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Mitochondrial Dysfunction Caused by Drugs and Environmental Toxicants


Mitochondrial Dysfunction Caused by Drugs and Environmental Toxicants


1. Aufl.

von: Yvonne Will, James A. Dykens

317,99 €

Verlag: Wiley
Format: EPUB
Veröffentl.: 23.03.2018
ISBN/EAN: 9781119329749
Sprache: englisch
Anzahl Seiten: 816

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Beschreibungen

Developed as a one-stop reference source for drug safety and toxicology professionals, this book explains why mitochondrial failure is a crucial step in drug toxicity and how it can be avoided. <br /><br />•    Covers both basic science and applied technology / methods<br />•    Allows readers to understand the basis of mitochondrial function, the preclinical assessments used, and what they reveal about drug effects<br />•    Contains both in vitro and in vivo methods for analysis, including practical screening approaches for drug discovery and development<br />•    Adds coverage about mitochondrial toxicity underlying organ injury, clinical reports on drug classes, and discussion of environmental toxicants affecting mitochondria
<p><b>Volume 1</b></p> <p>List of Contributors xvii</p> <p>Foreword xxix</p> <p><b>Part 1 Basic Concepts 1</b></p> <p>1 Contributions of Plasma Protein Binding and Membrane Transporters to Drug?]Induced Mitochondrial Toxicity 3<br /><i>Gavin P. McStay</i></p> <p>2 The Role of Transporters in Drug Accumulation and Mitochondrial Toxicity 15<br /><i>Kathleen M. Giacomini and Huan?]Chieh Chien</i></p> <p>3 Structure–Activity Modeling of Mitochondrial Dysfunction 25<br /><i>Steve Enoch, Claire Mellor, and Mark Nelms</i></p> <p>4 Mitochondria?]Targeted Cytochromes P450 Modulate Adverse Drug Metabolism and Xenobiotic Induced Toxicity 35<br /><i>Haider Raza, F. Peter Guengerich, and Narayan G. Avadhani</i></p> <p><b>Part 2 Organ Drug Toxicity: Mitochondrial Etiology 47</b></p> <p>5 Mitochondrial Dysfunction in Drug?]Induced Liver Injury 49<br /><i>Annie Borgne?]Sanchez and Bernard Fromenty</i></p> <p>6 Evaluating Mitotoxicity as Either a Single or Multi?]Mechanistic Insult in the Context of Hepatotoxicity 73<br /><i>Amy L. Ball, Laleh Kamalian, Carol E. Jolly, and Amy E. Chadwick</i></p> <p>7 Cardiotoxicity of Drugs: Role of Mitochondria 93<br /><i>Zoltan V. Varga and Pal Pacher</i></p> <p>8 Skeletal Muscle Mitochondrial Toxicity 111<br /><i>Eric K. Herbert, Saul R. Herbert, and Karl E. Herbert</i></p> <p>9 Manifestations of Drug Toxicity on Mitochondria in the Nervous System 133<br /><i>Jochen H. M. Prehn and Irene Llorente?]Folch</i></p> <p>10 Nephrotoxicity: Increasing Evidence for a Key Role of Mitochondrial Injury and Dysfunction and Therapeutic Implications 169<br /><i>Ana Belén Sanz, Maria Dolores Sanchez?]Niño, Adrian M. Ramos, and Alberto Ortiz</i></p> <p>11 Mammalian Sperm Mitochondrial Function as Affected by Environmental Toxicants, Substances of Abuse, and Other Chemical Compounds 185<br /><i>Sandra Amaral, Renata S. Tavares, Sara Escada?]Rebelo, Andreia F. Silva, and João Ramalho?]Santos</i></p> <p><b>Part 3 Methods to Detect Mitochondrial Toxicity: In Vitro, Ex Vivo, In Vivo, Using Cells, Animal Tissues,</b> <b>and Alternative Models 205</b></p> <p>12 Biological and Computational Techniques to Identify Mitochondrial Toxicants 207<br /><i>Robert B. Cameron, Craig C. Beeson, and Rick G. Schnellmann</i></p> <p>13 The Parallel Testing of Isolated Rat Liver and Kidney Mitochondria Reveals a Calcium?]Dependent Sensitivity to Diclofenac and Ibuprofen 217<br /><i>Sabine Schulz, Sabine Borchard, Tamara Rieder, Carola Eberhagen, Bastian Popper, Josef</i> <i>Lichtmannegger, Sabine Schmitt, and Hans Zischka</i></p> <p>14 In Vitro Methodologies to Investigate Drug?]Induced Toxicities 229<br /><i>Rui F. Simões, Teresa Cunha?]Oliveira, Cláudio F. Costa, Vilma A. Sardão, and Paulo J. Oliveira</i></p> <p>15 Combined Automated Measurement of Respiratory Chain Complexes and Oxidative Stress: A First Step to an Integrated View of Cell Bioenergetics 249<br /><i>Marc Conti, Thierry Delvienne, and Sylvain Loric</i></p> <p>16 Measurement of Mitochondrial Toxicity by Flow Cytometry 265<br /><i>Padma Kumar Narayanan and Nianyu Li</i></p> <p>17 MitoChip: A Transcriptomics Tool for Elucidation of Mechanisms of Mitochondrial Toxicity 275<br /><i>Varsha G. Desai, and G. Ronald Jenkins</i></p> <p>18 Using 3D Microtissues for Identifying Mitochondrial Liabilities 295<br /><i>Simon Messner, Olivier Frey, Katrin Rössger, Andy Neilson, and Jens M. Kelm</i></p> <p>19 Toward Mitochondrial Medicine: Challenges in Rodent Modeling of Human Mitochondrial Dysfunction 305<br /><i>David A. Dunn, Michael H. Irwin, Walter H. Moos, Kosta Steliou, and Carl A. Pinkert</i></p> <p>20 Measurement of Oxygen Metabolism In Vivo 315<br /><i>M. P. J. van Diemen, R. Ubbink, F. M. Münker, E. G. Mik, and G. J. Groeneveld</i></p> <p>21 Detection of Mitochondrial Toxicity Using Zebrafish 323<br /><i>Sherine S. L. Chan and Tucker Williamson</i></p> <p>22 MiRNA as Biomarkers of Mitochondrial Toxicity 347<br /><i>Terry R. Van Vleet and Prathap Kumar Mahalingaiah</i></p> <p>23 Biomarkers of Mitochondrial Injury After Acetaminophen Overdose: Glutamate Dehydrogenase and Beyond 373<br /><i>Benjamin L. Woolbright and Hartmut Jaeschke</i></p> <p>24 Acylcarnitines as Translational Biomarkers of Mitochondrial Dysfunction 383<br /><i>Richard D. Beger, Sudeepa Bhattacharyya, Pritmohinder S. Gill, and Laura P. James</i></p> <p>25 Mitochondrial DNA as a Potential Translational Biomarker of Mitochondrial Dysfunction in Drug?]Induced Toxicity Studies 395<br /><i>Afshan N. Malik</i></p> <p>26 Predicting Off?]Target Effects of Therapeutic Antiviral Ribonucleosides: Inhibition of Mitochondrial RNA Transcription 407<br /><i>Jamie J. Arnold and Craig E. Cameron</i></p> <p>27 Imaging of Mitochondrial Toxicity in the Kidney 419<br /><i>Andrew M. Hall, Joana R. Martins, and Claus D. Schuh</i></p> <p>28 Imaging Mitochondrial Membrane Potential and Inner Membrane Permeability 429<br /><i>Anna?]Liisa Nieminen, Venkat K. Ramshesh, and John J. Lemasters</i></p> <p>29 Quantifying Skeletal Muscle Mitochondrial Function In Vivo by 31P Magnetic Resonance Spectroscopy 443<br /><i>Graham J. Kemp</i></p> <p> </p> <p><b>Volume 2</b></p> <p>List of Contributors xiii</p> <p>Foreword xxv</p> <p><b>Part 4 Reports from the Clinic 457</b></p> <p>30 Statin and Fibrate?]Induced Dichotomy of Mitochondrial Function 459<br /><i>Viruna Neergheen, Alex Dyson, Luke Wainwright, and Iain P. Hargreaves</i></p> <p>31 Friend or Foe: Can Mitochondrial Toxins Lead to Similar Benefits as Exercise? 475<br /><i>Sofia Annis, Adeel Safdar, Eduardo Biala, Ayesha Saleem, Housaiyin Li, Priya Gandhi, Zoe Fleischmann,</i> <i>Carmen Castaneda?]Sceppa, Jonathan L. Tilly, Dori C. Woods, and Konstantin Khrapko</i></p> <p>32 Involvement of Mitochondrial Dysfunction on the Toxic Effects Caused by Drugs of Abuse and Addiction 487<br /><i>Daniel José Barbosa, João Paulo Capela, Maria de Lourdes Bastos, and Félix Carvalho</i></p> <p>33 Drug?]Induced Mitochondrial Toxicity during Pregnancy 509<br /><i>Diana Luz Juárez-Flores, Ana Sandra Hernández, Laura Garcia, Mariona Guitart?]Mampel, Marc Catalan?]Garcia, Ingrid Gonzalez?]Casacuberta, Jose César Milisenda, Josep Maria Grau, Francesc Cardellach,</i> <i>Constanza Morén, and Glòria Garrabou</i></p> <p>34 Mitochondrial Toxicity in Children and Adolescents Exposed to Antiretroviral Therapy 521<br /><i>Antoni Noguera?]Julian, Eneritz Velasco?]Arnaiz, and Clàudia Fortuny</i></p> <p>35 Drug?]Induced Mitochondrial Cardiomyopathy and Cardiovascular Risks in Children 529<br /><i>Neha Bansal, Mariana Gerschenson, Tracie L. Miller, Stephen E. Sallan, Jason Czachor, Hiedy Razoky,</i> <i>Ashley Hill, Miriam Mestre, and Steven E. Lipshultz</i></p> <p>36 Role of Mitochondrial Dysfunction in Linezolid?]Induced Lactic Acidosis 547<br /><i>Alessandro Santini, Dario Ronchi, Daniela Piga, and Alessandro Protti</i></p> <p>37 Metformin and Lactic Acidosis 559<br /><i>Jean?]Daniel Lalau</i></p> <p>38 Lessons Learned from a Phase I Clinical Trial of Mitochondrial Complex I Inhibition 563<br /><i>Cecilia C. Low Wang, Jeffrey L. Galinkin, and William R. Hiatt</i></p> <p>39 Pharmacological Activation of Mitochondrial Biogenesis for the Treatment of Various Pathologies 569<br /><i>Whitney S. Gibbs, Natalie E. Scholpa, Craig C. Beeson, and Rick G. Schnellmann</i></p> <p>40 Mitochondrial Toxicity Induced by Chemotherapeutic Drugs 593<br /><i>Luciana L. Ferreira, Ana Raquel Coelho, Paulo J. Oliveira, and Teresa Cunha?]Oliveira</i></p> <p><b>Part 5 Environmental Toxicants and Mitochondria 613</b></p> <p>41 The Mitochondrial Exposome 615<br /><i>Douglas I. Walker, Kurt D. Pennell, and Dean P. Jones</i></p> <p>42 Central Mitochondrial Signaling Mechanisms in Response to Environmental Agents: Integrated Omics for Visualization 639<br /><i>Young?]Mi Go, Karan Uppal, and Dean P. Jones</i></p> <p>43 Detection of Mitochondrial Toxicity of Environmental Pollutants Using Caenorhabditis elegans 655<br /><i>Laura L. Maurer, Anthony L. Luz, and Joel N. Meyer</i></p> <p>44 Persistent Organic Pollutants, Mitochondrial Dysfunction, and Metabolic Syndrome 691<br /><i>Hong Kyu Lee and Youngmi Kim Pak</i></p> <p>45 Cigarette Smoke and Mitochondrial Damage 709<br /><i>Jalal Pourahmad, Marjan Aghvami, Mohammad Hadi Zarei, and Parvaneh Naserzadeh</i></p> <p>Index 727</p>
<p><b>Yvonne Will, PhD,</b> is a Senior Director and the Head of Science and Technology Strategy, Drug Safety Research and Development at Pfizer, Connecticut, USA. In addition to the prior edition of this book, she co-edited <i>Drug Discovery Toxicology: From Target Assessment to Translational Biomarkers</i>(Wiley, 2016).</p> <b>James A. Dykens, PhD,</b> oversees EyeCyte Therapeutics, a start-up developing treatments for progressive blinding diseases via targeting mitochondrial dysfunction. He co-edited the first edition of this book.
<p>A major public health concern, despite regulatory vigilance, is untoward toxicity and other pharmaceutical side effects. This toxicity is often idiosyncratic, and usually not discovered until after a large population has been exposed and injured. Recent laboratory evaluations show that many of these drugs impact mitochondrial function. The realization that mitochondrial toxicity is a widespread and important issue in drug toxicity is increasingly appreciated, and most pharmaceutical companies now either have the technology to assess this risk themselves, or do so via contract research organizations.</p> <p>Developed as a one-stop reference source for drug safety and toxicology professionals, the  second edition of <i>Drug and Environmental Induced Mitochondrial Dysfunction</i> explains why mitochondrial failure is a crucial step in drug toxicity and how it can be avoided. It allows readers to understand the basis of mitochondrial function and the preclinical assessments used and what they reveal about drug effects. The focus is on how the requisite technology continues to evolve and the recent emergence of clinical techniques capable of detecting drug-induced mitochondrial toxicity in patients.</p> <p>Added coverage in the 2<sup>nd</sup> edition includes how and why mitochondrial toxicity underlies organ injury, clinical reports on drug classes, and discussion of environmental toxicants that can affect mitochondria. With chapters contributed by leading specialists in their areas, <i>Drug and Environmental Induced Mitochondrial Dysfunction</i>, <i>2<sup>nd</sup> Edition </i>continues to serve as a valuable resource for safety assessment professionals in the pharmaceutical industry – including bench scientists and managers – and for pharmacologists and toxicologists in both drug and environmental health sciences.<br /><br /><i>Drug and Environmental Induced Mitochondrial Dysfunction </i>provides ample reminders of the intimate connections between mitochondria, pharmacology, and toxicology.  The book takes a rather systematic approach to mitochondrial pharmacology and toxicology and, for this reason, will be of use to even those outside of strict drug discovery.</p>

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