<br> Introduction: Antibody Structure and Function (Pons, J., Rajpal, A., Strop, P., Yeung, Y.A., Chaparro-Riggers, J.)<br> <br> PART I: METHODS OF PRODUCTION FOR Fc-FUSION PROTEINS<br> Fc-Fusion Protein Expression Technology (Berry, J., Yang, C., Fisher, J., Mendoza, E., Young, S., Stupack, D.)<br> Cell Culture Based Production (Ryll, Th., Huang, Y.-M., Kshirsagar, R., Woppmann, B.)<br> Downstream Processing of Fc-Fusion Proteins (Shukla, A.A., Gottschalk, U.)<br> Formulation, Drug Product, and Delivery: Considerations for Fc-Fusion Proteins (Yeh, P.Y., Cao, W., Piedmonte, D.M., Ricci, M.S.)<br> Quality by Design Applied to a Fc-fusion Protein: A Case Study (Broly, H., Eon-Duval, A., Gleixner, R.;<br> Valax, P., Soos, M., Neunstoecklin, B., Morbidelli, M.)<br> Analytical Methods Used to Characterize Fc-fusion Proteins (Mulkerrin, M., Idusogie, E.)<br> <br> PART II: CASE STUDIES OF THERAPEUTIC Fc-FUSION PROTEINS<br> Introduction to Therapeutic Fc-fusion Proteins (Berry, J.D.)<br> Alefacept (Farson, D.A., Grossman, J.)<br> Etanercept (Grossman, J., Chamow, S.M.)<br> Abatacept and Belatacept (Peach, R.J.)<br> Aflibercept (Chamow, S.M., Linderholm, A.L.)<br> Recombinant Factor VIII- and Factor IX-Fc-Fusions (Peters, R.)<br> <br>