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<p><b>Foreword</b> <i>Mark P. Mattson</i> xi</p> <p><b>Preface</b> <i>Tahira Farooqui and Akhlaq A. Farooqui</i> xiii</p> <p><b>Acknowledgments</b> <i>Tahira Farooqui and Akhlaq A. Farooqui</i> xv</p> <p><b>Contributors xvii</b></p> <p><b>1 Insulin Resistance and Metabolic Failure Underlie Alzheimer Disease 1</b><br /> <i>Suzanne M. de la Monte and Ming Tong</i></p> <p><b>2 Insulin Receptor and the Pathophysiology of Alzheimer Disease 31</b><br /> <i>Johanna Zemva and Markus Schubert</i></p> <p><b>3 Contribution of Insulin Resistance in Pathogenesis of Alzheimer Disease 51</b><br /> <i>Adnan Erol</i></p> <p><b>4 Insulin–Leptin Signaling in the Brain 75</b><br /> <i>Vicente Barrios, Emma Burgos-Ramos, and Jes´us Argente</i></p> <p><b>5 The Janus Face of Insulin in Brain 85</b><br /> <i>Ana Duarte, Emanuel Candeias, S´onia C. Correia, Renato X. Santos, Cristina Carvalho, Susana Cardoso, Ana I. Pl´acido, Maria S. Santos, Catarina R. Oliveira, and Paula I. Moreira</i></p> <p><b>6 Modulation of Cognition by Insulin and Aging: Implications for Alzheimer Disease 115</b><br /> <i>Maite Solas and Maria J. Ram´ýrez</i></p> <p><b>7 Contribution of Phospholipid, Sphingolipids, and Cholesterol-Derived Lipid Mediators in the Pathogenesis of Metabolic Syndrome and Neurological Disorders 137</b><br /> <i>Akhlaq A. Farooqui and Tahira Farooqui</i></p> <p><b>8 Lipids, Cholesterol, and Oxidized Cholesterol in Alzheimer Amyloid Beta-Mediated</b><br /> <b>Neurotoxicity 163</b><br /> <i>Mun’delanji C. Vestergaard, Masamune Morita, Tsutomu Hamada, and Masahiro Takagi</i></p> <p><b>9 Of Sound Mind and Body: Dietary Lifestyles, Promotion of Healthy Brain Aging, and Prevention of Dementia in Healthy Individuals 179</b><br /> <i>Giulio Maria Pasinetti, Amanda Bilski, Lap Ho, Jun Wang, Mario Ferruzzi, Masahito Yamada, Kenjiro Ono, and Salvatore Mannino</i></p> <p><b>10 Metabolic Syndrome as an Independent Risk Factor of Silent Brain Infarction 191</b><br /> <i>Jae-Sung Lim and Hyung-Min Kwon</i></p> <p><b>11 Neurochemical Linkage Among Metabolic Syndrome, Alzheimer Disease, and Depression 197</b><br /> <i>Undurti N. Das</i></p> <p><b>12 Alterations in the Endocannabinoid System as a Link Between Unbalanced Energy Homeostasis, Neuroinflammation, and Neurological and Neuropsychiatric Disorders 219</b><br /> <i>Tiziana Bisogno and Vincenzo Di Marzo</i></p> <p><b>13 Metabolic Syndrome, Alzheimer Disease, Schizophrenia, and Depression: Role for Leptin, Melatonin, Kynurenine Pathways, and Neuropeptides 235</b><br /> <i>George Anderson and Michael Maes</i></p> <p><b>14 Binge Eating and Metabolic Syndrome 249</b><br /> <i>Ignacio J´auregui-Lobera</i></p> <p><b>15 Phytochemical Principles in the Traditional Indian System of Medicine Used for the Management of Metabolic Syndrome 261</b><br /> <i>Syed Ibrahim Rizvi and Neetu Mishra</i></p> <p><b>16 Oxidative Stress and Obesity: Their Impact on Metabolic Syndrome 275</b><br /> <i>Morihiro Matsuda and Iichiro Shimomura</i></p> <p><b>17 The Relationship Among Obesity, Inflammation, and Insulin Resistance 283</b><br /> <i>Jean-Philippe Bastard and Bruno F`eve</i></p> <p><b>18 Involvement of Adipocytokines in Pathogenesis of Insulin Resistance, Obesity, and Metabolic Syndrome 297</b><br /> <i>Hardik Gandhi and Ramachandran Balaraman</i></p> <p><b>19 Obesity, Inflammation, and Vascular Disease: Novel Insight in the Role of Adipose Tissue 311</b><br /> <i>Paolo Calabro, Enrica Golia, Valeria Maddaloni, Giuseppe Limongelli, Brunella Ziello, Fabio Fimiani, Ilaria Jane Romano, Mario Crisci, Maria Giovanna Russo, Edward T.H. Yeh, and Raffaele Calabro</i></p> <p><b>20 Is Diabetes a Risk Factor for Parkinson Disease? 327</b><br /> <i>Akhlaq A. Farooqui and Tahira Farooqui</i></p> <p><b>21 Role of Iron in the Pathogenesis of Diabetes and Metabolic Syndrome 335</b><br /> <i>Lu Cai</i></p> <p><b>22 Contributions of AMP Kinase to the Pathogenesis of Type 2 Diabetes and Neurodegenerative Diseases 363</b><br /> <i>Mohamed Kodiha, Hicham Mahboubi, and Ursula Stochaj</i></p> <p><b>23 A_ Deposition, Insulin Signaling, and Tau Phosphorylation in Animal Models of Alzheimer Disease and Diabetes 383</b><br /> <i>Naoyuki Sato and Ryuichi Morishita</i></p> <p><b>24 In Vivo Evidence of the Convergence of Type 2 Diabetes and Alzheimer Disease 395</b><br /> <i>Sun Ah Park</i></p> <p><b>25 Metabolic Syndrome and its Impact on Cardiovascular Disease 409</b><br /> <i>John A. Larry</i></p> <p><b>26 Contribution of Inflammation, Adiponectin, and Obesity in Cardiovascular Diseases 423</b><br /> <i>Harald Mangge and Gunter Almer</i></p> <p><b>27 Brain and Cardiovascular Diseases: Molecular Aspects 439</b><br /> <i>Ewa Szczepanska-Sadowska</i></p> <p><b>28 Molecular Aspects of Dietary–Exercise Regimen for the Prevention of Metabolic Syndrome 461</b><br /> <i>Wataru Aoi</i></p> <p><b>29 Ghrelin, Lipid Metabolism, and Metabolic Syndrome 475</b><br /> <i>Pablo B. Mart´ýnez de Morentin, Sulay Tovar, Rub´en Nogueiras, Miguel L´opez, and Carlos Di´eguez</i></p> <p><b>30 Leptin and Cognitive Function 485</b><br /> <i>Jenni Harvey</i></p> <p><b>31 Fructose, Sugar Consumption, and Metabolic Diseases 501</b><br /> <i>Virgile Lecoultre and Luc Tappy</i></p> <p><b>32 Inflammation-Mediated Cognitive and Emotional Alterations in Experimental Models of Metabolic Syndrome 515</b><br /> <i>Nathalie Castanon and Sophie Lay´e</i><br /> <br /> <b>33 Summary and Perspective 529</b><br /> <i>Tahira Farooqui and Akhlaq A. Farooqui</i></p> <p><i>Index 539</i></p> <p><i>Color plate section is located between pages 196 and 197.</i></p>

<b>AKHLAQ FAROOQUI</b> is an Adjunct Associate Professor of Medical Biochemistry at Ohio State University. He is author of over 180 peer-reviewed research articles, and author/editor of eight books and an expert in fields of glycerophospholipid metabolism, excitotoxicity, bioactive ether lipids, and phospholipases A2 in brain. <p><b>TAHIRA FAROOQUI</b> is a Research Scientist in the Department of Entomology at Ohio State University. She is the author of 40 peer-reviewed research articles and several monographs and an expert on glycerophospholipid and sphingolipid metabolism, biogenic amines, and neural plasticity.</p>

<p>Metabolic syndrome is a recognized suite of biological risk factors that increase the likelihood of developing long-term health problems including a wide range of neurological disorders. <i>Metabolic Syndrome and Neurological Disorders</i> brings together information on the cluster of common pathologies which cause metabolic syndrome - obesity, insulin resistance, and hypertension - to provide a comprehensive and cutting edge exploration of the link between metabolic syndrome and neurological disorders.</p> <p><i>Metabolic Syndrome and Neurological Disorders</i> covers the molecular mechanisms thought to connect metabolic syndrome with neurological disorders ranging from stroke to neurodegenerative diseases. Chapters also look at how other factors such as oxidative stress and inflammation may play a role in disease development.</p> <p>Grounded in a series of epidemiological studies of metabolic-cognitive syndrome, <i>Metabolic Syndrome and Neurological Disorders</i> is a valuable reference for researchers and clinicians in the field.<br /> <br /> </p> <ul> <li>Comprehensive coverage of the molecular mechanisms behind the link between metabolic syndrome and stroke, Alzheimer disease, and depression</li> <li>Timely investigation of a health issue which will be of increasing importance given the aging of the world's population </li> <li>Written by leaders in the field of metabolic syndrome</li> <li>Unique, accessible exploration of a topic with relevance for a wide variety of disciplines, including neuroscientists, pharmacologists, and clinicians</li> </ul>

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