Preface: A Mobile Society -<br /> The Constitutive Role of Cell Trafficking in the Organization of the Immune System (A. Hamann, B. Engelhardt)<br /> MOLECULAR MECHANISMS<br /> The Multistep Model of Leukocyte Trafficking: a Personal Perspective from 15 Years later (E. C. Butcher)<br /> Capture and Rolling: Selectins and their Ligands (C. S. Bonder, P. Kubes)<br /> Chemokines and their Receptors: Biochemical, Structural and Biological Properties (M. Oppermann and R. Förster)<br /> Mechanisms of Leukocyte Integrin Activation (G. Constantin, C. Laudanna)<br /> Mechanisms of Leukocyte Transmigration: Role of Immunoglobulin Superfamily Molecules (F. M. Marelli-Berg, S. Nourshargh)<br /> The Endothelial Cell Basement Membrane and its Role in Leukocyte Extravasation (L. M. Sorokin)<br /> TRAFFICKING IN VIVO<br /> Control of Homing Receptor Expression during Lymphocyte Differentiation, Activation and Function (D. J. Campbell)<br /> Trafficking of Lymphocyte Subpopulations (A. Hamann, C. N. Arnold, G. F. Debes)<br /> Trafficking of B Cells (R. A. Manz)<br /> Trafficking of Dendritic Cells (N. Romani, S. Holzmann, C. H. Tripp, M. Sixt, P. Stoitzner)<br /> INFLAMMATION<br /> Molecular and Cellular Contributions to Selectin-dependent Leukocyte Adhesion under Flow (R. P. McEver)<br /> Mechanisms of Inflammation: Neutrophils (M. Sperandio, B. Walzog)<br /> Chemokines drive the Inflammatory Leukocyte Recruitment (S. Floess, A. Rot)<br /> Mechanism of Inflammation: Activation of the Endothelium (M. Clauss, C. E. Patterson)<br /> TRAFFICKING MECHANISMS AS THERAPEUTIC TARGETS<br /> Integrins as Therapeutic Targets for Inflammatory Disease (M. Briskin)<br /> Chemokine Receptor Antagonists: From the Bench to the Clinic (S. Ribeiro, R. Horuk)<br /> METHODS TO STUDY CELL TRAFFICKING<br /> Leukocyte/Endothelial Cell-Cell Interactions in vitro: Static Assays and Adhesion under Shear Stress (M. Hammel, O. Zilles, R. Hallmann, and S. Jennrich, K. Siemund, A. Hamann)<br /> Chemotaxis Assay: Analysis of Lymphocyte Subsets (K. Siegmund, G. F. Debes, A. Hamann)<br /> In vitro Transendothelial Migration Assay (R. Lyck, B. Engelhardt)<br /> Real Time in vitro Assays for Studying Leukocyte Transendothelial Migration under Physiological Flow Conditions (R. Alon, G. Cinamon, F. W. Luscinskas)<br /> Intravital Microscopy and in vitro Flow Chamber: Techniques to Study Leukocyte Adhesion under Flow and in Real Time (J. V. Stein)<br /> Immune Processes in the Light of Two-photon Microscopy (A. Flügel, N. Kawakami)<br /> Use of labeled Lymphocytes to Analyze Trafficking in vivo (K. Siegmund, A. Hamann)