, silk fibroin, and many others</li><li>A logical, easy-to-use structure to facilitate rapid access to pertinent information</li></ul> <p><i>Natural Polymers for Biomedical Applications </i>is ideal for materials scientists, polymer chemists, biochemists, and any researcher or professional in biomedical or pharmaceutical industries.

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