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<p>Contributors, ix</p> <p>Preface, xi</p> <p><b>1 The Immune System, 1</b><br /><i>M. Julia B. Felippe</i></p> <p>1.1 Definition, 1</p> <p>1.2 The organs of the immune system, 1</p> <p>1.3 The immune cells and soluble molecules, 2</p> <p>1.4 B and T cell activation in lymphoid tissues, 6</p> <p>1.5 When the immune response goes wrong, 9</p> <p>References, 10</p> <p><b>2 The Immune System of the Young Horse, 11</b><br /><i>Rebecca L. Tallmadge</i></p> <p>2.1 Definition, 11</p> <p>2.2 Equine immune system development, 11</p> <p>2.3 Unique susceptibilities and disorders of young horses, 16</p> <p>2.4 Vaccinology teaches about neonatal immunity, 18</p> <p>References, 18</p> <p><b>3 The Immune System of the Older Horse, 23</b><br /><i>Amanda A. Adams and David W. Horohov</i></p> <p>3.1 Definition, 23</p> <p>3.2 Clinical conditions associated with aging, 23</p> <p>3.3 Immunosenescence and vaccination, 23</p> <p>3.4 Nutrition in enhancing immunity in the old horse, 26</p> <p>3.5 Conclusion, 27</p> <p>References, 27</p> <p><b>4 Anaphylaxis, 31</b><br /><i>Rolfe M. Radcliffe</i></p> <p>4.1 Definition, 31</p> <p>4.2 Signalment and clinical signs, 31</p> <p>4.3 Immunologic mechanisms and etiologic associations, 32</p> <p>4.4 Diagnostics, 33</p> <p>4.5 Treatment, 34</p> <p>4.6 Prevention, 36</p> <p>4.7 Prognosis and clinical outcomes, 37</p> <p>References, 37</p> <p><b>5 Allergy, 39</b><br /><i>Bettina Wagner</i></p> <p>5.1 Definition, 39</p> <p>5.2 Culicoides hypersensitivity, 39</p> <p>5.3 Urticaria, 43</p> <p>5.4 Recurrent airway obstruction, 44</p> <p>References, 44</p> <p><b>6 Immune-Mediated Cytopenias, 47</b><br /><i>Thomas J. Divers</i></p> <p>6.1 Definition, 47</p> <p>6.2 Immune-mediated hemolytic anemia, 47</p> <p>6.3 Immune-mediated thrombocytopenia, 50</p> <p>6.4 Immune-mediated neutropenia, 53</p> <p>References, 54</p> <p><b>7 Bullous Diseases of the Skin and Mucosa, 55</b><br /><i>Jeanine Peters-Kennedy and Rebecca E. Ruby</i></p> <p>7.1 Definition, 55</p> <p>7.2 Immune-mediated bullous dermatoses, 55</p> <p>7.3 Pemphigus complex, 57</p> <p>7.4 Cutaneous adverse drug reactions, 61</p> <p>7.5 Erythema multiforme, 62</p> <p>7.6 Lupus erythematosus, 64</p> <p>References, 65</p> <p><b>8 Serum Sickness, 69</b><br /><i>Lais R.R. Costa</i></p> <p>8.1 Definition, 69</p> <p>8.2 Signalment and clinical signs, 69</p> <p>8.3 Immunologic mechanisms and etiologic associations, 69</p> <p>8.4 Diagnostics, 71</p> <p>8.5 Treatment and prevention, 71</p> <p>References, 72</p> <p><b>9 Vasculitis, 73</b><br /><i>James S. W. Prutton and Nicola Pusterla</i></p> <p>9.1 Definition, 73</p> <p>9.2 Signalment and clinical signs, 73</p> <p>9.3 Immunologic mechanisms and etiologic associations, 73</p> <p>9.4 Diagnostics, 75</p> <p>9.5 Treatment, 75</p> <p>9.6 Thrombophlebitis, 75</p> <p>9.7 Pastern and cannon leukocytoclastic vasculitis, 76</p> <p>9.8 Drug-induced vasculitis, 76</p> <p>9.9 Photo-activated vasculitis (photodynamic drugs), 77</p> <p>9.10 Strongylus vulgaris, 77</p> <p>9.11 Equine granulocytic anaplasmosis, 77</p> <p>9.12 Equine viral arteritis, 78</p> <p>9.13 Equine herpesvirus-1, 78</p> <p>9.14 African horse sickness, 78</p> <p>References, 79</p> <p><b>10 Purpura Hemorrhagica, 83</b><br /><i>Laszlo M. Hunyadi and Nicola Pusterla</i></p> <p>10.1 Definition, 83</p> <p>10.2 Signalment and clinical signs, 83</p> <p>10.3 Immunologic mechanisms and etiologic associations, 83</p> <p>10.4 Diagnostics, 84</p> <p>10.5 Treatment and prevention, 85</p> <p>References, 86</p> <p><b>11 Glomerulonephritis, 87</b><br /><i>M. Julia B. Felippe</i></p> <p>11.1 Definition, 87</p> <p>11.2 Signalment and clinical signs, 87</p> <p>11.3 Immunologic mechanisms and etiologic associations, 87</p> <p>11.4 Diagnostics, 88</p> <p>11.5 Treatment and prognosis, 88</p> <p>References, 88</p> <p><b>12 Inflammatory and Immune-Mediated Muscle Disorders, 91</b><br /><i>Sian Durward-Akhurst and Stephanie J. Valberg</i></p> <p>12.1 Definition, 91</p> <p>12.2 Infarctive purpura hemorrhagica, 91</p> <p>12.3 Rhabdomyolysis associated with Streptococcus equi, 93</p> <p>12.4 Immune-mediated myositis in Quarter Horse-related breeds, 94</p> <p>12.5 Systemic calcinosis, 96</p> <p>12.6 Uncharacterized immune-mediated and inflammatory myopathies, 97</p> <p>12.7 Sarcocystis myositis, 97</p> <p>References, 98</p> <p><b>13 Granulomatous Diseases, 101</b><br /><i>Lais R.R. Costa</i></p> <p>13.1 Definition, 101</p> <p>13.2 Signalment and clinical signs, 101</p> <p>13.3 Immunologic mechanisms and etiologic associations, 101</p> <p>13.4 Diagnostics, 104</p> <p>13.5 Treatment and prevention, 105</p> <p>13.6 Types of cell-mediated hypersensitivity reactions, 105</p> <p>References, 110</p> <p><b>14 Chronic Inflammatory Bowel Disease, 113</b><br /><i>Gillian A. Perkins</i></p> <p>14.1 Definition, 113</p> <p>14.2 Signalment and clinical signs, 113</p> <p>14.3 Immunologic mechanisms and etiologic associations, 113</p> <p>14.4 Diagnostics, 115</p> <p>14.5 Treatment and prognosis, 116</p> <p>References, 117</p> <p><b>15 Recurrent Uveitis, 121</b><br /><i>Brian C. Gilger</i></p> <p>15.1 Definition, 121</p> <p>15.2 Signalment and clinical signs, 121</p> <p>15.3 Immunologic mechanisms and etiologic associations, 121</p> <p>15.4 Diagnostics, 123</p> <p>15.5 Treatment and prevention, 124</p> <p>15.6 Prognosis and clinical outcomes, 124</p> <p>References, 125</p> <p><b>16 Recurrent Airway Obstruction and Summer Pasture-Associated Obstructive Pulmonary Disease, 127</b><br /><i>Michela Bullone and Jean-Pierre Lavoie</i></p> <p>16.1 Definition, 127</p> <p>16.2 Signalment and clinical signs, 127</p> <p>16.3 Immunologic mechanisms and etiologic associations, 128</p> <p>16.4 Diagnostics, 134</p> <p>16.5 Treatments and prevention, 136</p> <p>References, 137</p> <p><b>17 Inflammatory Airway Disease, 145</b><br /><i>Mathilde Leclère and Jean-Pierre Lavoie</i></p> <p>17.1 Definition, 145</p> <p>17.2 Signalment and clinical signs, 145</p> <p>17.3 Immunologic mechanisms and etiologic associations, 145</p> <p>17.4 Types of bronchoalveolar lavage fluid inflammation and cytokine profile, 147</p> <p>17.5 Links between IAD and heaves, 148</p> <p>17.6 Links between IAD and EIPH, 148</p> <p>17.7 Diagnostics, 148</p> <p>17.8 Treatment and prevention, 149</p> <p>17.9 Prognosis and clinical outcomes, 150</p> <p>References, 150</p> <p><b>18 Inflammation, Endotoxemia and Systemic Inflammatory Response Syndrome, 153</b><br /><i>Erin L. McConachie and Kelsey A. Hart</i></p> <p>18.1 Definition, 153</p> <p>18.2 Signalment and clinical signs, 154</p> <p>18.3 Immunologic mechanisms and etiologic associations, 155</p> <p>18.4 Multi-systemic response triggered by inflammatory mediators, 157</p> <p>18.5 Diagnostics, 160</p> <p>18.6 Treatment, 162</p> <p>18.7 Prognosis and clinical outcome, 166</p> <p>References, 166</p> <p><b>19 Leukemia, 173</b><br /><i>Tracy Stokol</i></p> <p>19.1 Definition, 173</p> <p>19.2 Classification of leukemias, 173</p> <p>19.3 Specialized diagnostic techniques for leukemia, 173</p> <p>19.4 Chronic leukemia, 175</p> <p>19.5 Acute leukemia, 177</p> <p>References, 179</p> <p><b>20 Lymphoma, 181</b><br /><i>SallyAnne L. Ness</i></p> <p>20.1 Definition, 181</p> <p>20.2 Signalment and clinical signs, 181</p> <p>20.3 Forms of equine lymphoma, 182</p> <p>20.4 Immunologic mechanisms and etiologic associations, 183</p> <p>20.5 Diagnostics, 183</p> <p>20.6 Classification of lymphomas, 185</p> <p>20.7 Prognosis and treatment, 186</p> <p>20.8 Monitoring, 189</p> <p>References, 189</p> <p><b>21 Immunodeficiencies, 193</b><br /><i>M. Julia B. Felippe</i></p> <p>21.1 Definition, 193</p> <p>21.2 Classification of immunodeficiencies, 194</p> <p>References, 202</p> <p><b>22 Immunologic Testing, 205</b><br /><i>M. Julia B. Felippe</i></p> <p>22.1 Definition, 205</p> <p>22.2 Types of immunologic testing, 205</p> <p>References, 211</p> <p><b>23 Non-steroidal Anti-inflammatories, 213</b><br /><i>Michelle H. Barton</i></p> <p>23.1 Definition, 213</p> <p>23.2 Non-steroidal anti-inflammatory drugs, 213</p> <p>References, 228</p> <p><b>24 Immunosuppressive Therapy, 237</b><br /><i>M. Julia B. Felippe</i></p> <p>24.1 Definition, 237</p> <p>24.2 Types of immunosuppressive drugs, 237</p> <p>References, 240</p> <p><b>25 Immunomodulators, 243</b><br /><i>Elizabeth G. Davis</i></p> <p>25.1 Definition, 243</p> <p>25.2 Immunologic mechanisms, 243</p> <p>25.3 Commercially available immunostimulants for use in horses, 244</p> <p>References, 249</p> <p><b>26 Immunoglobulin Therapy, 251</b><br /><i>Elizabeth G. Davis</i></p> <p>26.1 Definition, 251</p> <p>26.2 Immunologic mechanisms, 251</p> <p>References, 254</p> <p><b>27 Plasmapheresis, 257</b><br /><i>Nathan M. Slovis</i></p> <p>27.1 Definition, 257</p> <p>27.2 Methods for preparing plasma products, 257</p> <p>27.3 Apheresis, 258</p> <p>27.4 Therapeutic plasmapheresis, 258</p> <p>27.5 Complications of therapeutic plasmapheresis, 260</p> <p>References, 260</p> <p><b>28 Principles of Vaccination, 263</b><br /><i>Noah D. Cohen and Angela I. Bordin</i></p> <p>28.1 Definition, 263</p> <p>28.2 Efficacy and effectiveness of vaccines, 263</p> <p>28.3 Safety of vaccines, 271</p> <p>28.4 Key knowledge-gaps in equine vaccinology, 273</p> <p>28.5 Protocols for vaccination, 275</p> <p>References, 276</p> <p><b>29 Types of Vaccines, 279</b><br /><i>Angela I. Bordin and Noah D. Cohen</i></p> <p>29.1 Definition, 279</p> <p>29.2 Immunologic mechanisms, 279</p> <p>29.3 Immune responses to vaccination, 282</p> <p>29.4 Routes of vaccination, 284</p> <p>29.5 Adjuvants and vaccine delivery systems, 285</p> <p>29.6 Important diseases with unavailable effective vaccines, 285</p> <p>References, 286</p> <p><b>30 Transplantation Immunology, 289</b><br /><i>Rebecca L. Tallmadge</i></p> <p>30.1 Definition, 289</p> <p>30.2 Equine MHC genes: genomic organization and variation, 289</p> <p>30.3 Determining equine MHC haplotypes, 290</p> <p>30.4 Immunosuppression and engraftment, 291</p> <p>30.5 Graft rejection, 292</p> <p>30.6 Current transplantation applications, 293</p> <p>References, 294</p> <p><b>31 Mesenchymal Stem Cell Therapy, 297</b><br /><i>Gerlinde R. Van de Walle, Catharina De Schauwer and Lisa A. Fortier</i></p> <p>31.1 Definition, 297</p> <p>31.2 Regenerative functions of mesenchymal stem cells, 297</p> <p>31.3 Immunologic mechanisms and associations, 298</p> <p>31.4 Sources of equine mesenchymal stem cells, 299</p> <p>31.5 Characterization of equine mesenchymal stem cells, 300</p> <p>31.6 Applications of equine mesenchymal stem cells in equine regenerative medicine, 302</p> <p>References, 306</p> <p><b>32 Hematopoietic Stem Cell Transplantation, 311</b><br /><i>M. Julia B. Felippe</i></p> <p>32.1 Definition, 311</p> <p>32.2 Hematopoietic stem cell sources, 311</p> <p>32.3 Pre-transplantation conditioning, 313</p> <p>32.4 Post-transplantation immunosuppression, 313</p> <p>32.5 Hematopoietic stem cell transplantation in the horse, 313</p> <p>References, 315</p> <p>Index, 317</p>

<p><b>M. Julia B. Felippe</b>, MedVet, MSc, PhD, DACVIM, is an Associate Professor of Large Animal Medicine and Veterinary Curriculum Director at Cornell University’s College of Veterinary Medicine in Ithaca, New York, USA.</p>

<p><i>Equine Clinical Immunology </i>offers comprehensive information on equine immunological disorders.  Focusing specifically on diagnosing, treating, and managing conditions of the immune system in horses, the book is edited by a leading clinician in this area and contributed to by top experts in equine immunology.  Offering a practical, clinically oriented approach, <i>Equine Clinical Immunology</i> covers topics ranging from basic immunology and pathophysiology to specific immune disorders, testing, vaccination, and stem cell therapy. </p> <p>Designed to present a complete resource on the topic, the book uses illustrations, photographs, and tables to explain the concepts discussed.  Text boxes provide key concepts, clinical assessment, and treatment approaches.  <i>Equine Clinical Immunology</i> offers a valuable resource for equine specialists seeking information related to immune disorders in equine patients.  </p> <p><b>Key features <br /></b></p> <ul> <li>Provides a complete, equine-specific reference on clinical immunology</li> <li>Focuses on clinically relevant information for the diagnosis and treatment of horses with immune disorders</li> <li>Illustrates the concepts discussed using drawings, photographs, and tables</li> <li>Presents key concepts, clinical assessment information, and treatment approaches in text boxes for ease of use</li> <li>Offers a practical, clinically oriented approach ideal for equine specialists</li> </ul>

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