N-Heterocyclic Carbenes in Organocatalysis
Summarizing the emerging field of N-heterocyclic carbenes used in organocatalysis, this is an excellent overview of the synthesis and applications of NHCs focusing on carbon-carbon and carbon-heteroatom bond formation. Alongside comprehensive coverage of the synthesis, characteristics and applications, this handbook and ready reference also includes chapters on NHCs for polymerization reactions and natural product synthesis.
Introduction to NHCs, synthesis, electronic and steric properties The various modes of action of NHCs in organocatalysis NHC-catalyzed umpolung of aldehydes: The benzoin reaction Acyl anion addition to Michael acceptors: The Stetter reaction NHC-catalyzed generation of homoenolates and related chemistry NHC-catalyzed cascade processes for carbocycles and heterocycles synthesis Oxidative NHC-catalysis Acyl anion free NHC-organocatalysis Dual-activation in NHC-catalysis alpha,beta-unsaturated acylazolium generation using NHCs and addition of bisnucleophiles Non-umpolung transformations in NHC-catalysis NHC-catalyzed reactions involving saturated acylazoliums NHC-catalyzed transformations of acid derivatives Umpolung of Michael acceptors, alkyl halides and imines Polymerization reactions catalyzed by NHCs (Dynamic) Kinetic resolution and Desymmetrization reactions using NHC-catalysis Application of NHCs in Natural products and biologically active compounds synthesis
A. T. Biju received his M. Sc. from Sacred Heart College Thevara (affiliated to MG University, Kerala, India) and Ph.D. under the guidance of Dr. Vijay Nair at the CSIR-NIIST (Formerly RRL), Trivandrum, India. Subsequently, he has been a post-doctoral fellow with Prof. Tien-YauLuh at the National Taiwan University, Taipei and an Alexander von Humboldt fellow with Prof. Frank Glorius at the Westfälische Wilhelms-Universität Münster, Germany. In June 2011, he began his independent research career at the CSIR-National Chemical Laboratory, Pune. From June 2017 onwards, he has been an Associate Professor at the Department of Organic Chemistry, Indian Institute of Science, Bangalore. His research focuses on the development of transition-metal-free carbon-carbon and carbon-heteroatom bond-forming reactions using aryne chemistry and N-heterocyclic carbene (NHC) organocatalysis, and their application in organic synthesis. He is the recipient of AVRA Young Scientist Award (2016), CRSI Young Scientist Award (2015), NCL-Research Foundation Scientist of the Year Award (2014), ISCB Young Scientist Award (2014), Thieme Chemistry Journals Award (2014), OPPI Young Scientist Award (2012), Alexander von Humboldt Fellowship (2009), and is a member of the National Academy of Sciences, India (NASI), Allahabad (2012).
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