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<p>Preface xv</p> <p><b>1 State of the Art in Nanomedicine 1</b><br /><i>Yujun Song and Wei Hou</i></p> <p>1.1 Intractable Diseases and Development of the Related Novel Therapy and Medicines 1</p> <p>1.2 Key Features of Nanomedicines 4</p> <p>1.3 Nanotechnology Translational Nanomedicine: Emergence and Progress 6</p> <p>1.4 Interdisciplinary Features of Nanomedicines: Multi-mode and Multi-function Features Promoting Nanomedicine-mediated Immunotherapy and/or Physical Field Ablation Therapy for Subversive Therapy 12</p> <p>1.5 Future Development of Nanomedicines by Coupling Advanced Biomedicines (Including Biochemistry and Biophysics), Modern Physicochemical Technologies, and Artificial Intelligence Technology 27</p> <p><b>2 Fundamentals in Nanomedicine 49</b><br /><i>Xiangrong Song, Mengran Guo, Zhongshan He, Xing Duan, and Wen Xiao</i></p> <p>2.1 Design Theory of Nanomedicines 49</p> <p>2.2 Progress in the Controlled Synthesis of Nanomaterials 55</p> <p>2.3 Progress in the Surface Modification and Functionalization of Nanomaterials for Nanomedicines 60</p> <p><b>3 Nanomedicine for Antitumors 73</b><br /><i>Qiong Wu, Xinzhu Yang, Ruixue Zhu, and Yujun Song</i></p> <p>3.1 Introduction 73</p> <p>3.2 Liposomal Nanoparticles 75</p> <p>3.3 Polymeric Nanoparticles 78</p> <p>3.4 Inorganic Nanoparticles 82</p> <p>3.5 Mixture (Hybrid) Nanoparticles 90</p> <p>3.6 Cell Membrane Coating Nanotechnology 93</p> <p>3.7 Challenges and Current Limitations 94</p> <p>3.8 Conclusions 96</p> <p><b>4 Nanomedicine for the Treatment of Nervous System Diseases 113</b><br /><i>Xiaojian Cui and Yujun Song</i></p> <p>4.1 Concepts and Types of Nanomedicines for Nervous System Diseases 113</p> <p>4.2 Therapeutical Methods for Nervous System Diseases and Features of Current Nanomedicines 114</p> <p>4.3 Synthesis Methods and Typical Examples (Including Clinical Trial) of Polymer-based Nanomedicines for Nervous System Diseases 116</p> <p>4.4 Inorganic-based Nanomedicines: Synthesis Methods and Typical Application (Including Clinical) 117</p> <p>4.5 Metallic-based Nanomedicines: Synthesis Methods and Typical Application (Including Clinical) 122</p> <p>4.6 Multifunctional Nanomedicines for Nervous System Diseases 125</p> <p><b>5 Nanomaterial Translational Nanomedicine for Anti-HIV and Anti-bacterial 131</b><br /><i>Hao Luo and Yujun Song</i></p> <p>5.1 Concepts, Anti-HIV Theory, and Types and Features of Current Nanomedicines 132</p> <p>5.2 Polymer-based Nanomedicines: Synthesis Methods and Typical Application 142</p> <p>5.3 Inorganic-based Nanomedicines: Synthesis Methods and Typical Application 146</p> <p>5.4 Metallic-based Nanomedicines: Synthesis Methods and Typical Application 148</p> <p>5.5 Multi-functional (Target) Nanomedicines 150</p> <p>5.6 Future Development 152</p> <p><b>6 Nanomedicine for Next-generation Dermal Management 157</b><br /><i>Haibin Wu, Qian Chen, and Shen Hu</i></p> <p>6.1 Introduction 157</p> <p>6.2 Nano-biomaterials-based Therapeutics forWound Healing 159</p> <p>6.3 Nano-biomaterials for Imaging and Monitoring of Cutaneous Wounds 176</p> <p>6.4 Conclusion and Future Outlook 181</p> <p><b>7 Nanomedicine for Targeting Delivery of Gene and Other DNA/RNA Therapies Based Viruses Engineering 197</b><br /><i>Xiangrong Song, Mengran Guo, Zhongshan He, Xing Duan, and Wen Xiao</i></p> <p>7.1 Targeting Delivery of Gene Therapies to the Tumors 198</p> <p>7.2 Targeting Delivery of Gene-based Nanovaccines to the Spleen 199</p> <p>7.3 Targeting Delivery of Gene-based Nanovaccines to the LNs 200</p> <p>7.4 Targeting Delivery of Gene-based Nanomedicines to the Liver 200</p> <p>7.5 Targeting Delivery of Gene-based Nanomedicines to the Lung 200</p> <p>7.6 Targeting Delivery of Gene-based Nanomedicines to the Brain 202</p> <p><b>8 Nanomedicine for Bio-imaging and Disease Diagnosis 207</b><br /><i>Ziqi Wang and Yujun Song</i></p> <p>8.1 Concepts, Types, and Features of Current Nanoprobes 207</p> <p>8.2 Synthesis Methods 214</p> <p>8.3 Typical Application Examples in the Disease Diagnosis and Study of Biological Events 219</p> <p>8.4 Future Development 224</p> <p><b>9 Magnetic Nanoparticles and Their Applications 227</b><br /><i>Xiuyu Wang and Yuting Tang</i></p> <p>9.1 Introduction 227</p> <p>9.2 Classification of Magnetic Nanoparticles 228</p> <p>9.3 Biomedical Applications 236</p> <p>9.4 Conclusion and Outlook 242</p> <p><b>10 Nanomedicine-mediated Immunotherapy 245</b><br /><i>Wei Hou and Yujun Song</i></p> <p>10.1 Immune System and Immune Response 245</p> <p>10.2 Mechanism of Tumor Immunotherapy 247</p> <p>10.3 Mechanism of Nanomedicine-enhancing Immunotherapy 248</p> <p>10.4 Immunological Applications of Nanomedicines 252</p> <p>10.5 Summary and Outlook 263</p> <p><b>11 Nanomedicine-mediated Ultrasound Therapy 269</b><br /><i>Qingwei Liao, Yaoyao Liao, and Wei Si</i></p> <p>11.1 Concept, Therapy Theory, and Devices 269</p> <p>11.2 Nanomedicine Synthesis with Ultrasound Field Response 274</p> <p>11.3 Application Examples 275</p> <p><b>12 Nanomedicine-mediated Photodynamic and/or Photothermal Therapy 279</b><br /><i>Shangqing Jing and Yujun Song</i></p> <p>12.1 Photodynamic and Photothermal Mechanism for Anti-cancer 281</p> <p>12.2 Nanomaterial-based PSs (Nano-PSs) for PDT 283</p> <p>12.3 Photodynamic and Photothermal Synergistic Therapy 291</p> <p>12.4 Opportunities and Challenges 292</p> <p>12.5 Summary 293</p> <p><b>13 Nanomedicine-mediated Pulsed Electric Field Ablation Therapy 299</b><br /><i>Xinzhu Yang, Qiong Wu, Ruixue Zhu, and Yujun Song</i></p> <p>13.1 Introduction 299</p> <p>13.2 Concept, Therapy Theory, and Devices 302</p> <p>13.3 Synthesis of Nanomedicine with Electric Field Response 312</p> <p>13.4 Application Examples 322</p> <p>13.5 Conclusion 323</p> <p><b>14 Nanomedicine-mediated Magneto-dynamic and/or Magneto-thermal Therapy 329</b><br /><i>Yangfei Wang and Yujun Song</i></p> <p>14.1 Concepts, Treatment Theories, and Methods 329</p> <p>14.2 Treatment Theories and Methods 330</p> <p>14.3 Magnetic Field-responsive Nanomedicine Synthesis 333</p> <p>14.4 Applications 337</p> <p><b>15 Nanomedicine-mediated Radiotherapy for Cancer Treatment 341</b><br /><i>Ruixue Zhu and Yujun Song</i></p> <p>15.1 Concept, Therapy Theory, and Devices 341</p> <p>15.2 Nanomaterials as Radiosensitizers for Radiation Therapy 347</p> <p>15.3 Nanomaterials Delivering Radioisotope for Internal Radioisotope Therapy 358</p> <p>15.4 Nanomedicine Synthesis with Radio/Nuclear Radiation Response 362</p> <p>15.5 Conclusion and Prospects 364</p> <p><b>16 Nanomedicine Conjugating with AI Technology and Genomics for Precise and Personalized Therapy 371</b><br /><i>Lin Liu, Siyu Chen, and Sen Zhang</i></p> <p>16.1 Concept 371</p> <p>16.2 Genomics of Nanomedicine 374</p> <p>16.3 Artificial Intelligence Technology in Nanomedicine Development 377</p> <p>16.4 Artificial Intelligence Facilitates Precise and Personalized Nanomedicine Based on Genomics 379</p> <p><b>17 Microfluidic Conjugating AI Platform for High-throughput Nanomedicine Screening 385</b><br /><i>Xing Huang, Wenya Liao, Zhongbin Xu, and Yujun Song</i></p> <p>17.1 Introduction 385</p> <p>17.2 Microfluidic Technologies for Medicine Development 386</p> <p>17.3 Microfluidic Preparation of Nanomedicines 391</p> <p>17.4 Microfluidic High-throughput Drug Screening 396</p> <p>17.5 AI-assisted Microfluidic Development of Nanomedicine 400</p> <p>17.6 Conclusions and Perspectives 402</p> <p>References 404</p> <p>Index 413</p>

<p><b>Yujun Song, PhD,</b> is Professor at the School of Mathematics and Physics, University of Science and Technology Beijing, China. He has conducted and published extensive research in bio-nanotechnology and biomedical engineering.</p>

<p><b>A comprehensive and multidisciplinary guide to nanomaterials-based medicine</b> <p>Nanomedicine is the study and application of nanomaterials-based medical techniques. In recent years it has very rapidly become indispensable in a huge range of medical contexts, from analysis of extreme life events to diagnosis and treatment of life-threatening intractable diseases, such as cancers and cardiovascular diseases. It has already transformed both research and clinical outcomes in many areas of medicine and promises to continue as the cutting-edge research and clinical area for the next generation of medical specialists. <p><i>Nanomedicine: Fundamentals, Synthesis, and Applications</i> constitutes a comprehensive guide to this subfield and its recent advances. Beginning with a brief history of the field and introduction to its core principles, it thoroughly treats recent developments in this vital and ever-growing field. Its multidisciplinary approach equips the reader with a systematic overview of these life-saving developments in medicine. <p><i>Nanomedicine</i> readers will also find: <ul><li>Edited by a leading researcher with decades of experience in both North America and China</li><li>Detailed treatment of subjects including nanocarriers, nanomaterial bioprobes, multi-function nanodrugs, nanomedicine-mediated immunotherapy and/or physical ablation, and more</li><li>A comprehensive volume treats every facet of the subject</li></ul> <p><i>Nanomedicine</i> is a vital resource for biochemists, biomedical engineers, pharmaceutical chemists, physicists, and professionals in the biotechnological industries, as well as for clinicians looking to familiarize themselves with nanomedical techniques and instrumentation.

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