<p><b>ROSALIND A. EELES, MA (Cantab), PhD, FRCP, FRCR, FMedSCI</b> is Professor of Oncogenetics and Team Leader in Oncogenetics at The Institute of Cancer Research and an Honorary Consultant in Cancer Genetics and Clinical Oncology at The Royal Marsden NHS Foundation Trust, London, UK <p><b>CHRISTINE D. BERG, MD</b> is Special Advisor to the Director, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Maryland, USA <p><b>JEFFREY S. TOBIAS, MA (Cantab), MD, FRCP, FRCR</b> is Professor of Cancer Medicine at the Department of Oncology, University College London, and Honorary Consultant at University College Hospital Foundation Trust, London, UK