<p>Foreword xv</p> <p>Preface xvii</p> <p><b>1 Introduction 1</b><br /><i>Yu-Feng Li and Hongzhe Sun</i></p> <p>1.1 A Brief Introduction to Metallomics 1</p> <p>1.2 Key Issues and Challenges in Metallomics 3</p> <p>1.3 About the Structure of this Book 4</p> <p><b>2 Nanometallomics 11</b><br /><i>Hongxin Xie, Liming Wang, Jiating Zhao, Yuxi Gao, Bai Li, and Yu-Feng Li</i></p> <p>2.1 The Concept of Nanometallomics 11</p> <p>2.2 The Analytical Techniques in Nanometallomics 12</p> <p>2.3 The Application of Nanometallomics in Nanotoxicology 17</p> <p>2.4 Conclusions and Perspectives 21</p> <p><b>3 Environmetallomics 33</b><br /><i>Lihong Liu, Ligang Hu, Baowei Chen, Bin He, and Guibin Jiang</i></p> <p>3.1 The Concept of Environmetallomics 33</p> <p>3.2 The Analytical Techniques in Environmetallomics 34</p> <p>3.3 The Application of Environmetallomics in Environmental Science and Ecotoxicological Science and the Perspectives 43</p> <p><b>4 Agrometallomics 49</b><br /><i>Xuefei Mao, Xue Li, Tengpeng Liu, and Yajie Lei</i></p> <p>4.1 The Concept of Agrometallomics 49</p> <p>4.2 Analytical Techniques in Agrometallomics 52</p> <p>4.3 Application and Perspectives of Agrometallomics in Agricultural Science and Food Science 127</p> <p><b>5 Metrometallomics 153</b><br /><i>Liuxing Feng</i></p> <p>5.1 The Concept of Metrometallomics 153</p> <p>5.2 The Analytical Techniques in Metrometallomics 154</p> <p>5.3 The Application of Metrometallomics in Life Science and the Perspectives 159</p> <p><b>6 Medimetallomics and Clinimetallomics 193</b><br /><i>Guohuan Yin, Ang Li, Meiduo Zhao, Jing Xu, Jing Ma, Bo Zhou, Huiling Li, and Qun Xu</i></p> <p>6.1 The Concept of Medimetallomics and Clinimetallomics 193</p> <p>6.2 The Analytical Techniques in Medimetallomics and Clinimetallomics 195</p> <p>6.3 The Application of Medimetallomics and Clinimetallomics in Medical and Clinical Science and the Perspectives 204</p> <p><b>7 Matermetallomics 237</b><br /><i>Qing Li, Zhao-Qing Cai, Wen-Xin Cui, and Zheng Wang</i></p> <p>7.1 The Concept of Matermetallomics 237</p> <p>7.2 The Analytical Techniques in Matermetallomics 243</p> <p>7.3 The Application of Matermetallomics in Material Science and the Perspectives 256</p> <p><b>8 Archaeometallomics 265</b><br /><i>Li Li, Yue Zhou, Sijia Li, Lingtong Yan, Heyang Sun, and Xiangqian Feng</i></p> <p>8.1 The Concept of Archaeometallomics 265</p> <p>8.2 The Analytical Techniques in Archaeometallomics 266</p> <p>8.3 The Application of Archaeometallomics in Archaeological Science 269</p> <p>8.4 Summary and Perspectives 279</p> <p><b>9 Metallomics in Toxicology 285</b><br /><i>Ruixia Wang, Ming Gao, Jiahao Chen, Mengying Qi, and Ming Xu</i></p> <p>9.1 Metallomic Research on the Toxicology of Metals 285</p> <p>9.2 Recent Progresses in Understanding the Health Effects of Heavy Metals 287</p> <p>9.3 Knowledge Gaps, Challenges, and Perspectives 297</p> <p><b>10 Pathometallomics: Taking Neurodegenerative Disease as an Example 311</b><br /><i>Xiubo Du, Xuexia Li, and Qiong Liu</i></p> <p>10.1 Introduction to Pathometallomics 311</p> <p>10.2 Application of Pathometallomics in Neurodegenerative Diseases 314</p> <p>10.3 The Perspectives of Pathometallomics 338</p> <p><b>11 Oncometallomics: Metallomics in Cancer Studies 349</b><br /><i>Xin Wang, Chao Li, and Yu-Feng Li</i></p> <p>11.1 Introduction to Oncometallomics 349</p> <p>11.2 The Application of Oncometallomics in Cancer Studies 351</p> <p>11.3 The Metallome that Involved in the Occurrence and Development of Cancer 355</p> <p>11.4 Conclusions and Perspectives 356</p> <p><b>12 Bio-elementomics 363</b><br /><i>Dongfang Wang, Jing Wu, Bing Cao, Lailai Yan, Qianqian Zhao, Tiebing Liu, and Jingyu Wang</i></p> <p>12.1 Introduction 363</p> <p>12.2 Basic Laws of Bio-elementomics 364</p> <p>12.3 Rare-Earth Elementome 367</p> <p>12.4 Limitations of Bio-elementomics 371</p> <p>12.5 Perspectives 373</p> <p><b>13 Methodology and Tools for Metallomics 377</b><br /><i>Xiaowen Yan, Ming Xu, and Qiuquan Wang</i></p> <p>13.1 Brief Description of Metallomics 377</p> <p>13.2 Methodologic Strategy for Metallomic Research 380</p> <p>13.3 Tools for Metallomics 383</p> <p>13.4 Concluding Remarks 387</p> <p><b>14 ICP-MS for Single-Cell Analysis in Metallomics 391</b><br /><i>Man He, Beibei Chen, and Bin Hu</i></p> <p>14.1 Introduction 391</p> <p>14.2 ICP-MS Instrumental Optimization for Single-Cell Analysis 392</p> <p>14.3 Microfluidic Platform for Single-Cells Analysis 401</p> <p>14.4 ICP-MS-Based Single-Cells Analysis in Metallomics 408</p> <p>14.5 Summary and Perspectives 419</p> <p><b>15 Novel ICP-MS-based Techniques for Metallomics 429</b><br /><i>Panpan Chang and Meng Wang</i></p> <p>15.1 Introduction 429</p> <p>15.2 ICP-MS: A Powerful Method in Metallomics 430</p> <p>15.3 Recent Advances in ICP-MS-based Metallomics 433</p> <p>15.4 Conclusions 442</p> <p><b>16 Machine Learning for Data Mining in Metallomics 449</b><br /><i>Wei Wang and Xin Wang</i></p> <p>16.1 Data Mining Methods in Metallomics 450</p> <p>16.2 Application of Machine Learning for Data Mining in Metallomics 463</p> <p>References 469</p> <p>Index 471</p>