<p>Preface xi</p> <p><b>1 Deciphering Plasmonic Modality to Address Challenges in Disease Diagnostics </b><b>1<br /></b><i>Esma Derin, Özgecan Erdem, and Fatih Inci</i></p> <p>1.1 Introduction 1</p> <p>1.2 Surface Plasmon Polaritons 2</p> <p>1.2.1 Excitation of the SPP 3</p> <p>1.3 Surface Plasmon Resonance (SPR) 4</p> <p>1.4 Localized Surface Plasmon Resonance (LPSR) 5</p> <p>1.5 Raman Spectroscopy and SERS 7</p> <p>1.6 Whispering Gallery Mode (WGM) 8</p> <p>1.7 Fiber Cables Sensors 9</p> <p>1.8 New Trends in Plasmonic Sensors for the Applications in Disease Diagnosis 11</p> <p>1.8.1 Mobile Phone-Integrated Platforms 11</p> <p>1.8.2 Smart Material Integration 12</p> <p>1.8.3 Naked-Eye Detection 16</p> <p>1.9 Outcomes and Conclusion 18</p> <p>References 19</p> <p><b>2 Nanosensors Based on Localized Surface Plasmon Resonance </b><b>23<br /></b><i>Deniz Umut Yildirim, Amir Ghobadi, and Ekmel Ozbay</i></p> <p>2.1 Historical and Theoretical Background 23</p> <p>2.2 Fabrication of Metal Nanostructures 29</p> <p>2.3 Improving Detection Limit of LSPR Sensors 31</p> <p>2.4 Integration of LSPR with Other Molecular Identification Techniques 34</p> <p>2.4.1 Metal-Enhanced Fluorescence 34</p> <p>2.4.2 Surface-Enhanced Raman Spectroscopy 37</p> <p>2.4.3 Matrix-Assisted Laser Desorption Ionization Mass Spectroscopy 39</p> <p>2.5 Practical Issues 39</p> <p>2.6 Conclusions and Future Prospects 43</p> <p>References 44</p> <p><b>3 Highly Sensitive and Selective Plasmonic Sensing Platforms </b><b>55<br /></b><i>Yeşeren Saylan and Adil Denizli</i></p> <p>3.1 Introduction 55</p> <p>3.2 What Is Highly Sensitive (Ultrasensitive)? 56</p> <p>3.3 Plasmonic Sensing Platforms 56</p> <p>3.4 Recent Applications 57</p> <p>3.4.1 Medical Applications 57</p> <p>3.4.2 Environmental Applications 61</p> <p>3.5 Conclusion Remarks 67</p> <p>References 67</p> <p><b>4 Plasmonic Sensors for Detection of Chemical and Biological Warfare Agents </b><b>71<br /></b><i>Semra Akgönüllü, Yeşeren Saylan, Nilay Bereli, Deniz Türkmen, Handan Yavuz, and Adil Denizli</i></p> <p>4.1 Introduction 71</p> <p>4.2 Sensors 72</p> <p>4.2.1 Plasmonic-based Sensors 72</p> <p>4.3 Biological Warfare Agents 72</p> <p>4.3.1 Detection of Biological Warfare Agents 73</p> <p>4.4 Chemical Warfare Agents 79</p> <p>4.4.1 Detection of Chemical Warfare Agents 79</p> <p>4.5 Conclusion and Future Perspective 81</p> <p>References 82</p> <p><b>5 A Plasmonic Sensing Platform Based on Molecularly Imprinted Polymers for Medical Applications </b><b>87<br /></b><i>Neslihan Idil, Monireh Bakhshpour, Sevgi Aslıyüce, Adil Denizli, and Bo Mattiasson</i></p> <p>5.1 Introduction 87</p> <p>5.2 Molecular Imprinting Technology 88</p> <p>5.3 Plasmonic Sensing 89</p> <p>5.4 Medical Applications 91</p> <p>5.4.1 Drug Detection Via MIP-based SPR Sensor 91</p> <p>5.4.2 Hormone Detection Via MIP-based SPR Sensor 94</p> <p>5.4.3 Microorganism and Virus Detection Via MIP-based SPR Sensor 95</p> <p>5.4.4 Antibody Detection Via MIP-based SPR Sensor 96</p> <p>5.4.5 Nucleic Acid Detection Via MIP-based SPR Sensor 97</p> <p>5.4.6 Biomarker Detection Via MIP-based SPR Sensor 97</p> <p>5.5 Conclusion 97</p> <p>References 100</p> <p><b>6 Magnetoplasmonic Nanosensors </b><b>103<br /></b><i>Recep Üzek, Esma Sari, and Arben Merkoçi</i></p> <p>6.1 Introduction 103</p> <p>6.2 Synthesis 104</p> <p>6.2.1 Core–Shell or Core–Satellite 105</p> <p>6.2.2 Heterodimers 107</p> <p>6.2.3 Multicomponent Doped Hybrids 108</p> <p>6.3 Biosensing Applications 109</p> <p>6.3.1 Protein 109</p> <p>6.3.2 Pathogens 111</p> <p>6.3.3 DNA 112</p> <p>6.4 Conclusion 113</p> <p>Acknowledgments 114</p> <p>References 114</p> <p><b>7 Plasmonic Sensors for Vitamin Detection </b><b>121<br /></b><i>Duygu Çimen and Nilay Bereli</i></p> <p>7.1 Introduction 121</p> <p>7.1.1 Vitamins 121</p> <p>7.2 Plasmonic Sensors 122</p> <p>7.2.1 Surface Plasmon Resonance Sensors 123</p> <p>7.2.2 Localized Surface Plasmon Resonance Sensors 124</p> <p>7.2.3 Colorimetric Sensors 125</p> <p>7.3 Vitamin Applications of Plasmonic Sensors 125</p> <p>7.4 Conclusions and Prospects 133</p> <p>References 133</p> <p><b>8 Proteomic Applications of Plasmonic Sensors </b><b>137<br /></b><i>Duygu Çimen, Merve Asena Özbek, Nilay Bereli, and Adil Denizli</i></p> <p>8.1 Introduction 137</p> <p>8.2 Plasmonic Sensors 139</p> <p>8.2.1 Surface Plasmon Resonance Sensors 140</p> <p>8.2.2 Localized Surface Plasmon Resonance 140</p> <p>8.2.3 Colorimetric Sensors 142</p> <p>8.3 Proteome Applications with Plasmonic Sensors 142</p> <p>8.3.1 Food Applications 142</p> <p>8.3.2 Biomedical Applications 145</p> <p>8.3.3 Agricultural Applications 151</p> <p>8.3.4 Oncology Applications 152</p> <p>8.4 Conclusions and Prospects 154</p> <p>References 154</p> <p><b>9 Cancer Cell Recognition via Sensors System </b><b>157<br /></b><i>Monireh Bakhshpour, Melek Özsevgiç, Ayşe Kevser Pişkin, and Adil Denizli</i></p> <p>9.1 Introduction 157</p> <p>9.2 Sensors Systems in Cancer Cell Detection 158</p> <p>9.3 Cancer Cells 158</p> <p>9.3.1 Prostate Cancer 159</p> <p>9.3.2 Liver Cancer 160</p> <p>9.3.3 Breast Cancer 160</p> <p>9.3.4 Lung Cancer 164</p> <p>9.3.5 Ovarian Cancer 164</p> <p>9.3.6 Other Cells 165</p> <p>9.4 Conclusion 168</p> <p>References 168</p> <p><b>10 Ultrasensitive Sensors Based on Plasmonic Nanoparticles </b><b>171<br /></b><i>Ilgım Göktürk, Fatma Denizli, Erdoğan Özgür, and Fatma Yılmaz</i></p> <p>10.1 Introduction 171</p> <p>10.2 SPR and LSPR 173</p> <p>10.3 SERS 176</p> <p>10.4 Colorimetric Sensing 178</p> <p>10.5 Luminescence Applications 179</p> <p>10.6 Conclusion 180</p> <p>References 181</p> <p><b>11 Surface-Enhanced Raman Scattering Sensors for Chemical/Biological Sensing </b><b>189<br /></b><i>Huma Shaikh, Zaib un Nisa Mughal, Saeed Memon, and Shahabuddin Memon</i></p> <p>11.1 Introduction 189</p> <p>11.2 Direct Method 192</p> <p>11.3 Indirect Method 193</p> <p>11.4 SERS-based Chemical Sensors (Chemosensors) 193</p> <p>11.5 Absolute Intensity-based Method 195</p> <p>11.6 Wavenumber Shift-based Method 195</p> <p>11.7 Ratiometric Method 196</p> <p>11.8 SERS-based Biological Sensors (Biosensors) 197</p> <p>11.9 Conclusion 202</p> <p>References 202</p> <p><b>12 Carbon Nanomaterials as Plasmonic Sensors in Biotechnological and Biomedical Applications </b><b>209<br /></b><i>Tahira Qureshi, Kemal Ҫetin, and Adil Denizli</i></p> <p>12.1 Introduction 209</p> <p>12.1.1 Graphene 210</p> <p>12.1.2 Carbon Nanotubes 210</p> <p>12.2 Biomedical and Biotechnological Applications of Carbon Nanomaterials as Plasmonic Sensors 211</p> <p>12.2.1 Graphene-based Plasmonic Sensors 211</p> <p>12.2.2 Carbon Nanotube-based Plasmonic Sensors 214</p> <p>12.3 Final Statement and Further Outlook 215</p> <p>References 217</p> <p><b>13 Surface Plasmon Resonance Sensors Based on Molecularly Imprinted Polymers </b><b>221<br /></b><i>Cem Esen and Sergey A. Piletsky</i></p> <p>13.1 Introduction 221</p> <p>13.1.1 Surface Plasmon Resonance 221</p> <p>13.1.2 Molecularly Imprinted Polymers 222</p> <p>13.2 MIP Based SPR Sensors 222</p> <p>13.2.1 MIP Film Based SPR Sensors 223</p> <p>13.2.2 Molecularly Imprinted Polymer Nanoparticles Based SPR Sensors 225</p> <p>13.3 Conclusions and Future Prospects 229</p> <p>References 230</p> <p>Index 237</p>