<p>Contributors ix</p> <p>Preface xv</p> <p>About the Editors xvii</p> <p><b>I. Cellular microbiology in the study of tissue and organ infections</b></p> <p>1. Interaction between Intracellular Bacterial Pathogens and Host Cell Mitochondria 3<br /><i>Anna Spier, Fabrizia Stavru, and Pascale Cossart</i></p> <p>2 Shigella Pathogenesis: New Insights through Advanced Methodologies 15<br /><i>Pamela Schnupf and Philippe J. Sansonetti</i></p> <p>3. The Interplay between Salmonella enterica Serovar Typhimurium and the Intestinal Mucosa during Oral Infection 41<br /><i>Annika Hausmann and Wolf-Dietrich Hardt</i></p> <p>4. New Age Strategies To Reconstruct Mucosal Tissue Colonization and Growth in Cell Culture Systems 59<br /><i>Alyssa C. Fasciano, Joan Mecsas, and Ralph R. Isberg</i></p> <p>5. The Many Faces of Bacterium-Endothelium Interactions during Systemic Infections 69<br /><i>Dorian Obino and Guillaume Duménil</i></p> <p>6. Reaching the End of the Line: Urinary Tract Infections 83<br /><i>Kevin O. Tamadonfar, Natalie S. Omattage, Caitlin N. Spaulding, and Scott J. Hultgren</i></p> <p>7. The Intracellular Life Cycle of Brucella spp. 101<br /><i>Jean Celli</i></p> <p>8. Infect and Inject: How <i>Mycobacterium</i> tuberculosis Exploits Its Major Virulence-Associated Type VII Secretion System, ESX-1 113<br /><i>Sangeeta Tiwari, Rosalyn Casey, Celia W. Goulding, Suzie Hingley-Wilson, and William R. Jacobs, JR.</i></p> <p>9. <i>Mycobacterium tuberculosis</i>: Bacterial Fitness within the Host Macrophage 127<br /><i>Lu Huang, Evgeniya V. Nazarova, and David G. Russell</i></p> <p>10. The <i>Wolbachia</i> Endosymbionts 139<br /><i>Frédéric Landmann</i></p> <p>11. Make It a Sweet Home: Responses of <i>Chlamydia trachomatis</i> to the Challenges of an Intravacuolar Lifestyle 155<br /><i>Sébastien Triboulet and Agathe Subtil</i></p> <p>12. <i>Salmonella</i> Single-Cell Metabolism and Stress Responses in Complex Host Tissues 167<br /><i>Dirk Bumann</i></p> <p>13. Manipulation of Host Cell Organelles by Intracellular Pathogens 179<br /><i>Titilayo O. Omotade and Craig R. Roy</i></p> <p><b>II. Subcellular microbiology</b></p> <p>14. The Role of the Type III Secretion System in the Intracellular Lifestyle of Enteric Pathogens 199<br /><i>Marcela de Souza Santos and Kim Orth</i></p> <p>15. Customizing Host Chromatin: A Bacterial Tale 215<br /><i>Michael Connor, Laurence Arbibe, and Mélanie Hamon</i></p> <p>16. Cell Biology of Intracellular Adaptation of <i>Mycobacterium leprae</i> in the Peripheral Nervous System 227<br /><i>Samuel Hess and Anura Rambukkana</i></p> <p>17. Multifaceted Roles of MicroRNAs in Host-Bacterial Pathogen Interaction 247<br /><i>Carmen Aguilar, Miguel Mano, and Ana Eulalio</i></p> <p>18. Modulation of Host Cell Metabolism by <i>Chlamydia trachomatis</i> 267<br /><i>Marion Rother, Ana Rita Teixeira da Costa, Rike Zietlow, Thomas F. Meyer, and Thomas Rudel</i></p> <p><b>III. Autonomous defense pathways in the cell</b></p> <p>19. Host-Encoded Sensors of Bacteria: Our Windows into the Microbial World 279<br /><i>Charlotte Odendall and Jonathan C. Kagan</i></p> <p>20. Recognition of Intracellular Bacteria by Inflammasomes 287<br /><i>Petr Broz</i></p> <p><b>IV. New technologies to move cellular microbiology to organs and tissues</b></p> <p>21. Modeling Infectious Diseases in Mice with a “Humanized” Immune System 301<br /><i>Yan Li and James P. di Santo</i></p> <p>22. A Cinematic View of Tissue Microbiology in the Live Infected Host 315<br /><i>Agneta Richter-Dahlfors and Keira Melican</i></p> <p>23. Cellular Imaging of Intracellular Bacterial Pathogens 325<br /><i>Virginie Stévenin and Jost Enninga</i></p> <p>24. Using a Systems Biology Approach To Study Host-Pathogen Interactions 337<br /><i>Amy Yeung, Christine Hale, Simon Clare, Sophie Palmer, Josefin Bartholdson Scott, Stephen Baker,</i> <i>and Gordon Dougan</i></p> <p>Index 349</p>