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ARYLATION REACTIONS: A HISTORICAL PERSPECTIVE<br> Structure and Bonding of Benzene<br> Syntheses of Substituted (Hetero)Arenes, and the Contents of this Book<br> METAL-CATALYZED COUPLING REACTIONS WITH ARYL CHLORIDES, TOSYLATES AND FLUORIDES<br> Introduction<br> Coupling Reactions of Aryl Chlorides<br> Coupling Reactions Aryl Fluorides<br> Coupling Reactions of Aryl Tosylates<br> PALLADIUM-CATALYZED ARYLATIONS OF AMINES AND ALPHA-C-H ACIDIC COMPOUNDS<br> Introduction<br> Palladium-Catalyzed Arylations of Amines<br> Palladium-Catalyzed Arylations of Alpha-C-H Acidic Compounds<br> COPPER-CATALYZED ARYLATIONS OF AMINES AND ALCOHOLS WITH BORON-BASED ARYLATING REAGENTS<br> Introduction<br> Discovery and Development of a New O-H Bond Arylation Reaction: From Stoichiometric to Catalytic in Copper<br> Mechanistic Considerations<br> Miscellaneous Applications<br> Development of a New N-H Bond Arylation Reaction<br> Development of a New N-H Bond Arylation Reaction: Catalytic in Copper<br> METAL-CATALYZED ARYLATIONS OF NONACTIVATED ALKYL (PSEUDO)HALIDES VIA CROSS-COUPLING REACTIONS<br> Introduction<br> Palladium-Catalyzed Arylations of Alkyl (Pseudo)Halides<br> Nickel-Catalyzed Arylations of Alkyl (Pseudo)Halides<br> Iron-Catalyzed Arylations of Alkyl (Pseudo)Halides<br> Copper- and Cobalt-Catalyzed Arylations of Alkyl (Pseudo)Halides<br> ARYLATION REACTIONS OF ALKYNES: THE SONOGASHIRA REACTION<br> Introduction<br> Palladium-Catalyzed Reactions: Ligands and Reaction Protocols<br> Alternative Metal Catalysts<br> Mechanism of the Sonogashira Reaction<br> PALLADIUM-CATALYZED ARYLATION REACTIONS OF ALKENES (MIZOROKI-HECK REACTION AND RELATED PROCESSES)<br> Introduction<br> Mizoroki-Heck Arylations<br> Reductive Mizoroki-Heck-Type Arylations<br> Oxidative Mizoroki-Heck-Type Arylations<br> MODERN ARYLATIONS OF CARBONYL COMPOUNDS<br> Introduction<br> Enantioselective Arylation of Aldehydes<br> Enantioselective Arylation of Ketones<br> Enantioselective Arylation of Imines<br> Conjugate Asymmetric Arylation<br> Tandem Processes<br> Enantioselective Friedel-Crafts Arylation<br> METAL-CATALYZED DIRECT ARYLATIONS (EXCLUDING PALLADIUM)<br> Introduction<br> Rhodium-Catalyzed Direct Arylations<br> Ruthenium-Catalyzed Direct Arylations<br> Iridium-, Copper- and Iron-Catalyzed Direct Arylations<br> PALLADIUM-CATALYZED DIRECT ARYLATION REACTIONS<br> Introduction<br> Intermolecular Arylation of Functionalized Arenes<br> Intramolecular Reaction of Haloaryl-Linked Arenes<br> Intermolecular Arylation Reactions of Heteroaromatic Compounds<br> MECHANISTIC ASPECTS OF TRANSITION METAL-CATALYZED DIRECT ARYLATION REACTIONS<br> Introduction<br> Palladium-Catalyzed Intramolecular Direct Arylation<br> Intermolecular Metal-Catalyzed Direct Arylation of Arenes<br> Metal-Catalyzed Heteroaryl-Aryl and Heteroaryl-Heteroaryl Bond Formation<br> Direct Arylation via Metallacycles<br> Cross-Dehydrogenative Couplings<br> ARYLATION REACTIONS INVOLVING THE FORMATION OF ARYNES<br> Introduction<br> Generation of Arynes<br> Electrophilic Coupling of Arynes<br> Pericyclic Reactions of Arynes<br> Transition Metal-Catalyzed Reactions Arynes<br> RADICAL-BASED ARYLATION METHODS<br> Introduction<br> SRN1-Type Radical Arylations<br> Homolytic Aromatic Substitutions<br> Arylations Using Aryl Radicals<br> PHOTOCHEMICAL ARYLATION REACTIONS<br> Introduction<br> Photochemical Formation of Aryl-C Bonds<br> Photochemical Formation of Aryl-N Bonds<br> <br> <br>

Lutz Ackermann was educated at the Christian-Albrechts-University Kiel, Germany, and obtained his Ph.D. in 2001 under the supervision of Alois Furstner, Max-Plank-Institut fur Kohlenforschung in Mulheim/Ruhr. He was a DAAD postdoctoral fellow in the laboratories of Robert G. Berman at the University of California at Berkeley, USA, and initiated his independent career - supported by the Emmy Noether-program (DFG) - in 2003 at the Ludwig-Maximilians-University in Munich. In 2007, he became a full professor at the Georg-August-University Gottingen. The unifying theme of his research program is represented by the development of novel concepts for efficient catalytic processes. Lutz Ackermann was visiting professor at the Universita degli Studi di Milano, Italy, as well as the University of Wisconsin at Madison, USA, and his recent awards include an ORCHEM-prize, an ADUC-prize, and a Dozentenstipendium (FCI).

Today, arylation methods belong to the most important reaction types in organic synthesis. The editor has gathered a number of top international authors to present the first comprehensive book on the topic.<br> Starting from a historical review, the book covers various hot topics, such as palladium- or copper-catalyzed arylations of amines, alcohols and alpha-C-H-acidic compounds, catalytic direct Arylation reactions, as well as arylations of alkenes and alkynes, among others.<br> This compact source of high quality information is indispensable to synthetic chemists in academia, as well as those working in the pharmaceutical and chemical industry. <br>

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