Flow and Microreactor Technology in Medicinal Chemistry
Methods & Principles in Medicinal Chemistry 1. Aufl.
<p><b>Learn to master a powerful technology to enable a faster drug discovery workflow</b> <p>The ultimate dream for medicinal chemists is the ability to synthesize new drug-like compounds with the push of a button. The key to synthesizing chemical compounds more quickly and accurately lies in computer-controlled technologies that can be optimized by machine learning. Recent developments in computer-controlled automated syntheses that rely on miniature flow reactors—with integrated analysis of the resulting products—provide a workable technology for synthesizing new chemical substances very quickly and with minimal effort. <p>In <i>Flow and Microreactor Technology in Medicinal Chemistry</i>, early adopters of this ground-breaking technology describe its current and potential uses in medicinal chemistry. Based on successful examples of the use of flow and microreactor synthesis for drug-like compounds, the book introduces current as well as emerging uses for automated synthesis in a drug discovery context. <p><i>Flow and Microreactor Technology in Medicinal Chemistry</i> readers will also find: <ul> <li>Numerous case studies that address the most common applications of this technology in the day-to-day work of medicinal chemists</li> <li>How to integrate flow synthesis with drug discovery</li> <li>How to perform enantioselective reactions under continuous flow conditions </li></ul><p><i>Flow and Microreactor Technology in Medicinal Chemistry</i> is<i> </i>a valuable practical reference for medicinal chemists, organic chemists, and natural products chemists, whether they are working in academia or in the pharmaceutical industry.
INTRODUCTION<br> Continuous flow technology for the fine chemical and pharmaceutical Industries.<br> CASE STUDIES<br> Novel (forbidden) chemistry towards NCE to increase chemical space<br> Enantioselective catalysis in continuous flow to improve throughput<br> Synthesis in continuous flow of important drugs and APIs<br> TECHNOLOGIES<br> HTE in continuous flow to speed library synthesis<br> Integration systems with continuous synthesis and biological screening<br> Microreactors for target validation (organ on a chip)<br> Process Analytical Technologies (PAT) and tools for controlled process design<br> Artificial Intelligence, Machine Learning and automatization in drug discovery<br> Emerging market challenges and on demand manufacturing<br>
<p><b>Esther Alza , PhD, </b>is the CEO and co-founder of Treellum Technologies in Barcelona, Spain. She previously managed the ERTFLOW group at the Institute of Chemical Research of Catalonia (ICIQ) in Tarragona, Spain. After receiving her PhD from ICIQ working on asymmetric catalysis and flow chemistry, she was a postdoctoral fellow at the University of Cambridge, before returning to ICIQ to lead the establishment the ERTFLOW technology development unit. <p><b> </b>
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