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PART I: GENE AND PROTEIN STRUCTURE <br /> 1 Gene Structure <br /> 2 Developmental Expression <br /> 3 Gene Regulation <br /> 4 Protein Structure and Functional Domains <br /> 5 Enzymatic Properties <br /> 6 Epitope Maps <br /> PART II: IN VIVO FUNCTIONS <br /> 7 The In Vivo Role of TNAP <br /> 8 Knockout Mouse Models <br /> PART III: AP EXPRESSION IN HEALTH AND DISEASE <br /> 9 APs as Physiological and Disease Markers <br /> 10 Neoplastic Expression of PLAP, GCAP, IAP (Regan, Nagao, Kasahara) and TNAP Isozymes <br /> PART IV: USES OF APS IN INDUSTRY AND BIOTECHNOLOGY <br /> 11 Applications of Recombinant APs <br /> 12 Use of APs in Prodrug Converting Strategies <br /> 13 APs as Therapeutic Agents <br /> 14 APs in the Food Industry <br /> 15 Veterinary Uses of AP Determinations <br /> 16 Methodologies <br /> <br />

José Luis Millán received his early training in Clinical Chemistry at the University of Buenos Aires, Argentina and received pre-doctoral training at the La Jolla Cancer Research Foundation (the predecessor of the Burnham Institute) from 1977-1980. He completed his Ph.D. studies at the University of Umeå, Sweden in 1983. After a period of postdoctoral training at the La Jolla Cancer Research Foundation he was appointed to the staff in 1986. He was promoted to Associate Professor in 1989 and to Professor in 1994 at that Institution. He also held the Chair of Medical Genetics at the Department of Medical Biosciences, School of Medicine, Umeå University, Umeå, Sweden from 1995 to 2000. Dr. Millán is currently Professor at The Burnham Institute and he maintains adjunct affiliations with Umeå University and the Royal Academy of Medicine and Surgery, Murcia, Spain. Professor Millán has dedicated most of his scientific carrier to the understanding of the structure and biological functions of alkaline phosphatases during development and the significance of their re-expression in malignancy. This book highlights and discusses the major advances made in this field in the last 25 years.

A review and discussion of new knowledge on the structure and function of mammalian alkaline phosphatases (APs) gained over the last 25 years. It covers:<br /> <br /> * The structure, regulation and expression of the AP genes<br /> * The three-dimensional structure of APs and mutagenesis work that further defined the structural/functional domains of the isozymes<br /> * The phenotypic abnormalities of the different AP knockout mice<br /> * Our current understanding of the in vivo role of the AP isozymes.<br /> <br /> The book also describes the possible use of APs as therapeutic agents and therapeutic targets and the many uses of these enzymes in clinical medicine and in biotechnology.<br />

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