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<p>List of contributors xi</p> <p>Preface xxvii</p> <p>Acknowledgments xxix</p> <p>Part 1: INTRODUCTION</p> <p>1 Cardinal manifestations of cancer 3</p> <p>James F. Holland, Robert C. Bast, Jr., John C. Byrd,</p> <p>Carlo M. Croce, Ernest Hawk, Fadlo R. Khuri, Raphael</p> <p>E. Pollock, Apostolia M. Tsimberadou, Christopher G.</p> <p>Willett, and Cheryl L.Willman</p> <p>2 Biological hallmarks of cancer 7</p> <p>Douglas Hanahan and Robert A.Weinberg</p> <p>Part 2: TUMOR BIOLOGY</p> <p>3 Molecular biology, genetics, and translational</p> <p>models of human cancer 19</p> <p>Benno Traub, Florian Scheufele, Srinivas R.</p> <p>Viswanathan, Matthew Meyerson, and David A. Tuveson</p> <p>4 Oncogenes 49</p> <p>Marco A. Pierotti, Milo Frattini, Samantha Epistolio,</p> <p>Gabriella Sozzi, and Carlo M. Croce</p> <p>5 Tumor suppressor genes 73</p> <p>Fred Bunz and Bert Vogelstein</p> <p>6 Epigenetic contributions to human cancer 89</p> <p>Stephen B. Baylin</p> <p>7 Cancer genomics and evolution 101</p> <p>William P. D. Hendricks, Aleksandar Sekulic, Alan H.</p> <p>Bryce, Muhammed Murtaza, Pilar Ramos, Jessica D.</p> <p>Lang, Timothy G. Whitsett, Timothy K. McDaniel,</p> <p>Russell C. Rockne, Nicholas Banovich, and Jeffrey M. Trent</p> <p>8 Chromosomal aberrations in cancer 125</p> <p>Megan E. McNerney, Ari J. Rosenberg, and Michelle M.</p> <p>Le Beau</p> <p>9 MicroRNA expression in cancer 143</p> <p>Serge P. Nana-Sinkam, Mario Acunzo, and Carlo M. Croce</p> <p>10 Aberrant signaling pathways in cancer 151</p> <p>Luca Grumolato and Stuart A. Aaronson</p> <p>11 Differentiation therapy 161</p> <p>Sai-Juan Chen, Xiao-Jing Yan, Guang-Biao Zhou, and</p> <p>Zhu Chen</p> <p>12 Cancer stem cells 177</p> <p>Grace G. Bushnell,Michael D. Brooks, andMax S.Wicha</p> <p>13 Cancer and cell death 187</p> <p>John C. Reed</p> <p>14 Cancer cell immortality: targeting telomerase and</p> <p>telomeres 201</p> <p>Ilgen Mender, Zeliha G. Dikmen, and JerryW. Shay</p> <p>15 Cancer metabolism 211</p> <p>Natalya N. Pavlova, Aparna D. Rao, Ralph J.</p> <p>DeBerardinis, and Craig B.Thompson</p> <p>16 Tumor angiogenesis 223</p> <p>John V. Heymach, Amado Zurita-Saavedra, Scott</p> <p>Kopetz, Tina Cascone, MoniqueNilsson, and IreneGuijarro</p> <p>Part 3: QUANTITATIVE ONCOLOGY</p> <p>17 Cancer bioinformatics 247</p> <p>John N.Weinstein</p> <p>18 Systems biology and genomics 261</p> <p>Saima Hassan, Joe W. Gray, and LauraM.Heiser</p> <p>19 Statistical innovations in cancer research 269</p> <p>J. Jack Lee and Donald A. Berry</p> <p>20 Biomarker based clinical trial design in the era of</p> <p>genomic medicine 285</p> <p>R.Donald Harvey, Yuan Liu, Taofeek K.Owonikoko,</p> <p>and Suresh S. Ramalingam</p> <p>21 Clinical and research informatics data strategy for</p> <p>precision oncology 293</p> <p>Douglas Hartman, Uma Chandran, Michael Davis,</p> <p>Rajiv Dhir,William E. Shirey, Jonathan C. Silverstein,</p> <p>and Michael J. Becich</p> <p>Part 4: CARCINOGENESIS</p> <p>22 Chemical carcinogenesis 305</p> <p>Lorne J. Hofseth, AinsleyWeston, and Curtis C. Harris</p> <p>23 Ionizing radiation 325</p> <p>David J. Grdina</p> <p>24 Ultraviolet radiation carcinogenesis 333</p> <p>James E. Cleaver, Susana Ortiz-Urda, and Sarah Arron</p> <p>25 Inflammation and cancer 339</p> <p>Jelena Todoric, Atsushi Umemura, Koji Taniguchi, and</p> <p>Michael Karin</p> <p>26 RNA tumor viruses 347</p> <p>Robert C. Gallo and Marvin S. Reitz</p> <p>27 Herpesviruses 359</p> <p>Jeffrey I. Cohen</p> <p>28 Papillomaviruses and cervical neoplasia 367</p> <p>Michael F. Herfs, Christopher P. Crum, and KarlMunger</p> <p>29 Hepatitis viruses and hepatoma 373</p> <p>HongyangWang</p> <p>30 Parasites 379</p> <p>Mervat El Azzouni, Charbel F. Matar, Radwa Galal,</p> <p>Elio Jabra, and Ali Shamseddine</p> <p>Part 5: EPIDEMIOLOGY, PREVENTION, AND</p> <p>DETECTION</p> <p>31 Cancer epidemiology 391</p> <p>Veronika Fedirko, Kevin T. Nead, Carrie Daniel, and</p> <p>Paul Scheet</p> <p>32 Hereditary cancer syndromes: risk assessment and</p> <p>genetic counseling 403</p> <p>Rachel Bluebond, Sarah A. Bannon, Samuel M. Hyde,</p> <p>Ashley H.Woodson, Nancy Y.-Q. You, Karen H. Lu, and</p> <p>Banu Arun</p> <p>33 Behavioral approaches to cancer prevention 425</p> <p>Roberto Gonzalez and Maher Karam-Hage</p> <p>34 Diet and nutrition in the etiology and prevention</p> <p>of cancer 433</p> <p>Steven K. Clinton, Edward L. Giovannucci, Fred K.</p> <p>Tabung, and Elizabeth M. Grainger</p> <p>35 Chemoprevention of cancer 453</p> <p>Ernest Hawk, Karen C. Maresso, Powel Brown, Michelle</p> <p>I. Savage, and Scott M. Lippman</p> <p>36 Cancer screening and early detection 473</p> <p>OtisW. Brawley</p> <p>Part 6: CLINICAL DISCIPLINES</p> <p>37 Clinical cancer genomic diagnostics and modern</p> <p>diagnostic pathology 493</p> <p>Katherine Roth, Stephen B. Gruber, and Kevin McDonnell</p> <p>38 Molecular diagnostics in cancer 505</p> <p>Zachary L. Coyne, Roshni D. Kalachand, Robert C. Bast</p> <p>Jr., Gordon B. Mills, and Bryan T. Hennessy</p> <p>39 Principles of imaging 519</p> <p>Lawrence H. Schwartz</p> <p>40 Interventional radiology for the cancer patient 521</p> <p>Zeyad A. Metwalli, Judy U. Ahrar, andMichael J. Wallace</p> <p>41 Principles of surgical oncology 531</p> <p>ToddW. Bauer, Kenneth K. Tanabe, and Raphael E. Pollock</p> <p>42 Principles of radiation oncology 543</p> <p>Scott R. Floyd, Justus Adamson, Philip P. Connell, Ralph</p> <p>R.Weichselbaum, and Christopher G.Willett</p> <p>43 Principles of medical oncology 553</p> <p>Apostolia M. Tsimberidou, Robert C. Bast, Jr., Fadlo R.</p> <p>Khuri, and John C. Byrd</p> <p>44 Pain and palliative care 567</p> <p>Laura Van Metre Baum and Cardinale B. Smith</p> <p>45 Psycho-oncology 577</p> <p>Diya Banerjee and Andrew J. Roth</p> <p>46 Principles of cancer rehabilitation medicine 585</p> <p>Michael D. Stubblefield, Miguel Escalon, Sofia A.</p> <p>Barchuk, Krina Vyas, and David C.Thomas</p> <p>47 Integrative oncology in cancer care 593</p> <p>Gabriel Lopez,Wenli Liu, Santhosshi Narayanan, and</p> <p>Lorenzo Cohen</p> <p>48 Health services research 599</p> <p>Michaela A. Dinan and Devon K. Check</p> <p>Part 7: INDIVIDUALIZED TREATMENT</p> <p>49 Precision medicine in oncology drug development 613</p> <p>Apostolia M. Tsimberidou, Elena Fountzilas, and</p> <p>Razelle Kurzrock</p> <p>Part 8: CHEMOTHERAPY</p> <p>50 Drug development of small molecule cancer</p> <p>therapeutics in an Academic Cancer Center 631</p> <p>Christopher C. Coss, Jeffrey T. Patrick, Damien Gerald,</p> <p>Gerard Hilinski, Reena Shakya, and John C. Byrd</p> <p>51 Principles of dose, schedule, and combination</p> <p>therapy 641</p> <p>Joseph P. Eder and Navid Hafez</p> <p>52 Pharmacology of small-molecule anticancer agents 655</p> <p>Zahra Talebi, Sharyn D. Baker, and Alex Sparreboom</p> <p>53 Folate antagonists 667</p> <p>Lisa Gennarini, Peter D. Cole, and Joseph R. Bertino</p> <p>54 Pyrimidine and purine antimetabolites 679</p> <p>Robert B. Diasio and StevenM. Offer</p> <p>55 Alkylating agents and platinum antitumor</p> <p>compounds 693</p> <p>Zahid H. Siddik</p> <p>56 DNA topoisomerase targeting drugs 701</p> <p>AnishThomas, Susan Bates,William D. Figg, Sr., and</p> <p>Yves Pommier</p> <p>57 Microtubule inhibitors 717</p> <p>Giuseppe Galletti and Paraskevi Giannakakou</p> <p>58 Drug resistance and its clinical circumvention 731</p> <p>Jeffrey A. Moscow, Shannon K. Hughes, Kenneth H.</p> <p>Cowan, and Branimir I. Sikic</p> <p>Part 9: BIOLOGICAL AND GENE THERAPY</p> <p>59 Cytokines, interferons, and hematopoietic growth</p> <p>factors 739</p> <p>Narendranath Epperla,Walter Hanel, and Moshe Talpaz</p> <p>60 Monoclonal antibody and targeted toxin therapy 755</p> <p>Robert C. Bast, Jr. andMichael R. Zalutsky</p> <p>61 Vaccines and immunomodulators 781</p> <p>Jeffrey Schlom, Sofia R. Gameiro, Claudia Palena, and</p> <p>James L. Gulley</p> <p>62 T cell immunotherapy of cancer 789</p> <p>M. Lia Palomba, Jae H. Park, and Renier Brentjens</p> <p>63 Cancer immunotherapy 799</p> <p>Padmanee Sharma, Swetha Anandhan, Bilal A.</p> <p>Siddiqui, Sangeeta Goswami, Sumit K. Subudhi, Jianjun</p> <p>Gao, Karl Peggs, Sergio Quezada, and James P. Allison</p> <p>64 Cancer gene therapy 817</p> <p>Haruko Tashiro, Lauren Scherer, and Malcolm Brenner</p> <p>65 Cancer nanotechnology 825</p> <p>Xingya Jiang, Yanlan Liu, Danny Liu, Jinjun Shi, and</p> <p>Robert Langer</p> <p>66 Hematopoietic cell transplantation 833</p> <p>Qaiser Bashir, Elizabeth J. Shpall, and Richard E. Champlin</p> <p>Part 10: SPECIAL POPULATIONS</p> <p>67 Principles of pediatric oncology 847</p> <p>Theodore P. Nicolaides, Elizabeth Raetz, andWilliam L.</p> <p>Carroll</p> <p>68 Cancer and pregnancy 867</p> <p>Jennifer K. Litton</p> <p>69 Cancer and aging 877</p> <p>Ashley E. Rosko, Carolyn J. Presley, Grant R.Williams,</p> <p>and Rebecca L. Olin</p> <p>70 Disparities in cancer care 885</p> <p>OtisW. Brawley</p> <p>71 Neoplasms in people living with human</p> <p>immunodeficiency virus 895</p> <p>Chia-Ching J.Wang and Elizabeth Y. Chiao</p> <p>72 Cancer survivorship 911</p> <p>Lewis Foxhall</p> <p>Part 11: DISEASE SITES</p> <p>73 Primary neoplasms of the brain in adults 921</p> <p>Matthew A. Smith-Cohn and Mark R. Gilbert</p> <p>74 Neoplasms of the eye and orbit 933</p> <p>Erica R. Alvarez, Claudia M. Prospero Ponce, Patricia</p> <p>Chevez-Barrios, and Dan S. Gombos</p> <p>75 Neoplasms of the endocrine glands and pituitary</p> <p>neoplasms 943</p> <p>Rui Feng, Chirag D. Gandhi, Margaret Pain, and</p> <p>Kalmon D. Post</p> <p>76 Neoplasms of the thyroid 949</p> <p>Matthew D. Ringel</p> <p>77 Malignant tumors of the adrenal gland 961</p> <p>Jeffrey E. Lee, Mouhammed A. Habra, andMatthew T.</p> <p>Campbell</p> <p>78 Tumors of the diffuse neuroendocrine and</p> <p>gastroenteropancreatic system 971</p> <p>Evan Vosburgh</p> <p>79 Neoplasms of the head and neck 981</p> <p>Robert L. Ferris, AdamS. Garden, andNabil F. Saba</p> <p>80 Cancer of the lung 1005</p> <p>Daniel Morgensztern, Daniel Boffa, Alexander Chen,</p> <p>Andrew Dhanasopon, Sarah B. Goldberg, Roy H.</p> <p>Decker, Siddhartha Devarakonda, Jane P. Ko, Luisa M.</p> <p>Solis Soto, Saiama N.Waqar, Ignacio I.Wistuba, and</p> <p>Roy S. Herbst</p> <p>81 Malignant pleural mesothelioma 1029</p> <p>Michele Carbone, Daniel R. Gomez, Anne S. Tsao,</p> <p>Haining Yang, and Harvey I. Pass</p> <p>82 Thymomas and thymic tumors 1043</p> <p>Mayur D. Mody,Gabriel L. Sica, Suresh S. Ramalingam,</p> <p>and Dong M. Shin</p> <p>83 Tumors of the heart and great vessels 1055</p> <p>Moritz C.Wyler von Ballmoos and Michael J. Reardon</p> <p>84 Primary germ cell tumors of the thorax 1061</p> <p>John D. Hainsworth and Frank A. Greco</p> <p>85 Neoplasms of the esophagus 1065</p> <p>MaxW. Sung and Virginia R. Litle</p> <p>86 Carcinoma of the stomach 1083</p> <p>Carl Schmidt, Nour Daboul, Carly Likar, and JoshuaWeir</p> <p>87 Primary neoplasms of the liver 1095</p> <p>Hop S. Tran Cao, Junichi Shindoh, and Jean-Nicolas</p> <p>Vauthey</p> <p>88 Gallbladder and bile duct cancer 1109</p> <p>Mariam F. Eskander, Christopher T. Aquina, and</p> <p>Timothy M. Pawlik</p> <p>89 Neoplasms of the exocrine pancreas 1123</p> <p>Robert A. Wolff, Donghui Li, AnirbanMaitra, Susan</p> <p>Tsai, Eugene Koay, and Douglas B. Evans</p> <p>90 Neoplasms of the appendix and peritoneum 1139</p> <p>Annie Liu, Diana Cardona, and Dan Blazer</p> <p>91 Carcinoma of the colon and rectum 1147</p> <p>Yota Suzuki, Douglas S. Tyler, and Uma R. Phatak</p> <p>92 Neoplasms of the anus 1169</p> <p>Alexandre A. A. Jácome and Cathy Eng</p> <p>93 Renal cell carcinoma 1181</p> <p>Claude M. Grigg, Earle F. Burgess, Stephen B. Riggs,</p> <p>Jason Zhu, and Derek Raghavan</p> <p>94 Urothelial cancer 1191</p> <p>Derek Raghavan, Richard Cote, Earle F. Burgess, Derek</p> <p>McHaffie, and Peter E. Clark</p> <p>95 Neoplasms of the prostate 1201</p> <p>Ana Aparicio, Patrick Pilie, Devaki S. Surasi, Seungtaek</p> <p>Choi, Brian F. Chapin, Christopher J. Logothetis, and</p> <p>Paul G. Corn</p> <p>96 Tumors of the penis and the urethra 1239</p> <p>Jad Chahoud, Andrea Necchi, and Philippe E. Spiess</p> <p>97 Testis cancer 1245</p> <p>Michael Hawking, Gladell Paner, Scott Eggener, and</p> <p>Walter M. Stadler</p> <p>98 Neoplasms of the vulva and vagina 1261</p> <p>Michael Frumovitz and Summer B. Dewdney</p> <p>99 Neoplasms of the cervix 1275</p> <p>Anuja Jhingran</p> <p>100 Endometrial cancer 1299</p> <p>Shannon N.Westin, Karen Lu, and Jamal Rahaman</p> <p>101 Epithelial ovarian, fallopian tube, and peritoneal</p> <p>cancer 1311</p> <p>Jonathan S. Berek, Malte Renz, Michael L. Friedlander,</p> <p>and Robert C. Bast, Jr.</p> <p>102 Nonepithelial ovarian malignancies 1329</p> <p>Jonathan S. Berek, Malte Renz, Michael L. Friedlander,</p> <p>and Robert C. Bast, Jr.</p> <p>103 Molar pregnancy and gestational trophoblastic</p> <p>neoplasia 1343</p> <p>Neil S. Horowitz, Donald P. Goldstein, and Ross S. Berkowitz</p> <p>104 Gynecologic sarcomas 1351</p> <p>Jamal Rahaman and Carmel J. Cohen</p> <p>105 Neoplasms of the breast 1361</p> <p>Debu Tripathy, Sukh Makhnoon, Banu Arun, Aysegul</p> <p>Sahin, Nicole M. Kettner, Senthil Damodaran, Khandan</p> <p>Keyomarsi,Wei Yang, Kelly K. Hunt, Mark Clemens,</p> <p>Wendy A. Woodward, Melissa P.Mitchell, Rachel</p> <p>Layman, Evthokia A. Hobbs, Bora Lim, MeganDupuis,</p> <p>Rashmi Murthy, Omar Alhalabi, Nuhad Ibrahim,</p> <p>Ishwaria M. Subbiah, and Carlos Barcenas</p> <p>106 Malignant melanoma 1413</p> <p>Michael J. Carr, JustinM. Ko, SusanM. Swetter, Scott E.</p> <p>Woodman, Vernon K. Sondak, Kim A. Margolin, and</p> <p>Jonathan S. Zager</p> <p>107 Other skin cancers 1437</p> <p>Stacy L. McMurray,William G. Stebbins, Eric A.</p> <p>Millican, and Victor A. Neel</p> <p>108 Bone tumors 1451</p> <p>Timothy A. Damron</p> <p>109 Soft tissue sarcomas 1477</p> <p>Katherine A.Thornton, Elizabeth H. Baldini, Robert G.</p> <p>Maki, Brian O’Sullivan, Yan Leyfman, and Chandrajit P. Raut</p> <p>110 Myelodysplastic syndromes 1501</p> <p>Uma M. Borate</p> <p>111 Acute myeloid leukemia in adults: mast cell</p> <p>leukemia and other mast cell neoplasms 1517</p> <p>RichardM. Stone, Charles A. Schiffer, and Daniel J. DeAngelo</p> <p>112 Chronic myeloid leukemia 1537</p> <p>Jorge Cortes, Richard T. Silver, and Hagop Kantarjian</p> <p>113 Acute lymphoblastic leukemia 1547</p> <p>Elias Jabbour, Nitin Jain, Hagop Kantarjian, and Susan</p> <p>O’Brien</p> <p>114 Chronic lymphocytic leukemia 1559</p> <p>Jacqueline C. Barrientos, Kanti R. Rai, and Joanna M. Rhodes</p> <p>115 Hodgkin lymphoma 1569</p> <p>David J. Straus and Anita Kumar</p> <p>116 Clonal hematopoiesis in cancer 1579</p> <p>Philipp J. Rauch and David P. Steensma</p> <p>117 Non-Hodgkin’s lymphoma 1587</p> <p>Arnold S. Freedman and Ann S. LaCasce</p> <p>118 Mycosis fungoides and Sézary syndrome 1603</p> <p>Walter Hanel, Catherine Chung, and John C. Reneau</p> <p>119 Plasma cell disorders 1611</p> <p>Andrew J. Yee, Teru Hideshima, Noopur Raje, and</p> <p>Kenneth C. Anderson</p> <p>120 Myeloproliferative disorders 1633</p> <p>Jeanne Palmer and Ruben Mesa</p> <p>Part 12: MANAGEMENT OF CANCER</p> <p>COMPLICATIONS</p> <p>121 Neoplasms of unknown primary site 1647</p> <p>John D. Hainsworth and Frank A. Greco</p> <p>122 Cancer cachexia 1659</p> <p>Assaad A. Eid, Rachel Njeim, Fadlo R. Khuri, and</p> <p>David K.Thomas</p> <p>123 Antiemetic therapy 1673</p> <p>Michael J. Berger andDavid S. Ettinger</p> <p>124 Neurologic complications of cancer 1683</p> <p>Luis Nicolas Gonzalez Castro, Tracy T. Batchelor, and</p> <p>Lisa M. DeAngelis</p> <p>125 Dermatologic complications of cancer</p> <p>chemotherapy 1701</p> <p>Anisha B. Patel, Padmavathi V. Karri, and Madeleine Duvic</p> <p>126 Skeletal complications 1715</p> <p>Michael A. Via, Ilya Iofin, Jerry Liu, and Jeffrey I. Mechanick</p> <p>127 Hematologic complications and blood bank</p> <p>support 1729</p> <p>Roger Belizaire and Kenneth C. Anderson</p> <p>128 Coagulation complications of cancer patients 1739</p> <p>Tzu-FeiWang and Kristin Sanfilippo</p> <p>129 Urologic complications related to cancer and its</p> <p>treatment 1747</p> <p>Omar Alhalabi, Ala Abudayyeh, and Nizar M. Tannir</p> <p>130 Cardiac complications 1757</p> <p>Michael S. Ewer, Steven M. Ewer, andThomas M. Suter</p> <p>131 Respiratory complications 1779</p> <p>Vickie R. Shannon, George A. Eapen, Carlos A. Jimenez,</p> <p>Horiana B. Grosu, Rodolfo C. Morice, Lara Bashoura,</p> <p>Ajay Sheshadre, Scott E. Evans, Roberto Adachi,</p> <p>Michael Kroll, Saadia A. Faiz, Diwakar</p> <p>D. Balachandran, Selvaraj E. Pravinkumar,</p> <p>and Burton F. Dickey</p> <p>132 Gastrointestinal and hepatic complications in</p> <p>cancer patients 1811</p> <p>Robert S. Bresalier, Emmanuel S. Coronel, and Hao Chi Zhang</p> <p>133 Oral complications of cancer and their treatment 1827</p> <p>Stephen T. Sonis, Anna Yuan, and Alessandro Villa</p> <p>134 Gonadal complications 1839</p> <p>RobertW. Lentz and Catherine E. Klein</p> <p>135 Sexual dysfunction 1849</p> <p>Leslie R. Schover</p> <p>136 Endocrine complications and paraneoplastic</p> <p>syndromes 1855</p> <p>Sai-Ching J. Yeung and Robert F. Gagel</p> <p>137 Infections in patients with cancer 1869</p> <p>Harrys A. Torres, Dimitrios P. Kontoyiannis, and</p> <p>Kenneth V.I. Rolston</p> <p>138 Oncologic emergencies 1883</p> <p>Sai-Ching J. Yeung and Carmen P. Escalante</p> <p>Part 13: THE FUTURE OF ONCOLOGY</p> <p>139 A vision for twenty-first century healthcare 1907</p> <p>Leroy Hood, Nathan D. Price, and James T. Yurkovich</p> <p>Index 1915</p> <p> </p>

<p>Edited by <p><b>Robert C. Bast Jr., MD,</b> Vice President for Translational Research, The University of Texas MD Anderson Cancer Center, Houston, TX, USA <p><b>John C. Byrd, MD,</b> The Gordon and Helen Hughes Taylor Professor and Chair, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA <p><b>Carlo Croce, MD,</b> Distinguished University Professor, The Ohio State University, The John W. Wolfe Chair in Human Cancer Genetics, Professor and Chair, Department of Cancer Biology and Genetics The Wexner Medical Center, The Ohio State University, Columbus, OH, USA <p><b>Ernest Hawk, MD, MPH, </b>Vice President for Cancer Prevention & Head, Division of Cancer Prevention and Population Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX, USA <p><b>Fadlo R. Khuri, MD,</b> President and Professor of Internal Medicine, Hematology and Medical Oncology, The American University of Beirut, Beirut, Lebanon <p><b>Raphael Pollock, MD, PhD, FACS,</b> Director, The Ohio State University Comprehensive Cancer Center, Kathleen Wellenreiter Klotz Chair in Cancer Research, The Ohio State University Wexner Medical Center, Columbus, OH, USA <p><b>Apostolia M. Tsimberidou, MD, PhD, </b>Professor, Department of Investigational Cancer Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA <p><b>Christopher Willett, MD, </b>Professor and Chair, Department of Radiation Oncology, Duke University School of Medicine, Boston, Massachusetts, USA <p><b>Cheryl Willman, MD, </b>Executive Director, Mayo Clinic Cancer Center Programs: Mayo Rochester/Midwest, Mayo Arizona, Mayo Florida, London, Abu Dhabi, Director, Mayo Clinic Comprehensive Cancer Center, Professor of Laboratory Medicine and Pathology, College of Medicine, Mayo Clinic Cancer Center, Rochester, NY, USA

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