<p>Contributors ix</p> <p>Preface xiii</p> <p>Important Notice xv</p> <p>Abbreviations xvii</p> <p><b>Section I General Principles of Antimicrobial Therapy 1</b></p> <p>1 Antimicrobial Drug Action and Interaction: An Introduction 3<br /><i>Steeve Giguère</i></p> <p>2 Antimicrobial Susceptibility Testing Methods and Interpretation of Results 11<br /><i>Joseph E. Rubin</i></p> <p>3 Antimicrobial Resistance and its Epidemiology 21<br /><i>Patrick Boerlin and David G. White</i></p> <p>4 Principles of Antimicrobial Drug Bioavailability and Disposition 41</p> <p><i>J. Desmond Baggot and Steeve Giguère</i></p> <p>5 The Pharmacodynamics of Antimicrobial Agents 79<br /><i>Marilyn N. Martinez, Pierre-Louis Toutain, and John Turnidge</i></p> <p>6 Principles of Antimicrobial Drug Selection and Use 105<br /><i>Steeve Giguère</i></p> <p>7 Antimicrobial Stewardship in Animals 117<br /><i>J. Scott Weese, Stephen W. Page, and John F. Prescott</i></p> <p><b>Section II Classes of Antimicrobial Agents 133</b></p> <p>8 Beta-lactam Antibiotics: Penam Penicillins 135<br /><i>John F. Prescott</i></p> <p>9 Beta-lactam Antibiotics: Cephalosporins 153<br /><i>John F. Prescott</i></p> <p>10 Other Beta-lactam Antibiotics: Beta-lactamase Inhibitors, Carbapenems, and Monobactams 175<br /><i>John F. Prescott</i></p> <p>11 Peptide Antibiotics: Polymyxins, Glycopeptides, Bacitracin, and Fosfomycin 189<br /><i>Patricia M. Dowling</i></p> <p>12 Lincosamides, Pleuromutilins, and Streptogramins 199<br /><i>Steeve Giguère</i></p> <p>13 Macrolides, Azalides, and Ketolides 211<br /><i>Steeve Giguère</i></p> <p>14 Aminoglycosides and Aminocyclitols 233<br /><i>Patricia M. Dowling</i></p> <p>15 Tetracyclines 257<br /><i>Jérôme R.E. del Castillo</i></p> <p>16 Chloramphenicol, Thiamphenicol, and Florfenicol 269<br /><i>Patricia M. Dowling</i></p> <p>17 Sulfonamides, Diaminopyrimidines, and Their Combinations 279<br /><i>John F. Prescott</i></p> <p>18 Fluoroquinolones 295<br /><i>Steeve Giguère and Patricia M. Dowling</i></p> <p>19 Miscellaneous Antimicrobials: Ionophores, Nitrofurans, Nitroimidazoles, Rifamycins, and Others 315<br /><i>Patricia M. Dowling</i></p> <p>20 Antifungal Chemotherapy 333<br /><i>Steeve Giguère</i></p> <p><b>Section III Special Considerations_357</b></p> <p>21 Prophylactic Use of Antimicrobial Agents, and Antimicrobial Chemotherapy for the Neutropenic Patient 359<br /><i>Steeve Giguère, Anthony C.G. Abrams-Ogg, and Stephen A. Kruth</i></p> <p>22 Performance Uses of Antimicrobial Agents and Non-antimicrobial Alternatives 379<br /><i>Thomas R. Shryock and Stephen W. Page</i></p> <p>23 Antimicrobial Therapy of Selected Organ Systems 395<br /><i>Patricia M. Dowling</i></p> <p>24 Antimicrobial Therapy of Selected Bacterial Infections 421<br /><i>Steeve Giguère</i></p> <p>25 Antimicrobial Drug Residues in Foods of Animal Origin 431<br /><i>Patricia M. Dowling</i></p> <p>26 Regulation of Antimicrobial Use in Animals 443<br /><i>Karolina Törneke and Christopher Boland</i></p> <p><b>Section IV A ntimicrobial Drug Use in Selected Animal Species 455</b><br /><br />27 Antimicrobial Drug Use in Horses 457<br /><i>Steeve Giguère and Tiago Afonso</i></p> <p>28 Antimicrobial Drug Use in Dogs and Cats 473<br /><i>Jane E. Sykes</i></p> <p>29 Antimicrobial Drug Use in Cattle 495<br /><i>Michael D. Apley and Johann F. Coetzee</i></p> <p>30 Antimicrobial Drug Use in Mastitis 519<br /><i>Sarah Wagner and Ron Erskine</i></p> <p>31 Antimicrobial Drug Use in Sheep and Goats 529<br /><i>Chris R. Clark</i></p> <p>32 Antimicrobial Drug Use in New World Camelids 541<br /><i>Christopher K. Cebra and Margaret L. Cebra</i></p> <p>33 Antimicrobial Drug Use in Swine 553<br /><i>David G.S. Burch</i></p> <p>34 Antimicrobial Drug Use in Poultry 569<br /><i>Charles L. Hofacre, Jenny A. Fricke, and Tom Inglis</i></p> <p>35 Antimicrobial Drug Use in Companion Birds 589<br /><i>Keven Flammer</i></p> <p>36 Antimicrobial Drug Use in Rabbits, Rodents, and Ferrets 601<br /><i>Colette L. Wheler</i></p> <p>37 Antimicrobial Drug Use in Reptiles 623<br /><i>Ramiro Isaza and Elliott R. Jacobson</i></p> <p>38 Antimicrobial Drug Use in Zoological Animals 637<br /><i>Ellen Wiedner and Robert P. Hunter</i></p> <p>39 Antimicrobial Drug Use in Aquaculture 645<br /><i>Renate Reimschuessel, Ron A. Miller, and Charles M. Gieseker</i></p> <p>Index 663</p>