<p>List of Contributors vii</p> <p>Introduction XIII<b><br /> </b><i>Abdulla Watad, Nicola Luigi Bragazzi, and Yehuda Sheonfeld</i></p> <p>1 Hyperstimulation of the Immune System 1<br /> <i>Hadas Hodadov and Abdulla Watad</i></p> <p>2 Autoimmune/Inflammatory Syndrome Induced by Adjuvants (ASIA): Genetics, Immunization, and Autoimmunity 7<br /> <i>Carlo Perricone, Elena Bartoloni Bocci, and Roberto Gerli</i></p> <p>3 Vaccine Adjuvants: History, Role, Mechanisms of Action, and Side Effects 15<br /> <i>Nicola Luigi Bragazzi, Abdulla Watad, and Yehuda Shoenfeld</i></p> <p>4 Commonly Used Food Additives Are Nutritional Adjuvants in ASIA Syndrome 29<br /> <i>Aaron Lerner and Carina Benzvi</i></p> <p>5 Silicone Implant Incompatibility Syndrome 51<br /> <i>Vânia Borba and Yehuda Shoenfeld</i></p> <p>7 Autoimmune/Inflammatory Syndrome Induced by Adjuvants (ASIA or Shoenfeld’s Syndrome) Due to Polypropylene Mesh Implants 67<br /> <i>Jan Willem Cohen Tervaert and Mohammed Osman</i></p> <p>8 Vaccines, Vaccinosis, and Autoimmunity 85<br /> <i>Nicola Luigi Bragazzi, Abdulla Watad, and Yehuda Shoenfeld</i></p> <p>9 Sustained Immune Activation in ASIA Syndrome – A Bridge to Lymphomagenesis 91<br /> <i>Dana Butnaru</i></p> <p>10 Chronic Fatigue Syndrome 107<br /> <i>Kassem Sharif</i></p> <p>11 Autoantibodies and Autonomic Nervous System 117<br /> <i>Iana Leineman, Varvara Ryabkova, and Natalia Gavrilova</i></p> <p>12 Postural Orthostatic Tachycardia Syndrome (POTS) as a Part of ASIA Syndrome 129<br /> <i>Paula David</i></p> <p>6 Silicone Breast Implants (SBIs) and Autoimmune Dysautonomya 63<br /> <i>Gilad Halpert, Abdulla Watad, Howard Amital, and Yehuda Shoenfeld</i></p> <p>13 Role of the Small-fiber Neuropathy in the Pathogenesis of ASIA Syndrome 137<br /> <i>N. Gavrilova, E. Kamaeva, M. Lukashenko, and L. Soprun</i></p> <p>14 Tattoo as a Possible Trigger for Autoimmune Syndrome Induced by Adjuvants 147<br /> <i>Paula David</i></p> <p>15 The Sick Building Syndrome as a Part of the Autoimmune (Autoinflammatory) Syndrome Induced by Adjuvant 155<br /> <i>Asher Pardo and Eitan Israeli</i></p> <p>22 Sjögren’s Syndrome as a Proof of Concept of the Hyperstimulation Syndrome 265<br /> <i>Vânia Borba and Yehuda Shoenfeld</i></p> <p>23 Gluteal Biopolymer Injections as a Case of ASIA Syndrome 283<br /> <i>Rojas-Villarraga Adriana, María Alejandra Martínez-Ceballos, Uribe Rosa, and Montealegre Giovanni</i></p> <p>16 Gulf War Syndrome (GWS) and ASIA Syndrome 167<br /> <i>Efrosiniia Talalai</i></p> <p>17 Vaccinations in Patients with Autoimmune Diseases 181<br /> <i>Isa Seida and Naim Mahroum</i></p> <p>18 Autoimmune Phenomena in Cancer Patients Treated with Immune Checkpoint Inhibitors 191<br /> <i>Milena Tocut, Michael Ehrenfeld, and Gisele Zandman-Goddard</i></p> <p>19 Heavy Metals in Autoimmune Diseases: Too Much Noise in Autoimmunity 201<br /> <i>Kassem Sharif and Howard Amital</i></p> <p>20 The Role of Bisphenol A in ASIA Syndrome 225<br /> <i>Zora Lazurova</i></p> <p>21 Sarcoidosis and Autoimmune Inflammatory Syndrome Induced by Adjuvants: Is There a Connection? 247<br /> <i>Anna Malkova, Yulia Zinchenko, Anna Starshinova, Igor Kudryavtsev, Piotr Yablonskiy, and Yehuda Shoenfeld</i></p> <p>24 The Chemical and Social Landscape of the Modern World and Increased Risk of ASIA 305<br /> <i>Albert Pinhasov, Elena Shmerkin, and Michael Kirby</i></p> <p>25 Oil Injections and ASIA Syndrome 323<br /> <i>Olga Vera-Lastra, Alberto Ordinola-Navarro, Abihai Lucas Hernández, Gabriela Medina, María P. Cruz-Domínguez, Gabriel M. Ramírez, and Luis J. Jara</i></p> <p>26 Metals in Dental Implants as a Trigger of Autoimmunity 337<br /> <i>Arad Dotan and Yehuda Shoenfeld</i></p> <p>27 Conclusions: State of the Art and Prospects 341<br /> <i>Abdulla Watad, Nicola Luigi Bragazzi, and Yehuda Shoenfeld</i></p> <p>Index 345</p>