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<p>Preface x</p> <p>Note to the Reader xi</p> <p>Acknowledgements xii</p> <p>Abbreviations xv</p> <p>1 Malaria – one swallow makes a summer 1</p> <p>2 The significance of irregularly contracted cells and hemighosts in sickle cell disease 2</p> <p>3 Striking dyserythropoiesis in sickle cell anemia following an aplastic crisis 3</p> <p>4 A normal mean cell volume does not exclude a diagnosis of megaloblastic anemia 4</p> <p>5 Prominent Howell–Jolly bodies when megaloblastic anemia develops in a hyposplenic patient 6</p> <p>6 A ghostly presence – G6PD deficiency 7</p> <p>7 G6PD deficiency in patients identified as female 8</p> <p>8 The cause of sudden anemia revealed by the blood film 9</p> <p>9 Choreo- acanthocytosis 10</p> <p>10 Lead poisoning 12</p> <p>11 Dysplastic neutrophils in an HIV- positive woman 14</p> <p>12 Help with HELLP 15</p> <p>13 Neutrophil dysplasia induced by granulocyte colony- stimulating factor 16</p> <p>14 COVID- 19 and acute kidney injury 17</p> <p>15 Diagnosis of pyrimidine 5′ nucleotidase deficiency suspected from a blood film 19</p> <p>16 Bone marrow aspirate in Chédiak–Higashi syndrome 20</p> <p>17 Phytosterolemia 21</p> <p>18 Pseudo- Chédiak–Higashi inclusions together with Auer rods in acute myeloid leukemia 22</p> <p>19 Botryoid nuclei resulting from cocaine abuse 23</p> <p>20 Infantile pyknocytosis 25</p> <p>21 Splenic rupture in cytomegalovirus infection 27</p> <p>22 A new diagnosis of monoclonal B- cell lymphocytosis with cytoplasmic inclusions in a patient with COVID- 19 29</p> <p>23 Pseudoplatelets and apoptosis in Burkitt lymphoma 31</p> <p>24 What is a promonocyte? 32</p> <p>25 Persistent neonatal jaundice resulting from hereditary pyropoikilocytosis 34</p> <p>26 Auer rods or McCrae rods? 36</p> <p>27 Observation of Auer rods in crushed cells in acute promyelocytic leukemia 37</p> <p>28 Alpha chain inclusions in peripheral blood erythroblasts and erythrocytes 39</p> <p>29 Dyserythropoiesis in visceral leishmaniasis 41</p> <p>30 Compound heterozygosity for hemoglobins S and D 42</p> <p>31 Granular B lymphoblastic leukemia 43</p> <p>32 Hyposplenism in adult T- cell leukemia/lymphoma 44</p> <p>33 Voxelotor in sickle cell disease 45</p> <p>34 The importance of a negative image 48</p> <p>35 Seeing what isn’t there 49</p> <p>36 A young woman with sudden onset of a severe coagulation abnormality 50</p> <p>37 Immature Plasmodium falciparum gametocytes in bone marrow 51</p> <p>38 Acute myeloid leukemia with myelodysplasia- related changes showing basophilic differentiation 52</p> <p>39 Thiamine- responsive megaloblastic anemia in an Iraqi girl 53</p> <p>40 Teardrop poikilocytes in metastatic carcinoma of the breast 54</p> <p>41 A blood film that could have averted a splenectomy 55</p> <p>42 Russell bodies and Mott cells 57</p> <p>43 Dutcher bodies 59</p> <p>44 Acute myeloid leukemia with inv(16)(p13.1q22) 61</p> <p>45 Dysplastic macropolycytes in myelodysplasia- related acute myeloid leukemia 63</p> <p>46 Diagnosis of cystinosis from a bone marrow aspirate 64</p> <p>47 Emperipolesis in a patient receiving romiplostim 65</p> <p>48 Mechanical hemolysis: a low mean cell volume does not always represent microcytosis 66</p> <p>49 Transplant- associated thrombotic microangiopathy 67</p> <p>50 Neuroblastoma in the bone marrow 69</p> <p>51 Gray platelet syndrome 70</p> <p>52 Diagnosis of systemic lupus erythematosus from a bone marrow aspirate 71</p> <p>53 Diagnosis from a blood film following a dog bite 72</p> <p>54 Interpreting a postpartum Kleihauer test 73</p> <p>55 Dengue fever in returning travellers 74</p> <p>56 Auer rod- like inclusions in multiple myeloma 76</p> <p>57 Azurophilic granules in myeloma cells 77</p> <p>58 Plasmodium knowlesi 78</p> <p>59 The cytological features of NPM1- mutated acute myeloid leukemia 79</p> <p>60 Irregularly contracted cells in Wilson disease 81</p> <p>61 Pseudo- Pelger–Huët neutrophil morphology due to sodium valproate toxicity 82</p> <p>62 The distinctive cytological features of T- cell prolymphocytic leukemia 83</p> <p>63 Eosinophil morphology in the reactive eosinophilia of Hodgkin lymphoma 86</p> <p>64 Malaria pigment 87</p> <p>65 Salmonella colonies in a bone marrow film 88</p> <p>66 Severe babesiosis due to Babesia divergens acquired in the UK 89</p> <p>67 Congenital acute megakaryoblastic leukemia 91</p> <p>68 Basophilic differentiation in transient abnormal myelopoiesis 92</p> <p>69 Methylene blue- induced Heinz body hemolytic anemia in a premature neonate 93</p> <p>70 Neutrophil vacuolation in acetominophen- induced acute liver failure 95</p> <p>71 Howell–Jolly bodies in acute hemolytic anemia 96</p> <p>72 The distinctive micromegakaryocytes of transformed chronic myeloid leukemia 97</p> <p>73 Copper deficiency 98</p> <p>74 Chronic neutrophilic leukemia 99</p> <p>75 Neutrophilic leukemoid reaction in multiple myeloma 101</p> <p>76 Persistent polyclonal B lymphocytosis 103</p> <p>77 Non- hemopoietic cells in the blood and bone marrow 104</p> <p>78 It’s a black day – metastatic melanoma in the bone marrow 105</p> <p>79 Dehydrated hereditary stomatocytosis 106</p> <p>80 Circulating lymphoma cells in intravascular large B- cell lymphoma 107</p> <p>81 Unusual inclusions in hemoglobin H disease post- splenectomy 108</p> <p>82 An unexpectedly bizarre blood film in hemoglobin H disease 109</p> <p>83 Acute myeloid leukemia with a severe coagulopathy and t(8;16)(p11;p13) 111</p> <p>84 Cold autoimmune hemolytic anemia secondary to atypical pneumonia 113</p> <p>85 A confusing ‘white cell count’ – circulating micromegakaryocytes in post- thrombocythemia myelofibrosis 114</p> <p>86 Diagnosis of follicular lymphoma from the peripheral blood 115</p> <p>87 Transformation of follicular lymphoma 117</p> <p>88 Cytology of systemic mastocytosis 118</p> <p>89 Systemic mastocytosis – the importance of looking within bone marrow fragments 119</p> <p>90 Schistocytosis is not always microangiopathic hemolytic anemia 120</p> <p>91 Hemoglobin C disease 121</p> <p>92 Hemoglobin St Mary’s 122</p> <p>93 Congenital sideroblastic anemia in a female 123</p> <p>94 A puzzling case of methemoglobinemia 125</p> <p>95 Hodgkin lymphoma in a bone marrow aspirate 127</p> <p>96 Giant proerythroblasts in pure red cell aplasia due to parvovirus B19 infection in a patient with rheumatoid arthritis 128</p> <p>97 A myeloid neoplasm with FIP1L1::PDGFRA presenting as acute myeloid leukemia 129</p> <p>98 Breast implant- associated anaplastic large cell lymphoma 131</p> <p>99 Large granular lymphocytosis induced by dasatinib 132</p> <p>100 The distinctive cytology and disease evolution of blastic plasmacytoid dendritic cell neoplasm 134</p> <p>101 Platelet phagocytosis as a cause of pseudothrombocytopenia 136</p> <p>Test yourself 137</p> <p>Answers to test cases 145</p> <p>Index 152</p>

<p><b>Barbara J. Bain</b> is a hematologist whose research is focused on morphology of blood cells, ethnic and biological differences in hematological variables and cytogenetics and molecular genetics in relation to hematology. She has collaborated with numerous experts in the field and contributed to the 2008 and 2016 editions of the WHO Classification of Tumours of Haemopoietic and Lymphoid Tissues.

<p><b>Timely morphology resource based on ongoing series of morphology updates published in the <i>American Journal of Hematology</i> since 2008</b> <p>This is the first book of its kind, written by renowned author Professor Barbara J. Bain, featuring a collection of instructive cases with interesting morphological features initially published in the <i>American Journal of Hematology</i>. This new book aims to bring these interesting and instructive cases to a wider readership. This book features updated cases and a “Test Yourself” section to aid in reader comprehension and information retention. <p>Cases covered in <i>Hematology: 101 Morphology Updates </i>include: <ul><li> The significance of irregularly contracted cells and hemighosts in sickle cell disease, and striking dyserythropoiesis in sickle cell anemia following an aplastic crisis</li> <li> Prominent Howell-Jolly bodies when megaloblastic anemia develops in a hyposplenic patient, and unusual aspects of G6PD deficiency</li> <li> The cause of sudden anemia revealed by the blood film, chorea-acanthocytosis and dysplastic neutrophils in an HIV-positive woman</li> <li> Neutrophil dysplasia induced by granulocyte colony-stimulating factor, and diagnosis of pyrimidine 5'-nucleotidase deficiency suspected from a blood film</li></ul> <p><i>Hematology: 101 Morphology Updates</i> is a key resource for consultant hematologists and clinical scientists, trainee hematologists and biomedical scientists. The audience may use this book to solve difficult diagnostic problems or as a source of teaching cases: for both personal learning, including exam revision or solving difficult cases, and as a teaching resource.

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