Details

Molecular and Biochemical Toxicology

5. Aufl.

von: Robert C. Smart, Ernest Hodgson
140,99 €
Verlag:	Wiley
Format:	EPUB
Veröffentl.:	06.11.2017
ISBN/EAN:	9781119042433
Sprache:	englisch
Anzahl Seiten:	1040

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Beschreibungen

Titelbeschreibung

Written as an advanced text for toxicology students, this book is much more than an introduction and provides in-depth information describing the underlying mechanisms through which toxicants produce their adverse responses. • Links traditional toxicology to modern molecular techniques, important for teaching to graduate courses and professional studies • Uses a didactic approach with basic biological or theoretical background for the methodology presented • Brings together and comprehensively covers a range of dynamic aspects in biochemical and molecular toxicology • Guides student and professional toxicologists in comprehending a broad range of issues, compiled and authored by a diverse group of experts • “A good introductory textbook covering the biochemical toxicology of organic substances and the relevant methodology in some detail.... It offers good value for money and can be recommended as a textbook for appropriate courses” – BTS Newsletter review of the 4th edition

Inhaltsverzeichnis

Preface xxix List of Contributors xxxi Section 1 Introduction 1 1 Molecular and Biochemical Toxicology: Definition and Scope 3 Ernest Hodgson and Robert C. Smart Section 2 Techniques in Biochemical and Molecular Toxicology 11 2 Molecular Techniques for the Study of Gene Function 13 Yoshiaki Tsuji and Robert C. Smart 3 Transcriptomics 55 B. Alex Merrick 4 Proteomics 91 Michael S. Bereman 5 Metabolomics 115 Susan C. J. Sumner, Wimal Pathmasiri, James E. Carlson, Susan L. McRitchie, and Timothy R. Fennell 6 Cellular Techniques 135 Sharon A. Meyer and Barbara A. Wetmore 7 Basic Concepts of Molecular Epidemiological Research Methods 159 Cathrine Hoyo, David A. Skaar, and Randy L. Jirtle Section 3 Mechanisms in Molecular and Biochemical Toxicology 187 8 Phase I and Phase II Metabolism and Metabolic Interactions: A Summary 189 Ernest Hodgson 9 Structure, Mechanism, and Regulation of Cytochromes P 450 209 John M. Seubert, Matthew L. Edin, and Darryl C. Zeldin 10 Polymorphisms in Phase I and Phase II Genes and Outcomes 239 Yoshiaki Tsuji, Edward L. Croom, and Ernest Hodgson 11 Cellular Transport and Elimination 273 David S. Miller and Ronald E. Cannon 12 Nuclear Receptors 293 Seth W. Kullman, William S. Baldwin, and Gerald A. LeBlanc 13 Mechanisms of Cell Death 327 Mac Law and Susan Elmore 14 Mitochondrial Dysfunction 371 Jun Ninomiya‐Tsuji 15 Reactive Metabolites, Reactive Oxygen Species (ROS), and Toxicity 391 Elizabeth L. MacKenzie and Yoshiaki Tsuji 16 DNA Damage and Mutagenesis 421 Zhigang Wang 17 DNA Repair 485 Isabel Mellon 18 Carcinogenesis 535 Robert C. Smart and Jonathan R. Hall Section 4 Molecular and Biochemical Aspects of Organ Toxicology 589 19 Molecular Mechanisms of Respiratory Toxicity 591 James C. Bonner 20 Molecular Mechanisms of Hepatotoxicity 629 Supriya R. Kulkarni, Andrew D. Wallace, Sharon A. Meyer, and Angela L. Slitt 21 Molecular Mechanisms of Renal Toxicology 665 Lawrence H. Lash 22 Molecular Mechanisms of Neurotoxicity 709 Kimberly P. Keil, Marianna Stamou, and Pamela J. Lein 23 Molecular Mechanisms of Immunotoxicity 773 Tai L. Guo, Joella Xu, Yingjia Chen, Daniel E. Lefever, Guannan Huang, and David A. Lawrence 24 Molecular Mechanisms of Reproductive Toxicity 823 Ayelet Ziv‐Gal, Catheryne Chiang, and Jodi Anne Flaws 25 Molecular Mechanisms of Developmental Toxicity 851 Antonio Planchart Section 5 Emerging Areas in Molecular and Biochemical Toxicology 877 26 Computational and Molecular Approaches to Risk Assessment 879 Richard S. Judson, John Wambaugh, Kristin Isaacs, and Russell S. Thomas 27 Nanotoxicology 909 James C. Bonner 28 Developmental Origins of Health and Disease 933 Michael Cowley 29 Exposome 945 Stephen M. Rappaport Index 969

Autorenportrait

ROBERT C. SMART, PhD, is a William Neal Reynolds Professor of Toxicology, the Director of the Center for Human Health and the Environment, and the former Director of the Toxicology Graduate Program at North Carolina State University. Together with Dr. Hodgson, he coedited the two previous editions of this book. ERNEST HODGSON, PhD, is Distinguished Professor Emeritus of Environmental and Molecular Toxicology and Executive Director of the Foundation for Agromedicine and Toxicology at North Carolina State University. Alongside the previous editions of this book, he edited four editions of A Textbook of Modern Toxicology (Wiley) and is the Editor of the Journal of Biochemical and Molecular Toxicology.

Back cover copy

An essential resource for students, academic, and industrial toxicologists and environmental health scientists Throughout its past editions, this text has been an important source for defining the biochemical, cellular, and molecular events that toxicants induce at the cellular and organismic levels and linking molecular and cellular biology as well as genomic sciences to mechanistic toxicology. Molecular and Biochemical Toxicology provides in-depth information describing the underlying mechanisms through which toxicants produce their adverse responses. Toxicological mechanisms are discussed and described in detail from the biomolecule, pathway, cell, tissue, organ, model organism, human to the individual human population. As the field of toxicology has evolved and advanced so has Molecular and Biochemical Toxicology. Changes in this new edition stress advances in our understanding in how toxicants produce their adverse outcomes as well as the use of cutting-edge technology/methodology in contemporary toxicology. The organization of the 5th edition is divided into sections which include: Techniques in Biochemical and Molecular Toxicology, Mechanisms in Molecular and Biochemical Toxicology, Molecular and Biochemical Aspects of Organ Toxicology; as well as a new section on Emerging Areas in Molecular and Biochemical Toxicology. The fifth edition has been substantially updated and includes 12 new chapters, like those on: nuclear receptors, nanotoxicology, computational and molecular approaches to risk assessment, developmental origins of health and disease, exposome, and basic concepts of molecular epidemiological research methods. Chapters on "Omics" technologies provide an understanding of these technologies/approaches and how they can be used to understand the complex mechanisms of toxicity. Whether used in the classroom or in industry, research, or academia; Molecular and Biochemical Toxicology remains essential for anyone interested in understanding the molecular mechanisms through which toxicant produce adverse effects.